Int J Mol Sci 2021 Aug 14;22(16). Epub 2021 Aug 14.
Alma Res Fertility Center, Obstetrics and Gynecology, Via Parenzo 12, 00198 Rome, Italy.
Nearly 40-50% of infertility problems are estimated to be of female origin. Previous studies dedicated to the analysis of metabolites in follicular fluid (FF) produced contrasting results, although some valuable indexes capable to discriminate control groups (CTRL) from infertile females (IF) and correlate with outcome measures of assisted reproduction techniques were in some instances found. In this study, we analyzed in blind FF of 35 control subjects (CTRL = patients in which inability to obtain pregnancy was exclusively due to a male factor) and 145 IF (affected by: endometriosis, = 19; polycystic ovary syndrome, = 14; age-related reduced ovarian reserve, = 58; reduced ovarian reserve, = 29; unexplained infertility, = 14; genetic infertility, = 11) to determine concentrations of 55 water- and fat-soluble low molecular weight compounds (antioxidants, oxidative/nitrosative stress-related compounds, purines, pyrimidines, energy-related metabolites, and amino acids). Read More