Search Our Scientific Publications & Authors

Resuscitation 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiology, University of Cologne, Kerpener Str.62, 50937 Cologne, Germany.

Aim: Intraosseous (IO)-access plays an alternative route during resuscitation. Our study in preterm and term stillborns was performed to find alternative IO puncture sites beside the recommended proximal tibia.

Methods: The cadavers used were legal donations. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):488-495

Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, P.R.China.

Objective: To explore the potential therapeutic effects of endothelial progenitor cells derived small extracellular vesicles (EPCs-sEVs) on spinal cord injury in mice.

Methods: EPCs were separated from femur and tibia bone marrow of 20 C57BL/6 male mice, and identified by double fluorescence staining and flow cytometry. Then the EPCs were passaged and the cell supernatants from P2-P4 generations EPCs were collected; the EPCs-sEVs were extracted by ultracentrifugation and identified by transmission electron microscopy, nanoflow cytometry, and Western blot. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Apr;35(4):409-413

Department of Orthopedics, the First Medical Center of Chinese PLA General Hospital, Beijing, 100853, P.R.China.

Objective: To simulate and validate the performance, accuracy, and safety of the Yuanhua robotic-assisted total knee arthroplasty system (YUANHUA-TKA) through cadaver-based experiment, thus optimizing the robotic system for the future human clinical application.

Methods: Six unilateral adult cadaver specimens of the lower limbs were scanned by three-dimensional CT before the experiment, and then the three-dimensional models of femur and tibia were obtained by using the preoperative software of YUANHUA-TKA system, so as to plan the type of prosthesis implant, the osteotomy volume and osteotomy angles [hip-knee-ankle angle (HKA), coronal frontal femoral component (FFC) and frontal tibial component (FTC)], the ideal value of HKA was set to 180°, and of FFC and FTC were set to 90°, respectively. The operator could further confirm the osteotomy plan according to the intraoperative situation before osteotomy, and then install the prosthesis after completing the osteotomy in each plane with the assistance of YUANHUA-TKA system. Read More

Int J Med Robot 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: We investigated the accuracy and safety of a new HURWA robotic-assisted total knee arthroplasty (TKA) system in a sheep model.

Methods: Ten male Small-tailed Han sheep were used in this study. Sheep were imaged by computed tomography scan before and after bone resection and the cutting errors between actual bone preparation and preoperative planning of the femur and tibia in 3 dimensions were measured . Read More

Orthop J Sports Med 2021 Mar 29;9(3):2325967121993045. Epub 2021 Mar 29.

Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.

Background: Anterior cruciate ligament (ACL) injury has been reported to have a higher incidence in women than in men.

Purpose/hypothesis: The purpose was to examine the relationship of anterior knee laxity (AKL), stiffness, and generalized joint laxity (GJL) with respect to the menstrual cycle. It was hypothesized that AKL and GJL would increase during the ovulation phase, when estrogen levels are high. Read More

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

American Sports Medicine Institute, Birmingham, Alabama.

Injuries to the anterolateral ligament (ALL) of the knee are commonly associated with anterior cruciate ligament (ACL) ruptures. Biomechanical studies have demonstrated conflicting results with regard to the role of the ALL in limiting tibial internal rotation. Clinically, residual pivot shift following ACL reconstruction has been reported to occur up to 25% and has been correlated with poor outcomes. Read More

J Orthop Surg Res 2021 Apr 13;16(1):248. Epub 2021 Apr 13.

Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Background: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. Read More

Acta Orthop Traumatol Turc 2021 Mar;55(2):184-188

Department of Orthopaedics and Traumatology, Hacettepe University, School of Medicine, Ankara, Turkey.

Focal fibrocartilaginous dysplasia (FFCD) is a rare disease that can cause angular deformities of long bones. The common pathologic finding is a thick fibrotic band extending from epiphysis to metaphysis on one side of the bone. The tethering effect of the fibrotic band around the growth plate is thought to be the main etiology for the development and progression of the deformity. Read More

Acta Orthop Traumatol Turc 2021 Mar;55(2):159-165

Department of Orthopaedic Surgery and Traumatology, Marmara University, School of Medicine, İstanbul, Turkey.

Objective: This study aimed to assess the pain and functional status of patients who underwent various surgical interventions for the stabilization of selected multiple myeloma (MM) lesions in the extremities and pelvis and to investigate the rate of complications requiring reintervention.

Methods: Patients with MM who underwent various surgical interventions for the extremity or pelvic lesions were retrospectively reviewed. Change in the pain intensity was assessed using visual analogous scale (VAS) preoperatively, at the time of discharge, and at the final follow-up. Read More

J Feline Med Surg 2021 Apr 13:1098612X211005886. Epub 2021 Apr 13.

Department of Clinical Science and Services, Queen Mother Hospital for Animals, The Royal Veterinary College, Hatfield, UK.

Objectives: The aim of this study was to describe the demography, aetiology, location and classification of physeal fractures in cats, and to describe their management and outcomes.

Methods: Clinical records and radiographs of cats referred for management of physeal fractures were retrospectively reviewed. Fractures of the proximal femoral physis were excluded. Read More

Front Pharmacol 2021 26;12:643482. Epub 2021 Mar 26.

Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Osteoporosis is a common skeletal disease in post-menopausal women. -tang, an herbal medicine, has been treated for gynecological disease such as anemia, anorexia, anti-fatigue, unspecified menstruation and female infertility in East Asia. In this study, ameliorative effects of -tang soft extracts (PMT), a Korean Medicine, on osteoporosis were investigated. Read More

J Arthroplasty 2021 Mar 18. Epub 2021 Mar 18.

Department of Orthopedic Surgery, McGill University Health Centre, Montreal, Canada.

Background: Both cemented and cementless stemmed endoprosthetic implants have been used to reconstruct large skeletal defects after tumor resection with similar outcomes. In this study, we examined the oncologic, clinical, and functional outcomes in patients undergoing distal femur replacement using the French paradox technique.

Methods: A total of 125 patients who underwent distal femur replacement between 1990 and 2019 using the line-to-line cementation technique were reviewed. Read More

BMC Med Inform Decis Mak 2021 Apr 8;21(1):121. Epub 2021 Apr 8.

School of Mechanical and Power Engineering, Henan Polytechnic University, Jiaozuo, 454000, China.

Background: The motion capture has been used as the usual method for measuring movement parameters of human, and most of the measuring data are obtained by partial manual process based on commercial software. An automatic kinematics data process was developed by programming on MATLAB software in this paper.

Methods: The motion capture measurement of healthy volunteers was carried out and the MATLAB program was used for data process. Read More

Am J Sports Med 2021 Apr 8:363546521999672. Epub 2021 Apr 8.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA.

Background: It remains unclear if use of the lateral meniscus anterior horn (LMAH) as a landmark will produce consistent tunnel positions in the anteroposterior (AP) distance across the tibial plateau.

Purpose: To evaluate the AP location of anterior cruciate ligament (ACL) reconstruction tibial tunnels utilizing the LMAH as an intra-articular landmark and to examine how tunnel placement affects knee stability and clinical outcomes.

Study Design: Cohort study; Level of evidence, 3. Read More

J Zoo Wildl Med 2021 Apr;52(1):366-372

Department of Veterinary Clinic and Surgery, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, São Paulo, Brazil.

The fixation of fractures in wild animals has been a great challenge for veterinarians, because they will inevitably face a unique anatomical characteristic with scarce studies or reports published. Fracture fixation should promote adequate stability and early return to limb function, taking into account biomechanical characteristics of the bones, body weight, and natural habits of wildlife. Three bone fractures from two giant anteaters () referred at the veterinary teaching hospital on different occasions were treated by a double plating technique. Read More

Skeletal Radiol 2021 Apr 7. Epub 2021 Apr 7.

Department of Orthopedics and Traumatology, Federal University of São Paulo, São Paulo, SP, Brazil.

Objective: Several anatomical parameters have been associated with increased risk of anterior cruciate ligament rupture; however, published studies provide conflicting results. The objectives of this study are to assess whether there is a relationship between anterior cruciate ligament rupture and the lateral and medial posterior tibial slopes, as well as the lateral and medial posterior meniscal slopes and posterior tibial and meniscal delta-slopes.

Materials And Methods: A retrospective case-control study was conducted in professional soccer athletes, using images from knee magnetic resonance imaging scans in athletes with clinical and radiological diagnosis of anterior cruciate ligament rupture, and control group, with no signs of ligament rupture. Read More

Leg Med (Tokyo) 2021 Mar 29;51:101873. Epub 2021 Mar 29.

Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Forensic Medicine, University of Helsinki, Helsinki, Finland; Forensic Medicine Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.

Sex estimation is an important part of osteological analysis of skeletons and forensic identification process. Traditionally cranial and pelvic traits are utilized for accurate sex estimation. However, post-cranial measurements have also been proven to accurately estimate sex especially from robust bones such as the femur. Read More

Int J Gen Med 2021 26;14:1121-1129. Epub 2021 Mar 26.

Department of Endocrinology, China Rehabilitation Research Center, Beijing, People's Republic of China.

Background: Spinal cord injury (SCI) can lead to disuse osteoporosis. The most vulnerable sites for fragility-induced fractures are the distal femur (DF) and proximal tibia (PT). The aim of this study was to evaluate changes in bone mineral density (BMD) at the DF and PT, as well as related factors, during the first year of SCI. Read More

SICOT J 2021 26;7:19. Epub 2021 Mar 26.

Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Lyon University Hospital, 69004 Lyon, France - Univ Lyon, Claude Bernard Lyon 1 University, IFSTTAR, LBMC UMR_T9406, 69622 Lyon, France.

Traditionally in total knee arthroplasty (TKA), a post-operative neutral alignment was the gold standard. This principle has been contested as functional outcomes were found to be inconsistent. Analysis of limb alignment in the non-osteoarthritic population reveals variations from neutral alignment and consideration of a personalized or patient-specific alignment in TKA is challenging previous concepts. Read More

J Biomech 2021 Mar 9;120:110365. Epub 2021 Mar 9.

Department of Biomedical Engineering, Department of Mechanical Engineering, Department of Orthopaedic Surgery, University of California Davis Medical Center, Sacramento, CA 95817, United States.

A common method used to study tibiofemoral joint biomechanics following total knee arthroplasty (TKA) is the lowest point method, which finds the lowest points of each femoral condyle in relation to the plane of the resected tibia. The objectives of this paper were twofold: 1) to use a circle-based model to demonstrate the large inherent error introduced when the lowest points are used to indicate anterior-posterior (AP) positions of contact by the femur on the tibial insert, 2) to use the circle-based model to estimate the magnitude of error. A circle-based model was created to simulate articular surfaces of the tibial insert and condyles of the femoral component and to demonstrate the error. Read More

Tissue Eng Part C Methods 2021 Apr 2. Epub 2021 Apr 2.

Matsumoto Dental University, 12933, Institute for Oral Science, 1780 Hirooka Gobara, Shiojiri, Japan, 399-0781;

Spontaneously formed spheroids from mouse compact bone-derived cells (CBDCs) possess enhanced stemness and superior plasticity. Here, the effect of cryopreservation on viability, stemness, and osteogenic differentiation capability of spontaneous CBDCs spheroids were investigated. CBDCs were isolated from mouse femur and tibia. Read More

Orthop J Sports Med 2021 Mar 18;9(3):2325967121991054. Epub 2021 Mar 18.

Department of Orthopaedic Surgery, Duke University, Durham, North Carolina, USA.

Background: There is little in vivo data that describe the relationships between patellar tendon orientation, patellar tendon strain, and anterior cruciate ligament (ACL) strain during dynamic activities. Quantifying how the quadriceps load the ACL via the patellar tendon is important for understanding ACL injury mechanisms.

Hypothesis: We hypothesized that flexion angle, patellar tendon orientation, and patellar tendon strain influence ACL strain during a single-leg jump. Read More

Acta Ortop Bras 2021 Jan-Feb;29(1):17-20

Universidade Federal Rural do Semi-Árido. Mossoró, RN, Brazil.

Objective: To report the incidence of deep vein thrombosis (DVT) in ipsilateral femur and tibial fractures (floating knee).

Methods: This is a retrospective, analytical, observational study conducted with the medical records of thirty patients admitted to a trauma hospital between October 2016 and July 2017 with floating knee.

Results: Patients aged between 21-30 years were the most affected by the condition (36%). Read More

Acta Ortop Bras 2021 Jan-Feb;29(1):12-16

Takatsuki General Hospital, Department of Orthopedic Surgery and Joint Surgery Center, Takatsuki, Osaka, Japan.

Objective: Although the mobile-bearing Oxford unicompartmental knee arthroplasty (OUKA) seems an appropriate procedure to treat spontaneous osteonecrosis of the knee (SONK), aseptic tibial component loosening was the leading cause for medial UKA failure. This study aimed to observe short-term and midterm clinical outcomes following OUKA and determine whether tibial lesion affects the procedure clinical and radiographic outcomes.

Methods: Sixty patients (mean age 73. Read More

PLoS One 2021 1;16(4):e0248809. Epub 2021 Apr 1.

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

Background: Fractures around the knee joint are inherently complex in terms of treatment; complication rates are high, and they are difficult to diagnose on a plain radiograph. An automated way of classifying radiographic images could improve diagnostic accuracy and would enable production of uniformly classified records of fractures to be used in researching treatment strategies for different fracture types. Recently deep learning, a form of artificial intelligence (AI), has shown promising results for interpreting radiographs. Read More

Am J Sports Med 2021 Apr 1:3635465211002160. Epub 2021 Apr 1.

Department of Orthopaedic Surgery, Seoul National University College of Medicine, Bundang Hospital, Seoul, Republic of Korea.

Background: Subchondral insufficiency fracture of the knee (SIFK) is characterized by a subchondral lesion that may lead to end-stage osteoarthritis (OA). In patients who have SIFK in a precollapse state with varus malalignment, a joint-preserving technique such as open wedge high tibial osteotomy (OWHTO) should be considered.

Purpose: To evaluate the efficacy of OWHTO in primary OA and SIFK-dominant OA by clinical and radiological evaluations including magnetic resonance imaging (MRI). Read More

BMJ Mil Health 2021 Mar 31. Epub 2021 Mar 31.

Department of Bioengineering, Imperial College London, London, UK.

Introduction: Current external fixator systems used by the US and UK military for stabilising extremity fractures require specialised tools to build a construct. The goal of obtaining and maintaining limb length and alignment is not achieved if these tools are misplaced. An alternative, tool-less system is currently available, namely the Dolphix Temporary Fixation System. Read More

Bone Joint J 2021 Apr;103-B(4):769-774

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Aims: Complex fractures of the femur and tibia with associated severe soft tissue injury are often devastating for the individual. The aim of this study was to describe the two-year patient-reported outcomes of patients in a civilian population who sustained a complex fracture of the femur or tibia with a Mangled Extremity Severity Score (MESS) of ≥ 7, whereby the score ranges from 2 (lowest severity) to 11 (highest severity).

Methods: Patients aged ≥ 16 years with a fractured femur or tibia and a MESS of ≥ 7 were extracted from the Victorian Orthopaedic Trauma Outcomes Registry (January 2007 to December 2018). Read More

Anticancer Res 2021 Mar;41(3):1693-1699

Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

Aim: To report two cases in which treatment with pembrolizumab for advanced non-small cell lung cancer (NSCLC) with bone metastasis of the long bone of the lower extremity in a state of impending fracture significantly ameliorated both lung tumor and bone metastasis.

Case Report: Case 1 was a 74-year-old woman diagnosed with metastasis of NSCLC in the left tibia and case 2 was a 71-year-old man diagnosed with metastasis of NSCLC in the right femur; their bone metastases were in a state of impending fracture. Disease in both cases was already in stage IVB and they received systemic therapy using pembrolizumab, whilst the bone metastases were treated conservatively. Read More

J Neurophysiol 2021 Mar 31. Epub 2021 Mar 31.

Animal Physiology, University of Cologne, Germany.

In legged animals integration of information from various proprioceptors in and on the appendages by local premotor networks in the central nervous system is crucial for controlling motor output. To ensure posture maintenance and precise active movements, information about limb loading and movement is required. In insects, various groups of campaniform sensilla (CS) measure forces and loads acting in different directions on the leg, and the femoral chordotonal organ (fCO) provides information about movement of the femur-tibia (FTi) joint. Read More