FASEB J 2016 Mar 7;30(3):1155-70. Epub 2015 Dec 7.
*Renal Division, Brigham and Women's Hospital, Department of Medicine, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; Renal Division, Amiens Southern Hospital, Amiens, France; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA; and Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Group IVA phospholipase A2 [cytosolic phospholipase A2α (cPLA2α)] is a key mediator of inflammation and tumorigenesis. In this study, by using a combination of chemical inhibition and genetic approaches in zebrafish and murine cells, we identify a mechanism by which cPLA2α promotes cell proliferation. We identified 2 cpla2α genes in zebrafish, cpla2αa and cpla2αb, with conserved phospholipase activity. Read More