34,899 results match your criteria fibrinolysis

Significant difference between coagulation parameters and clinicopathological characteristics in breast cancer.

Zhengwu Lei Dan Guo

Blood Coagul Fibrinolysis 2021 Sep 20. Epub 2021 Sep 20.

Health management center, Second Affiliated Hospital of Chongqing Medical University and Department of Breast Thyroid Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The purpose of this research is to investigate the correlation between coagulation parameters and survival on patients with breast cancer. A total of 244 patients with breast cancer and 84 patients with metastatic advanced breast cancer admitted to the Second Affiliated Hospital of Chongqing Medical University from January 2017 to February 2019 were selected as the research objects. Their age, tumor size, status of estrogen receptor and progesterone receptor status, status of Her-2 receptor and lymph node were evaluated. Read More

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September 2021

Association Between the Change of Coagulation Parameters and Clinical Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis With rt-PA.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211039285

Department of Neurology, Beijing Tiantan Hospital, 105738Capital Medical University, Beijing, China.

Acute ischemic stroke patients with intravenous (IV) recombinant tissue plasminogen activator (rt-PA) thrombolysis have different outcomes. The degree of thrombolysis depends largely on the delicate balance of coagulation and fibrinolysis. Thus, our study aimed to investigate the prognostic value of routine coagulation parameters in acute stroke patients treated with rt-PA. Read More

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September 2021

The α-globin Chain of Hemoglobin Potentiates Tissue Plasminogen Activator Induced Hyperfibrinolysis in vitro.

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Department of Surgery, School of Medicine University of Colorado Denver, Aurora Department of Surgery, Denver Health Medical Center, Denver Department of Biochemistry and Molecular Genetics Department of Pediatrics, School of Medicine University of Colorado Denver, Aurora Vitalant Research Institute, Vitalant Mountain Division, Denver, CO.

Background: Severe injury predisposes patients to trauma-induced coagulopathy (TIC), which may be subdivided by the state of fibrinolysis. Systemic hyperfibrinolysis (HF) occurs in ~25% of these patients with mortality as high as 70%. Severe injury also causes the release of numerous intracellular proteins which may affect coagulation, one of which is hemoglobin, and hemoglobin substitutes induce HF in vitro. Read More

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September 2021

Tranexamic acid in cardiac surgery: Are low doses enough?

Rev Esp Anestesiol Reanim 2021 Sep 15. Epub 2021 Sep 15.

Servicio de Anestesiología y Reanimación, Consorcio Hospital General Universitario de Valencia, Valencia, España; Departamento de Cirugía, Facultad de Medicina y Odontología, Universidad de Valencia, Valencia, España.

Objectives: Tranexamic acid is used to prevent hyperfibrinolysis and reduce postoperative bleeding and blood transfusions in on-pump cardiac surgery. We evaluate the efficacy of low or high dose tranexamic acid in a prospective cohort study conducted in Valencia.

Materials And Methods: A total of 427 patients were recruited between January 2019 and January 2020, 207 in the Hospital General Universitario (low dose [LD]) and 220 in the Hospital Universitario y Politécnico La Fe (high dose [HD] and intermediate dose [ID]). Read More

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September 2021

Acute ischemic stroke with cervical internal carotid artery steno-occlusive lesion: multicenter analysis of endovascular approaches.

BMC Neurol 2021 Sep 17;21(1):362. Epub 2021 Sep 17.

UOC Neurologia e Rete Stroke metropolitana Ospedale Maggiore CA Pizzardi - IRCCS delle scienze Neurologiche di Bologna, Bologna, Italy.

Background: Occlusion of the internal carotid artery (ICA), whether isolated or in the setting of a tandem lesion (TL) have a poor response to treatment with intravenous thrombolysis. Previous studies ​​have demonstrated the superiority of mechanical thrombectomy in the treatment of acute ischemic stroke (AIS) following large vessel occlusion, compared to standard intravenous fibrinolysis. The aim of our study was to describe endovascular treatment (EVT) in AIS due to isolated ICA occlusion or TL. Read More

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September 2021

Coagulation profiles and viscoelastic testing in multisystem inflammatory syndrome in children.

Pediatr Blood Cancer 2021 Sep 17:e29355. Epub 2021 Sep 17.

Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.

Objective: To characterize viscoelastic testing profiles of children with multisystem inflammatory syndrome in children (MIS-C).

Methods: This single-center retrospective review included 30 patients diagnosed with MIS-C from March 1 to September 1, 2020. Thromboelastography (TEG) with platelet mapping was performed in 19 (63%) patients and compared to age- and sex-matched controls prior to cardiac surgery. Read More

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September 2021

Preoperative serum fibrinogen as a valuable predictor in the nomogram predicting overall survival of postoperative patients with gallbladder cancer.

J Gastrointest Oncol 2021 Aug;12(4):1661-1672

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Coagulation and fibrinolysis activation are frequently observed in cancer patients, and the tumors in these cases are thought to be associated with a higher risk of invasion, metastasis and worse long-term outcome. The specific aim of this study was to develop an effective prognostic nomogram to help make individualized estimates for patients with resected gallbladder cancer (GBC).

Methods: Patients with resected GBC who were diagnosed between 2006 and 2014 at Xinhua Hospital were selected. Read More

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Mechanism of Intervention in Cerebral Infarction: A Research Based on Chemoinformatics and Systematic Pharmacology.

Evid Based Complement Alternat Med 2021 6;2021:6789835. Epub 2021 Sep 6.

Hunan University of Chinese Medicine, Changsha, Hunan Province, China.

Objective: To explore the therapeutic targets, network modules, and coexpressed genes of intervention in cerebral infarction (CI), and to predict significant biological processes and pathways through network pharmacology. To explore the differential proteins of intervention in CI, conduct bioinformatics verification, and initially explain the possible therapeutic mechanism of intervention in CI through proteomics.

Methods: The TCM database was used to predict the potential compounds of Radix Rhei Et Rhizome, and the PharmMapper was used to predict its potential targets. Read More

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September 2021

Polycystic ovary syndrome: clinical and laboratory variables related to new phenotypes using machine-learning models.

J Endocrinol Invest 2021 Sep 15. Epub 2021 Sep 15.

Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Purpose: Polycystic Ovary Syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. Machine learning (ML) is the area of artificial intelligence with a focus on predictive computing algorithms. We aimed to define the most relevant clinical and laboratory variables related to PCOS diagnosis, and to stratify patients into different phenotypic groups (clusters) using ML algorithms. Read More

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September 2021

The proteomes of endometrial stromal cell-derived extracellular vesicles following a decidualising stimulus define the cells' potential for decidualisation success.

Mol Hum Reprod 2021 Sep 15. Epub 2021 Sep 15.

Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, 3168, Australia.

Adequate endometrial stromal cell (ESC) decidualisation is vital for endometrial health. Given the importance of extracellular vesicles (EVs) in intercellular communication, we investigated how their protein landscape is reprogrammed and dysregulated during decidual response. Small EVs (sEVs) from human ESC-conditioned media at day-2 and -14 following decidual stimuli, were grouped as well- (WD) or poorly-decidualised (PD) based on their prolactin secretion and subjected to mass spectrometry-based quantitative proteomics. Read More

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September 2021

Derangement of protein S and C4b-binding protein levels as acquired thrombophilia in HIV-infected adult Nigerians.

South Afr J HIV Med 2021 23;22(1):1253. Epub 2021 Aug 23.

Harvard School of Public Health, Boston, Massachusetts, United States of America.

Background: HIV is a chronic inflammatory state with the production of many acute-phase-reactant proteins. Some of these proteins have procoagulant activities that predispose HIV-infected patients to thrombosis.

Objectives: The aim of the study was to evaluate the effects of HIV infection on the serum levels of C4b-binding protein (C4BP) and protein S as markers of predisposition to thrombosis in HIV-infected adults. Read More

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Inflammation/coagulopathy/fibrinolysis: Dynamic indicators of COVID-19 progression in patients with moderate COVID-19 in Wenzhou, China.

Clin Immunol 2021 Sep 11:108852. Epub 2021 Sep 11.

School of Basic Medical Science, Wenzhou Medical University, Wenzhou, China. Electronic address:

Background: Majority of coronavirus disease 2019 (COVID-19) non-survivors meet the criteria for disseminated intravascular coagulation (DIC). Although timely monitoring of clotting hemorrhagic development during the natural course of COVID-19 is critical for understanding pathogenesis, diagnosis, and treatment of the disease, however, limited data are available on the dynamic processes of inflammation/coagulopathy/fibrinolysis (ICF).

Methods: We monitored the dynamic progression of ICF in patients with moderate COVID-19. Read More

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September 2021

Eltrombopag treatment for severe immune thrombocytopenia during pregnancy: a case report.

Blood Coagul Fibrinolysis 2021 Sep 13. Epub 2021 Sep 13.

Hematology Unit AO of Cosenza, Cosenza Hematology, University Hospital Policlinico Umberto I Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome Obstetrics and Ginecology Unit AUSL of Parma, Parma Obstetrics and Gynecology Unit AO of Cosenza, Cosenza, Italy.

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia (platelet count <100 × 109/l) in the absence of other causes or disorders associated. The incidence of ITP in pregnancy is one to two cases per 1000 gestations. ITP could be diagnosed before or during pregnancy; sometimes a relapse of a previously diagnosed ITP can occur. Read More

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September 2021

Coagulation and Fibrinolysis Biomarkers as Potential Indicators for the Diagnosis and Classification of Ovarian Hyperstimulation Syndrome.

Front Med (Lausanne) 2021 25;8:720342. Epub 2021 Aug 25.

Department of Clinical Laboratory, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Accurate diagnosis and classification of ovarian hyperstimulation syndrome (OHSS) is important for its management. We employed a new high-sensitivity chemiluminescence immunoassay to detect the thrombin-antithrombin complex (TAT), plasmin alpha2-plasmin inhibitor complex (PIC), soluble thrombomodulin (sTM), and tissue plasminogen activator-inhibitor complex (TPAI-C), and evaluated their diagnostic and classification performance for OHSS. A total of 106 women were enrolled, including 51 patients with OHSS (25 mild or moderate OHSS, 26 severe OHSS), and 55 without OHSS (control group). Read More

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Comparative Analysis of the Hemostasiological Profile in Sheep and Patients with Cardiovascular Pathology as the Basis for Predicting Thrombotic Risks During Preclinical Tests of Vascular Prostheses.

Sovrem Tekhnologii Med 2021;13(1):52-56. Epub 2021 Feb 28.

Professor, Academician of the Russian Academy of Sciences, Chief Researcher, Research Institute for Complex Issues of Cardiovascular Diseases, 6 Sosnovy Blvd, Kemerovo, 650002, Russia.

was to study the details of hemostasiological profile in sheep and patients with coronary heart disease (CHD) and to find the possibility of predicting thrombotic risks during preclinical tests of vascular prostheses on a large laboratory animal model.

Materials And Methods: The functional activity of platelets was measured in platelet-rich plasma with inductors: ADP, epinephrine, collagen. Prothrombin activity, international normalized ratio, activated partial thromboplastin time (APTT), thrombin time, fibrinogen concentration, antithrombin III and protein C activity, fibrinolysis were determined in blood plasma. Read More

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February 2021

Atherothrombotic factors and atherosclerotic cardiovascular events: the multi-ethnic study of atherosclerosis.

Eur Heart J 2021 Sep 11. Epub 2021 Sep 11.

Division of Cardiology, Department of Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

Aims: Traditional atherosclerotic cardiovascular disease (ASCVD) risk factors fail to address the full spectrum of the complex interplay of atherosclerotic and atherothrombotic factors integral to ASCVD events. This study sought to examine the association between atherothrombotic biomarkers and ASCVD events.

Methods And Results: The association between atherothrombotic biomarkers and 877 ASCVD events with and without adjustment for traditional risk factors was evaluated via Cox proportional hazards models and factor analysis in 5789 Multi-Ethnic Study of Atherosclerosis participants over a median follow-up of 14. Read More

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September 2021

Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons.

Proc Natl Acad Sci U S A 2021 Sep;118(37)

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104;

Late-stage anthrax infections are characterized by dysregulated immune responses and hematogenous spread of , leading to extreme bacteremia, sepsis, multiple organ failure, and, ultimately, death. Despite the bacterium being nonhemolytic, some fulminant anthrax patients develop a secondary atypical hemolytic uremic syndrome (aHUS) through unknown mechanisms. We recapitulated the pathology in baboons challenged with cell wall peptidoglycan (PGN), a polymeric, pathogen-associated molecular pattern responsible for the hemostatic dysregulation in anthrax sepsis. Read More

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September 2021

Fibrin Network Formation and Lysis in Septic Shock Patients.

Int J Mol Sci 2021 Sep 2;22(17). Epub 2021 Sep 2.

Thrombosis and Haemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus, Denmark.

Background: Septic shock patients are prone to altered fibrinolysis, which contributes to microthrombus formation, organ failure and mortality. However, characterisation of the individual patient's fibrinolytic capacity remains a challenge due to a lack of global fibrinolysis biomarkers. We aimed to assess fibrinolysis in septic shock patients using a plasma-based fibrin clot formation and lysis (clot-lysis) assay and investigate the association between clot-lysis parameters and other haemostatic markers, organ dysfunction and mortality. Read More

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September 2021

Remission of Diabetes Following Bariatric Surgery: Plasma Proteomic Profiles.

J Clin Med 2021 Aug 28;10(17). Epub 2021 Aug 28.

Diabetes, Obesity and Human Reproduction Research Group, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Universidad de Alcalá, E-28034 Madrid, Spain.

Bariatric surgery restores glucose tolerance in many, but not all, severely obese subjects with type 2 diabetes (T2D). We aimed to evaluate the plasma protein profiles associated with the T2D remission after obesity surgery. We recruited seventeen women with severe obesity submitted to bariatric procedures, including six non-diabetic patients and eleven patients with T2D. Read More

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Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention.

Front Cell Dev Biol 2021 20;9:732015. Epub 2021 Aug 20.

Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.

The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and migration. uPAR belongs to the Ly6/uPAR (LU) gene superfamily and the high-affinity binding site for uPA is assembled by a dynamic association of its three consecutive LU domains. In most human solid cancers, uPAR is expressed at the invasive areas of the tumor-stromal microenvironment. Read More

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Protein C deficiency: Report of a challenging case with recurrent multiorgan thrombosis.

Int J Surg Case Rep 2021 Sep 2;86:106361. Epub 2021 Sep 2.

Golestan University of Medical Sciences, Gorgan, Iran.

Introduction And Importance: Protein C deficiency is a rare disorder associated with an increased risk of developing abnormal blood clots. Mild and heterozygous cases are usually asymptomatic and may present with recurrent thrombosis. These recurrent thrombi are usually associated with ischemic stroke or concomitant thrombosis during pregnancy and recurrent miscarriage, but arterial thrombosis is relatively uncommon. Read More

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September 2021

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor.

TH Open 2021 Jul 31;5(3):e363-e375. Epub 2021 Aug 31.

Department of Molecular Hematology, Sanquin Research, Amsterdam, The Netherlands.

 Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation. The prohemostatic properties of aprotinin likely are related to its antifibrinolytic effects, but other mechanisms including preservation of platelet function have been proposed.  Here we assessed effects of aprotinin on various hemostatic pathways in vitro, and compared effects to tranexamic acid(TXA), which is an antifibrinolytic but not a serine protease inhibitor. Read More

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ChAdOx1 nCoV-19 vaccine-associated thrombocytopenia: three cases of immune thrombocytopenia after 107 720 doses of ChAdOx1 vaccination in Thailand.

Blood Coagul Fibrinolysis 2021 Sep 3. Epub 2021 Sep 3.

Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Research Unit in Translational Hematology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Synphaet Ramintra Hospital Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

We reported three cases of immune thrombocytopenia (ITP) that developed within 6 weeks after ChAdOx1 nCoV-19 vaccination. Antiplatelet factor 4 antibodies were undetectable in all three cases. Therefore, vaccine-induced immune thrombotic thrombocytopenia was very unlikely. Read More

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September 2021

Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy.

Biomaterials 2021 Aug 30;277:121102. Epub 2021 Aug 30.

Université de Paris, Université Sorbonne Paris Nord, UMR S1148, INSERM, F-75018, Paris, France. Electronic address:

Intravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Read More

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In-vitro thromboelastographic characterization of reconstituted whole blood utilizing cryopreserved platelets.

Blood Coagul Fibrinolysis 2021 Sep 1. Epub 2021 Sep 1.

Emergency Medicine Department, Indiana University School of Medicine, Indianapolis Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA.

Conducting in-vitro thrombosis research presents numerous challenges, the primary of which is working with blood products, whether whole blood or fractionated whole blood, that have limited functional shelf-lives. As a result, being able to significantly prolong the clotting functionality of whole blood via fractionation and recombination promises greater accessibility via resource minimization in the realm of thrombosis research. Whole blood with CPDA1 from healthy volunteers was fractionated and stored as frozen platelet-free plasma (PFP, -20°C), refrigerated packed red blood cells (pRBCs, 4°C) and cryopreserved platelets (-80°C). Read More

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September 2021

Whole blood viscosity in patients with aortic stenosis.

Blood Coagul Fibrinolysis 2021 Sep 1. Epub 2021 Sep 1.

University of Health Sciences, Department of Cardiology, Ankara City Hospital University of Health Sciences, Department of Cardiology, Dr Abdurrahman Yurtaslan Ankara Onkoloji Education and Research Hospital, Ankara, Turkey.

Whole blood viscosity (WBV) may promote endothelial shear stress, inflammation, and can accelerate the atherosclerotic process. We aimed to evaluate the relationship between WBV and aortic stenosis. The study included 209 participants of whom 49 patients had severe aortic stenosis, 98 patients had mild-to-moderate aortic stenosis and 62 patients served as control. Read More

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September 2021

Levels of procoagulant microparticles expressing phosphatidylserine contribute to bleeding phenotype in patients with inherited thrombocytopenia.

Blood Coagul Fibrinolysis 2021 Sep 1. Epub 2021 Sep 1.

Department of Hematology Department of Clinical Immunology Center for Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, København, Denmark.

Inherited thrombocytopenia is a heterogeneous group of hereditary disorders with varying bleeding tendencies, not simply related to platelet count. Platelets transform into different subpopulations upon stimulation, including procoagulant platelets and platelet microparticles (PMPs), which are considered critical for haemostasis. We aimed to investigate whether abnormalities in PMP and procoagulant platelet function were associated with the bleeding phenotype of inherited thrombocytopenia patients. Read More

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September 2021

The roles of platelets in COVID-19-associated coagulopathy and vaccine-induced immune thrombotic thrombocytopenia.

Trends Cardiovasc Med 2021 Aug 27. Epub 2021 Aug 27.

Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA. Electronic address:

In coronavirus disease 2019 (COVID-19), multiple thromboinflammatory events contribute to the pathophysiology, including coagulation system activation, suppressed fibrinolysis, vascular endothelial cell injury, and prothrombotic alterations in immune cells such as macrophages and neutrophils. Although thrombocytopenia is not an initial presentation as an infectious coagulopathy, recent studies have demonstrated the vital role of platelets in COVID-19-associated coagulopathy SARS-CoV-2 and its spike protein have been known to directly or indirectly promote release of prothrombotic and inflammatory mediators that lead to COVID-19-associated coagulopathy. Although clinical features of vaccine-induced immune thrombotic thrombocytopenia include uncommon locations of thrombosis, including cerebral venous sinus, we speculate coronavirus spike-protein-initiated prothrombotic pathways are involved in the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia, as current evidence suggests that the spike protein is the promotor and other cofactors such as perturbed immune response and inflammatory reaction enhance the production of anti-platelet factor 4 antibody. Read More

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The D-dimer level predicts the prognosis in patients with lung cancer: a systematic review and meta-analysis.

J Cardiothorac Surg 2021 Aug 28;16(1):243. Epub 2021 Aug 28.

Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, No. 519 Kunzhou Road, Xishan District, Kunming City, Yunnan Province, China.

Objective: Although the significance of increased plasma D-dimer levels in activating coagulation and fibrinolysis has been reported, it is still controversial whether it can be used to predict the prognosis of lung cancer patients. This meta-analysis was performed to explore the beneficial role of plasma D-dimer as a prognostic factor in lung cancer patients according to a larger sample capacity.

Materials And Methods: MEDLINE, EMBASE, and Cochrane Central databases were searched from inception to January 2021. Read More

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Coagulopathy in Acute Puumala Hantavirus Infection.

Viruses 2021 Aug 6;13(8). Epub 2021 Aug 6.

Department of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, Finland.

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein-kinin systems, have been reported. Read More

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