11,301 results match your criteria fertilization assisted

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction.

Environ Int 2021 Jun 8;155:106666. Epub 2021 Jun 8.

Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, United States.

Background: Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.

Objective: To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth. Read More

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The psychological impact of the COVID-19 pandemic on fertility care: a qualitative systematic review.

Hum Fertil (Camb) 2021 Jun 11:1-8. Epub 2021 Jun 11.

Department of Obstetrics & Gynecology, University of Toronto, Toronto, Canada.

The objective of this systematic review was to characterise psychological impacts of the COVID-19 pandemic related to fertility care. We conducted a systematic search following PRISMA guidelines of five databases (EMBASE, Medline-OVID, CINAHL, Web of Science, and PsycINFO) from March 17 2020 to April 10 2021. Citing articles were also hand-searched using Scopus. Read More

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Albumin used in human IVF contain different levels of lipids and modify embryo and fetal growth in a mouse model.

J Assist Reprod Genet 2021 Jun 11. Epub 2021 Jun 11.

Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.

Purpose: Different commercial human embryo culture mediums can alter embryo quality and change birthweight. One component that could be contributing to variations but is not widely investigated is human serum albumin (HSA). HSA plays a multitude of roles during embryo culture and is a carrier for molecules including lipids. Read More

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Effect of a "Dual Trigger" Using a GnRH Agonist and hCG on the Cumulative Live-Birth Rate for Normal Responders in GnRH-Antagonist Cycles.

Front Med (Lausanne) 2021 25;8:683210. Epub 2021 May 25.

Reproductive Center of Peking University Peoples' Hospital, Beijing, China.

"Dual triggering" for final oocyte maturation using a combination of a gonadotropin-releasing hormone agonist (GnRHa) and human chorionic gonadotropin (hCG) can improve clinical outcomes in high responders during fertilization-intracytoplasmic sperm injection (IVF-ICSI) GnRH-antagonist cycles. However, whether this dual trigger is also beneficial to normal responders is not known. We retrospectively analyzed the data generated from 469 normal responders from 1 January to 31 December 2017. Read More

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Delivering embryos following 10 years of cryopreservation, using unpaired freeze/thaw techniques: A case report.

JBRA Assist Reprod 2021 Jun 9. Epub 2021 Jun 9.

Monteleone Centro de Reprodução Humana, São Paulo, SP, Brazil.

Although frozen embryo transfer is a widely established route for assisted reproduction, successful frozen embryo transfer using embryos that have undergone long term cryopreservation remains relatively unexplored, and its efficacy remains a matter of some debate. This case report describes two successful frozen embryo transfer conceptions in the same patient, one after 3 months of cryopreservation and the second 10 years after cryopreservation. These embryos were cryopreserved using the slow freezing technique and were thawed using an unpaired technique (ultra-rapid warming) after 10 years of storage. Read More

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Predictive Significance of Sperm DNA Fragmentation Testing in Early Pregnancy Loss in Infertile Couples Undergoing Intracytoplasmic Sperm Injection.

Res Rep Urol 2021 1;13:313-323. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.

Objective: This study aimed to determine the role of sperm DNA fragmentation as a marker that could predict early pregnancy loss (EPL), either independently or in combination with another marker or markers, after intracytoplasmic sperm injection (ICSI) cycles.

Methods: This prospective descriptive cohort study retrieved data from 162 couples who underwent their first ICSI cycles at the Center for Reproductive Endocrinology and Infertility of Hue University Hospital in Vietnam from May 2018 to December 2019. General characteristics, semen parameters, sperm DNA fragmentation index (DFI), fertilization, embryo development, pregnancy rates, and EPL were assessed. Read More

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Live Birth Rate Comparison Between Single vs. Double Ovary Women With Assisted Reproduction: A Single Tertiary Center Study.

Cureus 2021 May 6;13(5):e14876. Epub 2021 May 6.

Department of In-Vitro Fertilization, King Abdulaziz Medical City, Riyadh, SAU.

Introduction One of the major hardships faced by married couples is the inability to conceive a child. This issue is becoming more prevalent given the increasing rate of infertility worldwide. Assisted reproductive technology (ART) has brought hope to infertile couples. Read More

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Factors contributing to persistent disparate outcomes of in vitro fertilization treatment.

Curr Opin Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Program in Reproductive Endocrinology and Infertility, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland Department of Gynecologic Surgery and Obstetrics, Womack Army Medical Center, Fort Bragg, North Carolina Veterans Health Administration, Washington, DC, USA.

Purpose Of Review: Disparate healthcare outcomes are ubiquitous and occur across all fields of medicine, specifically for racial and ethnic minorities. Within reproductive health, minority women face disparate access to care, particularly infertility services, poor outcomes of fertility treatment, alarmingly higher rates of maternal morbidity and mortality as well as higher rates of preterm birth, lower live birth rates when they conceive spontaneously or when they conceive with assisted reproductive technology. The objective of this review is to highlight factors contributing to the persistent racial/ethnic disparities in in vitro fertilization (IVF) outcomes. Read More

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Nutrient-assisted phytoremediation of wood preservative-contaminated technosols with co-planting of Salix interior and Festuca arundinacea.

Environ Sci Pollut Res Int 2021 Jun 8. Epub 2021 Jun 8.

Institut de recherche en biologie végétale, Département de Sciences biologiques, Université de Montréal, 4101 Sherbrooke St E, Montreal, Quebec, H1X 2B2, Canada.

The remediation of wood preservative-contaminated sites is an important issue due to the carcinogenic nature of some contaminants derived from wood preservatives (e.g., Cr, arsenate, and pentachlorophenol). Read More

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What is the optimum number of follicular flushing in mono-follicular IVF cycles in poor responder women population?

J Turk Ger Gynecol Assoc 2021 Jun 8. Epub 2021 Jun 8.

American Hospital, Women's Health Center, İstanbul, Turkey.

Objective: The assessment of the optimal number of follicular flushing on retrieval rate and quality of oocytes in mono-follicular IVF cycles.

Material And Methods: This is a retrospective analysis of 246 oocyte pick-up procedures in mono-follicular IVF cycles of 226 poor responder women. The primary endpoint was oocyte retrieval rate in the initial aspirate versus subsequent flushing episodes. Read More

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Analysis of related factors affecting cumulative live birth rates of the first ovarian hyperstimulation in vitro fertilization or intracytoplasmic sperm injection cycle: a population-based study from 17,978 women in China.

Chin Med J (Engl) 2021 Jun 4. Epub 2021 Jun 4.

Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing 100191, China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Background: More and more scholars have called for the cumulative live birth rate (CLBR) of a complete ovarian stimulation cycle as a key indicator for assisted reproductive technology. This research aims to study the CLBR of the first ovarian hyperstimulation cycles and analyze the related prognosis factors that might affect the CLBR.

Methods: Our retrospective study included first in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) cycles performed between January 2013 to December 2014. Read More

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Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer.

J Assist Reprod Genet 2021 Jun 4. Epub 2021 Jun 4.

IVI-Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA.

Purpose: To evaluate embryology and pregnancy outcomes following individual and group embryo culture in the setting of contemporary laboratory practices and freeze-all cycles.

Methods: Patients underwent ovarian stimulation followed by intracytoplasmic sperm injection (ICSI). Embryos proceeded through individual culture and then underwent preimplantation genetic testing for aneuploidy (PGT-A) via trophectoderm biopsy. Read More

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Do basal Luteinizing Hormone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio Have Significance in Prognosticating the Outcome of Fertilization Cycles in Polycystic Ovary Syndrome?

J Hum Reprod Sci 2021 Jan-Mar;14(1):21-27. Epub 2021 Mar 30.

Department of Obstetrics and Gynaecology, ART Center, All India Institute of Medical Sciences, New Delhi, India.

Context: Tonic hypersecretion of luteinizing hormone (LH) appears to impact both fertility and pregnancy outcomes in women with polycystic ovary syndrome (PCOS).

Aim: Whether high basal day 2/3 serum LH levels and day 2/3 LH/follicle-stimulating hormone (FSH) ratio affect fertilization (IVF) cycle outcomes in PCOS patients undergoing controlled ovarian hyperstimulation using gonadotropin-releasing hormone (GnRH) antagonists.

Settings And Design: A retrospective cohort study was conducted in Assisted Reproductive Technique Center, Department of Obstetrics and Gynaecology, at a tertiary care institute, on PCOS patients undergoing IVF/intracytoplasmic sperm injection (ICSI) using GnRH antagonist protocol with human chorionic gonadotropin trigger between January 2014 to December 2019. Read More

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Successful pregnancy following transmyometrial embryo transfer after robot-assisted radical trachelectomy.

Clin Exp Reprod Med 2021 Jun 25;48(2):184-187. Epub 2021 May 25.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Radical trachelectomy is a fertility-preserving alternative to radical hysterectomy in carefully selected young women with early-stage cervical cancer. However, in cases with subsequent severe cervical stenosis, assisted reproductive techniques can be difficult. This is a case report of a 34-year-old patient who underwent robot-assisted radical trachelectomy and cerclage for early-stage (IB2) adenosquamous carcinoma. Read More

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Staphylococcus saprophyticus and Escherichia coli: Tracking from sperm fertility potential to assisted reproductive outcomes.

Clin Exp Reprod Med 2021 Jun 26;48(2):142-149. Epub 2021 May 26.

Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

Objective: Bacteriospermia and urogenital infections are common problems in male infertility. This study aimed to evaluate the effects of bacteriospermia on sperm parameters and clinical outcomes in semen samples infected with two common bacteria (Staphylococcus saprophyticus and Escherichia coli) in northern Iran.

Methods: Microbiological tests were performed to isolate and identify organisms from 435 semen samples from infertile couples. Read More

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Hysteroscopy Findings in Women with Thin Endometrium Scheduled for In Vitro fertilization in Niger Delta Region, Nigeria.

Jude E Okohue

Afr J Reprod Health 2020 Jun;24(2):123-128

Assisted Reproduction Unit, Gynescope Specialist Hospital: 22/24 Gynescope Drive Port Harcourt, Rivers State.

The effect of endometrial thickness on in vitro fertilization (IVF) outcome is still a subject of debate. It is unclear why a thin endometrium reduces IVF success rates. Our objective was to analyze the hysteroscopic findings in women scheduled for IVF who had an endometrial thickness less than 7 mm. Read More

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Preimplantation Genetic Testing for Rare Inherited Disease of MMA-CblC: an Unaffected Live Birth.

Reprod Sci 2021 Jun 2. Epub 2021 Jun 2.

Center of Prenatal Diagnosis, Department of Obstetrics & Gynecology, West China Second University Hospital, Sichuan University, 17 South Renmin Road, Chengdu, China.

Methylmalonic acidemia combined with homocysteinemia and cobalamin C type (MMA-CblC, MIM # 277400) is a rare inherited disease with cobalamin metabolic disorder, which are caused by deficiency in the MMACHC gene. A couple with a proband child carried with compound heterozygous mutations of MMACHC (c.609G>A and c. Read More

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Multivariate analysis of the factors associated with live births during in vitro fertilisation in Southeast Asia: a cross-sectional study of 104,015 in vitro fertilisation records in Taiwan.

J Assist Reprod Genet 2021 Jun 1. Epub 2021 Jun 1.

Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Purpose: To investigate the factors associated with live births and the interaction between age and the number of embryos transferred after in vitro fertilisation (IVF) treatment.

Methods: This study analyses data from a population-based-assisted reproductive database of all registered artificial reproduction institutions (n = 80) from 2010 to 2016 in Taiwan. The probability of a live birth in correlation with the treatment parameters was measured with multivariate logistic regression analyses using the generalised additive model (GAM) and Pearson's chi-square exact test. Read More

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Changes in Phenotypes and DNA Methylation of In Vitro Aging Sperm in Common Carp .

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia in České Budějovice, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

The purpose of the current study was to analyze phenotypic and functional characteristics of common carp () spermatozoa during in vitro aging and to investigate whether global DNA methylation is affected by sperm aging. Milt was collected from five individual males, stored in vitro on ice in a refrigerator for up to 96 h post stripping (HPS) and used to fertilize eggs with intervals of 1, 24 and 96 h. Computer-assisted sperm analysis and a S3e Cell Sorter was employed to determine the spermatozoa phenotypic characteristics (motility, velocity, concentration and viability). Read More

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Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence.

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

Department of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Gagarina Street 7, 87-100 Torun, Poland.

The oocyte is the major determinant of embryo developmental competence in all mammalian species. Although fundamental advances have been generated in the field of reproductive medicine and assisted reproductive technologies in the past three decades, researchers and clinicians are still trying to elucidate molecular factors and pathways, which could be pivotal for the oocyte's developmental competence. The cell-to-cell and cell-to-matrix communications are crucial not only for oocytes but also for multicellular organisms in general. Read More

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The Impact of Internalized Stigma on LGBT Parenting and the Importance of Health Care Structures: A Qualitative Study.

Int J Environ Res Public Health 2021 May 18;18(10). Epub 2021 May 18.

Facultad de Humanidades, Escuela de Psicología, Universidad Católica del Norte, Antofagasta 1270709, Chile.

Research on LGBTIQ+ families has focused on the effects of being in a diverse family on the development of children. We seek to show the experience of parenthood from the perspective of LGBTIQ+ people, considering its particularities and the role that health care services play as a potential support network. We used the biographical method through open-ended interviews, participants were LGBT people, and key informants from Chile, Colombia, and Mexico were selected based on a sociostructural sampling. Read More

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The Addition of Endometrial Injury to Freeze-All Strategy in Women with Repeated Implantation Failures.

J Clin Med 2021 May 17;10(10). Epub 2021 May 17.

Assisted Reproduction Unit, Second Department of Obstetrics and Gynecology, "Aretaieion Hospital", Medical School, National and Kapodistrian University of Athens, Vas. Sofias 76, 11528 Athens, Greece.

(1) Background: Recurrent implantation failure (RIF) after IVF remains a challenging topic for fertility specialists and a frustrating reality for patients with infertility. Various approaches have been investigated and applied towards the improvement of clinical outcomes. Through a nonrandomized clinical trial, we evaluated the effect of the combination of hysteroscopic endometrial injury and the freeze-all technique on pregnancy parameters in a cohort of RIF patients; (2) Methods: The study group comprised of 30 patients with RIF that underwent a hysteroscopic endometrial injury prior to a frozen embryo transfer cycle; another 30 patients with RIF, comprising the control group, underwent a standard frozen cycle with no adjuvant treatment before. Read More

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Sperm DNA fragmentation and male age: results of in vitro fertilization treatments.

JBRA Assist Reprod 2020 Nov 5. Epub 2020 Nov 5.

Argentina Fertilis Reproductive Medicine, San Isidro, Buenos Aires, Argentina.

Objective: This study aimed to assess the effects of sperm DNA fragmentation in parents belonging to different age groups. The couples included in the study comprised normozoospermic men and infertile women undergoing conventional IVF.

Methods: The results obtained from 163 conventional IVF cycles were analyzed retrospectively. Read More

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November 2020

SARS-CoV-2 vs. human gametes, embryos and cryopreservation.

Syst Biol Reprod Med 2021 Jun 1:1-10. Epub 2021 Jun 1.

Department of Obstetrics and Gynaecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is an unprecedented global situation, and all countries have adopted their own measurements to mitigate the spread of the virus in the first as well as in the subsequent waves of infection. All measures, especially in the first wave of the pandemic, were in combination with recommendations provided by professional and scientific organizations. Similar measures were applied to specific procedures, such as the management of infertility, including in vitro fertilization-embryo transfer (IVF-ET) treatments. Read More

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Treatment with assisted reproduction technologies in women with acute hepatic porphyria.

Acta Obstet Gynecol Scand 2021 Jun 1. Epub 2021 Jun 1.

Porphyria Centre Sweden, Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.

Introduction: The acute porphyrias are rare disorders of the heme biosynthetic pathway and present with acute neurovisceral symptoms that can be induced by hormonal changes and medications. Women are far more likely to present with clinical symptoms than men, particularly during parts of their lifetime with changes in the level of female sex hormones such as ovulation, menstruation and pregnancy. Treatment of ovulatory dysfunction and controlled ovarian hyperstimulation require the administration of hormones, which are considered porphyrinogenic. Read More

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Sperm migration, selection, survival and fertilizing ability in the mammalian oviduct.

Biol Reprod 2021 May 31. Epub 2021 May 31.

CNRS, IFCE, INRAE, Université de Tours, PRC, 37380, Nouzilly, France.

In vitro fertilization (IVF) gives rise to embryos in a number of mammalian species and is currently widely used for assisted reproduction in humans and for genetic purposes in cattle. However, the rate of polyspermy is generally higher in vitro than in vivo and IVF remains ineffective in some domestic species like pigs and horses, highlighting the importance of the female reproductive tract for gamete quality and fertilization. In this review, the way the female environment modulates sperm selective migration, survival and acquisition of fertilizing ability in the oviduct is being considered under six aspects: (1) the utero-tubal junction which selects a sperm sub-population entering the oviduct; (2) the presence of sperm binding sites on luminal epithelial cells in the oviduct, which prolong sperm viability and plays a role in limiting polyspermic fertilization; (3) the contractions of the oviduct, which promote sperm migration toward the site of fertilization in the ampulla; (4) the regions of the oviduct, which play different roles in regulating sperm physiology and interactions with oviduct epithelial cells; (5) the time of ovulation and (6) the steroid hormonal environment which regulates sperm release from the luminal epithelial cells and facilitates capacitation in a finely orchestrated manner. Read More

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Identification and treatment of a cervical sinus tract in a patient with 10 years of infertility.

Fertil Steril 2021 May 27. Epub 2021 May 27.

Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China. Electronic address:

Objective: To introduce a special case of endometrial cavity fluid (ECF), highlighting the application of hysteroscopy and laparoscopic surgical techniques in the treatment of cervical sinus tract.

Design: Narrated video featuring the diagnosis and surgical management of a case of recurrent ECF. Informed consent was obtained from the patient, and approval was granted by the ethics committee of the First Affiliated Hospital of the Wenzhou Medical University. Read More

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A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI.

Hum Reprod 2021 May 29. Epub 2021 May 29.

Hull Health Trials Unit, The University of Hull, Hull, HU6 7RX, UK.

Study Question: What is the clinical-effectiveness and safety of the endometrial scratch (ES) procedure compared to no ES, prior to usual first time in vitro fertilisation (IVF) treatment?

Summary Answer: ES was safe but did not improve pregnancy outcomes when performed in the mid-luteal phase prior to the first IVF cycle, with or without intracytoplasmic sperm injection (ICSI).

What Is Known Already: ES is an 'add-on' treatment that is available to women undergoing a first cycle of IVF, with or without ICSI, despite a lack of evidence to support its use.

Study Design, Size, Duration: This pragmatic, superiority, open-label, multi-centre, parallel-group randomised controlled trial involving 1048 women assessed the clinical effectiveness and safety of the ES procedure prior to first time IVF, with or without ICSI, between July 2016 and October 2019. Read More

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Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study.

Front Endocrinol (Lausanne) 2021 11;12:628169. Epub 2021 May 11.

Center for Assisted Reproduction, Krishna IVF Clinic, Visakhapatnam, India.

Infertility is a major concern for couples wanting to have progeny. Despite recent advances in the field of IVF, success rates still need improvement. Understanding the patient's variability and addressing it with personalized interventions may improve the success rate of fertilization and live births. Read More

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Clinical Efficacy of Follitropin Alfa in GnRH-Antagonist Protocols: A Prospective Observational Phase IV Study on the Use of Biosimilar Follitropin Alfa r-hFSH in Assisted Reproductive Technology in a Routine Care Setting.

J Reprod Infertil 2021 Apr-Jun;22(2):116-124

Universitaeres interdisziplinäres Kinderwunschzentrum Duesseldorf (UniKiD), Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Duesseldorf, Duesseldorf, Germany.

Background: This phase IV routine care study evaluated ovarian responses when using a biosimilar follitropin alfa r-hFSH (Bemfola) for controlled ovarian stimulation (COS) in women undergoing assisted reproductive technology (ART) treatment who were pituitary-suppressed with a gonadotrophin-releasing hormone (GnRH) antagonist.

Methods: This multicenter, prospective, non-comparative, non-interventional study (Germany/Austria) was conducted with 885 women (Mean age of 34.0±4. Read More

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