15,164 results match your criteria fibrosis markers

Human mesenchymal stem cells derived from amniotic membrane attenuate isoproterenol (ISO)-induced myocardial injury by targeting apoptosis.

Med J Islam Repub Iran 2021 26;35:82. Epub 2021 Jun 26.

Physiology Research Center, Iran University of Medical Sciences. Tehran, Iran.

Currently, stem cell therapy has been proposed as an efficient strategy to prevent or treat myocardial injuries. The current study was conducted to examine cardioprotective effects of human mesenchymal stem cells derived from amniotic membrane (hAMSCs) against isoproterenol (ISO)-induced myocardial injury and explore its potential mechanisms. The hAMSCs were injected intramyocardially in male Wistar rats 28 days after last injection of ISO (170 mg/kg body weight for 4 consecutive days). Read More

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AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects.

Sci Rep 2021 Jul 21;11(1):14834. Epub 2021 Jul 21.

INBB, National Institute for Biostructures and Biosystems, Viale delle Medaglie d'Oro 305, 00136, Rome, Italy.

Visceral obesity is characterized by a low-grade inflammatory systemic state that contributes to the genesis of non-alcoholic fatty liver disease (NAFLD), frequently associated with liver fibrosis. Non-invasive serum markers have recently emerged as reliable, easy-to-use scores to predict liver fibrosis. NAFLD is often linked to metabolic and cardiovascular risk. Read More

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The expression of FLNA and CLU in PBMCs as a novel screening marker for hepatocellular carcinoma.

Sci Rep 2021 Jul 21;11(1):14838. Epub 2021 Jul 21.

Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Early detection improves survival and increases curative probability in hepatocellular carcinoma (HCC). Peripheral blood mononuclear cells (PBMCs) can provide an inexpensive, less-invasive and highly accurate method. The objective of this study is to find the potential marker for HCC screening, utilizing gene expression of the PBMCs. Read More

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NR4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts.

Am J Physiol Gastrointest Liver Physiol 2021 07 21. Epub 2021 Jul 21.

Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.

Background: Intestinal fibrosis is a common complication of the inflammatory bowel diseases(IBD), contributing to tissue stiffening and luminal narrowing. NR4A1 was previously reported to regulate mesenchymal cell function and dampen fibrogenic signaling. NR4A1 gene variants are associated with IBD risk, and it has been shown to regulate intestinal inflammation. Read More

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Early intrahepatic duct defects in a cystic fibrosis porcine model.

Physiol Rep 2021 Jul;9(14):e14978

Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Hepatobiliary disease causes significant morbidity and mortality in people with cystic fibrosis (CF), yet this problem remains understudied. Previous studies in the newborn CF pig demonstrated decreased bile flow into the small intestine and a microgallbladder with increased luminal mucus and fluid secretion defects. In this study, we examined the intrahepatic bile ducts of the newborn CF pig. Read More

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Effects of intravenous furosemide plus small-volume hypertonic saline solutions on markers of heart failure.

ESC Heart Fail 2021 Jul 20. Epub 2021 Jul 20.

U.O. C di Medicina Interna con Stroke Care, Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro" (PROMISE), University of Palermo, Piazza delle Cliniche n.2, Palermo, 90127, Italy.

Aims: We sought to compare the effects of furosemide + hypertonic saline solution (HSS) treatment in patients with acute decompensated heart failure in comparison with furosemide alone and the response in a compensated state after an acute saline load with regard to serum levels of heart failure biomarkers.

Methods And Results: We enrolled 141 patients with acute decompensated heart failure with reduced ejection fraction admitted to our Internal Medicine ward from March 2017 to November 2019. A total of 73 patients were randomized to treatment with i. Read More

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Impact of switching to raltegravir and/or adding losartan in lymphoid tissue fibrosis and inflammation in people living with HIV. A randomized clinical trial.

HIV Med 2021 Jul 20. Epub 2021 Jul 20.

Infectious Diseases Department, Hospital Clínic, Barcelona, Spain.

Background: Persistent inflammation and immune activation are associated with lymph node fibrosis and end-organ diseases in treatment-suppressed people living with HIV (PLWH). We investigated the effect of switching to raltegravir and/or adding losartan on lymphoid tissue fibrosis and on the inflammatory/immune-activation mediators in treated HIV patients.

Methods: Chronic HIV-infected patients treated with two nucleoside reverse transcriptase inhibitors (2NRTI) and one non-NRTI (NNRTI) or protease inhibitor (PI) during at least 48 weeks were randomized to four groups (n = 48): 2NRTI + efavirenz (EFV), 2NRTI + EFV + losartan, 2NRTI + raltegravir and 2NRTI + raltegravir + losartan for 48 weeks. Read More

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Severe degeneration of a sub-coronary pulmonary autograft in a young adult.

Glob Cardiol Sci Pract 2021 Jun 30;2021(2):e202114. Epub 2021 Jun 30.

Magdi Yacoub Institute, Heart Science Centre, Harefield Hospital, Harefield, Middx UB9 6JH, UK.

The pulmonary autograft is currently the best valve substitute in terms of longevity and performance. However, there is no agreement about the optimal method of insertion (sub-coronary position or freestanding root). We sought to examine the clinical status, detailed imaging and morphometric changes in an explanted pulmonary autograft 22 years after sub-coronary implantation. Read More

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lncRNA PAPPA-AS1 Induces the Development of Hypertrophic Scar by Upregulating TLR4 through Interacting with TAF15.

Mediators Inflamm 2021 3;2021:3170261. Epub 2021 Jul 3.

Department of Burn and Plastic, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Hypertrophic scar (HTS) is a complicated pathological process induced mainly by burns and wounds, with abnormal proliferation of fibroblasts and the transformation of fibroblasts to myofibroblasts. PAPPA-AS1, a differentially expressed long noncoding RNA (lncRNA) in the HTS tissues, attracted our interests in its potential role and mechanism in the development and process of HTS. In the present study, the regulatory effect of lncRNA PAPPA-AS1 on the Toll-like receptor 4 (TLR4) signal pathway, as well as the molecular mechanism, was investigated. Read More

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Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):29

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.

Purpose: Uncontrolled coagulation reactions contribute to pathological fibroproliferation in several organs, and yet their role in proliferative vitreoretinopathy (PVR) remains to be elucidated. In this study, we evaluated the profibrotic effects of FXa in RPE cells and in a mouse model of PVR.

Methods: FXa levels in the eyes of traumatic PVR patients and rabbit models of mechanical ocular trauma was measured by ELISA and immunohistochemistry. Read More

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Myofibroblast transcriptome indicates SFRP2 fibroblast progenitors in systemic sclerosis skin.

Nat Commun 2021 07 19;12(1):4384. Epub 2021 Jul 19.

Division of Rheumatology and Clinical Immunology, School of Medicine, University of Pittsburgh, Department of Medicine, Pittsburgh, PA, USA.

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the modified Rodnan skin score, the most widely used clinical measure of skin disease severity. Murine fibrosis models indicate that myofibroblasts can arise from a variety of different cell types, but their origin in SSc skin has remained uncertain. Read More

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Methoxyeugenol deactivates hepatic stellate cells and attenuates liver fibrosis and inflammation through a PPAR-ɣ and NF-kB mechanism.

J Ethnopharmacol 2021 Jul 16;280:114433. Epub 2021 Jul 16.

School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.

Ethnopharmacological Relevance: Studies have shown interest in nutraceuticals for the prevention of liver diseases. Methoxyeugenol, is a molecule found in foods, such as nutmeg (Myristica fragrans Houtt.) and Brazilian red propolis. Read More

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Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats.

Nutr Cancer 2021 Jul 19:1-11. Epub 2021 Jul 19.

Laboratory of Physiology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating and fatal disease characterized by aberrant fibroblasts proliferation, oxidative stress and collagen accumulation in the interstitial tissue. We aimed to evaluate in the present study the efficacy of Thymus vulagris extract (TVE) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM). Wistar rats were given a single dose of BLM (4 mg/kg, intratracheal), while TVE (50, 100 and 200 mg/kg, intraperitoneal) was administered 3 days later and continued for 4 weeks. Read More

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Role of the S100 protein family in liver disease (Review).

Int J Mol Med 2021 Sep 19;48(3). Epub 2021 Jul 19.

Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.

Liver disease is a significant health challenge worldwide and comprises liver fibrosis and cirrhosis, viral hepatitis, fatty liver, non‑alcoholic fatty liver disease, alcoholic liver disease and hepatocellular carcinoma (HCC). Due to the lack of effective treatments, the prognosis of end‑stage liver disease (including advanced liver cirrhosis and HCC) is often poor. S100 proteins are a type of Ca binding protein, which are expressed in a cell‑specific manner in vertebrates. Read More

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September 2021

Increased Frequency of Activated Switched Memory B Cells and Its Association With the Presence of Pulmonary Fibrosis in Diffuse Cutaneous Systemic Sclerosis Patients.

Front Immunol 2021 30;12:686483. Epub 2021 Jun 30.

Department of Immunology and Biotechnology, Clinical Center, University of Pécs Medical School, Pécs, Hungary.

Disease-associated, high-affinity pathological autoantibody production is a well-described consequence of immune dysregulation affecting B cells in systemic sclerosis (SSc), including the distribution of B-cell subsets. We have previously shown that the increased relative frequency of CD19+CD27+IgD- switched memory B cells is associated with the severe form of SSc. This study sought to analyze memory B cell subsets using an extended range of markers for further subdivision based on CD19, IgD, CD27, CD38 and CD95 phenotype, to define relationship between the alterations of memory B cell subsets and the clinical features of SSc. Read More

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Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys.

Front Pharmacol 2021 2;12:626510. Epub 2021 Jul 2.

Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Kidney impairment is observed in patients with COVID-19. The effect of anti-COVID-19 agent remdesivir on kidneys is currently unknown. We aimed to determine the effect of remdesivir on renal fibrosis and its downstream mechanisms. Read More

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Cardiac Pathology in COVID-19: A Single Center Autopsy Experience.

Cardiovasc Pathol 2021 Jul 14:107370. Epub 2021 Jul 14.

Section of Heart Failure and Transplantation Cardiology, Division of Cardiovascular Disease, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is commonly associated with myocardial injury and heart failure. The pathophysiology behind this phenomenon remains unclear, with many diverse and multifaceted hypotheses. To contribute to this understanding, we describe the underlying cardiac findings in fifty patients who died with coronavirus disease 2019 (COVID-19). Read More

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Binge-eating disorder is associated with an unfavorable body mass composition in patients with non-alcoholic fatty liver disease.

Int J Eat Disord 2021 Jul 17. Epub 2021 Jul 17.

Section of Endocrinology and Metabolic Medicine, St Mary's Hospital, Imperial College NHS Trust, London, UK.

The interaction between eating disorders and non-alcoholic fatty liver disease (NAFLD) remains unexplored, especially with regards to binge-eating disorder (BED). Our team conducted a service evaluation project in order to assess risk factors for the presence of BED among patients with NAFLD and the impact of BED on body mass composition. The overall prevalence of patients screening positive to BED Screener-7 (BEDS-7) was 28. Read More

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Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.

J Hepatol 2021 Jul 13. Epub 2021 Jul 13.

National Institute for Infectious Diseases L. Spallanzani, IRCCS; Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

Background & Aims: HCV SVR, achievable now by means of DAA therapy, identifies a new class of patients requiring medical surveillance to be designed in relation to the liver disease stage advancement. To this end, identification of both disease biomarkers and therapeutic targets appears necessary.

Methods: Extracellular Vesicles (EVs) purified from plasma of 15 healthy donors (HD), and 16 HCV infected patients before (T0) and after (T6) DAA treatment have been utilised for functional and miRNA cargo analysis. Read More

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Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway.

Ann Transl Med 2021 May;9(9):803

Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University/Jinan Maternity and Child Care Hospital Affiliated, Jinan, China.

Background: Integrin β6 (ITGB6), a key submonomer of integrin αvβ6, plays an important role in epithelial-to-mesenchymal transition (EMT), wound healing, epithelial-derived tumor growth, fibrosis, and epithelial repair. However, the role of ITGB6 in cervical carcinoma (CC) remains elusive.

Methods: The expression levels of ITGB6 in CC tissues and cell lines were determined using quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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Increased Inflammation and Liver Disease in HIV/HBV-coinfected Individuals.

J Acquir Immune Defic Syndr 2021 Jul 14. Epub 2021 Jul 14.

Kombewa Clinical Research Center, U.S. Army Medical Research Directorate-Africa, Kombewa, Kenya U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA Makerere University Walter Reed Project, Kampala, Uganda.

Objective: HIV and HBV co-infection can accelerate morbidity and mortality, especially in sub-Saharan Africa where both infections are common. While inflammation contributes to disease progression, more information is needed to better understand the pathology. This study compared markers of cirrhosis and inflammation in HIV/HBV coinfected individuals compared to monoinfected and uninfected patients. Read More

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Bone morphogenetic protein-7 inhibits endothelial-to-mesenchymal transition in primary human umbilical vein endothelial cells and mouse model of systemic sclerosis via Akt/mTOR/p70S6K pathway.

J Dermatol Sci 2021 Jun 27. Epub 2021 Jun 27.

Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Background: Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder that causes tissue fibrosis of the skin and internal organs. Endothelial-to-mesenchymal transition (EndoMT) has been considered an important mechanism in the pathogenesis of vascular remodeling in SSc. Recent studies suggested that bone morphogenic protein 7 (BMP-7) has anti-fibrotic effects in several fibrotic diseases. Read More

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Long-term outcome of Wilson's disease complicated by liver disease.

JGH Open 2021 Jul 5;5(7):793-800. Epub 2021 Jun 5.

Department of Internal Medicine, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan.

Background And Aim: Wilson's disease (WD) is a rare inherited disease that causes systemic copper accumulation. This study examined the long-term course of WD patients with liver disease.

Methods: The 12 patients (9 female patients) enrolled in the study had a median age of 28 years (range: 19-57 years) at their first visit to our hospital. Read More

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Noninvasive measure of treatment response in non-alcoholic steatohepatitis: Insights from EMMINENCE and meta-analysis.

JGH Open 2021 Jul 1;5(7):740-749. Epub 2021 Jun 1.

Chief Medical Officer Cirius Therapeutics, Inc. San Diego California USA.

Background And Aim: Liver histology changes are the current gold standard for evaluating non-alcoholic steatohepatitis (NASH), but are limited by their invasiveness and variability for sampling and interpretation. We evaluated noninvasive biomarkers as an indication of histologic changes in NASH.

Methods: Associations between 12-month biomarker and NASH Clinical Research Network histologic score changes in 339 patients with NASH in the EMMINENCE trial was examined with multivariable models and partial canonical correlation. Read More

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Liver Stiffness Measurement by Using Transient Elastography in Bangladeshi Patients with Type 2 Diabetes Mellitus and Ultrasonography-Diagnosed Nonalcoholic Fatty Liver Disease.

Diabetes Metab Syndr Obes 2021 6;14:3089-3096. Epub 2021 Jul 6.

Department of Endocrinology, Maynamati Medical College, Comilla, Bangladesh.

Purpose: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD), and the presence of T2DM tremendously drives NAFLD progression. The use of transient elastography (TE) for assessment of NAFLD has been increasing due to its high sensitivity and specificity. This study aimed to measure liver stiffness in patients with T2DM and ultrasonography (USG)-diagnosed NAFLD and assess the correlations between liver stiffness and other clinical and biochemical parameters. Read More

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A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling.

Circ Res 2021 Jul 15. Epub 2021 Jul 15.

Sunnybrook Research Institute, University of Toronto, CANADA.

Fibrotic cardiac remodeling is a maladaptive response to acute or chronic injury that leads to arrythmia and progressive heart failure. The underlying mechanisms remain unclear. We performed high-throughput RNA sequencing to analyze circular RNA (circRNA) profile in human cardiac disease and developed transgenic mice to explore the roles of circNlgn. Read More

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Efficacy and safety of apararenone (MT-3995) in patients with nonalcoholic steatohepatitis: A randomized controlled study.

Hepatol Res 2021 Jul 14. Epub 2021 Jul 14.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Aim: To evaluate the efficacy, safety, and tolerability of apararenone 10 mg/day in patients with nonalcoholic steatohepatitis (NASH).

Methods: In this multicenter, randomized, double-blind, placebo-controlled phase 2 study, patients received apararenone 10 mg or placebo once daily for 72 weeks. The primary efficacy endpoint was percent change in serum alanine aminotransferase (ALT) from baseline to 24 weeks after randomization. Read More

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Liver X Receptor β regulates bile volume and the expression of Aquaporins and Cystic Fibrosis Transmembrane Conductance Regulator in the gallbladder.

Am J Physiol Gastrointest Liver Physiol 2021 Jul 14. Epub 2021 Jul 14.

Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, United States.

The gallbladder is considered an important organ in maintaining digestive and metabolic homeostasis. Given that therapeutic options for gallbladder diseases are often limited to cholecystectomy, understanding gallbladder pathophysiology is essential in developing novel therapeutic strategies.Since Liver X Receptor β (LXRβ), an oxysterol-activated transcription factor, is strongly expressed in gallbladder cholangiocytes, the aim was to investigate LXRβ physiological function in the gallbladder. Read More

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Classification of Left Atrial Diseased Tissue Burden Determined by Automated Voltage Analysis Predicts Outcomes after Ablation for Atrial Fibrillation.

Dis Markers 2021 22;2021:5511267. Epub 2021 Jun 22.

Atrial Fibrillation Institute, Mater Private Hospital, Eccles Street, Dublin 7, Ireland.

Background: The burden and persistence of atrial fibrillation (AF) have been associated with the presence and extent of left atrial (LA) fibrosis. Recent reports have implicated an association between the extent of LA fibrosis and the outcome of pulmonary vein isolation (PVI). We aimed to analyse the value of an automated scar quantification method in the prediction of success following PVI. Read More

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Adipose-Derived Stem Cell-Derived Extracellular Vesicles Inhibit the Fibrosis of Fibrotic Buccal Mucosal Fibroblasts via the MicroRNA-375/FOXF1 Axis.

Stem Cells Int 2021 22;2021:9964159. Epub 2021 Jun 22.

Department of Stomatology, Rizhao People's Hospital, Rizhao, 276826 Shandong Province, China.

Oral submucous fibrosis (OSF) is a precancerous lesion. Adipose-derived stem cell- (ADSC-) derived extracellular vesicles (EVs) (ADSC-EVs) regulate multiple oral diseases. Hence, this study explored the mechanism of ADSC-EVs in OSF. Read More

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