467 results match your criteria fet biosensor


Detection of Bacterial Metabolic Volatile Indole Using a Graphene-Based Field-Effect Transistor Biosensor.

Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Department of Biomedical Engineering, Centre for Robotics and Automation, City University of Hong Kong, Kowloon Tong, Hong Kong 999077, China.

The existence of bacteria is a great threat to food safety. Volatile compounds secreted by bacteria during their metabolic process can be dissected to evaluate bacterial contamination. Indole, as a major volatile molecule released by (), was chosen to examine the presence of in this research. Read More

View Article and Full-Text PDF

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases.

Biosensors (Basel) 2021 Apr 2;11(4). Epub 2021 Apr 2.

Biologically Sensors and Actuators (BioSA) Laboratory, Lassonde School of Engineering, York University, Keel Street, Toronto, ON M3J 1P3, Canada.

Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). Read More

View Article and Full-Text PDF

An optic-fiber graphene field effect transistor biosensor for the detection of single-stranded DNA.

Anal Methods 2021 04;13(15):1839-1846

School of Physics and Electronics, Shandong Normal University, Jinan 250014, P. R. China.

Herein, a graphene field effect transistor (GFET) was constructed on an optic fiber end face to develop an integrated optical/electrical double read-out biosensor, which was used to detect target single-stranded DNA (tDNA). Two isolated Au electrodes were, respectively, prepared as the drain and source at the ends of an optic fiber and coated with a graphene film to construct a field effect transistor (FET). Probe aptamers modified with fluorophore 6'-carboxy-fluorescein (6'-FAM) were immobilized on the graphene for specific capture of tDNA. Read More

View Article and Full-Text PDF

Graphene FET Sensors for Alzheimer's Disease Protein Biomarker Clusterin Detection.

Front Mol Biosci 2021 26;8:651232. Epub 2021 Mar 26.

Wolfson Nanomaterials and Devices Laboratory, School of Engineering, Computing and Mathematics, Faculty of Science and Engineering, University of Plymouth, Plymouth, United Kingdom.

We report on the fabrication and characterisation of graphene field-effect transistor (GFET) biosensors for the detection of Clusterin, a prominent protein biomarker of Alzheimer's disease (AD). The GFET sensors were fabricated on Si/SiO substrate using photolithographic patterning and metal lift-off techniques with evaporated chromium and sputtered gold contacts. Raman Spectroscopy was performed on the devices to determine the quality of the graphene. Read More

View Article and Full-Text PDF

Sensitivity, Noise and Resolution in a BEOL-Modified Foundry-Made ISFET with Miniaturized Reference Electrode for Wearable Point-of-Care Applications.

Sensors (Basel) 2021 Mar 4;21(5). Epub 2021 Mar 4.

DIEF, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Ion-sensitive field-effect transistors (ISFETs) form a high sensitivity and scalable class of sensors, compatible with advanced complementary metal-oxide semiconductor (CMOS) processes. Despite many previous demonstrations about their merits as low-power integrated sensors, very little is known about their noise characterization when being operated in a liquid gate configuration. The noise characteristics in various regimes of their operation are important to select the most suitable conditions for signal-to-noise ratio (SNR) and power consumption. Read More

View Article and Full-Text PDF

Surface Potential-Controlled Oscillation in FET-Based Biosensors.

Sensors (Basel) 2021 Mar 10;21(6). Epub 2021 Mar 10.

Department of Electronics Engineering, Chungnam National University, Daejeon 34134, Korea.

Field-effect transistor (FET)-based biosensors have garnered significant attention for their label-free electrical detection of charged biomolecules. Whereas conventional output parameters such as threshold voltage and channel current have been widely used for the detection and quantitation of analytes of interest, they require bulky instruments and specialized readout circuits, which often limit point-of-care testing applications. In this study, we demonstrate a simple conversion method that transforms the surface potential into an oscillating signal as an output of the FET-based biosensor. Read More

View Article and Full-Text PDF

Ultrasensitive and easily reproducible biosensor based on novel doped MoS nanowires field-effect transistor in label-free approach for detection of hepatitis B virus in blood serum.

Anal Chim Acta 2021 Apr 6;1156:338360. Epub 2021 Mar 6.

Medical Physics Department, School of Medicine, Iran University of Medical Sciences, P.O. Box 14155-6183, Tehran, Iran. Electronic address:

An ultrasensitive field-effect transistor (FET) for hepatitis B virus deoxyribonucleic acid (HBV DNA) detection in label free approach and easily reproducible setup was reported. The fabricated FET biosensor was materialized by ZnO doped MoS nanowires (NWs). This report introduced a novel structure of the MoS in bio-sensing approach. Read More

View Article and Full-Text PDF

A supersensitive silicon nanowire array biosensor for quantitating tumor marker ctDNA.

Biosens Bioelectron 2021 Jun 5;181:113147. Epub 2021 Mar 5.

Ministry of Education Engineering Research Center of Smart Microsensors and Microsystems, College of Electronics and Information, Hangzhou Dianzi University, Hangzhou, 310018, China. Electronic address:

Cancer has become one of the major diseases threatening human health and life. Circulating tumor DNA (ctDNA) testing, as a practical liquid biopsy technique, is a promising method for cancer diagnosis, targeted therapy and prognosis. Here, for the first time, a field effect transistor (FET) biosensor based on uniformly sized high-response silicon nanowire (SiNW) array was studied for real-time, label-free, super-sensitive detection of PIK3CA E542K ctDNA. Read More

View Article and Full-Text PDF

Nanomaterial Biointerfacing via Mitochondrial Membrane Coating for Targeted Detoxification and Molecular Detection.

Nano Lett 2021 Mar 9;21(6):2603-2609. Epub 2021 Mar 9.

Department of NanoEngineering, Chemical Engineering Program, Moores Cancer Center, University of California San Diego, La Jolla, California 92093, United States.

Natural cell membranes derived from various cell sources have been successfully utilized to coat nanomaterials for functionalization. However, intracellular membranes from the organelles of eukaryotes remain unexplored. Herein, we choose mitochondrion as a representative cell organelle and coat outer mitochondrial membrane (OMM) from mouse livers onto nanoparticles and field-effect transistors (FETs) through a membrane vesicle-substrate fusion process. Read More

View Article and Full-Text PDF

An ultrasensitive heart-failure BNP biosensor using B/N co-doped graphene oxide gel FET.

Biosens Bioelectron 2021 May 26;180:113114. Epub 2021 Feb 26.

Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON, Canada; Waterloo Institute for Nanotechnology (WIN), University of Waterloo, Waterloo, ON, Canada.

Heart failure (HF) is the number one cause of death in the world. B-type natriuretic peptide (BNP) is a recognized biomarker for HF and can be used for early detection. Field effect transistor (FET) biosensors have the ability to sense BNP in much shorter times than conventional clinical studies. Read More

View Article and Full-Text PDF

Rapid Detection of SARS-CoV-2 Antigens Using High-Purity Semiconducting Single-Walled Carbon Nanotube-Based Field-Effect Transistors.

ACS Appl Mater Interfaces 2021 Mar 17;13(8):10321-10327. Epub 2021 Feb 17.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Early diagnosis of SARS-CoV-2 infection is critical for facilitating proper containment procedures, and a rapid, sensitive antigen assay is a critical step in curbing the pandemic. In this work, we report the use of a high-purity semiconducting (sc) single-walled carbon nanotube (SWCNT)-based field-effect transistor (FET) decorated with specific binding chemistry to assess the presence of SARS-CoV-2 antigens in clinical nasopharyngeal samples. Our SWCNT FET sensors, with functionalization of the anti-SARS-CoV-2 spike protein antibody (SAb) and anti-nucleocapsid protein antibody, detected the S antigen (SAg) and N antigen (NAg), reaching a limit of detection of 0. Read More

View Article and Full-Text PDF

Label-free chemiresistor biosensor based on reduced graphene oxide and M13 bacteriophage for detection of coliforms.

Anal Chim Acta 2021 Mar 21;1150:338232. Epub 2021 Jan 21.

Department of Chemical and Environmental Engineering, University of California, Riverside, CA, 92521, USA; Center for Environmental Research and Technology (CE-CERT), University of California, Riverside, CA, 92507, USA. Electronic address:

Coliform bacteria are well known as informative indicators for bacterial contamination in water. This study presents a novel chemiresistor biosensor using M13 phage-modified reduced graphene oxide (rGO) for detection of Escherichia coli (E. coli), as coliform bacteria. Read More

View Article and Full-Text PDF

Simulation and Performance Analysis of Dielectric Modulated Dual Source Trench Gate TFET Biosensor.

Nanoscale Res Lett 2021 Feb 12;16(1):34. Epub 2021 Feb 12.

Key Laboratory for Wide Band Gap Semiconductor Materials and Devices of Education, School of Microelectronics, Xidian University, Xi'an, 710071, China.

In this paper, a dielectric modulated double source trench gate tunnel FET (DM-DSTGTFET) based on biosensor is proposed for the detection of biomolecules. DM-DSTGTFET adopts double source and trench gate to enhance the on-state current and to generate bidirectional current. In the proposed structure, two cavities are etched over 1 nm gate oxide for biomolecules filling. Read More

View Article and Full-Text PDF
February 2021

Multidrug resistant tuberculosis - Diagnostic challenges and its conquering by nanotechnology approach - An overview.

Chem Biol Interact 2021 Mar 26;337:109397. Epub 2021 Jan 26.

Department of Conservative Dentistry & Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Poonamallee High Road, Chennai, Tamil Nadu, 600 077, India. Electronic address:

One of the leading killer diseases that target the parenchymal tissues of lungs is Tuberculosis. Although antimycobacterial drugs are available, there are increased incidences of drug resistance encountered in Mycobacterium sp. They have been categorized into MDR (Multidrug resistant) and XDR (Extensively drug-resistant) strains exhibiting resistance toward successive treatment regimen. Read More

View Article and Full-Text PDF

Finite Element Modelling of Bandgap Engineered Graphene FET with the Application in Sensing Methanethiol Biomarker.

Sensors (Basel) 2021 Jan 15;21(2). Epub 2021 Jan 15.

Department of Electrical and Computer Engineering, Concordia University, Montreal, QC H3G1M8, Canada.

In this work, we have designed and simulated a graphene field effect transistor (GFET) with the purpose of developing a sensitive biosensor for methanethiol, a biomarker for bacterial infections. The surface of a graphene layer is functionalized by manipulation of its surface structure and is used as the channel of the GFET. Two methods, doping the crystal structure of graphene and decorating the surface by transition metals (TMs), are utilized to change the electrical properties of the graphene layers to make them suitable as a channel of the GFET. Read More

View Article and Full-Text PDF
January 2021

Electrochemical device based on nonspecific DNAzyme for the high-accuracy determination of Ca with Pb interference.

Bioelectrochemistry 2020 Dec 29;140:107732. Epub 2020 Dec 29.

State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China. Electronic address:

Calcium is one of the most abundant and indispensable elements in biology, as it is a vital component of nerves, bones, and muscles and maintains the excitability of normal neuromuscular muscles. However, it may be harmful to the human body and even damage the organs if the calcium content exceeds the standard value by several times. To evaluate the level of calcium ions (Ca), an electrochemical biosensor (FET/SWNTs/Cazyme) was developed using a nonspecific DNAzyme with high stability, which combined the unique advantage of field-effect transistors and single-walled carbon nanotubes, while being easy-to-use and having excellent sensitivity. Read More

View Article and Full-Text PDF
December 2020

Nano-FET-enabled biosensors: Materials perspective and recent advances in North America.

Biosens Bioelectron 2021 Mar 30;176:112941. Epub 2020 Dec 30.

Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA; Center for Environmental Research and Technology (CE-CERT), University of California, Riverside, CA 92507, USA. Electronic address:

Field-effect transistor (FET) is a very promising platform for biosensor applications due to its magnificent properties, including label-free detection, high sensitivity, fast response, real-time measurement capability, low running power, and the feasibility to miniaturize to a portable device. 1D (e.g. Read More

View Article and Full-Text PDF

Divalent Cation Dependence Enhances Dopamine Aptamer Biosensing.

ACS Appl Mater Interfaces 2021 Mar 7;13(8):9425-9435. Epub 2021 Jan 7.

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.

Oligonucleotide receptors (aptamers), which change conformation upon target recognition, enable electronic biosensing under high ionic-strength conditions when coupled to field-effect transistors (FETs). Because highly negatively charged aptamer backbones are influenced by ion content and concentration, biosensor performance and target sensitivities were evaluated under application conditions. For a recently identified dopamine aptamer, physiological concentrations of Mg and Ca in artificial cerebrospinal fluid produced marked potentiation of dopamine FET-sensor responses. Read More

View Article and Full-Text PDF

Utilization of silicon nanowire field-effect transistors for the detection of a cardiac biomarker, cardiac troponin I and their applications involving animal models.

Sci Rep 2020 12 16;10(1):22027. Epub 2020 Dec 16.

Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Chiao Tung University, 75 Bo-Ai Street, Hsinchu, 300, Taiwan, ROC.

This study develops an ultrasensitive electrical device, the silicon nanowire-field effect transistor (SiNW-FET) for detection of cardiac troponin I (cTnI) in obesity induced myocardial injury. The biosensor device utilizes metal-oxide-semiconductor (MOS) compatible top-down methodology for the fabrication process. After fabrication, the surface of the SiNW is modified with the cTnI monoclonal antibody (Mab-cTnI) upon covalent immobilization to capture cTnI antigen. Read More

View Article and Full-Text PDF
December 2020

A Reliable BioFET Immunosensor for Detection of p53 Tumour Suppressor in Physiological-Like Environment.

Sensors (Basel) 2020 Nov 8;20(21). Epub 2020 Nov 8.

Biophysics and Nanoscience Centre, DEB, Università degli Studi della Tuscia, 01100 Viterbo, Italy.

The concentration of wild-type tumour suppressor p53 in cells and blood has a clinical significance for early diagnosis of some types of cancer. We developed a disposable, label-free, field-effect transistor-based immunosensor (BioFET), able to detect p53 in physiological buffer solutions, over a wide concentration range. Microfabricated, high-purity gold electrodes were used as single-use extended gates (EG), which avoid direct interaction between the transistor gate and the biological solution. Read More

View Article and Full-Text PDF
November 2020

Nanobiosensors as new diagnostic tools for SARS, MERS and COVID-19: from past to perspectives.

Mikrochim Acta 2020 11 5;187(12):639. Epub 2020 Nov 5.

Department of Chemistry and Drug Technologies, Sapienza University of Rome, P.le Aldo Moro 5, 00185, Rome, Italy.

The severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and novel coronavirus 19 (COVID-19) epidemics represent the biggest global health threats in the last two decades. These infections manifest as bronchitis, pneumonia or severe, sometimes fatal, respiratory illness. The novel coronavirus seems to be associated with milder infections but it has spread globally more rapidly becoming a pandemic. Read More

View Article and Full-Text PDF
November 2020

Reliable and highly sensitive biosensor from suspended MoS atomic layer on nano-gap electrodes.

Biosens Bioelectron 2021 Jan 17;172:112724. Epub 2020 Oct 17.

Department of Mechanical Engineering, Wayne State University, Detroit, MI, 48202, USA. Electronic address:

The uneven morphology and the trapped charges at the surface of the traditionally used supporting substrate-based 2D biosensors produces a scattering effect, which leads to a irregular signals from individually fabricated devices. Though suspended 2D channel material has the potential to overcome scattering effects from the substrates but achieving reliability and selectivity, have been limiting the using of this biosensor technology. Here, we have demonstrated nanogap electrodes fabrication by using the self-assembly technique, which provides suspension to the 2D-MoS. Read More

View Article and Full-Text PDF
January 2021

An origami electrical biosensor for multiplexed analyte detection in body fluids.

Biosens Bioelectron 2021 Jan 12;171:112721. Epub 2020 Oct 12.

Department of Chemical and Environmental Engineering, University of California, Riverside, Riverside, CA, 92521, USA; Center for Environmental Research and Technology (CE-CERT), University of California, Riverside, Riverside, CA, 92507, USA. Electronic address:

We developed an affordable, highly sensitive, and specific paper-based microfluidic platform for fast multiplexed detections of important biomarkers in various body fluids, including urine, saliva, serum, and whole blood. The sensor array consisted of five individual sensing channels with various functionalities that only required a micro liter-sized sample, which was equally split into aliquots by the built-in paper microfluidics. We achieved the individual functionalizations of various bioreceptors by employing the use of wax barriers and 'paper bridges' in an easy and low-cost manner. Read More

View Article and Full-Text PDF
January 2021

Flexible Multiplexed InO Nanoribbon Aptamer-Field-Effect Transistors for Biosensing.

iScience 2020 Sep 18;23(9):101469. Epub 2020 Aug 18.

Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

Flexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within and on the body. Developing biosensors for monitoring multiple neurotransmitters in real time represents a key application that will increase understanding of information encoded in brain neurochemical fluxes. Here, arrays of devices having multiple InO nanoribbon field-effect transistors (FETs) were fabricated on 1. Read More

View Article and Full-Text PDF
September 2020

High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks.

Biosens Bioelectron 2021 Jan 15;171:112736. Epub 2020 Oct 15.

Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

Accurate detection of glucose is essential for the diagnosis of diabetes, wherein effective and sensitive biosensors for glucose detection are needed. Here, we fabricated a glucose sensor based on field-effect transistor (FET) with bimetallic nickel-copper metal-organic frameworks (Ni/Cu-MOFs) as its channel layers which were grown in-situ through a simple one-step hydrothermal method and modified with glucose oxidase (GOD) by using glutaraldehyde (GA) as linkers. Due to the synergistic effect of Ni ions and Cu ions in MOFs, the sensor (GOD-GA-Ni/Cu-MOFs-FET) showed good field effect performance and great responses to glucose through enzymatic reactions. Read More

View Article and Full-Text PDF
January 2021

Biosensing based on field-effect transistors (FET): Recent progress and challenges.

Trends Analyt Chem 2020 Dec 9;133:116067. Epub 2020 Oct 9.

Biologically Inspired Sensors and Actuators (BioSA), Faculty of Science, Dept. of Biology, York University, Toronto, Canada.

The use of field-Effect-Transistor (FET) type biosensing arrangements has been highlighted by researchers in the field of early biomarker detection and drug screening. Their non-metalized gate dielectrics that are exposed to an electrolyte solution cover the semiconductor material and actively transduce the biological changes on the surface. The efficiency of these novel devices in detecting different biomolecular analytes in a real-time, highly precise, specific, and label-free manner has been validated by numerous research studies. Read More

View Article and Full-Text PDF
December 2020

Long-term and label-free monitoring for osteogenic differentiation of mesenchymal stem cells using force sensor and impedance measurement.

J Mater Chem B 2020 11;8(43):9913-9920

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China.

Stem cells have attracted increasing research interest in the field of regenerative medicine due to their unique abilities to differentiate into multiple cell lineages. Label-free, real-time, and long-term monitoring for stem cell differentiation is requisite in studying directional differentiation and development mechanisms for tissue engineering applications, but a great challenge because of the rigorous demands for sensitivity, stability and biocompatibility of devices. In this article, a label-free and real-time monitoring approach using a zinc oxide (ZnO) nanorod field effect transistor (FET) is proposed to detect cell traction forces (CTFs) exerted by cells on underlying substrates. Read More

View Article and Full-Text PDF
November 2020

Label-free detection of DNA by a dielectric modulated armchair-graphene nanoribbon FET based biosensor in a dual-nanogap setup.

Mater Sci Eng C Mater Biol Appl 2020 Dec 24;117:111293. Epub 2020 Jul 24.

Computational Optics Research Group, Advanced Institute of Materials Science, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

A Double-Gate Armchair-Graphene Nanoribbon FET is proposed to realize a high-sensitive and small-size biosensor in order to detect DNA without high-cost and time-consuming labeling process. Two nanogap cavities open inside the top and bottom gate oxides by the method of sacrificed layer etching. When the DNA biomolecule is introduced to the nanogap cavity, the hybridization event which is actually the formation of a double-strand of DNA will occur thus electrically modulating the GNR channel leading to a change in the drain current. Read More

View Article and Full-Text PDF
December 2020

Graphene functionalized field-effect transistors for ultrasensitive detection of Japanese encephalitis and Avian influenza virus.

Sci Rep 2020 09 3;10(1):14546. Epub 2020 Sep 3.

DBT-National Institute of Animal Biotechnology (NIAB), Hyderabad, Telangana, 500032, India.

Graphene, a two-dimensional nanomaterial, has gained immense interest in biosensing applications due to its large surface-to-volume ratio, and excellent electrical properties. Herein, a compact and user-friendly graphene field effect transistor (GraFET) based ultrasensitive biosensor has been developed for detecting Japanese Encephalitis Virus (JEV) and Avian Influenza Virus (AIV). The novel sensing platform comprised of carboxy functionalized graphene on Si/SiO substrate for covalent immobilization of monoclonal antibodies of JEV and AIV. Read More

View Article and Full-Text PDF
September 2020

Non-Carbon 2D Materials-Based Field-Effect Transistor Biosensors: Recent Advances, Challenges, and Future Perspectives.

Sensors (Basel) 2020 Aug 26;20(17). Epub 2020 Aug 26.

Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA.

In recent years, field-effect transistors (FETs) have been very promising for biosensor applications due to their high sensitivity, real-time applicability, scalability, and prospect of integrating measurement system on a chip. Non-carbon 2D materials, such as transition metal dichalcogenides (TMDCs), hexagonal boron nitride (h-BN), black phosphorus (BP), and metal oxides, are a group of new materials that have a huge potential in FET biosensor applications. In this work, we review the recent advances and remarkable studies of non-carbon 2D materials, in terms of their structures, preparations, properties and FET biosensor applications. Read More

View Article and Full-Text PDF