4,062 results match your criteria fetal macrosomia

Are body roundness index and a body shape index in the first trimester related to foetal macrosomia?

J Obstet Gynaecol 2021 Jun 24:1-7. Epub 2021 Jun 24.

Department of Anesthesiology and Reanimation, Konya Research and Education Hospital, Konya, Turkey.

This study investigated the effectiveness of maternal Body Roundness Index (BRI), Body Shape Index (ASBI), and Visceral Adiposity Index (VAI) in predicting foetal macrosomia and small for gestational age (SFGA) babies in obese and non-obese pregnant women. This prospective trial included 168 pregnant women (99 obese and 69 non-obese). A logistic regression model was used to identify the independent risk factors of foetal macrosomia and SFGA. Read More

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Comparison of one hour versus 90 minute postprandial glucose measurement in women with gestational diabetes; which one is more effective?

J Obstet Gynaecol 2021 Jun 23:1-5. Epub 2021 Jun 23.

Department of Perinatology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.

In the present study, we aimed to compare postprandial 90 minute measurements and postprandial 1 hour (PP1-HR) measurements for prediction of foetal growth disturbances and pregnancy complications. This was a prospective study conducted in Acıbadem Mehmet Ali Aydınlar University Altunizade Hospital in Department of Perinatology. The study group consisted of patients diagnosed with gestational diabetes. Read More

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Pre-pregnancy overweight and obesity prevalence and relation to maternal and perinatal outcomes.

Enferm Clin 2021 Jun 19. Epub 2021 Jun 19.

Department of Nursing: Public, Mental and Maternity and Child Health, School of Nursing, Faculty of Medicine and Health Science, University of Barcelona, 08907 L'Hospitalet del Llobregat, Barcelona, Spain; Research Group on Sexual and Reproductive Health Care "GRASSIR", 08007 Barcelona, Spain.

Objective: To identify the prevalence of pre-pregnancy overweight/obesity in pregnant women and its relationship with socio-demographic factors and to describe the maternal and perinatal outcomes in a Barcelona hospital (Spain).

Method: A descriptive cross-association study, with retrospective data collection, was performed Barcelona Hospital. The data of 5447 pregnant women who delivered at >=23 weeks of gestation were included. Read More

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Postpartum ultrasound for the diagnosis of obstetric anal sphincter injury.

Am J Obstet Gynecol MFM 2021 Jun 12:100421. Epub 2021 Jun 12.

Department of Obstetrics, Gynecology, and Neonatology, Sydney Medical School Nepean, University of Sydney, Kingswood, New South Wales, Australia.

This review presents the available data on the diagnosis of obstetric anal sphincter injury (OASI) by postnatal ultrasound imaging. There is increasing evidence that anal sphincter tears are often missed after childbirth and, even when diagnosed, often sub- optimally repaired, with a high rate of residual defects after reconstruction. Even after postpartum diagnosis and primary repair, 25-50% of patients will have persistent anal incontinence (AI). Read More

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Macrosomia and large for gestational age in Asia: One size does not fit all.

J Obstet Gynaecol Res 2021 Jun;47(6):1929-1945

Department of Pediatrics, University Medical Centre Groningen, Groningen, The Netherlands.

Macrosomia, usually defined as infant birth weight of ≥4000 g, does not consider gestational age, sex, or country/region-specific differences in mean birth weight and maternal body weight. This issue is particularly relevant for Asia, where 60% of the world's population lives, due to variations in maternal size and birth weights across populations. Large for gestational age (LGA), defined as birth weight > 90th centile, is a more sensitive measure as it considers gestational age and sex, though it is dependent on the choice of growth charts. Read More

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The Impact of First Trimester TSH Level on Fetal Growth and Post-Term Pregnancy.

Fetal Pediatr Pathol 2021 Jun 9:1-8. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, University of Health Sciences, Etlik Zübeyde Hanım, Education and Research Hospital, Ankara, Turkey.

Objective: First trimester thyroid-stimulating hormone (TSH) level is an important determiner of neonatal outcome. In this study we investigated the relationship between first-trimester TSH level and fetal birthweight. First-trimester serum TSH, age, gravidity, parity, body mass index (BMI), gestational age, and birth weight were analyzed. Read More

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Survey of factors influencing women's selection of the delivery method of their second child in Shanxi Province, China.

Jin-Qiong Li

Pak J Med Sci 2021 May-Jun;37(3):846-850

Jin-qiong Li Department of Obstetrics and Gynecology, Heji Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, 046000, P. R. China.

Objective: To explore the factors influencing women's selection of the delivery method of their second child.

Methods: A questionnaire survey was administered among 431 women in the age range of interest from January 2015 to January 2017, and the survey results were evaluated and analyzed statistically. The experts evaluating the questionnaire are professionals in the Department of Obstetrics and Gynecology, Heji Hospital Affiliated to Changzhi Medical College. Read More

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Cell death mechanisms and their roles in pregnancy related disorders.

Adv Protein Chem Struct Biol 2021 27;126:195-225. Epub 2021 Feb 27.

Department of Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India. Electronic address:

Autophagy and apoptosis are catabolic pathways essential for homeostasis. They play a crucial role for normal placental and fetal development. These cell death mechanisms are exaggerated in placental disorders such as preeclampsia, intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM). Read More

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February 2021

Asia-Pacific consensus on physical activity and exercise in pregnancy and the postpartum period.

BMJ Open Sport Exerc Med 2021 17;7(2):e000967. Epub 2021 May 17.

Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.

Physical activity and exercise in pregnancy are generally beneficial and enhance the physical and mental health of women. These benefits also prevent excessive weight gain and reduce risks of obesity in pregnancy, such as gestational diabetes, hypertensive disorders, higher rates of caesarean delivery, macrosomia and stillbirth. Thus, there is a need to optimise perinatal exercise and physical activity globally. Read More

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Universal HbA1c screening and gestational diabetes: a comparison with clinical risk factors.

J Matern Fetal Neonatal Med 2021 May 27:1-7. Epub 2021 May 27.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Maternal and Child Health Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Screening strategies for gestational diabetes mellitus (GDM), particularly early GDM, have traditionally relied upon the use of clinical risk factors (CRFs). Although commonly used in nonpregnant patients, HbA1c screening is not widely used despite reports of abnormal HbA1c values being predictive of GDM development. The aims of this study are to assess the utility of universal HbA1c screening in predicting GDM and to compare universal screening to targeted CRF-based screening for the diagnosis of GDM. Read More

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Counseling and Behavioral Interventions for Healthy Weight and Weight Gain in Pregnancy: Evidence Report and Systematic Review for the US Preventive Services Task Force.

JAMA 2021 05;325(20):2094-2109

Pacific Northwest Evidence-based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland.

Importance: Counseling and active behavioral interventions to limit excess gestational weight gain (GWG) during pregnancy may improve health outcomes for women and infants. The 2009 National Academy of Medicine (NAM; formerly the Institute of Medicine) recommendations for healthy GWG vary according to prepregnancy weight category.

Objective: To review and synthesize the evidence on benefits and harms of behavioral interventions to promote healthy weight gain during pregnancy to inform the US Preventive Services Task Force recommendation. Read More

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Behavioral Counseling Interventions for Healthy Weight and Weight Gain in Pregnancy: US Preventive Services Task Force Recommendation Statement.

JAMA 2021 05;325(20):2087-2093

Tufts University School of Medicine, Boston, Massachusetts.

Importance: The prevalence of overweight and obesity is increasing among persons of childbearing age and pregnant persons. In 2015, almost half of all persons began pregnancy with overweight (24%) or obesity (24%). Reported rates of overweight and obesity are higher among Black, Alaska Native/American Indian, and Hispanic women and lower among White and Asian women. Read More

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Effects of vitamin and omega-3 fatty acid co-supplementation on blood glucose in women with gestational diabetes mellitus: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 May;100(21):e26106

Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu.

Background: There is limited study that has conducted a review investigating the clinical effects of vitamin and omega-3 fatty acid co-supplementation on blood glucose in women with gestational diabetes mellitus (GDM). Therefore, in order to provide new evidence-based medical evidence for clinical treatment, we undertook a systematic review and meta-analysis to assess the effectiveness and safety of vitamin and omega-3 fatty acid co-supplementation on blood glucose in women with GDM.

Methods: This protocol was written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement guidelines. Read More

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Second-trimester maternal lipid profiles rather than glucose levels predict the occurrence of neonatal macrosomia regardless of glucose tolerance status: A matched cohort study in Beijing.

Chong Rao Fan Ping

J Diabetes Complications 2021 May 15:107948. Epub 2021 May 15.

Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Key Laboratory of Endocrinology Assigned by Ministry of Health, Beijing 100730, China. Electronic address:

Aims: The mechanism underlying fetal overgrowth during pregnancy remains elusive. We aimed to establish a predictive model to identify the high-risk individuals with macrosomia in the second trimester of pregnancy.

Design: A total of 2577 pregnant women with a routine 75-g oral glucose tolerance test during 24-28 gestational weeks were screened in a prospective cohort. Read More

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[Risk factors for neonatal congenital hypothyroidism: a Meta analysis].

Ji Zhang Yang Li

Zhongguo Dang Dai Er Ke Za Zhi 2021 May;23(5):505-512

Institute of Endemic Disease, Guizhou Provincial Center for Disease Prevention and Control, Guiyang 550004, China.

Objective: To investigate the risk factors for congenital hypothyroidism (CH) in neonates, and to provide a reference for the prevention of CH.

Methods: The databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, SpringerLink, and Elsevier/ScienceDirect were searched for studies on the risk factors for CH in neonates published up to August 1, 2020. R 3. Read More

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Antenatal management and maternal/fetal outcomes associated with hyperglycaemia in pregnancy (HIP) in Uganda; a prospective cohort study.

BMC Pregnancy Childbirth 2021 May 19;21(1):386. Epub 2021 May 19.

Non-Communicable Diseases Theme, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI & LSHTM) Uganda Research Unit, Plot 51-59, Nakiwogo Road, P. O. BOX 49, Entebbe, Uganda.

Background: Hyperglycaemia in pregnancy (HIP) is associated with complications for both mother and baby. The prevalence of the condition is likely to increase across Africa as the continent undergoes a rapid demographic transition. However, little is known about the management and pregnancy outcomes associated with HIP in the region, particularly less severe forms of hyperglycaemia. Read More

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Pregabalin Does Not Cause Midline Closure Defects But It Is Not As Innocent As Thought.

Turk Neurosurg 2020 Dec 10. Epub 2020 Dec 10.

Kahramanmaras Sutcu Imam University School of Medicine, Department of Neurosurgery, Kahramanmaraş, Turkey.

Aim: Pregabalin binds specifically to α2-δ subunits of voltage gated Ca++ channels. Tissues which are rich in these subunits are the target for possible effects and side effects of Pregabalin. The effect of Pregabalin used during pregnancy was investigated on chicken embryo model against causing neural tube closure defect and other potential effects on other organ systems which are rich in α2-δ subunits. Read More

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December 2020

Evaluation and Management of Fetal Macrosomia.

Obstet Gynecol Clin North Am 2021 Jun;48(2):387-399

Department of Obstetrics and Gynecology, USC/Keck School of Medicine, 2020 Zonal Avenue, IRD 236, Los Angeles, CA 90033, USA. Electronic address:

Macrosomia results from abnormal fetal growth and can lead to serious consequences for the mother and fetus. In cases of suspected macrosomia, patients must be counseled carefully regarding a delivery plan, and Cesarean section should be considered when indicated. Techniques to assess for suspected macrosomia include clinical measurements, ultrasound, and MRI. Read More

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Abnormal Fetal Growth: Small for Gestational Age, Fetal Growth Restriction, Large for Gestational Age: Definitions and Epidemiology.

Obstet Gynecol Clin North Am 2021 Jun;48(2):267-279

Department of Obstetrics and Gynaecology, University Medical Center of Groningen, CB20, Hanzeplein 1, 9700RB Groningen, the Netherlands.

Abnormal fetal growth (growth restriction and overgrowth) is associated with perinatal morbidity, mortality, and lifelong risks to health. To describe abnormal growth, "small for gestational age" and "large for gestational age" are commonly used terms. However, both are statistical definitions of fetal size below or above a certain threshold related to a reference population, rather than referring to an abnormal condition. Read More

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Obesity modifies the implantation window and disrupts intrauterine embryo positioning in rats.

Reproduction 2021 May 31;162(1):61-72. Epub 2021 May 31.

Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina.

Obesity is a chronic disease that impairs female reproduction. When gestation is achieved, maternal obesity can cause offspring's health complications. We intended to evaluate the effects of maternal pre-conceptional obesity on uterine contractile activity, embryo implantation and offspring development. Read More

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New genetic and clinical evidence associated with fetal Beckwith-Wiedemann syndrome.

Prenat Diagn 2021 Jun 11;41(7):823-827. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University, Meaung, Chiang Mai, Thailand.

Early detection of Beckwith-Wiedemann syndrome (BWS) is very important since it is very useful regarding counseling of parents concerning the risk of developing embryonic tumors, selection of the mode of delivery due to potential adrenal cysts that might bleed during labor, prevention of neonatal hypoglycemia and even options of pregnancy termination in non-viable fetuses. This report describes the prenatal classic sonographic triad of fetal BWS (omphalocele, macrosomia, macroglossia) and other supporting findings (hepatomegaly, adrenal enlargement) as well as additional postnatal evidence. Also, it demonstrates new molecular genetic evidence potentially associated with the disease (the presence of a novel heterozygous c. Read More

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Effect of pre-pregnancy body mass index on neonatal outcomes in women undergoing autologous frozen-thawed embryo transfer.

Fertil Steril 2021 Apr 26. Epub 2021 Apr 26.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, People's Republic of China. Electronic address:

Objective: To investigate the associations between pre-pregnancy body mass index (BMI) and neonatal outcomes in women undergoing autologous frozen-thawed embryo transfer (FET).

Design: Retrospective cohort study.

Setting(s): University-affiliated reproductive medical center. Read More

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Maternal Obesity and Risk of Low Birth Weight, Fetal Growth Restriction, and Macrosomia: Multiple Analyses.

Nutrients 2021 Apr 7;13(4). Epub 2021 Apr 7.

Medical Faculty, Lazarski University, 02-662 Warsaw, Poland.

The associations between maternal pre-pregnancy obesity and low birth weight (LBW, <2500 g) remain inconclusive. Therefore, birth weight in a Polish prospective cohort of 912 mothers was investigated depending on the pre-pregnancy body mass index (BMI). The whole cohort and the subgroup of gestational weight gain (GWG) in the range of the Institute of Medicine (IOM) recommendations, as well as 'healthy' women (who did not develop diabetes or hypertension in this pregnancy) were investigated. Read More

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Large birth size, infancy growth pattern, insulin resistance and β-cell function.

Eur J Endocrinol 2021 May 24;185(1):77-85. Epub 2021 May 24.

Department of Obstetrics and Gynecology, Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Objective: Large birth size programs an elevated risk of type 2 diabetes in adulthood, but data are absent concerning glucose metabolic health impact in infancy. We sought to determine whether the large birth size is associated with insulin resistance and β-cell function in infancy and evaluate the determinants.

Design And Participants: In the Canadian 3D birth cohort, we conducted a nested matched (1:2) study of 70 large-for-gestational-age (LGA, birth weight >90th percentile) and 140 optimal-for-gestational-age (OGA, 25th-75th percentiles) control infants. Read More

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Predicting fetal weight by three-dimensional limb volume ultrasound (AVol/TVol) and abdominal circumference.

Chin Med J (Engl) 2021 Apr 20;134(9):1070-1078. Epub 2021 Apr 20.

Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Background: Fetal weight is an important parameter to ensure maternal and child safety. The purpose of this study was to use three-dimensional (3D) limb volume ultrasound combined with fetal abdominal circumference (AC) measurement to establish a model to predict fetal weight and evaluate its efficiency.

Methods: A total of 211 participants with single pregnancy (28-42 weeks) were selected between September 2017 and December 2018 in the Beijing Obstetrics and Gynecology Hospital of Capital Medical University. Read More

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Sequencing cell-free fetal DNA in pregnant women with GCK-MODY: a proof-of-concept study.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.

Context: Persons with monogenic diabetes due to inactivating glucokinase (GCK) variants typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal GCK genotype determines whether treatment is indicated, but non-invasive methods are not clinically available.

Objective: To develop a method to determine fetal GCK genotype non-invasively using maternal cell-free fetal DNA. Read More

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Gestational diabetes and fetal growth in twin compared with singleton pregnancies.

Am J Obstet Gynecol 2021 Apr 17. Epub 2021 Apr 17.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Background: Gestational diabetes mellitus is associated with accelerated fetal growth in singleton pregnancies but may affect twin pregnancies differently because of the slower growth of twin fetuses during the third trimester of pregnancy and their greater predisposition to fetal growth restriction.

Objective: This study aimed to evaluate the association of gestational diabetes mellitus with longitudinal fetal growth in twin pregnancies and to compare this association with that observed in singleton pregnancies.

Study Design: This was a retrospective cohort study of all women with a singleton or twin pregnancy who were followed up at a single tertiary referral center between January 2011 and April 2020. Read More

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Maternal Prepregnancy Weight and Pregnancy Outcomes in Saudi Women: Subgroup Analysis from Riyadh Mother and Baby Cohort Study (RAHMA).

Biomed Res Int 2021 1;2021:6655942. Epub 2021 Apr 1.

College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

The objectives of this study were to estimate the prevalence of prepregnancy overweight/obesity and underweight among Saudi mothers and to determine the adverse pregnancy outcomes associated with them. . This is a subgroup analysis from a Riyadh mother and baby cohort study. Read More

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Predicting the risk of fetal macrosomia at pregnancy in Shandong province: a case-control study.

J Matern Fetal Neonatal Med 2021 Apr 18:1-7. Epub 2021 Apr 18.

Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Shandong University, Jinan, China.

Background And Aim: Macrosomia is used to describe an infant born with excessively high weight, and it brings lots of unexpected risks in clinical work. Macrosomia causes considerable challenges for both physicians and pregnant women. Our objectives were to identify factors in gravida to be associated with the risk of macrosomia, to guide clinical prevention and treatment. Read More

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Current Resources for Evidence-Based Practice, May 2021.

J Obstet Gynecol Neonatal Nurs 2021 05 15;50(3):352-362. Epub 2021 Apr 15.

An extensive review of new resources to support the provision of evidence-based care for women and infants. The current column includes a discussion of the prenatal prediction of fetal macrosomia and commentaries on reviews focused on the effects of date palm and dill seed on labor outcomes and the current research available on SARS-CoV-2 and pregnancy outcomes. Read More

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