102 results match your criteria ferulic 300


: chemical composition, thermal behavior, antioxidant and antimicrobial activities of leaf and gum hydroalcoholic extracts.

J Food Sci Technol 2021 Jun 17;58(6):2148-2159. Epub 2020 Aug 17.

Department of Food Safety and Quality Control, Research Institute of Food Science and Technology, Mashhad, Iran.

This is the first original study on chemical, thermal, antimicrobial, and antioxidant activity of the leaf and gum hydroethanolic (20:80 v/v) extracts of endemic for Iran. The ratio of solvent to the dried matters was 3:1 (w/w) and after filtering, the solvent was evaporated under vacuum (at 40 °C). Leaf extract contained greater phenolic and flavonoid compounds and thus higher DPPH scavenging and ferric reducing power. Read More

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Evaluation of the tolerance and biotransformation of ferulic acid by Klebsiella pneumoniae TD 4.7.

Braz J Microbiol 2021 Mar 4. Epub 2021 Mar 4.

Department of Biology, São Paulo State University-UNESP, Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, SP, Brazil.

Derived compounds from lignin have been used as substrates for chemical and biological processes for obtainment bioproducts. The ferulic acid is a lignocellulosic biomass whose biotransformation in flavors compounds was described. The objective of this study was the bioconversion of ferulic acid to 4-vinylguaiacol by Klebsiella pneumoniae TD 4. Read More

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Enzymatic Browning in Wheat Kernels Produces Symptom of Black Point Caused by .

Front Microbiol 2020 9;11:526266. Epub 2020 Dec 9.

National Engineering Research Centre for Wheat/National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, China.

To understand the blackening mechanism in black point diseased kernels, ultraviolet-visible light (UV-Vis) and Fourier-transform infrared (FT-IR) absorbance spectra of extracts made from the blackening parts of black point-affected (BP) kernels and the analogous part of black point-free (BPF) kernels were measured using susceptible wheat genotypes "PZSCL6" inoculated with (the dominant pathogen causing this disease). In addition, metabolite differences between BP and BPF kernels were identified by a method that combines gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-high resolution mass spectrometry (LC-MS). Successively, symptoms of black point were produced . Read More

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December 2020

Identification of Phenolic Compounds and Determination of Antioxidant Activity in Extracts and Infusions of Salvia Leaves.

Materials (Basel) 2020 Dec 19;13(24). Epub 2020 Dec 19.

Department of Biochemistry, Faculty of Science, Ege University, Izmir 35040, Turkey.

The influence of harvest period and drying method of L. leaves on the content of essential oils, polyphenols and antioxidant properties was investigated. Sage leaves were collected twice during plant blossoming (in June and July) and dried traditionally in natural conditions and at 35 °C. Read More

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December 2020

A Robust Method to Quantify Cell Wall Bound Phenolics in Plant Suspension Culture Cells Using Pyrolysis-Gas Chromatography/Mass Spectrometry.

Front Plant Sci 2020 9;11:574016. Epub 2020 Sep 9.

Center for Renewable Carbon, University of Tennessee, Knoxville, TN, United States.

The wide-scale production of renewable fuels from lignocellulosic feedstocks continues to be hampered by the natural recalcitrance of biomass. Therefore, there is a need to develop robust and reliable methods to characterize and quantify components that contribute to this recalcitrance. In this study, we utilized a method that incorporates pyrolysis with successive gas chromatography and mass spectrometry (Py-GC/MS) to assess lignification in cell suspension cultures. Read More

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September 2020

Hydrothermal liquefaction of Prosopis juliflora biomass for the production of ferulic acid and bio-oil.

Bioresour Technol 2021 Jan 14;319:124116. Epub 2020 Sep 14.

Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

The objective of this work was to study the hydrothermal liquefaction (HTL) of Prosopis juliflora biomass for the production of ferulic acid and bio-oil. Biomass was processed with various solvents (NaOH, KOH, HCl and HSO) to produce ferulic acid (FA). FA oxidation was carried out using the Nano ZnO catalyst to produce an optimum vanillin yield of 0. Read More

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January 2021

Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice.

Inflammopharmacology 2021 Apr 10;29(2):439-450. Epub 2020 Sep 10.

Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil.

Information on the health benefits of ethanolic extracts obtained from Blutaparon portulacoides stem (EEBP) hasn´t been consistently described in the literature until the present moment. This study investigated the antimycobacterial, anti-inflammatory and toxicological effects of EEBP in models of inflammation/infection, as well as its chemical composition. Chemical analysis of EEBP by electrospray ionization-mass spectrometry/HPLC-MS/MS identified 3,5,3'-Trihydroxy-4'-methoxy-6,7-methylenedioxy-flavone, gomphrenol, ferulic, vanillic, and caffeic acids. Read More

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Stabilization of ferulic acid in topical gel formulation via nanoencapsulation and pH optimization.

Sci Rep 2020 07 23;10(1):12288. Epub 2020 Jul 23.

Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, 627833, Singapore.

Ferulic acid is a potent anti-oxidant with scientifically proven skin care efficacies. However, instability of this active in the skin care products restricted its wide application in beauty and skin care industries. This study aimed to stabilize ferulic acid in topical hydrogel formulation via nanoencapsulation technique. Read More

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Application of Autoclave Treatment for Development of a Natural Wheat Bran Antioxidant Ingredient.

Foods 2020 Jun 12;9(6). Epub 2020 Jun 12.

Agrarian Technological Institute of Castilla and Leon (ITACyL), Ctra. Burgos Km 119, Finca Zamadueñas, 47071 Valladolid, Spain.

The study evaluated the effect of autoclaving as a hydrothermal treatment on the quality and bioactivity of wheat bran (WB) with the objective of producing a natural ingredient with enhanced healthy properties. Nutritional, antioxidant, techno-functional and sensorial parameters were studied, and temperatures of 100, 115 and 130 °C were explored. Of these, 130 °C was found to be the best treatment, resulting in an ingredient with high storage stability, antioxidant properties, a four-fold increase in the concentration of free ferulic acid (compared with non-treated WB), and increased content of apigenin-6-C-arabinoside-8-C-hexoside, a flavonoid with reported antioxidant and antifungal properties. Read More

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Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f.

J Ethnopharmacol 2020 Sep 11;259:112966. Epub 2020 May 11.

Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan. Electronic address:

Ethnopharmacological Relevance: Indigofera argentea Burm. f.; commonly known as neel, jantari, hathio; is traditionally used for the treatment of headache, fever, inflammation and body pain. Read More

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September 2020

UPLC-MS/MS simultaneous determination of seven active ingredients of Yaobitong capsule in rat plasma and its integrated pharmacokinetic application.

Biomed Chromatogr 2020 Sep 17;34(9):e4866. Epub 2020 Jun 17.

School of Pharmacy, Shenyang Pharmaceutical University, Benxi, China.

A reliable and sensitive UPLC-MS/MS method was first established and validated for the simultaneous determination of seven active ingredients of Yaobitong capsule in rat plasma: ginsenoside Rg1, ginsenoside Rb1, osthole, tetrahydropalmatine, paeoniflorin, albiflorin, and ferulic acid. And this method was further applied for the integrated pharmacokinetic study of Yaobitong capsule in rats after oral administration. Plasma samples (100 μL) were precipitated with 300 μL of methanol using carbamazepine as internal standard. Read More

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September 2020

Lentil sprouts: a nutraceutical alternative for the elaboration of bread.

J Food Sci Technol 2020 May 16;57(5):1817-1829. Epub 2019 Dec 16.

5Institut Pprime, CNRS, Université de Poitiers, ISAE-ENSMA, 86962 Futuroscope, Chasseneuil, France.

The pro-health action of germinated lentils could be useful to be added with wheat flour in the production of box bread. In this work, we spectroscopically evaluate the germinated and non-germinated lentils, and use them at the concentrations of 5 and 10% for the production of box bread. The chemical and physical tests of the bread and its determination of phenolic acids and flavonoids (by HPLC) were also performed. Read More

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The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages.

J Reprod Immunol 2020 06 21;139:103104. Epub 2020 Feb 21.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, 113-8655, Japan.

Objectives: To evaluate the anti-inflammatory and anti-angiogenetic effects of Tokishakuyakusan (TSS), a traditional Japanese medicine (Kampo), and its ingredients, ferulic acid (FA) and paeoniflorin (PA) on endometriotic stromal cells (ESC) and peritoneal macrophages.

Study Design: Endometriotic tissues were obtained from 16 patients and peritoneal macrophages were obtained from 11 patients that had undergone laparoscopic surgery for ovarian endometriosis. ESC isolated from endometriotic tissues and peritoneal macrophages were cultured, and pre-treated with 300 μg/mL of TSS, 500 μM FA or 50 μM PA. Read More

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Piper umbellatum L. (Piperaceae): Phytochemical profiles of the hydroethanolic leaf extract and intestinal anti-inflammatory mechanisms on 2,4,6 trinitrobenzene sulfonic acid induced ulcerative colitis in rats.

J Ethnopharmacol 2020 May 27;254:112707. Epub 2020 Feb 27.

Área de Farmacologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá, MT, Brazil. Electronic address:

Ethnopharmacological Relevance: Piper umbellatum L. leaves, commonly found in the Amazon, Cerrado and Atlantic rain forest regions of Brazil, are widely used as a traditional medicine to treat gastrointestinal disorders and inflammation, among others diseases. Also, previous scientific studies demonstrated that P. Read More

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Micelle-nanogel platform for ferulic acid ocular delivery.

Int J Pharm 2020 Feb 21;576:118986. Epub 2019 Dec 21.

Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, Catania, Italy.

Corneal wound healing after a trauma or a chemical injury has been shown to correlate with antioxidant levels at the ocular surface. However, ocular bioavailability of efficient antioxidants (e.g. Read More

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February 2020

In Situ Study of Metabolic Response of Leaves to Salt Stress by Neutral Desorption-Extractive Electrospray Ionization Mass Spectrometry.

J Agric Food Chem 2019 Nov 11;67(46):12945-12952. Epub 2019 Nov 11.

School of Life Sciences , Nanchang University , Nanchang 330031 , China.

Salt stress is one of the most common factors limiting plant cultivation. In this study, metabolic responses to salt stress in () leaves were analyzed in situ by neutral desorption-extractive electrospray ionization mass spectrometry (ND-EESI-MS) without any sample pretreatment. Metabolic changes of leaves were observed in response to salt stress conditions, including the levels of serine, glutamic acid, arginine, cinnamic acid, ferulic acid, caffeic acid, protocatechuic acid, epicatechin, morin, myricetin, apigravin, and β-cotonefuran. Read More

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November 2019

HPLC-DAD Analysis, Antioxidant and Protective Effects of Tunisian Rhanterium suaveolens against Acetamiprid Induced Oxidative Stress on Mice Erythrocytes.

Chem Biodivers 2019 Dec 28;16(12):e1900428. Epub 2019 Nov 28.

Laboratory of Toxicology-Microbiology Environmental and Health, LR17ES06, University of Sfax, Faculty of Sciences of Sfax, BP1171, CP 3000, Sfax, Tunisia.

The present study was performed to assess the HPLC-DAD analysis as well as antioxidant and protective effects of Tunisian Rhanterium suaveolens (Rs) against acetamiprid (ACT) induced oxidative stress on mice erythrocytes. The in vitro assays showed that the methanolic extract of Rs has an impressive antioxidant effect proved by testing the total antioxidant and scavenging activities using BCB, DPPH and ABTS assays, respectively. Moreover, qualitative and quantitative analysis using HPLC-DAD revealed the richness of Rs in polyphenols where p-Coumaric, Apigenin-7-glucoside and Ferulic acid were detected as the most abundant polyphenols. Read More

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December 2019

Digestion behavior and antidepressant-like effect promoted by acute administration of blueberry extract on mice.

Food Res Int 2019 11 14;125:108618. Epub 2019 Aug 14.

Department of Food Science and Technology, Federal University of Santa Catarina, 1346 Admar Gonzaga Rd., Itacorubi, 88034-001 Florianópolis, Santa Catarina, Brazil. Electronic address:

The aim of this study was to evaluate the antidepressant-like effect of the acute administration of blueberry extract in mice. In addition, the digestion behavior of individual phenolic compounds using an in vitro digestion model was also investigated and the main bioaccessible compounds were determined. During digestion, important changes were observed in the polyphenols concentrations and antioxidant capacity upon the passage through the gastric and enteric phases. Read More

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November 2019

Biological and Chemical Insights of Beech ( L.) Bark: A Source of Bioactive Compounds with Functional Properties.

Antioxidants (Basel) 2019 Sep 19;8(9). Epub 2019 Sep 19.

Department of Organic Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, -α-glucosidase, and -tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). Read More

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September 2019

Effect of ferulic acid sugar ester with high molecular mass from corn bran on proliferation of intestinal bifidobacteria in aged mice induced by D-galactose: The role of HFASE in the intestine.

J Food Biochem 2019 11 7;43(11):e13000. Epub 2019 Aug 7.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, China.

Our experiment was to study the effect of high molecular mass ferulic acid sugar ester (HFASE) from corn bran on proliferation of intestinal bifidobacteria in aged mice induced by D-galactose. The number of bifidobacteria in the intestine of D-galactose-induced aging mice was lower than that of normal mice. After the intragastric administration of different doses of HFASE (100, 200, and 300 mg kg  day body weight) in experimental groups, the number of bifidobacteria was also higher than the aging group. Read More

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November 2019

New generation of sequential injection chromatography: Great enhancement of capabilities of separation using flow analysis.

Talanta 2019 Nov 4;204:272-277. Epub 2019 Jun 4.

Department of Analytical Chemistry, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203/8, 500 05, Hradec Králové, Czech Republic.

Since its inception, sequential injection chromatography (SIC) has evolved through several stages. Key moments including introduction of the novel technique combining sequential injection analysis and monolithic column, the first generation of commercial SIC system employing robust pump, the utilization of columns packed with fused-core particles, the on-line hyphenation of extraction and separation steps in SIC, are now followed by the second generation of commercial SIC system employing stainless steel syringe pump and parts optimized for chromatographic separation. The key developments always mean acceleration of the evolution by opening new avenues and reduction of compromises in automated analytical methods based on the flow analysis. Read More

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November 2019

Preparation, characterization, rheological and antioxidant properties of ferulic acid-grafted curdlan conjugates.

Food Chem 2019 Dec 23;300:125221. Epub 2019 Jul 23.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

In this study, water-soluble curdlan products (Cur and Cur-D) were prepared by an alkali-neutralization treatment process, after which ferulic acid (FA)-grafted Cur conjugates (Cur-g-FA and Cur-D-g-FA) were fabricated in the presence and absence of salt by adopting an approach involving free-radicals generated by the ascorbic acid/hydrogen peroxide redox pair under an inert atmosphere. Results showed that FA was successfully grafted onto the C-6 and C-4 positions of the Cur chains through covalent linkages and that the presence of salt exerted minor influences on the grafting ratios and structural characterizations of the products. Cur-g-FA and Cur-D-g-FA showed decreased crystallinity, thermal stability, and rheological properties, as well as a distinct surface morphology, when compared with those of native Cur. Read More

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December 2019

Biotransformation of phenolic compounds by Bacillus aryabhattai.

Bioprocess Biosyst Eng 2019 Oct 5;42(10):1671-1679. Epub 2019 Jul 5.

Industrial Biotechnology and Environmental Engineering Group "BiotecnIA", Chemical Engineering Department, University of Vigo (Campus Ourense), As Lagoas s/n, 32004, Ourense, Spain.

Phenolic compounds could pose environmental problems if they are in excess, although they could be a renewable resource of substances with industrial interest. The novel strain Bacillus aryabhattai BA03 is able to produce high-added value metabolites from different phenolic compounds such as vanillin, 4-vinylguaiacol and 4-vinylphenol while inducing ligninolytic enzymes such as laccases (Lac) and lignin peroxidases (LiP). In comparison with the medium without inducers, the presence of 500 mg/L caffeic acid improved 9. Read More

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October 2019

Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol.

Nutrients 2019 May 25;11(5). Epub 2019 May 25.

Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi 980-8572, Japan.

γ-Oryzanol (OZ), a bioactive phytochemical abundant in cereals such as rice, has been reported to be mainly hydrolyzed to ferulic acid (FA) in the body. Meanwhile, in our previous study, we revealed that a part of OZ is absorbed into the body and exists in its intact form. However, the comprehensive absorption profile of OZ and its metabolites (e. Read More

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Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p-coumaric acid is a pivotal bioactive compound to this action.

Biofactors 2019 May 11;45(3):479-489. Epub 2019 Apr 11.

Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, South Carolina, Brazil.

Baccharis dracunculifolia is a medicinal plant native to southeastern Brazil and is the main botanical source used by bees (Apis mellifera) in the manufacture of green propolis and display similar gastroprotective action and chemical profile. This article reports the healing gastric ulcer activity of the hydroethanolic extract of B. dracunculifolia (HEBD) in an acetic acid-induced ulcer model. Read More

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Modulation of Metabolome and Bacterial Community in Whole Crop Corn Silage by Inoculating Homofermentative and Heterofermentative .

Front Microbiol 2018 23;9:3299. Epub 2019 Jan 23.

State Key Laboratory of Grassland and Agro-ecosystems, School of Life Sciences, Lanzhou University, Lanzhou, China.

The present study investigated the species level based microbial community and metabolome in corn silage inoculated with or without homofermentative and heterofermentative using the PacBio SMRT Sequencing and time-of-flight mass spectrometry (GC-TOF/MS). Chopped whole crop corn was treated with (1) deionized water (control), (2) , or (3) . The chopped whole crop corn was ensiled in vacuum-sealed polyethylene bags containing 300 g of fresh forge for 90 days, with three replicates for each treatment. Read More

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January 2019

Antioxidant activity and phycoremediation ability of four cyanobacterial isolates obtained from a stressed aquatic system.

Mol Phylogenet Evol 2019 05 24;134:300-310. Epub 2019 Jan 24.

Department of Physiology, National Organization for Drug Control and Research (NODCAR), Giza 12553, Egypt.

Cyanobacteria are natural enormous sources of various biologically active compounds with great contributions in different industries. This study aimed to explore and characterize novel cyanobacterial isolates with antioxidant activity and potent phycoremediation ability from Egyptian wastewater canals. The in vitro biological activity of these isolates and their potential ability to take up nutrients and heavy metals from wastewater were examined. Read More

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Screening of novel feruloyl esterases from Talaromyces wortmannii for the development of efficient and sustainable syntheses of feruloyl derivatives.

Enzyme Microb Technol 2019 Jan 30;120:124-135. Epub 2018 Aug 30.

Biochemical Process Engineering, Division of Chemical Engineering, Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, SE-97187, Luleå, Sweden. Electronic address:

The feruloyl esterases Fae125, Fae7262 and Fae68 from Talaromyces wortmannii were screened in 10 different solvent: buffer systems in terms of residual hydrolytic activity and of the ability for the transesterification of vinyl ferulate with prenol or l-arabinose. Among the tested enzymes, the acetyl xylan-related Fae125 belonging to the phylogenetic subfamily 5 showed highest yield and selectivity for both products in alkane: buffer systems (n-hexane or n-octane). Response surface methodology, based on a 5-level and 6-factor central composite design, revealed that the substrate molar ratio and the water content were the most significant variables for the bioconversion yield and selectivity. Read More

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January 2019

Simultaneous determination of fourteen compounds of Hedyotis diffusa Willd extract in rats by UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study.

J Pharm Biomed Anal 2018 Sep 18;159:490-512. Epub 2018 Jul 18.

State Key Laboratory of Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Nanning 530004, China; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. Electronic address:

A rapid, sensitive and selective ultra high-performance liquid chromatography-tandem mass spectrometry UHPLC-MS/MS method has been developed and validated for the simultaneous determination of fourteen bioactive ingredients (gallic acid, geniposidic acid, protocatechuic acid, caffeic acid, ferulic acid, scopoletin, apigenin-7-o-glucuronide, daidzein, apigenin, ursolic acid, oleanolic acid, β-sitosterol, coniferin, and stigmasterol) in the plasma and tissues of rats. Danshensu and icariin were used as internal standards (IS1 and IS2). The chromatographic separation was achieved by using an Agilent ZORBAX RRHD Eclipse Plus C18 column (2. Read More

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September 2018