128 results match your criteria fetoplacental endothelium


Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease.

Biomedicines 2021 Mar 30;9(4). Epub 2021 Mar 30.

Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Universitätsplatz 4, 8010 Graz, Austria.

Cholesterol and other lipids carried by lipoproteins play an indispensable role in fetal development. Recent evidence suggests that maternally derived high-density lipoprotein (HDL) differs from fetal HDL with respect to its proteome, size, and function. Compared to the HDL of adults, fetal HDL is the major carrier of cholesterol and has a unique composition that implies other physiological functions. Read More

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Placental blood flow sensing and regulation in fetal growth restriction.

Placenta 2021 Jan 18. Epub 2021 Jan 18.

Division of Women's and Children's Health, School of Medicine, University of Leeds, LS2 9NS, UK. Electronic address:

The mechanical force of blood flow is a fundamental determinant of vascular homeostasis. This frictional stimulation of cells, fluid shear stress (FSS), is increasingly recognised as being essential to placental development and function. Here, we focus on the role of FSS in regulating fetoplacental circulatory flow, both in normal pregnancy and that affected by fetal growth restriction (FGR). Read More

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January 2021

Insulin requires A adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.

Biochim Biophys Acta Mol Basis Dis 2021 01 21;1867(1):165993. Epub 2020 Oct 21.

Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville E-41012, Spain; Medical School (Faculty of Medicine), São Paulo State University (UNESP), Brazil; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, Herston, QLD, 4029, Australia. Electronic address:

Late-onset preeclampsia (LOPE) associates with reduced umbilical vein reactivity and endothelial nitric oxide synthase (eNOS) activity but increased human cationic amino acid (hCAT-1)-mediated L-arginine transport involving A adenosine receptor in the fetoplacental unit. This study addresses the A adenosine receptor (AAR)-mediated response to insulin in the fetoplacental vasculature from LOPE. Umbilical veins and HUVECs were obtained from women with normal (n = 37) or LOPE (n = 35) pregnancies. Read More

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January 2021

The Role of Inflammation in the Pathogenesis of Preeclampsia.

Mediators Inflamm 2020 5;2020:3864941. Epub 2020 Oct 5.

Department of Gynecology and Obstetrics, Collegium Medicum, University of Zielona Góra, Zielona Góra, Poland.

Preeclampsia (PE) affects 5-8% of pregnant women, and it is the major cause of perinatal morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of gestation which cooccurs with proteinuria (300 mg/d) or as arterial hypertension which is accompanied by one of the following: renal failure, liver dysfunction, hematological or neurological abnormalities, intrauterine growth restriction, or uteroplacental insufficiency. Currently, pathophysiology of preeclampsia poses a considerable challenge for perinatology. Read More

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October 2020

Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia.

Int J Mol Sci 2020 Sep 15;21(18). Epub 2020 Sep 15.

Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia.

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Read More

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September 2020

Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2020 12 29;1866(12):165948. Epub 2020 Aug 29.

Laboratory of Cell Bioenergetics, Center for Biophysics and Biochemistry (CBB), Venezuelan Institute for Scientific Research (IVIC), AP 21827, Caracas 1020A, Venezuela.

Gestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with d-glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial dysfunction in the placental endothelium and trophoblast. Additionally, GDM is associated with reduced placental oxidative phosphorylation due to diminished activity of the mitochondrial FF-ATP synthase (complex V). Read More

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December 2020

Nitric oxide synthase and VEGF expression in full-term placentas of obese women.

Histochem Cell Biol 2019 Dec 24;152(6):415-422. Epub 2019 Sep 24.

Department of Clinical Sciences, Università Politecnica delle Marche, Via Tronto, 10/A, 60126, Ancona, Italy.

An adequate placental vascularization allows the proper development of the fetus and it is crucial for the gestational success. A number of factors regulate angiogenesis, including vascular endothelial growth factor (VEGF), which induces the synthesis of nitric oxide (NO), a potent vasodilator produced by three different nitric oxide synthase (NOS) isoforms. NO is essential to maintain a low vascular resistance in the fetoplacental circulation, although at high concentrations, it may combine with excess superoxide to produce peroxynitrite, which reacts with proteins giving rise to nitrotyrosine. Read More

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December 2019

[The architectonics of fetal placental veins in second-trimester cytomegalovirus infection].

Arkh Patol 2019 ;81(4):43-47

Far Eastern Research Center for Physiology and Pathology of Respiration, Blagoveshchensk, Russia.

Objective: To study a change in the architectonics of fetal surface veins of the placenta and the structure of the latter in cytomegalovirus infection in pregnant women.

Material And Methods: Placentas were studied and divided in 3 groups: 1) 35 placentas from women with physiological pregnancy; 2) 37 placentas from women with an exacerbation of latent cytomegalovirus infection and with chronic compensated placental insufficiency; 3) 30 placentas from those with an exacerbation of latent cytomegalovirus infection and with chronic subcompensated placental insufficiency. After X-ray contrasting the fetal surface veins of the placenta and collecting its sections for morphological analysis, the changes in the blood vessels were compared with the structure of the villous chorion. Read More

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October 2019

Effects of fast versus slow-releasing hydrogen sulfide donors in hypertension in pregnancy and fetoplacental growth restriction.

Naunyn Schmiedebergs Arch Pharmacol 2019 12 30;392(12):1561-1568. Epub 2019 Jul 30.

Department of Pharmacology, Biosciences Institute of Botucatu, Sao Paulo State University-UNESP, Distrito de Rubiao Junior, S/N,, Botucatu, SP, 18.618-689, Brazil.

Hydrogen sulfide (HS) is a vasorelaxant gas with therapeutic potential in several diseases. However, effects of HS donors in hypertensive pregnancy complicated by feto-placental growth restriction are unclear. Therefore, we aimed to examine and compare the effects of fast-releasing HS donor (sodium hydrosulfide-NaHS) and slow-releasing HS donor (GYY4137) in hypertension-in-pregnancy. Read More

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December 2019

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 05 19;597(10):2639-2650. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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Emerging concepts of shear stress in placental development and function.

Mol Hum Reprod 2019 06;25(6):329-339

Academic department of Obstetrics and Gynaecology, Level, Worsley Building, University of Leeds, UK.

Blood flow, and the force it generates, is critical to placental development and function throughout pregnancy. This mechanical stimulation of cells by the friction generated from flow is called shear stress (SS) and is a fundamental determinant of vascular homeostasis, regulating remodelling and vasomotor tone. This review describes how SS is fundamental to the establishment and regulation of the blood flow through the uteroplacental and fetoplacental circulations. Read More

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Plasticity of the Maternal Vasculature During Pregnancy.

Annu Rev Physiol 2019 02;81:89-111

Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

Maternal cardiovascular changes during pregnancy include an expansion of plasma volume, increased cardiac output, decreased peripheral resistance, and increased uteroplacental blood flow. These adaptations facilitate the progressive increase in uteroplacental perfusion that is required for normal fetal growth and development, prevent the development of hypertension, and provide a reserve of blood in anticipation of the significant blood loss associated with parturition. Each woman's genotype and phenotype determine her ability to adapt in response to molecular signals that emanate from the fetoplacental unit. Read More

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February 2019

Peculiarities of nitric oxide donor drugs administration in obstetric practice.

Wiad Lek 2018;71(9):1765-1769

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: Introduction: Endothelial dysfunction is a universal mechanism for the development of many pathological conditions of the body. In obstetric practice, endothelial dysfunction underlies the development of many pathological conditions. Nitric oxide (NO) deficiency is a key element in endothelial dysfunction. Read More

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Adenosine kinase and cardiovascular fetal programming in gestational diabetes mellitus.

Biochim Biophys Acta Mol Basis Dis 2020 02 27;1866(2):165397. Epub 2019 Jan 27.

Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD, 4029, Queensland, Australia. Electronic address:

Gestational diabetes mellitus (GDM) is a detrimental condition for human pregnancy associated with endothelial dysfunction and endothelial inflammation in the fetoplacental vasculature and leads to increased cardio-metabolic risk in the offspring. In the fetoplacental vasculature, GDM is associated with altered adenosine metabolism. Adenosine is an important vasoactive molecule and is an intermediary and final product of transmethylation reactions in the cell. Read More

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February 2020

Features of hemodynamics of fetoplacental complex in pregnant with perinatal infections.

Wiad Lek 2019 ;72(12 cz 1):2277-2281

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: Introduction: Perinatal infections are an important issue in modern obstetrics, perinatal and pediatric care and one of the main causes of perinatal morbidity and mortality. The persistence of infection in the mother's body can lead to an adverse outcome of pregnancy and childbirth, but it does not always mean the infection of the fetus and the development of an infectious disease. The presence of foci of infection in the body of a pregnant woman is only one of the reasons for the development of intrauterine infection. Read More

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FMS-like tyrosine kinase 1 (FLT1) is a key regulator of fetoplacental endothelial cell migration and angiogenesis.

Placenta 2018 10 20;70:7-14. Epub 2018 Aug 20.

Division of Reproductive Sciences, University of Colorado School of Medicine, Aurora, CO, USA; Division of Maternal-Fetal Medicine, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

Introduction: Fetoplacental angiogenesis plays a vital role in pregnancy outcome. Vascular endothelial growth factor A (VEGFA) is one major regulator of angiogenesis. It primarily binds to FMS-like tyrosine kinase (FLT1) and kinase insert domain receptor (KDR). Read More

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October 2018

Piezo1 channels are mechanosensors in human fetoplacental endothelial cells.

Mol Hum Reprod 2018 10;24(10):510-520

Leeds Institute of Cardiovascular and Metabolic Medicine, LIGHT Laboratories, University of Leeds, 6 Clarendon Way, Leeds, UK.

Study Question: Does the shear stress sensing ion channel subunit Piezo1 have an important mechanotransduction role in human fetoplacental endothelium?

Summary Answer: Piezo1 is present and functionally active in human fetoplacental endothelial cells, and disruption of Piezo1 prevents the normal response to shear stress.

What Is Known Already: Shear stress is an important stimulus for maturation and function of placental vasculature but the molecular mechanisms by which the force is detected and transduced are unclear. Piezo1 channels are Ca2+-permeable non-selective cationic channels which are critical for shear stress sensing and maturation of murine embryonic vasculature. Read More

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October 2018

Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy.

J Obstet Gynaecol Res 2018 Aug 28;44(8):1377-1383. Epub 2018 Jun 28.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of SooChow University, Suzhou, China.

Aim: To analyze inducible nitric oxide synthase (iNOS) and neuropeptide Y (NPY) expression in maternal plasma and placentas of human with intrahepatic cholestasis of pregnancy (ICP).

Methods: The plasma and placentas were collected from 35 women with normal pregnancies and 33 women with ICP. Enzyme-linked immunosorbent assays were used to investigate maternal plasma iNOS and NPY levels. Read More

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Fetoplacental endothelial exosomes modulate high d-glucose-induced endothelial dysfunction.

Placenta 2018 06 21;66:26-35. Epub 2018 Apr 21.

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands; Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. Electronic address:

Introduction: Gestational diabetes mellitus (GDM) is associated with fetoplacental endothelial dysfunction, which may be induced by hyperglycemia. We hypothesized that endothelial exosomes, which are extracellular nanovesicles affecting endothelial function, play a role in the high glucose (HG)-induced endothelial dysfunction.

Methods: Exosomes were isolated from HUVECs incubated with basal glucose (5. Read More

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Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 09 18;1863(9):968-979. Epub 2018 May 18.

Immunology and Pathophysiology, Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Austria. Electronic address:

Gestational diabetes mellitus (GDM) is associated with excessive oxidative stress which may affect placental vascular function. Cholesterol homeostasis is crucial for maintaining fetoplacental endothelial function. We aimed to investigate whether and how GDM affects cholesterol metabolism in human fetoplacental endothelial cells (HPEC). Read More

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September 2018

Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?

FASEB J 2018 10 3;32(10):5436-5446. Epub 2018 May 3.

Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom.

Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. Read More

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October 2018

Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta.

Mol Cell Endocrinol 2018 11 30;476:79-83. Epub 2018 Apr 30.

Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, IA, United States. Electronic address:

It has been shown in both human and mouse placentas that follicle stimulating hormone receptor (FSHR) is expressed in fetal vascular endothelium. There are conflicting reports, however, on the role of FSH to stimulate angiogenesis in vitro in cultured endothelial cells from umbilical veins. Therefore, in this study we undertook an in vivo approach utilizing Fshr null mice to definitively address this question. Read More

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November 2018

LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries.

J Cell Physiol 2018 10 9;233(10):6723-6733. Epub 2018 May 9.

Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Maternal obesity is associated with large-for-gestational-age (LGA) neonates and programming of obesity-related cardiovascular disease in the offspring, however, the mechanisms that lead to the later are unclear. Presently, interpretations of NO-dependent changes in vascular function in LGA newborn from obese mothers are conflicting. Adiponectin improves endothelial function by increasing eNOS activity and NO production. Read More

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October 2018

CD15 as a marker of fetoplacental endothelial immaturity in IUGR placentas.

J Matern Fetal Neonatal Med 2019 May 17;32(10):1646-1653. Epub 2017 Dec 17.

b Division of Molecular Medicine , St. John's Research Institute , Koramangala , Bangalore , India.

Background: Structural or functional defects in the placenta, are the primary cause of growth restriction of the fetus. Morphological examination of such placentas from intrauterine growth restricted (IUGR) fetuses often appears deceptively normal. Evaluation of angiogenesis and fetoplacental vasculature is critical to understand the underlying pathogenesis of fetal growth restriction in both idiopathic as well as cases where it is thought to be secondary to complications like preeclampsia (PE). Read More

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Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells†.

Biol Reprod 2017 Apr;96(4):866-876

Department of Ob/Gyn, University of Wisconsin, Madison, Wisconsin, USA.

Leptin regulates body weight, reproductive functions, blood pressure, endothelial function, and fetoplacental angiogenesis. Compared to the luteal phase, the follicular phase and pregnancy are physiological states of elevated estrogen, angiogenesis, and uterine blood flow (UBF). Little is known concerning regulation of uterine artery (UA) angiogenesis by leptin and its receptors. Read More

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Postnatal Cardiovascular Consequences in the Offspring of Pregnant Rats Exposed to Smoking and Smoking Cessation Pharmacotherapies.

Reprod Sci 2017 06 12;24(6):919-933. Epub 2016 Oct 12.

1 Department of Obstetrics & Gynecology, The University of Texas Medical Branch, Galveston, TX, USA.

Approximately 20% of pregnant women smoke despite intentions to quit. Smoking cessation drugs, such as nicotine replacement therapy (NRT) and bupropion, are recommended treatments. Adverse cardiovascular outcomes in offspring have raised concerns about NRT's safety during pregnancy. Read More

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Ultrasonographic peculiarities of fetoplacental complex in pregnancy complicated by intrauterine infection.

Wiad Lek 2016;69(3 pt 2):480-482

Kharkiv National Medical University, Kharkiv, Ukraine, e-mail:

Introduction: the relevance of intrauterine infections is determined by significant peri- and postnatal loss as well as health impairment, which often results in disability and reduced quality of life. Ultrasonography is employed in order to provide a reliable assessment of the functional state of the fetoplacental system secondary to intrauterine fetal infection in the course of pregnancy. Ultrasound imaging is essential in diagnosis of various preclinical complications of pregnancy and detection of abnormalities in the developing fetus. Read More

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February 2017

Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus.

Front Physiol 2016 31;7:119. Epub 2016 Mar 31.

Cellular and Molecular Physiology Laboratory, Division of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Católica de Chile Santiago, Chile.

Gestational diabetes mellitus (GDM) is a disease of the mother that associates with altered fetoplacental vascular function. GDM-associated maternal hyperglycaemia result in fetal hyperglycaemia, a condition that leads to fetal hyperinsulinemia and altered L-arginine transport and synthesis of nitric oxide, i.e. Read More

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Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy.

Curr Vasc Pharmacol 2016 ;14(3):237-59

Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile.

Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic disruptions leading to alterations of the mother, fetus and neonate health. These syndromes result in fetoplacental vascular dysfunction, where nitric oxide (NO) plays a crucial role. PE characterizes by abnormal increase in the placental blood pressure and a negative correlation between NO level and fetal weight, suggesting that increased NO level and oxidative stress could be involved. Read More

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December 2016

Ultrasonographic peculiarities of fetoplacental complex in pregnancy complicated by intrauterine infection.

Wiad Lek 2016;69(3 pt 2):480-482

Kharkiv National Medical University, Kharkiv, Ukraine, e-mail:

Introduction: the relevance of intrauterine infections is determined by significant peri- and postnatal loss as well as health impairment, which often results in disability and reduced quality of life. Ultrasonography is employed in order to provide a reliable assessment of the functional state of the fetoplacental system secondary to intrauterine fetal infection in the course of pregnancy. Ultrasound imaging is essential in diagnosis of various preclinical complications of pregnancy and detection of abnormalities in the developing fetus. Read More

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September 2018