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Capacity for increased surface area in the hydrophobic core of β-sheet peptide bilayer nanoribbons.

J Pept Sci 2021 Jun 20:e3334. Epub 2021 Jun 20.

Department of Chemistry, University of Rochester, Rochester, New York, USA.

Amphipathic peptides with amino acids arranged in alternating patterns of hydrophobic and hydrophilic residues efficiently self-assemble into β-sheet bilayer nanoribbons. Hydrophobic side chain functionality is effectively buried in the interior of the putative bilayer of these nanoribbons. This study investigates consequences on self-assembly of increasing the surface area of aromatic side chain groups that reside in the hydrophobic core of nanoribbons derived from Ac-(XKXE) -NH peptides (X = hydrophobic residue). Read More

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: Language Mixing and Biographical Information Processing.

Brain Sci 2021 May 26;11(6). Epub 2021 May 26.

Centro de Investigación Nebrija en Cognición, Universidad Antonio de Nebrija, 28015 Madrid, Spain.

In bilingual communities, social interactions take place in both single- and mixed-language contexts. Some of the information shared in multilingual conversations, such as interlocutors' personal information, is often required in consequent social encounters. In this study, we explored whether the autobiographical information provided in a single-language context is better remembered than in an equivalent mixed-language situation. Read More

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Efficacy of Acupuncture for Insomnia: A Systematic Review and Meta-Analysis.

Am J Chin Med 2021 May 27:1-16. Epub 2021 May 27.

Department of Meridian and Acupoint, College of Korean Medicine, Republic of Korea.

Patients with insomnia frequently use acupuncture as an alternative treatment to pharmacotherapy globally. The aim of this paper is to assess the effect of acupuncture on insomnia. Seven medical databases, including MEDLINE, EMBASE, CENTRAL, CNKI, RISS, NDSL, and OASIS, were used to identify studies published through July 09, 2020. Read More

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Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation.

J Clin Oncol 2021 Apr 7:JCO2003286. Epub 2021 Apr 7.

Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN.

Purpose: Brentuximab vedotin, an effective anti-CD30 antibody-drug conjugate approved for use in adults with classical Hodgkin lymphoma (HL), was introduced in this frontline trial to reduce prescribed radiation in children and adolescents with classical HL.

Methods: Open-label, single-arm, multicenter trial for patients (age ≤ 18 years) with stage IIB, IIIB, or IV classical HL was conducted. Brentuximab vedotin replaced each vincristine in the OEPA/COPDac (vincristine, etoposide, prednisone, and doxorubicin/cyclophosphamide, vincristine, prednisone, and dacarbazine) regimen according to GPOH-HD2002 treatment group 3 (TG3); two cycles of AEPA and four cycles of CAPDac. Read More

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Development and validation of a new nursing diagnosis: Perioperative thirst.

Int J Nurs Knowl 2021 Mar 25. Epub 2021 Mar 25.

Associate Professor, State University of Londrina, Londrina, Paraná, Brazil.

Purpose: To develop and validate the content of the nursing diagnosis proposal for perioperative thirst.

Methods: A content analysis by 34 judges. An online Delphi panel was used in one round, evaluating criteria of relevance, clarity and precision. Read More

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Diabulimia: An updated perspective.

Enferm Clin (Engl Ed) 2021 Mar 6. Epub 2021 Mar 6.

Médico especialista en Medc¡cina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, España. Electronic address:

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The clinical characteristics and prognosis of COVID-19 patients with comorbidities: a retrospective analysis of the infection peak in Wuhan.

Ann Transl Med 2021 Feb;9(4):280

Trauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing, China.

Background: This study aims to determine the clinical characteristics and prognosis of COVID-19 patients with comorbidities and to identify survival factors.

Methods: A retrospective study was conducted in Wuhan, China, between February 8, 2020, and March 9, 2020. Based on underlying diseases, patients were assigned to either the comorbidity group or the non-comorbidity group. Read More

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February 2021

Efficacy of Traditional Chinese Medicine Combined with Selective Serotonin Reuptake Inhibitors on the Treatment for Parkinson's Disease with Depression: A Systematic Review and Meta-Analysis.

Am J Chin Med 2021 3;49(3):627-643. Epub 2021 Mar 3.

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, P. R. China.

Depression is a common neuropsychiatric symptom of Parkinson's disease (PD), resulting in a lower quality of life and cognitive impairment in PD patients. Traditional Chinese medicine (TCM) formulas have been widely used in neurodegenerative disease and neuropsychic disorders to improve life quality of patients in ethnomedicine. TCM formulas combined with selective serotonin reuptake inhibitors (SSRIs) also have a positive effect on depressed PD compared with SSRIs as reported by several clinical studies. Read More

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Development and Feasibility of an App to Decrease Risk Factors for Type 2 Diabetes in Hispanic Women With Recent Gestational Diabetes (Hola Bebé, Adiós Diabetes): Pilot Pre-Post Study.

JMIR Form Res 2020 Dec 31;4(12):e19677. Epub 2020 Dec 31.

Environment and Health Group, Cambridge, MA, United States.

Background: Hispanic women have increased risk of gestational diabetes mellitus (GDM), which carries an increased risk for future type 2 diabetes, compared to non-Hispanic women. In addition, Hispanic women are less likely to engage in healthy eating and physical activity, which are both risk factors for type 2 diabetes. Supporting patients to engage in healthy lifestyle behaviors through mobile health (mHealth) interventions is increasingly recognized as a viable, underused tool for disease prevention, as they reduce barriers to access frequently experienced in face-to-face interventions. Read More

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December 2020

Improves Spatial Learning and Memory by Regulating N-methyl-D-aspartate Receptors and Tau Phosphorylation in Chronic Restraint Stress-Induced Memory Impaired Mice.

Am J Chin Med 2021 26;49(1):69-94. Epub 2020 Dec 26.

Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources, Research (JINR), Jeollanamdo 59338, Republic of Korea.

Thunb. Leaves (VBL) are a component of traditional herbal medicines. However, molecular mechanisms of VBL in stress-related memory impairment are still unclear. Read More

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December 2020

The NF-[Formula: see text]B Signaling and Wnt/[Formula: see text]-catenin Signaling in MCF-7 Breast Cancer Cells in Response to Bioactive Components from Mushroom .

Am J Chin Med 2021 26;49(1):199-215. Epub 2020 Dec 26.

Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, 01003, USA.

Breast cancer is the leading cancer, accounting for approximately 15% cancer deaths in women worldwide. This study investigated the anti-inflammation and anticancer properties of two bioactive components from (), a rare medicinal mushroom natively grown in Taiwan and commonly used in Chinese traditional medicine. The anti-inflammatory and antitumorigenic functions of Antroquinonol (AQ) and 4-Acetylantroquinonol B (4-AAQB) from were examined on breast cancer cell line MCF-7 with/without TNF-[Formula: see text] stimulation. Read More

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December 2020

The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer's disease.

J Chem Neuroanat 2021 01 12;111:101885. Epub 2020 Nov 12.

Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia. Electronic address:

The aim of this study was to identify the effects of Ocimum sanctum Linn. ethanolic extract (OSE) on the neurons of the CA1, CA3, and DG hippocampal areas with the use of in vivo and in vitro models of Alzheimer's diseases (AD). Twenty-one two-month-old male rats were divided into three groups: untreated (Group A, n = 3), AD rats model pretreated with OSE followed by induction for Trimethyltin (TMT) on day 7 (group B, n = 9), and AD rats model treated with OSE both as pre-TMT introduction for 7 days and post-TMT induction for 21 days (group C, n = 9). Read More

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January 2021

Spatial differentiation of gully clusters based on the regional scale: an example from northeastern China.

PeerJ 2020 19;8:e9907. Epub 2020 Oct 19.

Sichuan Provincial Engineering Laboratory of Monitoring and Control for Soil Erosion on Dry Valleys, China West Normal University, Nanchong, China.

Gully erosion represents a serious environmental threat around the world, but their spatial distribution law are unclear at the regional scale. To quantitatively characterize the spatial distribution model of gullies and determine the regularity of regional differentiation, this paper used spatial analyst and statistics method to study the spatial distribution of gullies in 34 sample areas of northeastern China based on interpretations of high-resolution remote sensing images. The results showed that the kernel density could quantitatively describe the continuous spatial clustering of gullies. Read More

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October 2020

Effects of a Head Support on Children with Hypotonia in the Cervical Spine.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:4783-4786

Children with hypotonia of the muscles near the cervical spine have reduced head control and are unable to maintain an upright head posture. These children often use an external head support to hold their heads upright. With their head held in the proper position, they often develop more functional head movements. Read More

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Is It Better to Mobilize Hematopoietic Stem Cells With Pegfilgrastim in Healthy Donors During Allogeneic Hematopoietic Stem Cell Transplantation?

Front Oncol 2020 3;10:1598. Epub 2020 Sep 3.

Medical Center of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China.

The mobilization of hematopoietic stem cells (HSCs) using granulocyte colony-stimulating factor is a classic method. Recently, a single injection of pegfilgrastim was used to mobilize CD34+ cells in some small-sample studies. To confirm the efficacy and safety of pegfilgrastim in the mobilization of CD34+ cells from healthy donors, we conducted a retrospective multicenter study. Read More

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September 2020

Novel insight into the coordination between pelvic floor muscles and the glottis through ultrasound imaging: a pilot study.

Int Urogynecol J 2020 Dec 26;31(12):2645-2652. Epub 2020 Aug 26.

Southhills School¡ of Business and Technology, Diagnostic Medical Sonography, State College, USA.

Introduction: Pelvic floor physical therapists have long utilized breathing cues with exercises and are beginning to incorporate vocalization tasks. To date, there have been no publications describing pelvic floor displacement during vocalization tasks. This study is a preliminary investigation into the changes in bladder shape distortion as a proxy for pelvic floor muscle displacement during respiratory and phonatory tasks. Read More

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December 2020

Underwater Localization System Combining iUSBL with Dynamic SBL in ¡VAMOS! Trials.

Sensors (Basel) 2020 Aug 20;20(17). Epub 2020 Aug 20.

INESC Technology and Science, Centre for Robotics and Autonomous Systems, 4200-465 Porto, Portugal.

Emerging opportunities in the exploration of inland water bodies, such as underwater mining of flooded open pit mines, require accurate real-time positioning of multiple underwater assets. In the mining operation scenarios, operational requirements deny the application of standard acoustic positioning techniques, posing additional challenges to the localization problem. This paper presents a novel underwater localization solution, implemented for the ¡VAMOS! project, based on the combination of raw measurements from a short baseline (SBL) array and an inverted ultrashort baseline (iUSBL). Read More

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The conversion of forestland into agricultural land without appropriate measures to conserve SOM leads to the degradation of physical and rheological soil properties.

Sci Rep 2020 08 12;10(1):13668. Epub 2020 Aug 12.

Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080, Belgrade, Serbia.

This study was conducted to compare soil particle density (ρ), soil total porosity (TP), liquid limit (LL), plastic limit (PL), and plasticity index, and their relations with soil organic matter (SOM), of non-carbonate silty clay Fluvisols under different land uses. Three neighboring land uses were studied: native deciduous forest, arable land, and meadow, managed in the same way for more than 100 years. Soil was collected from 27 soil profiles and from three depths (0-15, 15-30 and 30-45 cm). Read More

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A Web-Based Positive Psychological Intervention to Improve Blood Pressure Control in Spanish-Speaking Hispanic/Latino Adults With Uncontrolled Hypertension: Protocol and Design for the ¡Alégrate! Randomized Controlled Trial.

JMIR Res Protoc 2020 Aug 4;9(8):e17721. Epub 2020 Aug 4.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Background: Growing evidence links psychological well-being and resilience with superior cardiac health, but there remains a critical scientific gap about whether (or how) interventions that aim to cultivate psychological well-being reduce cardiac risk. Hispanic/Latino people in the United States have high cardiovascular disease risk and poorly controlled blood pressure (BP) compared with their peers of European ancestry, and they represent a population in need of new and innovative therapeutic approaches. As such, a focused intervention to boost psychological well-being holds promise as a novel therapeutic target for hypertension in Hispanic/Latino adults; to date, however, no research has explored whether a causal link is evident. Read More

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Experimental kernel-based quantum machine learning in finite feature space.

Sci Rep 2020 Jul 23;10(1):12356. Epub 2020 Jul 23.

Theoretical Quantum Physics Laboratory, RIKEN Cluster for Pioneering Research, Wako-shi, 351-0198, Japan.

We implement an all-optical setup demonstrating kernel-based quantum machine learning for two-dimensional classification problems. In this hybrid approach, kernel evaluations are outsourced to projective measurements on suitably designed quantum states encoding the training data, while the model training is processed on a classical computer. Our two-photon proposal encodes data points in a discrete, eight-dimensional feature Hilbert space. Read More

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Social and spatial distribution of soil lead concentrations in the City of Santa Ana, California: Implications for health inequities.

Sci Total Environ 2020 Nov 6;743:140764. Epub 2020 Jul 6.

Program in Public Health, University of California, Irvine, CA 92697, USA; Center for Occupational and Environmental Health, University of California, Irvine 92617, CA, USA. Electronic address:

Background: Lead (Pb) exposure is a problem that disproportionately impacts low-income communities and communities of color. We applied a community-based participatory research approach to assess the distribution of soil Pb concentrations and related social vulnerabilities across Census tracts in Santa Ana, CA.

Methods: Soil Pb samples (n = 1528) were collected by the ¡Plo-NO! Santa Ana! Lead-Free Santa Ana! partnership in 2018 across Santa Ana, CA, at a high spatial resolution and measured using XRF analysis. Read More

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November 2020

¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production.

FEMS Yeast Res 2020 09;20(6)

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

The mitochondria, often referred to as the powerhouse of the cell, offer a unique physicochemical environment enriched with a distinct set of enzymes, metabolites and cofactors ready to be exploited for metabolic engineering. In this review, we discuss how the mitochondrion has been engineered in the traditional sense of metabolic engineering or completely bypassed for chemical production. We then describe the more recent approach of harnessing the mitochondria to compartmentalize engineered metabolic pathways, including for the production of alcohols, terpenoids, sterols, organic acids and other valuable products. Read More

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September 2020

The Influence of Evidence-Based Exercise and Age Reattribution on Physical Function in Hispanic Older Adults: Results From the Randomized Controlled Trial.

J Appl Gerontol 2021 Mar 8;40(3):278-288. Epub 2020 Jun 8.

University of Illinois at Urbana-Champaign, USA.

Older Hispanics routinely exhibit unhealthy beliefs about "normal" aging trajectories, particularly related to exercise and physical function. We evaluated the prospective effects of age reattribution on physical function in older Hispanics. Participants ( = 565, ≥60 years) were randomly assigned into (a) treatment group-attribution-retraining, or (b) control group-health education. Read More

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Enhancing nicotine replacement therapy usage and adherence through a mobile intervention: Secondary data analysis of a single-arm feasibility study in Mexico.

Tob Induc Dis 2020 4;18:36. Epub 2020 May 4.

James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, United States.

Instroduction: Nicotine Replacement Therapy (NRT) is an effective treatment for smoking cessation. However, medication usage and adherence remain a challenge that contributes to low smoking cessation rates. In Mexico, 8 in 10 smokers are interested in quitting. Read More

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A Self-Management Randomized Controlled Pilot Trial for Low-Income Adults with Type 2 Diabetes in Mexico City.

Curr Dev Nutr 2020 May 14;4(5):nzaa074. Epub 2020 Apr 14.

Yale School of Public Health, New Haven, CT, USA.

Background: Type 2 diabetes (T2D) is a worldwide epidemic and a leading cause of death in Mexico, with a prevalence of 15.9%, and >70% of diagnosed adults have poor glycemic control [glycated hemoglobin (HbA1c) >7.5%]. Read More

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An fMRI Study of the Brain Network Involved in Teeth Tapping in Elderly Adults.

Front Aging Neurosci 2020 17;12:32. Epub 2020 Mar 17.

Department of Physiology, School of Dentistry, Iwate Medical University, Shiwa-gun, Japan.

Cortical activity during jaw movement has been analyzed using various non-invasive brain imaging methods, but the contribution of orofacial sensory input to voluntary jaw movements remains unclear. In this study, we used functional magnetic resonance imaging (fMRI) to observe brain activities during a simple teeth tapping task in adult dentulous (AD), older dentulous (OD), and older edentulous subjects who wore dentures (OEd) or did not wear dentures (OE) to analyze their functional network connections. (1) To assess the effect of age on natural activation patterns during teeth tapping, a comparison of groups with natural dentition-AD and OD-was undertaken. Read More

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Development of a diabetes self-management + mHealth program: tailoring the intervention for a pilot study in a low-income setting in Mexico.

Pilot Feasibility Stud 2020 14;6:25. Epub 2020 Feb 14.

4Yale School of Public Health, 60 College Street, New Haven, CT 06510 USA.

Background: Type 2 diabetes (T2D) is a public health pandemic disproportionately affecting low- and middle-income countries. The purpose of this formative research was to adapt evidence-based diabetes self-management education programs to the context of Seguro Popular clinics in Mexico. A theory-based mHealth (pictorial text messaging) component was developed. Read More

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February 2020

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device.

J Diabetes Clin Res 2020 ;2(3):86-99

Protein Genomics, Sedona, AZ, USA.

Chronic wounds in patients suffering from type II diabetes mellitus (DMII) where wounds remain open with a complicated pathophysiology, healing, and recovery process is a public health concern. Normal wound healing plays a critical role in wound closure, restoration of mechanical properties, and the biochemical characteristics of the remodeled tissue. Biological scaffolds provide a tissue substitute to help facilitate wound healing by mimicking the extracellular matrix (ECM) of the dermis. Read More

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January 2020

"¡Viva La Clinica!": The United Farm Workers' Fight for Medical Care.

Beatrix Hoffman

Bull Hist Med 2019 ;93(4):518-549

Farm work is among the most dangerous and unhealthy occupations in the United States, but efforts to address farm workers' health needs have been sporadic and inadequate. In the 1960s and 1970s, the United Farm Workers of America (UFW) famously organized workers in California's grape and lettuce fields and won national and international recognition through its boycott tactics. The UFW also opened several medical clinics, staffed by volunteer nurses and physicians, and created the Robert F. Read More

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