511 results match your criteria fentanyl linear


Effect of total intravenous anesthesia or inhalation anesthesia on postoperative quality of recovery in patients undergoing total laparoscopic hysterectomy: A randomized controlled trial.

J Clin Anesth 2021 Jun 2;73:110374. Epub 2021 Jun 2.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, 209 Tongshan, Xuzhou, Jiangsu, China; Department of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, No.99 Huaihai West Road, Xuzhou, Jiangsu, China. Electronic address:

Study Objective: To investigate the effect of propofol-based total intravenous anesthesia (TIVA) or sevoflurane-based inhalation anesthesia on postoperative quality of recovery in patients undergoing total laparoscopic hysterectomy.

Design: A prospective randomized controlled trial.

Setting: An operating room, a postoperative recovery area, and a hospital ward. Read More

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Maternal haemodynamics during labour epidural analgesia with and without adrenaline.

Scand J Pain 2021 May 10. Epub 2021 May 10.

Department of Anaesthesia, Akershus University Hospital, Lørenskog, Norway.

Objectives: Labour is one of the most painful experiences in a woman's life. Epidural analgesia using low-concentration local anaesthetics and lipophilic opioids is the gold standard for pain relief during labour. Pregnancy in general, particularly labour, is associated with changes in maternal haemodynamic variables, such as cardiac output and heart rate, which increase and peak during uterine contractions. Read More

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Comparative Efficacy of Fentanyl and Morphine in Patients with or At Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study.

Drugs R D 2021 Jun 19;21(2):149-155. Epub 2021 Apr 19.

Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital, No. 1017 Dongmen North Road, Shenzhen, 518020, Guangdong, China.

Introduction: Opioids are potent painkillers but can have severe adverse effects in the intensive care unit (ICU). The aim of this study was to compare the outcomes of fentanyl and morphine use among patients at risk for and with acute respiratory distress syndrome (ARDS).

Methods: We developed a dataset of real-world data to enable the comparison of the effectiveness and safety of opioids and the associated outcomes from the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC)-III database and the eICU Collaborative Research Database. Read More

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Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.

Drug Alcohol Depend 2021 Jun 12;223:108700. Epub 2021 Apr 12.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD, 21205, USA.

Background: The substances driving the overdose epidemic in the United States have changed over time. Since 2013, fentanyl-analogues have become the primary opioids driving the epidemic. Recently, polysubstance related deaths have come to the forefront of the epidemic. Read More

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Variation in opioid utilization among neonates with gastroschisis.

J Pediatr Surg 2021 Mar 26. Epub 2021 Mar 26.

Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.250, Houston, TX 77030, United States; Center for Surgical Trials and Evidence-based Practice (C-STEP), McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.256, Houston, TX 77030, United States; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX 77030, United States.

Purpose: Repetitive painful stimuli and early exposure to opioids places neonates at risk for neurocognitive delays. We aimed to understand opioid utilization for neonates with gastroschisis.

Methods: We performed a retrospective review of infants with gastroschisis at a tertiary children's hospital (2017-2019). Read More

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Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients.

Eur J Clin Pharmacol 2021 Apr 3. Epub 2021 Apr 3.

UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, Australia.

Purpose: Subcutaneous fentanyl injection is commonly prescribed to manage acute pain in older patients; however, there is a gap in the literature describing the pharmacokinetic parameters for this route of administration in this population. The aim of this study was to develop and evaluate a population pharmacokinetic model for subcutaneous fentanyl injection in older patients.

Methods: Twenty-one patients who received subcutaneous fentanyl injections (50 to 75 μg) were recruited. Read More

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Prevalence and longitudinal correlates of recent exposure to fentanyl among HIV-positive people who use unregulated drugs during a community-wide overdose crisis.

AIDS Care 2021 Mar 25:1-9. Epub 2021 Mar 25.

British Columbia Centre on Substance Use, St. Paul's Hospital, Vancouver, BC, Canada.

The United States and Canada are experiencing an opioid overdose crisis driven largely by exposure to fentanyl (a potent synthetic opioid), with little known about fentanyl exposure among HIV-positive people who use unregulated drugs (PWUD). We sought to estimate the prevalence and correlates of fentanyl exposure among a community-recruited sample derived from a prospective cohort study of HIV-positive PWUD in Vancouver, Canada. Generalized linear mixed-effects analyses were used to identify longitudinal factors associated with a fentanyl-positive urine drug screen test. Read More

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Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit.

Ann Pharmacother 2021 Mar 20:10600280211003170. Epub 2021 Mar 20.

University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.

Background: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children.

Objective: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1. Read More

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Opioid ordering habits in the acute emergency department visit: Before and after implementation of departmental prescribing guidelines.

J Am Coll Emerg Physicians Open 2020 Dec 16;1(6):1472-1479. Epub 2020 Nov 16.

Department of Emergency Medicine Beaumont Hospital-Royal Oak Royal Oak Michigan USA.

Objective: At our emergency department (ED), opioid prescribing guidelines were implemented in September 2016. The opioid prescribing guidelines were adopted and revised from collective efforts and advocacy of the Michigan College of Emergency Physicians for ED-led opioid stewardship. We performed a retrospective before and after study to determine if opioid prescribing guidelines would change the use of intravenous opioids per patient and the morphine equivalent units (MEU) per patient in a suburban academic ED. Read More

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December 2020

Severe Potential Drug-Drug Interactions and the Increased Length of Stay of Children in Intensive Care Unit.

Front Pharmacol 2020 3;11:555407. Epub 2020 Dec 3.

Graduate Course of Pharmaceutical Science, Universidade de Sorocaba, Sorocaba, Brazil.

Children are exposed to drug-drug interactions (DDI) risks due to their organism's complexity and the need for several medicines prescriptions in pediatric intensive care units (PICU). This study aimed to assess the prevalence of potential DDIs in a Brazilian PICU. We carried out a cross-sectional study at a pediatric teaching hospital from Rio de Janeiro (Brazil) over one year. Read More

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December 2020

Cannabis use is associated with reduced risk of exposure to fentanyl among people on opioid agonist therapy during a community-wide overdose crisis.

Drug Alcohol Depend 2021 02 17;219:108420. Epub 2020 Dec 17.

British Columbia Centre on Substance Use, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: The ongoing opioid overdose crisis is driven largely by exposure to illicitly-manufactured fentanyl. Preliminary observational and experimental research suggests that cannabis could potentially play a role in reducing use of prescription opioids among individuals with chronic pain. However, there is limited data on the effects of cannabis on illicit opioid consumption, particularly fentanyl, especially among individuals on opioid agonist therapy (OAT). Read More

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February 2021

Alpha-Methylfentanyl and Beta-Hydroxyfentanyl LC-MS-MS Quantification in Rat Plasma after Long-Term Ethanol Exposure.

J Anal Toxicol 2020 Dec;44(8):896-904

Shanghai Key Laboratory of Crime Scene Evidence, Shanghai 200437, China.

Fentanyl and its analogues are highly abused drugs that dominate the illicit drug trade. alpha-Methylfentanyl (A-F) and beta-hydroxyfentanyl (B-F) are two fentanyl analogues that require the development of rapid detection technologies. The current study established and validated a rapid and high-sensitivity liquid chromatography-tandem mass spectrometry (LC-MS-MS) method to measure A-F and B-F concentrations in rat plasma following intravenous drug administration (20 μg/kg). Read More

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December 2020

Synthesis and Biological Characterization of Cyclic Disulfide-Containing Peptide Analogs of the Multifunctional Opioid/Neuropeptide FF Receptor Agonists That Produce Long-Lasting and Nontolerant Antinociception.

J Med Chem 2020 12 3;63(24):15709-15725. Epub 2020 Dec 3.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, and Institute of Physiology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.

In a previously described chimeric peptide, we reported that the multifunctional opioid/neuropeptide FF (NPFF) receptor agonist (BN-9) produced antinociception for 1.5 h after supraspinal administration. Herein, four cyclic disulfide analogs containing l- and/or d-type cysteine at positions 2 and 5 were synthesized. Read More

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December 2020

Efficacy and Safety in Combining Primary Palatoplasty and Myringotomy in Patients with Cleft Palate.

Plast Reconstr Surg Glob Open 2020 May 27;8(5):e2824. Epub 2020 May 27.

Division of Plastic and Reconstructive Surgery, Children's National Hospital, Washington, D.C.

Patients born with a cleft lip and palate undergo multiple surgical procedures, increasing the infants' exposure to anesthesia and potential risk of neurocognitive delays. In addition, these numerous procedures lead to greater use of hospital resources. This study analyzes the differences in anesthetic exposure and perioperative characteristics between performing combined versus separate primary palatoplasty (PP) and placement of bilateral myringotomy tubes (BMT). Read More

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A Semi-quantitative method for the detection of fentanyl using surface-enhanced Raman scattering (SERS) with a handheld Raman instrument.

J Forensic Sci 2021 Mar 2;66(2):505-519. Epub 2020 Nov 2.

Field Detection, Molecular Spectroscopy, Agilent Technologies UK Ltd, Oxford, UK.

A handheld, spatially offset Raman spectroscopy (SORS) system was successfully used to obtain Surface-enhanced Raman Scattering (SERS) spectra of fentanyl under simulated field conditions. A series of aqueous fentanyl solutions were prepared with commercially available gold nanoparticle solution, at concentrations ranging from 0.003 to 1697 μM. Read More

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Does carrier fluid reduce low flow drug infusion error from syringe size?

World J Clin Pediatr 2020 Sep 19;9(2):17-28. Epub 2020 Sep 19.

Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.

Background: Critically ill neonates and pediatric patients commonly require multiple low flow infusions. Volume limitations are imposed by small body habitus and co-morbidities like cardiopulmonary disease, renal failure, or fluid overload. Vascular access is limited by diminutive veins. Read More

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September 2020

Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.

Forensic Sci Int 2020 Dec 6;317:110437. Epub 2020 Sep 6.

Université de Lorraine, CHRU-Nancy, Department of Clinical Pharmacology and Toxicology, F-54000, Nancy, France; Université de Lorraine, CNRS, IMoPA, F-54000 Nancy, France. Electronic address:

Synthetic opioids (SO) associated with the recent alarming increase of deaths and intoxications in United States of America and Europe are not detected by the usual first-line opiates drug screening assays. We developed a liquid chromatography tandem mass spectrometry analytical method for the multiplex detection of 14 fentanyl analogues (2-furanylfentanyl, 4-ANPP, 4-methoxybutyrylfentanyl, acrylfentanyl, alfentanil, carfentanil, despropionyl-2-fluorofentanyl, fentanyl, methoxyacetylfentanyl, norfentanyl, ocfentanil, remifentanil, sufentanil and valerylfentanyl) and U-47700 in whole blood and urine samples. The method was validated according to the requirements of ISO 15189. Read More

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December 2020

Detection of trace drugs of abuse in baby formula using solid-phase microextraction direct analysis in real-time mass spectrometry (SPME-DART-MS).

J Forensic Sci 2021 Jan 28;66(1):172-178. Epub 2020 Sep 28.

National Institute of Standards and Technology, Gaithersburg, MD, USA.

The intentional or unintentional adulteration of baby formula with drugs of abuse is one of the many increasingly complex samples forensic chemists may have to analyze. This sample type presents a challenge because of a complex matrix that can mask the detection of trace drug residues. To enable screening of baby formula for trace levels of drugs, the use of solid-phase microextraction (SPME) coupled with direct analysis in real-time mass spectrometry (DART-MS) was investigated. Read More

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January 2021

The New Zealand white rabbit animal model of acute radiation syndrome: hematopoietic and coagulation-based parameters by radiation dose following supportive care.

Int J Radiat Biol 2020 Oct 26:1-18. Epub 2020 Oct 26.

Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Animal models that accurately reflect human responses to radiation injury are needed for advanced mechanistic investigation and development of effective therapeutics. The rabbit is an established animal model accepted by the FDA for studies of cardiovascular disease, lipid metabolism, the development of anticoagulants, testing of bone implants, and the development of treatments for infectious diseases such as HIV. The purpose of this study was to investigate the New Zealand White (NZW) Rabbit model as a model of acute radiation exposure because of its established similarity to human vascular, immune, and coagulation responses. Read More

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October 2020

Opioid-Sparing Cardiac Anesthesia: Secondary Analysis of an Enhanced Recovery Program for Cardiac Surgery.

Anesth Analg 2020 12;131(6):1852-1861

From the Department of Anesthesiology and Critical Care Medicine.

Background: Cardiac anesthetics rely heavily on opioids, with the standard patient receiving between 70 and 105 morphine sulfate equivalents (MSE; 10-15 µg/kg of fentanyl). A central tenet of Enhanced Recovery Programs (ERP) is the use of multimodal analgesia. This study was performed to assess the association between nonopioid interventions employed as part of an ERP for cardiac surgery and intraoperative opioid administration. Read More

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December 2020

Effects of Massage on Postoperative Pain in Infants With Complex Congenital Heart Disease.

Nurs Res 2020 Sep/Oct;69(5S Suppl 1):S36-S46

Tondi M. Harrison, PhD, RN, FAAN, is Associate Professor, The Ohio State University College of Nursing, Columbus. Roger Brown, PhD, is Professor, University of Wisconsin-Madison School of Nursing. Travis Duffey, LMT, is Licensed Massage Therapist, Nationwide Children's Hospital, Columbus, Ohio. Corrie Frey, LMT, CIMI, CPMT, is Licensed Massage Therapist, Nationwide Children's Hospital, Columbus, Ohio. Jacob Bailey, BSN, RN, is Staff Nurse, COPC Ohio Center for Pediatrics, Dublin. Marliese Dion Nist, PhD, RNC, is Postdoctoral Fellow, The Ohio State University College of Nursing, Columbus, Ohio. Lauren Renner, MSN, RN, CPNP, is APRN Clinical Leader, Nationwide Children's Hospital, Columbus, Ohio. Jill Fitch, MD, is Pediatric Intensivist, Nationwide Children's Hospital, Columbus, OH.

Background: Pain management is an essential component of care for pediatric patients following surgery. Massage reduces self-reported postoperative pain in adults with heart disease but has received little attention in postoperative pediatric patients with complex congenital heart disease (CCHD).

Objectives: The aim of the study was to evaluate the effectiveness of massage compared to a rest period on postoperative pain scores and physiological responses in infants with CCHD. Read More

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February 2021

The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery.

J Pharmacokinet Pharmacodyn 2020 12 25;47(6):583-596. Epub 2020 Aug 25.

Department of Biopharmacy and Pharmacodynamics, Medical University of Gdansk, Hallera 107 Street, 80-416, Gdansk, Poland.

Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacodynamics of propofol and fentanyl administrated during total intravenous anesthesia (TIVA). The data were obtained from 22 ASA III patients undergoing abdominal aortic surgery. Read More

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December 2020

Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia.

Anesth Analg 2021 03;132(3):735-742

From the Department of Anesthesia, Intensive Care, Emergency and Pain Medicine, Kantonsspital St.Gallen, St.Gallen, Switzerland.

Background: Internationally, propofol is commonly titrated by target-controlled infusion (TCI) to maintain a processed electroencephalographic (EEG) parameter (eg, bispectral index [BIS]) within a specified range. The overall variability in propofol target effect-site concentrations (CeT) necessary to maintain adequate anesthesia in real-world conditions is poorly characterized, as are the patient demographic factors that contribute to this variability. This study explored these issues, hypothesizing that the variability in covariate-adjusted propofol target concentrations during BIS-controlled anesthesia would be substantial and that most of the remaining interpatient variability in drug response would be due to random effects, thus suggesting that the opportunity to improve on the Schnider model with further demographic data is limited. Read More

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Rapid quantitative determination of fentanyl in human urine and serum using a gold-based immunochromatographic strip sensor.

J Mater Chem B 2020 09;8(37):8573-8584

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China. and International Joint Research Laboratory for Biointerface and Biodetection, and School of Food Science and Technology, Jiangnan University, Wuxi, People's Republic of China.

Fentanyl is a typical opioid that is used in surgical anesthesia. However, when abused, fentanyl can lead to addiction and even death. To better control the use of fentanyl, it is necessary to develop rapid and sensitive detection methods. Read More

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September 2020

Nonmedical Use of Prescription Opioids, Heroin Use, Injection Drug Use, and Overdose Mortality in U.S. Adolescents.

J Stud Alcohol Drugs 2020 07;81(4):484-488

Division of Adolescent and School Health, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Objective: We assessed overdose mortality by opioid types involved as well as interrelationships between nonmedical use of prescription opioids (NUPO) and heroin and injection drug use (IDU) among adolescents.

Method: We examined 2010 and 2016 overdose data by drug type for decedents in the United States ages 15-19 years from the Multiple Cause of Death Files. We also analyzed data from the 2017 National Youth Risk Behavior Survey, a nationally representative survey of high school students. Read More

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Do potent immobilising-opioids induce different physiological effects in impala and blesbok?

J S Afr Vet Assoc 2020 Aug 6;91(0):e1-e8. Epub 2020 Aug 6.

School of Veterinary Medicine, College of Science, Health, Engineering and Education, Murdoch University, Perth, Australia; and, School of Biology and Environmental Sciences, Faculty of Agriculture and Natural Sciences, University of Mpumalanga, Nelspruit.

Potent opioids are known to cause negative alterations to the physiology of immobilised antelope. How these effects differ between species has not been studied. This study aimed to compare time to recumbence and effects of opioid-based immobilisation on the physiology of impala (Aepyceros melampus) and blesbok (Damaliscus pygargus phillipsi). Read More

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Quantifying enhanced risk from alcohol and other factors in polysubstance-related deaths.

Forensic Sci Int 2020 Aug 31;313:110352. Epub 2020 May 31.

West Virginia Office of the Chief Medical Examiner, West Virginia Department of Health and Human Resources, 619 Virginia Street West, Charleston, WV 25302, United States.

Background: To quantify how alcohol, polysubstance use and other factors influence opioid concentrations in drug-related deaths in West Virginia (WV), United States.

Methods: Multiple linear regression models were employed to identify relationships among alcohol, other factors, and the concentrations of four commonly identified opioids (fentanyl, hydrocodone, oxycodone, methadone), accounting for demographic, toxicological and comorbid characteristics in WV drug-related deaths from 2005 to 2018.

Results: Alcohol concentrations of 0. Read More

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2D MS/MS Spectra Recorded in the Time Domain Using Repetitive Frequency Sweeps in Linear Quadrupole Ion Traps.

Anal Chem 2020 07 7;92(14):10016-10023. Epub 2020 Jul 7.

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Ion trap mass spectrometers have emerged as powerful on-site analytical platforms, in spite of limited mass resolution, due to their compatibility with ambient ionization methods and ready implementation of tandem mass spectrometry (MS/MS). When operated at constant trapping voltage, ions can be activated at their secular frequencies and all MS/MS experiments can be performed, including the two-dimensional tandem mass scan (2D MS/MS scan) in which all precursor ions and their subsequent product ions are both identified and correlated. In the new method of performing this 2D MS/MS experiment presented here, the precursor ions are excited by a nonlinear (inverse Mathieu ) frequency sweep while the resulting product ions are identified by their ejection time within a repeating orthogonally applied nonlinear (inverse Mathieu ) frequency sweep. Read More

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A Novel Bioanalytical Method for the Determination of Opioids in Blood and Pericardial Fluid.

J Anal Toxicol 2020 Dec;44(8):754-768

Instituto Nacional de Medicina Legal e Ciências Forenses, I.P. (INMLCF, I.P.), Laboratório de Toxicologia Forense da Delegação do Centro, Azinhaga de Santa Comba - Polo das Ciências da Saúde, 3000-548 Coimbra, Portugal.

Opioids are the drugs most commonly detected in overdose deaths and the second most consumed worldwide. An analytical methodology has been optimized and fully validated for the determination of codeine, morphine, 6-acetylmorphine, 6-acetylcodeine, oxycodone, oxymorphone and fentanyl in whole blood and pericardial fluid. The internal standards used were codeine-d3, morphine-d3, 6-acetylmorphine-d3 and fentanyl-d5. Read More

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December 2020

The Haemodynamic Response to Endotracheal Intubation at Different Time of Fentanyl Given During Induction: A Randomised Controlled Trial.

Sci Rep 2020 06 1;10(1):8829. Epub 2020 Jun 1.

MacKay Junior College of Medicine, Nursing and Management College, Taipei, Taiwan, ROC.

Endotracheal intubation elicits huge spectrum of stress responses which are hazardous in high-risk patients. Numerous drugs and techniques have been applied to attenuate the stress responses. In this double-blind study, one hundred and forty-five patients over 20 years old, ASA physical status I and II, undergoing elective surgeries requiring general anaesthesia with endotracheal intubation were included. Read More

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