4,304 results match your criteria fertility stimulation

[Desire to have children in the menopausal transition].

Bruno Imthurn

Ther Umsch 2021 ;78(8):407-411

Medizinische Fakultät Universität Zürich.

Desire to have children in the menopausal transition The menopausal transition is characterized by the loss of ovarian reserve, i. e. the number and quality of oocytes. Read More

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January 2021

Planned oocyte cryopreservation in women with blepharophimosis-ptosis-epicanthus inversus syndrome: a case series.

F S Rep 2021 Sep 27;2(3):332-337. Epub 2021 May 27.

Division of Reproductive Endocrinology and Infertility, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Objective: To describe the experiences of three women with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) who desired to pursue planned oocyte cryopreservation.

Design: Case series.

Setting: An academic institution and a private clinic. Read More

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September 2021

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles.

F S Rep 2021 Sep 27;2(3):314-319. Epub 2021 May 27.

Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Objective: To study the birth rates of normal vs. high responders after dual trigger of final oocyte maturation with gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin in fresh in vitro fertilization (IVF) cycles in which ovarian stimulation was achieved by a flexible GnRH antagonist protocol.

Design: Retrospective cohort study. Read More

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September 2021

Sperm deoxyribonucleic acid fragmentation: predictors, fertility outcomes, and assays among infertile males.

F S Rep 2021 Sep 19;2(3):282-288. Epub 2021 Jun 19.

Duke University School of Medicine, Durham, North Carolina.

Objective: To examine the factors associated with increased deoxyribonucleic acid fragmentation index (DFI), evaluate the pregnancy outcomes of men with increased DFI, and compare three independent DFI assays.

Design: Secondary analysis.

Setting: Nine US-based fertility centers. Read More

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September 2021

Outcomes of Fertility Preservation Consults for Women at Risk for Primary Ovarian Insufficiency Due to History of Cancer Treatment or Mosaic Turner Syndrome.

J Adolesc Young Adult Oncol 2021 Sep 22. Epub 2021 Sep 22.

Division of REI, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.

Adolescents and young adults (AYAs) at risk of primary ovarian insufficiency (POI) often request fertility preservation consultation. We report consult/treatment outcomes for 21 cancer survivors and 3 mosaic Turner syndrome (TS) patients (mean age 21.6 at consult, 3 with POI). Read More

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September 2021

[Fertility preservation options before gonadotoxic antirheumatic treatment : A review].

Z Rheumatol 2021 Sep 22. Epub 2021 Sep 22.

Universitäres Interdisziplinäres Kinderwunschzentrum Düsseldorf, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Cyclophosphamide is still clinically used in rheumatic diseases with severe disease courses. Cyclophosphamide has a pronounced gonadotoxic effect largely depending on the cumulative dose. The risk of amenorrhea is reported to be in the range of 12-54% and is dependent on the age of the patient at initiation of treatment. Read More

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September 2021

Trisomy 21 and Assisted Reproductive Technologies: A review.

JBRA Assist Reprod 2021 Sep 20. Epub 2021 Sep 20.

EmbryoFertility Reproductive Biomedicine, Lima, Peru.

Trisomy 21 is the most common genetic disorder seen among infants, and it causes spontaneous abortions, abnormal neural development and other pathologies associated with newborn development. In newborns with this trisomy, 90-95% have full trisomy, 1.4-1. Read More

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September 2021

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility.

Eur Urol 2021 Sep 9. Epub 2021 Sep 9.

Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy.

Context: The European Association of Urology (EAU) has updated its guidelines on sexual and reproductive health for 2021.

Objective: To present a summary of the 2021 version of the EAU guidelines on sexual and reproductive health, including advances and areas of controversy in male infertility.

Evidence Acquisition: The panel performed a comprehensive literature review of novel data up to January 2021. Read More

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September 2021

Two cases of polycystic ovary syndrome with onset of severe ovarian hyperstimulation syndrome following controlled ovarian stimulation with aromatase inhibitors for fertility preservation before breast cancer treatment.

Taiwan J Obstet Gynecol 2021 Sep;60(5):931-934

Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.

Objective: The risks of ovarian hyperstimulation syndrome (OHSS) involve high estrogen (E) levels. We report two breast cancer patients with polycystic ovarian syndrome who underwent fertility preservation and had severe OHSS; their E levels were lowered using aromatase inhibitors (AI).

Case Reports: A 36-year-old woman underwent controlled ovarian stimulation (COS) with AI and cryopreserved 10 blastocysts. Read More

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September 2021

Ovarian steroid hormone secretion by human granulosa cells after supplementation of sambucus nigra L. extract.

Physiol Res 2021 Sep 10. Epub 2021 Sep 10.

AgroBioTech Research Centre, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic. Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic.

Beneficial effects of Sambucus nigra L. (black elder) as a traditional medicine have been associated with the phytoconstituents including polyphenols, terpenes and lectins. Various antioxidant rich natural products have also been implicated with improvement of reproductive health and fertility, however, the effect of Sambucus nigra on the ovarian cell functions has not been investigated yet. Read More

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September 2021

and AKT/mTOR Signaling in Human Granulosa Cells: Functional Interaction and Impact on Ovarian Response.

J Clin Med 2021 Aug 30;10(17). Epub 2021 Aug 30.

Division of Reproductive Genetics, Department of Gynecological Endocrinology and Fertility Disorders, University Women's Hospital Heidelberg, 69120 Heidelberg, Germany.

We aimed to determine whether a functional link with impact on female ovarian reserve exists between expression and expression ratios of AKT/mTOR signaling genes in human granulosa cells in vivo, as suggested from prior in vitro data. Three hundred and nine women, who were classified as normal (NOR; = 225) and poor (POR; = 84) responders based on their ovarian reserve, were recruited during stimulation for assisted reproductive techniques. Expressions of and of key genes of the AKT/mTOR and AKT/FOXO1/3 signaling pathways were comparatively analyzed in their granulosa cells. Read More

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Acute Ischemic Priapism: An AUA/SMSNA Guideline.

J Urol 2021 Sep 8:101097JU0000000000002236. Epub 2021 Sep 8.

Northwestern University, Chicago, Illinois (Vice Chair).

Purpose: Priapism is a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation and results in a prolonged and uncontrolled erection. Given its time-dependent and progressive nature, priapism is a situation that both urologists and emergency medicine practitioners must be familiar with and comfortable managing. Acute ischemic priapism, characterized by little or no cavernous blood flow and abnormal cavernous blood gases (ie, hypoxic, hypercarbic, acidotic) represents a medical emergency and may lead to cavernosal fibrosis and subsequent erectile dysfunction. Read More

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September 2021

Do stage and grade of malignancy impact fertility preservation in breast cancer patients?

J Gynecol Obstet Hum Reprod 2021 Sep 2;50(10):102215. Epub 2021 Sep 2.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Introduction: The impact of cancer on basal fertility and ovarian response to stimulation has not yet been clarified. Evidence on this topic is scarce and conflicting. Aim of this study was to assess the impact of breast cancer stage and grade on the number of retrieved mature oocytes during controlled ovarian stimulation for fertility preservation. Read More

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September 2021

Awareness of maternal stress, consequences for the offspring and the need for early interventions to increase stress resilience.

J Perinat Med 2021 Sep 6. Epub 2021 Sep 6.

Clara Angela Foundation, Berlin, Germany.

Experimental and clinical studies suggest that prenatal experiences may influence health trajectories up to adulthood and high age. According to the hypothesis of developmental origins of health and disease exposure of pregnant women to stress, nutritional challenges, infection, violence, or war may "program" risks for diseases in later life. Stress and anxieties can exist or be provoked in parents after fertility treatment, after information or diagnosis of fetal abnormalities and demand simultaneous caring concepts to support the parents. Read More

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September 2021

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.

Mol Hum Reprod 2021 Aug 31. Epub 2021 Aug 31.

Department of Pharmacology, Weill Cornell Medicine, New York City, NY, USA.

Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for male fertility in mice and humans. In mice, ex vivo studies of dormant, caudal epididymal sperm demonstrated that sAC is required for initiating capacitation and activating motility. We now use an improved sAC inhibitor, TDI-10229, for a comprehensive analysis of sAC function in mouse and human sperm. Read More

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Altered Follicular Fluid Metabolic Pattern Correlates with Female Infertility and Outcome Measures of In Vitro Fertilization.

Int J Mol Sci 2021 Aug 14;22(16). Epub 2021 Aug 14.

Alma Res Fertility Center, Obstetrics and Gynecology, Via Parenzo 12, 00198 Rome, Italy.

Nearly 40-50% of infertility problems are estimated to be of female origin. Previous studies dedicated to the analysis of metabolites in follicular fluid (FF) produced contrasting results, although some valuable indexes capable to discriminate control groups (CTRL) from infertile females (IF) and correlate with outcome measures of assisted reproduction techniques were in some instances found. In this study, we analyzed in blind FF of 35 control subjects (CTRL = patients in which inability to obtain pregnancy was exclusively due to a male factor) and 145 IF (affected by: endometriosis, = 19; polycystic ovary syndrome, = 14; age-related reduced ovarian reserve, = 58; reduced ovarian reserve, = 29; unexplained infertility, = 14; genetic infertility, = 11) to determine concentrations of 55 water- and fat-soluble low molecular weight compounds (antioxidants, oxidative/nitrosative stress-related compounds, purines, pyrimidines, energy-related metabolites, and amino acids). Read More

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Fertility preservation and PGT-M in women with familial adenomatous polyposis-associated desmoid tumours.

Reprod Biomed Online 2021 Jul 22. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Research Question: Is ovarian stimulation and pregnancy in women with familial adenomatous polyposis (FAP)-associated desmoid tumours safe?

Design: The study included women with FAP-associated desmoid tumours who underwent fertility treatments at the authors' tertiary medical centre between the years 2011 and 2021. Data were collected from the fertility unit's charts and from the oncological registries. The main outcome measures were the number of vitrified oocytes and embryos, and the number of live births in preimplantation genetic testing for monogenic/single gene defects (PGT-M) cycles. Read More

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A Comparative Study to Assess the Efficacy of Two Different Estradiol Formulations during In Vitro Fertilization.

Int J Reprod Med 2021 10;2021:3153307. Epub 2021 Aug 10.

Nova IVF Fertility, Ahmedabad, India.

Improvements in stimulation protocols, introduction of vitrification, and changes in clinical practices have contributed to improved efficacy and safety of assisted reproductive technology (ART) procedures. This has also led to a concomitant increase in number of cycles requiring hormone replacement therapy (HRT) protocol for performing an embryo transfer. Successful implantation is dependent on endometrial thickness which in turn is regulated by temporal regulation of hormones. Read More

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Erzhi Tiangui Granules Improve In Vitro Fertilization Outcomes in Infertile Women with Advanced Age.

Evid Based Complement Alternat Med 2021 12;2021:9951491. Epub 2021 Aug 12.

Women's Health Department, Maternal and Child Health Care Hospital of Shandong Province, Jinan 250011, Shandong, China.

Background: The fertility of females with advanced age declines with aging. Therefore, for medical and social reasons, it is important to establish mechanisms to protect and improve the fertility of such populations. With widespread use of traditional Chinese medicine (TCM) in in vitro fertilization (IVF), studies have evaluated their impact on improving the fertility of females with advanced age. Read More

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Circulating Tumor DNA to Interrogate the Safety of Letrozole-Associated Controlled Ovarian Stimulation for Fertility Preservation in Breast Cancer Patients.

Front Oncol 2021 3;11:686625. Epub 2021 Aug 3.

Fertility Clinic, CUB-Erasme Hospital, Brussels, Belgium.

Background: Current fertility preservation strategies for young breast cancer patients planning a future motherhood include the association of controlled ovarian stimulation with the aromatase inhibitor letrozole (let-COS) to harvest mature oocytes while maintaining low estradiol levels. Despite this is a widely adopted protocol, the safety of let-COS on breast cancer outcomes has been poorly investigated and its use remains off-label. We assessed the safety of let-COS in breast cancer patients using circulating tumor DNA (ctDNA) as a surrogate biomarker of disease recurrence. Read More

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Prior iodine exposure and impact on thyroid function during controlled ovarian hyperstimulation: A prospective study.

Aust N Z J Obstet Gynaecol 2021 Aug 18. Epub 2021 Aug 18.

Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, New South Wales, Australia.

Aims: Iodine supplements are recommended for women planning pregnancy, but their impact on thyroid function during controlled ovarian hyperstimulation (COH) and into pregnancy is unknown. The aim of this study was to assess the impact of iodine supplementation on thyroid function during COH.

Methods: One-hundred and six euthyroid women (thyroid stimulating hormone (TSH) 0. Read More

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PPOS Protocol Effectively Improves the IVF Outcome Without Increasing the Recurrence Rate in Early Endometrioid Endometrial Cancer and Atypical Endometrial Hyperplasia Patients After Fertility Preserving Treatment.

Front Med (Lausanne) 2021 27;8:581927. Epub 2021 Jul 27.

Shanghai JIAI Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

To investigate the effectiveness and recurrence risk of different ovulation stimulation protocols in early-stage endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH) patients after successful fertility preserving treatment. A retrospective review of clinical files between June 2012 and July 2018. University hospital. Read More

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Educational needs of fertility healthcare professionals using ART: a multi-country mixed-methods study.

Reprod Biomed Online 2021 Sep 2;43(3):434-445. Epub 2021 Jul 2.

AXDEV Group Inc., Brossard Québec J4W 3H2, Canada.

Research Question: What are the most pressing educational needs of fertility healthcare professionals using assisted reproductive technologies (ART)?

Design: This mixed-methods study combined qualitative interviews with quantitative surveys. Participants included physicians and nurses specialized in reproductive endocrinology or in obstetrics/gynaecology, and laboratory specialists, with a minimum of 3 years of experience, practising in Australia, Brazil, Canada, China, France, Germany, India, Italy, Japan, Mexico, Spain or the UK. Maximum variation purposive sampling was used to ensure a mix of experience and settings. Read More

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September 2021

Controlled ovarian stimulation outcomes of fertility preservation procedures in newly diagnosed breast cancer patients: a retrospective study from a single-tertiary-IVF centre.

J Obstet Gynaecol 2021 Aug 12:1-6. Epub 2021 Aug 12.

Ege University, Family Planning and Infertility Research and Practice Center, Izmir, Turkey.

The aim of this study was to evaluate the effectiveness of controlled ovarian stimulation (COS) using the letrozole-supplemented stimulation protocol in breast cancer (BC) patients prior to their cancer treatment. Sixty-one BC patients (Stages 0-3) who were referred to a university IVF unit for fertility preservation (FP) and underwent embryo and/or oocyte cryopreservation between 2008 - 2020 were included in this retrospective study. Time intervals between breast surgery and initial fertility consultation (IFC)/completion of FP procedures were evaluated. Read More

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Urinary phthalate metabolite concentrations are negatively associated with follicular fluid anti-müllerian hormone concentrations in women undergoing fertility treatment.

Environ Int 2021 Aug 7;157:106809. Epub 2021 Aug 7.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Harvard Medical School & Brigham and Women's Hospital, United States.

Exposure to phthalates, endocrine-disrupting chemicals commonly used as plasticizers and in consumer products, has been associated with infertility and premature ovarian failure. Our objective was to investigate whether urinary phthalate metabolite concentrations were associated with pre-ovulatory follicular fluid (FF) anti-müllerian hormone (AMH) concentrations in women undergoing fertility treatment. This cross-sectional analysis included 138 women with urinary phthalate data available in the Environment and Reproductive Health (EARTH) Study (2010-2016) in whom FF AMH concentrations were quantified using a sandwich enzyme-linked immunosorbent assay (ELISA). Read More

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The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis.

Hum Reprod 2021 Sep;36(10):2676-2686

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Study Question: Does ultra-long downregulation with a GnRH agonist (triptorelin depot) in previously operated patients with endometriosis improve the rate of clinical pregnancy with positive fetal heart beat (CPHB) in the subsequent initiated fresh ART cycle?

Summary Answer: Ultra-long downregulation with a GnRH agonist prior to ART did not improve the rate of CPHB in the subsequent fresh ART cycle in previously completely operated patients but the trial was underpowered due to early termination.

What Is Known Already: Administration of GnRH agonists for a period of 3-6 months prior to ART in women with endometriosis may increase the odds of clinical pregnancy. However, the quality of the studies on which this statement is based is questionable, so these findings need confirmation. Read More

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September 2021

Ovarian Telomerase and Female Fertility.

Biomedicines 2021 Jul 20;9(7). Epub 2021 Jul 20.

Laboratory of Biology of Reproduction, University Hospital of Nancy, 54000 Nancy, France.

Women's fertility is characterized both quantitatively and qualitatively mainly by the pool of ovarian follicles. Monthly, gonadotropins cause an intense multiplication of granulosa cells surrounding the oocyte. This step of follicular development requires a high proliferation ability for these cells. Read More

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Management of endometrial polyps in infertile women: A mini-review.

Clin Exp Reprod Med 2021 Sep 30;48(3):198-202. Epub 2021 Jul 30.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Considerable disagreement exists regarding whether endometrial polyps should be removed before attempting natural pregnancy and before pregnancy via intrauterine insemination (IUI) or in vitro fertilization (IVF). Through a literature review, we obtained information on the impact of endometrial polyps and polypectomy on fertility outcomes. Several observational studies have suggested that women with unexplained infertility may benefit from endometrial polypectomy for a future natural pregnancy. Read More

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September 2021

Impact of Intrauterine Administration of Human Chorionic Gonadotropin before Intrauterine Insemination in Infertile Women: A Randomized Controlled Trial.

J Hum Reprod Sci 2021 Apr-Jun;14(2):156-161. Epub 2021 Jun 28.

Department of Obstetrics and Gynaecology, IVF and Fertility Research Centre, ESI-PGIMSR, New Delhi, India.

Background: Implantation is the rate-limiting step in the success of both intrauterine Insemination (IUI) and fertilization cycles. Numerous interventions that target various local signals have been tried to improve the implantation and clinical pregnancy rate (CPR). The most significant of these signals is human chorionic gonadotropin (hCG) which acts as immunomodulator and improves implantation by decidualization of the endometrial stromal cells, trophoblast invasion, proliferation of uterine natural killer cells, stimulation of endometrial angiogenesis, and maintenance of progesterone secretion by the corpus luteum. Read More

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IVF impact on the risk of recurrence of endometrial adenocarcinoma after fertility-sparing management.

Reprod Biomed Online 2021 Sep 16;43(3):495-502. Epub 2021 Jun 16.

AP-HP, Department of Obstetrics and Gynecology, Hôpital Bichat-Claude Bernard, Paris, France; Université de Paris, Paris, France; Groupe PREFERE (Préservation de la fertilité et cancer de l'endomètre) Hôpital Bichat-Claude Bernard, Paris, France.

Research Question: Do IVF treatments after conservative management of endometrial atypical hyperplasia or grade 1 endometrial adenocarcinoma (AH/EC) increase the risk of disease recurrence?

Design: This is a prospective cohort study from a national registry from January 2008 to July 2019. Sixty patients had an AH/EC and received progestin treatment using chlormadinone acetate for at least 3 months. After remission, 31 patients underwent IVF and 29 did not. Read More

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September 2021