6,395 results match your criteria fetal viability

Fetomaternal Hemorrhage: Evaluation of Recurrence Within a Large Integrated Health Care System.

Am J Obstet Gynecol 2021 May 4. Epub 2021 May 4.

Kaiser Permanente Oakland Department of Pathology, 275 W MacArthur Boulevard Oakland, CA 94610.

Background: Fetomaternal hemorrhage is associated with severe fetal morbidity and mortality. The recurrence risk of fetomaternal hemorrhage is unknown.

Objective: We sought to establish the recurrence rate of fetomaternal hemorrhage in a large integrated healthcare system over a 10-year period. Read More

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Sodium metabisulfite as a cytotoxic food additive induces apoptosis in HFFF2 cells.

Food Chem 2021 Apr 20;358:129910. Epub 2021 Apr 20.

Department of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100 Burjassot, Valencia, Spain. Electronic address:

Sodium metabisulfite (SMB), an antioxidant agent, is extensively used as a preservative in food industry. The current study was aimed to clarify its potential toxic effects on human fetal foreskin fibroblasts (HFFF2) cells, in vitro. Subsequently, MTT results illustrated that exposure to SMB significantly (p < 0. Read More

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A Tool for Accurate Stoichiometric Composition of Cryopreservative Media for Fetal and Induced Pluripotent Stem Cell-Derived Human Neural Stem Cells.

Curr Protoc 2021 May;1(5):e123

Center for Stem Cells and Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, Sanford Consortium for Regenerative Medicine, La Jolla, California.

Fetal human neural stem cells (fhNSC) are of considerable interest as potential regenerative therapies for neuronal or glial degeneration or destruction resulting from genetic abnormalities, disease, or injury. Realization of this potential requires securing a supply of cells sufficient to meet the needs of transplantation, which are often tens to hundreds of millions of cells per dose. This challenge necessitates the establishment of safe and efficient cell banking protocols. Read More

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PLAC1 Regulates the Occurrence of Fetal Growth Restriction by Inhibiting the Apoptosis of Trophoblast Cells.

Ann Clin Lab Sci 2021 Mar;51(2):182-189

Department of Obstetrics, Jiaxing Municipal Maternal and Child Health Care Hospital

Objective: Fetal growth restriction (FGR) refers to impaired and insufficient intrauterine growth potential caused by a variety of adverse factors and is a serious perinatal complication that leads to fetal or neonatal mortality and morbidity. FGR has numerous causes, and its pathogenesis has not been fully understood. Recently, increasing numbers of researchers have begun to focus on the placenta, the only link between the fetus and the mother. Read More

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Recombinant Human erythropoietin reduces viability of MCF-7 breast cancer cells from 3D culture without caspase activation.

Saudi J Biol Sci 2021 Apr 11;28(4):2549-2557. Epub 2021 Feb 11.

College of Science, Imam Abdul Rahman bin Faisal University, Saudi Arabia.

Recombinant human erythropoietin (rHuEPO) is the erythropoiesis-stimulating hormone that is being used concurrently with chemotherapeutic drugs in the treatment of anemia of cancer. The effect of rHuEPO on cancer cells in 3-dimensional (3D) cultures is not known. The objective of the study was to determine the effect of rHuEPO on the viability of MCF-7 breast cancer cells from 2-dimensional (2D) and 3D cell cultures. Read More

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Viability and thresholds for treatment of extremely preterm infants: survey of UK neonatal professionals.

Arch Dis Child Fetal Neonatal Ed 2021 Apr 29. Epub 2021 Apr 29.

Newborn Care, John Radcliffe Hospital, Oxford, UK

Background: Decisions about treatments for extremely preterm infants (EPIs) born in the 'grey zone' of viability can be ethically complex. This 2020 survey aimed to determine views of UK neonatal staff about thresholds for treatment of EPIs given a recently revised national Framework for Practice from the British Association of Perinatal Medicine.

Methods: The online survey requested participants indicate the lowest gestation at which they would be willing to offer active treatment and the highest gestation at which they would withhold active treatment of an EPI at parental request (their lower and upper thresholds). Read More

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Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss.

Lancet 2021 May 27;397(10285):1658-1667. Epub 2021 Apr 27.

Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Miscarriage is generally defined as the loss of a pregnancy before viability. An estimated 23 million miscarriages occur every year worldwide, translating to 44 pregnancy losses each minute. The pooled risk of miscarriage is 15·3% (95% CI 12·5-18·7%) of all recognised pregnancies. Read More

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Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy?

Front Endocrinol (Lausanne) 2021 12;12:607539. Epub 2021 Apr 12.

Adelaide Medical School and The Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.

Endocrine disrupting compounds (EDCs) are prevalent and ubiquitous in our environment and have substantial potential to compromise human and animal health. Amongst the chronic health conditions associated with EDC exposure, dysregulation of reproductive function in both females and males is prominent. Human epidemiological studies demonstrate links between EDC exposure and infertility, as well as gestational disorders including miscarriage, fetal growth restriction, preeclampsia, and preterm birth. Read More

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Bifenthrin reduces pregnancy potential via induction of oxidative stress in porcine trophectoderm and uterine luminal epithelial cells.

Sci Total Environ 2021 Apr 16;784:147143. Epub 2021 Apr 16.

Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Exposure to pesticides has become a serious concern for the environment and human health. Bifenthrin, a synthetic pyrethroid pesticide, is one of the most frequently used pesticides worldwide. Despite the toxic potential of bifenthrin, no studies have elucidated the cytotoxic response of bifenthrin in maternal and fetal cells that are involved in the implantation process. Read More

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Gestational gigantomastia-a rare entity complicated by life-threatening haemorrhage.

J Surg Case Rep 2021 Apr 14;2021(4):rjab050. Epub 2021 Apr 14.

Clinic of Trauma Surgery, Masaryk Hospital, Usti nad Labem, Czech Republic.

Gestational gigantomastia is a psychologically and physically debilitating disease of unknown aetiology. Underlying diseases that present as gigantomastia should be excluded by a thorough workup. Most cases respond to the preferred approach: conservative management, as foetal viability and well-being is of significant importance. Read More

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Handheld transabdominal ultrasound, after limited training, may confirm first trimester viable intrauterine pregnancy: a prospective cohort study.

Scand J Prim Health Care 2021 Apr 14:1-8. Epub 2021 Apr 14.

Department of Clinical Science, University of Bergen, Bergen, Norway.

Objectives: Handheld point-of-care abdominal ultrasound (POCUS) may be used by primary care physicians while vaginal ultrasound is limited to use in specialist care. We aimed to compare abdominal handheld ultrasound to vaginal ultrasound in determining first trimester viable intrauterine pregnancy and estimate gestational length.

Design: Prospective cohort study. Read More

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Cryopreservation of human cerebral microvascular endothelial cells and astrocytes in suspension and monolayers.

PLoS One 2021 14;16(4):e0249814. Epub 2021 Apr 14.

Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada.

The blood-brain barrier (BBB) keeps pathogens and toxins out of the brain but also impedes the entry of pharmaceuticals. Human cerebral microvascular endothelial cells (hCMECs) and astrocytes are the main functional cell components of the BBB. Although available commercially as cryopreserved cells in suspension, improvements in their cryopreservation and distribution as cryopreserved monolayers could enhance BBB in vitro studies. Read More

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The effects of hypothyroidism and hyperthyroidism on placental Hofbauer cells of pregnant rats.

Biotech Histochem 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Histology and Embryology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

We investigated the effects of maternal thyroid disorders on Hofbauer cells of both the placenta and the fetus in pregnant rats. We divided 21 rats into three groups: control group, induced hypothyroidism (hypo) group and induced hyperthyroidism (hyper) group. Hypothyroidism was induced using propylthiouracil and hyperthyroidism was induced using L-thyroxine. Read More

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The effect of four lanthanides onto a rat kidney cell line (NRK-52E) is dependent on the composition of the cell culture medium.

Toxicology 2021 Apr 5;456:152771. Epub 2021 Apr 5.

Technische Universität Dresden, School of Science, Faculty of Biology, Institute of Zoology, Chair of Molecular Cell Physiology and Endocrinology, Zellescher Weg 20b, 01217, Dresden, Germany. Electronic address:

Lanthanide (Ln) exposure poses a serious health risk to animals and humans. In this study, we investigated the effect of 10-10 M La, Ce, Eu, and Yb exposure onto the viability of rat renal NRK-52E cells in dependence on Ln concentration, exposure time, and composition of the cell culture medium. Especially, the influence of fetal bovine serum (FBS) and citrate onto Ln cytotoxicity, solubility, and speciation was investigated. Read More

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Effects of histone H4 hyperacetylation on inhibiting MMP2 and MMP9 in human amniotic epithelial cells and in premature rupture of fetal membranes.

Exp Ther Med 2021 May 22;21(5):515. Epub 2021 Mar 22.

School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063021, P.R. China.

Histone modification is closely associated with several diseases. The aim of the current study was to investigate the associations among histone acetylation, matrix metalloproteinases (MMPs) and premature rupture of membranes (PROM) during pregnancy. A total of 180 puerperants were divided into three groups: i) Preterm-PROM (PPROM), ii) term-PROM (TPROM) and iii) full-term labor (FTL). Read More

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Graphene Oxide-Silver Nanoparticle Nanocomposites Induce Oxidative Stress and Aberrant Methylation in Caprine Fetal Fibroblast Cells.

Cells 2021 Mar 19;10(3). Epub 2021 Mar 19.

College of Veterinary Medicine/Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.

Graphene oxide-silver nanoparticle (GO-AgNPs) nanocomposites have drawn much attention for their potential in biomedical uses. However, the potential toxicity of GO-AgNPs in animals and humans remains unknown, particularly in the developing fetus. Here, we reported the GO-AgNP-mediated cytotoxicity and epigenetic alteration status in caprine fetal fibroblast cells (CFFCs). Read More

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Ultrastructure of mitochondria of human oocytes in different clinical conditions during assisted reproduction.

Arch Biochem Biophys 2021 May 30;703:108854. Epub 2021 Mar 30.

Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100, L'Aquila, Italy. Electronic address:

Infertility affects around 8% of couples with a slight change in percentage in the last years. Despite the significant efforts made in Assisted Reproductive Technologies (ARTs) in handling this disorder, oocyte quality remains a crucial factor for a positive outcome. A better understanding of the dynamics underlying oocyte maturation, fertilization, and embryo development remains one of the main areas for progress in the ARTs field. Read More

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Overexpressed Hsa_circ_0001326 Contributes to the Decreased Cell Viability in SWAN71 Cells by Regulating MiR-186-5p/p27 Kip1 Axis.

Biol Pharm Bull 2021 ;44(4):507-514

Maternity Group Health Department, Lianyungang Maternal and Child Health Hospital.

Preeclampsia (PE) is a severe pregnancy-specific complication responsible for a majority of maternal and fetal mortality. The dysfunction of trophoblast cells is known to be associated with the etiology of PE. Moreover, elevated expression of hsa_circ_0001326 was found in patients with PE without elucidating specific mechanisms. Read More

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January 2021

Why appeals to the moral significance of birth are saddled with a dilemma.

J Med Ethics 2021 Mar 31. Epub 2021 Mar 31.

Center for Biomedical Ethics, Stanford University, Stanford, California, USA.

In 'Dilemma for Appeals to the Moral Significance of Birth', we argued that a dilemma is faced by those who believe that birth is the event at which infanticide is ruled out. Those who reject the moral permissibility of infanticide by appeal to the moral significance of birth must either accept the moral permissibility of a late-term abortion for a non-therapeutic reason or not. If they accept it, they need to account for the strong intuition that her decision is wrong as well as deny the underlying normative principle that killing a viable fetus requires good reason, and not wanting to care for the child when the child could be easily placed for adoption is not a good enough reason to abort. Read More

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A simple method to isolate term trophoblasts and maintain them in extended culture.

Placenta 2021 Mar 19;108:1-10. Epub 2021 Mar 19.

Department of Obstetrics and Gynaecology, University of Auckland, New Zealand.

Introduction: Primary trophoblast cultures obtained from term placentae are an important research tool. Term trophoblasts, while isolated as mononuclear cells, spontaneously fuse to form multinucleated syncytial clusters. Since term trophoblast cells do not replicate in vitro, contaminating cells can overgrow the culture limiting the lifespan of primary trophoblast cultures to about seven days. Read More

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Using 3D-bioprinting scaffold loaded with adipose-derived stem cells to burns wound healing.

J Tissue Eng Regen Med 2021 Mar 28. Epub 2021 Mar 28.

Deputy of Education and Research, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Three dimensional (3D) printing has recently expanded in popularity and has become an effective approach for tissue engineering. Advances in tissue engineering have increased the effectiveness of cell-based therapies. Indeed, the ultimate goal of such treatment is the development of conditions similar to fetal wound regeneration. Read More

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Ovarian Dysgerminoma in Pregnant Women with Viable Fetus: A Rare Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):141-146. Epub 2021 Mar 1.

Hematopathology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

Dysgerminoma is an uncommon malignant tumor arising from the germ cells of the ovary. Its association with pregnancy is extremely rare, with a reported incidence of about 0.2-1 per 100,000 pregnancies. Read More

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Poly (I:C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment.

Brain Behav Immun 2021 Mar 23. Epub 2021 Mar 23.

School of Arts & Sciences, Health Psychology Program, Massachusetts College of Pharmacy and Health Sciences, Boston, MA 02115, United States. Electronic address:

Environmental enrichment (EE) has been successfully implemented in human rehabilitation settings. However, the mechanisms underlying its success are not understood. Incorporating components of EE protocols into our animal models allows for the exploration of these mechanisms and their role in mitigation. Read More

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Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy.

Biol Reprod 2021 Mar 24. Epub 2021 Mar 24.

Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

A physiologic increase in reactive oxygen species (ROS) throughout pregnancy is required to remodel the cervix. Oxidative stress (OS) can cause cellular damage that contributes to dysfunctional tissue. This study determined the effects of OS and the OS-induced cell fate of human cervical epithelial and cervical stromal cells. Read More

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Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium.

Sci Rep 2021 03 23;11(1):6621. Epub 2021 Mar 23.

Université de Paris, BFA, UMR 8251, CNRS, 75013, Paris, France.

The human bronchial epithelium is the first line of defense against atmospheric particles, pollutants, and respiratory pathogens such as the novel SARS-CoV-2. The epithelial cells form a tight barrier and secrete proteins that are major components of the mucosal immune response. Functional in vitro models of the human lung are essential for screening the epithelial response and assessing the toxicity and barrier crossing of drugs, inhaled particles, and pollutants. Read More

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The Epigenetics of Gametes and Early Embryos and Potential Long-Range Consequences in Livestock Species-Filling in the Picture With Epigenomic Analyses.

Front Genet 2021 3;12:557934. Epub 2021 Mar 3.

AgCenter, School of Animal Sciences, Louisiana State University, Baton Rouge, LA, United States.

The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA species. Increasing lines of evidence support the concept that certain acquired traits are derived from environmental exposure during early embryonic and fetal development, i.e. Read More

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Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator.

J Physiol 2021 Mar 21. Epub 2021 Mar 21.

Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Key Points: The margin of human viability has extended to the extremes of gestational age (<24 weeks) when the lungs are immature and ventilator-induced lung injury is common. Artificial placenta technology aims to extend gestation ex utero in order to allow the lungs additional time to develop prior to entering an air-breathing environment. We compared the haemodynamics and cerebral oxygenation of piglets in the immediate period post-oxygenator (OXY) transition against both paired in utero measures and uniquely against piglets transitioned onto mechanical ventilation (VENT). Read More

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Factors and outcomes associated with the induction of labor in referral hospitals of Amhara regional state, Ethiopia: a multicenter study.

BMC Pregnancy Childbirth 2021 Mar 20;21(1):225. Epub 2021 Mar 20.

Department of Clinical Midwifery, School of Midwifery, College of Medicine and Health Sciences, University of Gondar, PO. Box 196, Gondar, Ethiopia.

Background: Induction of labor is an artificial initiation of uterine contractions after fetal viability with the aim of vaginal delivery prior to the onset of spontaneous labor. Prevalence of induction of labor is increasing worldwide with subsequent increase in failure rate. However, there is limited evidence on labor induction in Ethiopia. Read More

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Stillbirth in Canada: anachronistic definition and registration processes impede public health surveillance and clinical care.

Can J Public Health 2021 Mar 19. Epub 2021 Mar 19.

McGill University, Montreal, Quebec, Canada.

The archaic definition and registration processes for stillbirth currently prevalent in Canada impede both clinical care and public health. The situation is fraught because of definitional problems related to the inclusion of induced abortions at ≥20 weeks' gestation as stillbirths: widespread uptake of prenatal diagnosis and induced abortion for serious congenital anomalies has resulted in an artefactual temporal increase in stillbirth rates in Canada and placed the country in an unfavourable position in international (stillbirth) rankings. Other problems with the Canadian stillbirth definition and registration processes extend to the inclusion of fetal reductions (for multi-fetal pregnancy) as stillbirths, and the use of inconsistent viability criteria for reporting stillbirth. Read More

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Generation of UCiPSC-derived neurospheres for cell therapy and its application.

Stem Cell Res Ther 2021 Mar 18;12(1):188. Epub 2021 Mar 18.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Background: Neural stem cell (NSC) therapy remains one of the most potential approaches for the treatment of neurological disorders. The discovery of human induced pluripotent stem cells (hiPSCs) and the establishment of hiPSC-derived human neural stem cells (hiNSCs) have revolutionized the technique of cell therapy. Meanwhile, it is often required that NSCs are stored and transported to a long distance for research or treatment purposes. Read More

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