9,197,726 results match your criteria females

Are sniffer dogs a reliable approach for diagnosing SARS-CoV-2 infection?

Diagnosis (Berl) 2021 Apr 20. Epub 2021 Apr 20.

Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Objectives: Despite inter-individual variations in their diagnostic efficiency, dogs have been trained to investigate many human pathologies, especially cancer, diabetes, migraine, seizures and even infectious diseases. To this end, we performed a critical review and pooled analysis of current scientific literature on the performance of dogs trained for identifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive human specimens.

Methods: We carried out an electronic search in PubMed, Scopus and Web of Science with the keywords "dog(s)" AND "sniffer" OR "scent" OR "smell" AND "SARS-CoV-2" OR "severe acute respiratory syndrome coronavirus 2" OR "coronavirus disease 2019" OR "COVID-19" within all fields, without date or language restrictions, to identify studies describing dogs' performance for identifying SARS-CoV-2 infected material. Read More

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The Relationship between Psychoacoustic and Electrophysiological Assessments of Temporal Resolution.

J Am Acad Audiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Audiology, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background:  Temporal resolution is essential to speech acoustic perception. However, it may alter in individuals with auditory disorders, impairing the development of spoken and written language. The envelope of speech signals contains amplitude modulation (AM) that has critical information. Read More

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[Therapeutic options in female stress urinary incontinence].

Albert Kaufmann

Aktuelle Urol 2021 Apr 19. Epub 2021 Apr 19.

Kliniken Maria Hilf GmbH, Zentrum für Kontinenz und Neuro-Urologie, Mönchengladbach.

Stress urinary incontinence in female patients is characterised by loss of urine without the need to urinate. Causes are manifold and require a good knowledge of the pelvic floor structures and the functionality of the bladder's occlusion system. Before any treatment can be initiated, differentiated diagnostic investigation must uncover the causes in order to be able to show incontinent women the ideal therapeutic options. Read More

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Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort.

Respiration 2021 Apr 19:1-12. Epub 2021 Apr 19.

Department of Respiratory, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Background And Objective: The research term "interstitial pneumonia with autoimmune features" (IPAF) encompasses interstitial lung disease (ILD) patients with autoimmune features not meeting diagnostic criteria for a defined connective tissue disease (CTD). It remains unclear if IPAF is a distinct disease entity with implications for management and prognosis. We describe an Australian IPAF population and compare their baseline characteristics and outcomes with distinct cohorts of idiopathic interstitial pneumonia (IIP), CTD-ILD, and unclassifiable ILD. Read More

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Weaker McGurk Effect for Rubin's Vase-Type Speech in People With High Autistic Traits.

Multisens Res 2021 Apr 16:1-17. Epub 2021 Apr 16.

School of Psychology, Chukyo University, 101-2 Yagoto Honmachi, Showa-ku, Nagoya-shi, Aichi, 466-8666, Japan.

While visual information from facial speech modulates auditory speech perception, it is less influential on audiovisual speech perception among autistic individuals than among typically developed individuals. In this study, we investigated the relationship between autistic traits (Autism-Spectrum Quotient; AQ) and the influence of visual speech on the recognition of Rubin's vase-type speech stimuli with degraded facial speech information. Participants were 31 university students (13 males and 18 females; mean age: 19. Read More

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Aspergillus candidus eumycetoma with review of literature.

J Mycol Med 2021 Apr 3;31(3):101135. Epub 2021 Apr 3.

Department of Microbiology, Government Medical College Hospital, Sector 32-B, Chandigarh, India.

Objective: Mycetoma is a slowly progressive, chronic granulomatous infection of skin and subcutaneous tissues with involvement of underlying fasciae and bones, usually affecting extremities. In India, among mycetoma, the eumycetoma constitutes about 35% of cases. Hereby, we report the first case of eumycetoma caused by uncommon fungus, Aspergillus candidus. Read More

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EASY score (Eloquent, Age and baseline SYmptoms score) for outcome prediction in patients with acute ischemic stroke.

Clin Neurol Neurosurg 2021 Apr 1;205:106626. Epub 2021 Apr 1.

Department of Neuroradiology, University Hospital of Southampton, Tremona Rd, Southampton, UK.

Objective: A pragmatic tool for the early and reliable prediction of recovery in patients with acute ischemic stroke is needed. We aimed to test the addition of brain eloquent areas involvement in variables predicting poor outcome, using a simple scoring system.

Methods: Retrospective study of patients with anterior circulation acute ischemic stroke treated with best medical treatment and/or endovascular reperfusion. Read More

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Lower extremity muscle contributions to ACL loading during a stop-jump task.

J Biomech 2021 Apr 9;121:110426. Epub 2021 Apr 9.

Department of Kinesiology, Recreation, and Sport Studies, The University of Tennessee, Knoxville, TN, USA. Electronic address:

Landing is considered a high-risk movement, especially landings from a stop-jump task, as they are often associated with lower extremity injuries, such as anterior cruciate ligament injuries (ACL). Females demonstrate lower extremity landing mechanics that often place them at a larger risk of injury compared to their male counterparts. While efforts have been made to understand lower extremity mechanics during stop-jump landings, little is known regarding the musculature function during these tasks and how they may influence ACL loading. Read More

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Employing metabolomic approaches to determine the influence of age on experimental autoimmune encephalomyelitis (EAE).

Mol Immunol 2021 Apr 16;135:84-94. Epub 2021 Apr 16.

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST-School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea. Electronic address:

The immune system plays a critical role not only in homeostasis of the body but also in pathogenesis. Autoimmunity and dysregulation of the immune balance are closely related to age. To examine the influence of age on autoimmunity, the pathophysiological features of experimental autoimmune encephalomyelitis (EAE) induced at different ages were elucidated on the basis of plasma-level metabolic changes. Read More

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Effects of cigarette smoke on the aggravation of ovalbumin-induced asthma and the expressions of TRPA1 and tight junctions in mice.

Mol Immunol 2021 Apr 16;135:62-72. Epub 2021 Apr 16.

School of Traditional Chinese Medicine & Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China.

The occurrence of asthma is closely related to environmental factors such as cigarette smoke (CS), one of the common risk factors. Environmental stimuli have the potential to activate transient receptor potential ankyrin 1 (TRPA1) and cause or aggravate asthma. The destruction of tight junctions (TJs) between airway epithelial cells by environmental stimuli in asthma has been researched. Read More

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Validity of telephone calls to assess percentage of syllables stuttered with adolescents in clinical research.

J Commun Disord 2021 Apr 10;91:106103. Epub 2021 Apr 10.

Australian Stuttering Research Centre, University of Technology Sydney, Australia. Electronic address:

Purpose: Karimi, O'Brian, Onslow, and Jones (2013) reported, for adults, no systematic differences between percentage of syllables stuttered (%SS) scores during a 12-hour day and 10-minute phone calls. The present study replicated that finding with adolescents, using valid methods for the age group. The present study also extended that initial report by determining whether the gender of the caller influenced %SS scores. Read More

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Exploratory analysis of the genetics of impulse control disorders in Parkinson's disease using genetic risk scores.

Parkinsonism Relat Disord 2021 Apr 11;86:74-77. Epub 2021 Apr 11.

Paris Brain Institute, F-75013, Paris, France; Inserm, U 1127, F-75013, Paris, France; CNRS, UMR 7225, F-75013, Paris, France; Sorbonne Université, F-75013, Paris, France; Assistance Publique Hôpitaux de Paris, Department of Neurology, Centre d'Investigation Clinique Neurosciences, Hôpital Pitié-Salpêtrière, F-75013, Paris, France. Electronic address:

Objective: To study the association between impulse control disorders (ICDs) in Parkinson's disease (PD) and genetic risk scores (GRS) for 40 known or putative risk factors (e.g. depression, personality traits). Read More

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CT-based structural analyses of vertebral fractures with polymeric augmentation: A study of cadaveric three-level spine segments.

Comput Biol Med 2021 Apr 16;133:104395. Epub 2021 Apr 16.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Pathologic vertebral fractures due to metastasis can occur under normal physiologic activities, leading to pain and neurologic deficit. Prophylactic vertebroplasty is a technique used to augment vertebral strength and reduce the risk of fracture. Currently, no technique is available to objectively assess vertebral fracture risk in metastatically-involved vertebral bodies. Read More

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The co-occurrence of autistic spectrum disorder and schizophrenia: A nationwide population-based study.

J Psychiatr Res 2021 Apr 11;138:280-283. Epub 2021 Apr 11.

Shalvata Mental Health Center, Affiliated with the Sackler School of Medicine, Tel Aviv University, Israel; Department of Behavioral Sciences, Ariel University, Israel. Electronic address:

Although the co-occurrence of autistic spectrum disorder (ASD) and schizophrenia have been previously reported, the scope and magnitude of this comorbidity across large samples have not been sufficiently established. This study was aimed to assess the co-occurrence between schizophrenia and ASD in a large dataset, and to examine its predominance across different age and sex groups. Schizophrenia patients and age and sex frequency controls (n = 49,334) were assessed for the prevalence of autism spectrum disorder. Read More

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Triiodothyronine and cortisol levels in the face of energetic challenges from reproduction, thermoregulation and food intake in female macaques.

Horm Behav 2021 Apr 16;131:104968. Epub 2021 Apr 16.

Department of Behavioral Ecology, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, University of Goettingen, Goettingen, Germany; Leibniz Science Campus Primate Cognition, Goettingen, Germany; Primate Social Evolution Group, German Primate Centre, Leibniz Institute for Primate Research, Goettingen, Germany.

Energy availability drives an individual's fitness and can be affected by diverse energetic challenges. The assessment of hormones involved in metabolic activity and energy mobilization provides a gateway to the study of physiological adaptations in response to changes in energy availability. Here, we investigated immunoreactive urinary total triiodothyronine (uTT3, thyroid hormone secreted through the hypothalamus-pituitary-thyroid axis and regulating the basal metabolic rate) alongside glucocorticoids (i. Read More

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Brain-derived neurotrophic factor (BDNF) affects the activity of the gonadotrophic axis in sheep.

Horm Behav 2021 Apr 16;131:104980. Epub 2021 Apr 16.

Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.

This study aimed to examine the hypothesis that BDNF modulates the activity of the gonadotrophic axis in sheep. Central infusions of BDNF were administered to sexually mature Polish Merino sheep. The sheep were randomly divided into three groups: the control group received intracerebroventricular (ICV) infusions of the vehicle, the BDNF 10 group received ICV infusions of BDNF at 10 μg/480 μL/day, and the BDNF 60 group was infused with BDNF at 60 μg/480 μL/day. Read More

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Detection of age related differences in CBF with PCASL using 2 post label delays.

Clin Imaging 2021 Apr 12;79:36-42. Epub 2021 Apr 12.

Department of Magnetic Resonance, Shanxi Cardiovascular Hospital, Taiyuan, China.

Background: The brain is reliant on an abundant and uninterrupted CBF for normal neural function because it is an organ with high metabolic activity and limited ability to store energy.

Purpose: This study aimed to compare age-related variations in CBF measured with PCASL.

Methods: This prospective study included healthy volunteers at the Radiology Department of Shanxi Cardiovascular Hospital between October 2018 and July 2019. Read More

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Hybrid Anterior Column Realignment - Pedicle Subtraction Osteotomy for Severe Rigid Sagittal Deformity.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, Houston Methodist Hospital Neurological Institute 6560 Fannin Street Suite 802, Houston, TX USA 77030.

Objective: Recently, a hybrid anterior column realignment-pedicle subtraction osteotomy (ACR-PSO) approach has been conceived for patients with severe rigid sagittal deformity, the clinical and radiographic outcomes of which require further investigation compared to ACR only.

Methods: A single-center, retrospective chart review identified patients undergoing a combination of hyperlordotic lateral lumbar interbody grafting (ACR) and concurrent Schwab grade 3 three-column osteotomy and propensity-matched patients undergoing ACR only in the same timeframe. Anterior longitudinal ligament was directly released or partially sectioned in all patients. Read More

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Efficient in vitro and in vivo docetaxel delivery mediated by pH-sensitive LPHNPs for effective breast cancer therapy.

Colloids Surf B Biointerfaces 2021 Apr 11;203:111760. Epub 2021 Apr 11.

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Centre (VUMC), 2215 Garland Avenue, 1075 Lab Suite MRB IV, Nashville, TN, 37232, USA; Biomedical Parasitology and Nano-immunology Lab, CSIR Institute of Microbial Technology (IMTECH), CH, India. Electronic address:

The present study was designed to develop pH-sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) for specific cytosolic-delivery of docetaxel (DTX). The pHS-LPHNPs-DTX formulation was prepared by self-assembled nano-precipitation technique and characterized for zeta potential, particle size, entrapment efficiency, polydispersity index (PDI), and in vitro drug release. In vitro cytotoxicity of pHS-LPHNPs-DTX was assessed on breast cancer cells (MDA-MB-231 and MCF-7) and compared with DTX-loaded conventional LPHNPs and bare DTX. Read More

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Quality of life and mental health of patients with vascular malformations in a single specialist center in the United Kingdom.

J Vasc Surg Venous Lymphat Disord 2021 Apr 16. Epub 2021 Apr 16.

Department of Vascular Surgery, Royal Free London NHS Foundation Trust, London, United Kingdom; Department of Surgical Biotechnology, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, United Kingdom. Electronic address:

Objective: Patients with vascular malformations suffer from chronic debilitating symptoms that have been shown to contribute negatively to their quality of life (QoL) and mental health. Despite this, the current literature evaluating the QoL and mental health of patients with vascular malformations remains scarce. The aim was to evaluate the QoL and mental health of patients with vascular malformations. Read More

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Intrinsic exercise capacity induces divergent vascular plasticity via arachidonic acid-mediated inflammatory pathways in female rats.

Vascul Pharmacol 2021 Apr 16:106862. Epub 2021 Apr 16.

Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA. Electronic address:

Metabolic syndrome prevalence has increased among US adults, particularly among non-hispanic white and black women. Sedentary behavior often leads to chronic inflammation, a triggering factor of metabolic syndrome. Given that intrinsic exercise capacity is genetically inherited, we questioned if low-grade chronic inflammation would be present in a female rat model of low intrinsic exercise capacity-induced metabolic syndrome, while beneficial increase of resolution of inflammation would be present in a female rat model of high intrinsic exercise capacity. Read More

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Hypospadias in ring X syndrome.

Eur J Med Genet 2021 Apr 16:104225. Epub 2021 Apr 16.

Division of Genetic and Metabolic Medicine, Department of Pediatrics, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University , Riyadh , Saudi Arabia.

Ring X is a chromosomal anomaly mainly seen in females with turner syndrome and usually present in mosaic form with 45,X cells (45,X/46,X,r(X)) because of their mitotic instability. In males it is an extremely rare finding because large nullisomy for X chromosome material is likely not compatible with survival. Only two cases of male with ring chromosome X were previously reported. Read More

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Persistence, Reward Dependence and Sensitivity to Reward are Associated With Unexpected Salience Response in Girls But Not Adult Women - Implications for Psychiatric Vulnerabilities.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Apr 16. Epub 2021 Apr 16.

ED Care, Denver, Colorado, USA.

Background: Adolescence is a critical period for development of personality but also psychopathology. Those processes may be specific to sex and brain reward circuits may have a role. Here we studied how reward processing and temperament associations differ across adolescent and adult females. Read More

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Direct Measurement of Pregnanediol 3-Glucuronide (PDG) In Dried Urine Spots by Liquid Chromatography-Mass Spectrometry to Detect Ovulation.

J Steroid Biochem Mol Biol 2021 Apr 16:105900. Epub 2021 Apr 16.

MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Scotland, UK.

Background: Non-invasive self-testing using an objective chemical method to detect ovulation is valuable for women planning conception, practising contraception or undergoing infertility investigations or treatment.

Methods: Based on luteal phase secretion of progesterone (P) and excretion of its major metabolite, pregnanediol glucuronide (PDG), we developed a novel direct liquid chromatography-mass spectrometry (LCMS) method to measure PDG and other steroid glucuronides in urine and in dried urine spots (DUS) without deconjugation or derivatization. Urine PDG by LCMS and immunoassay (P3G) and P by immunoassay with and without adjustment for creatinine were evaluated in daily first void urine samples from 10 women through a single menstrual cycle in which ovulation was confirmed by serial transvaginal ultrasound. Read More

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Stress effects on the oddball P300 and N2 in males and females.

Biol Psychol 2021 Apr 16:108095. Epub 2021 Apr 16.

Department of Biological and Clinical Psychology, University of Trier, Germany.

We examined the effect of psychosocial stress on electrophysiological markers of novelty and deviance processing, the N2 and P300, as well as sex differences therein. Participants underwent the Trier Social Stress Test (TSST) or a control procedure, followed by an oddball paradigm. A physiological stress response was induced in both sexes in the TSST condition. Read More

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Lower extremity muscle power - A critical determinant of physical function in aging and multiple sclerosis.

Exp Gerontol 2021 Apr 16:111347. Epub 2021 Apr 16.

Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark. Electronic address:

Background And Purpose: In aging, lower extremity muscle power is undoubtedly one of the most important parameters of neuromuscular function implicating lower extremity physical function (e.g. walking capacity). Read More

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Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons.

Brain Behav Immun 2021 Apr 16. Epub 2021 Apr 16.

Centre de Recherche du CHUM. Department of; Nutrition; Montreal Diabetes Research Center; Center for Studies in Behavioural Neurobiology (Concordia University). Electronic address:

The central signalling actions of cytokines are mediated by signal transducer and activator of transcription (STAT3). STAT3 activation plays a pivotal role in the behavioral responses to the adiposity hormone leptin, including in midbrain dopamine (DA) neurons where it mediates the influence of leptin to diminish physical activity and running reward in male mice. Leptin also has anxiolytic effects which have been tied to the mesolimbic DA system. Read More

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Burden of Kidney Disease, Health-Related Quality of Life, and Employment Among Patients Receiving Peritoneal Dialysis and In-Center Hemodialysis: Findings From the DOPPS Program.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

Rationale & Objective: Individuals faced with decisions regarding kidney replacement therapy options need information on how dialysis treatments might affect daily activities and quality of life, and what factors might influence the evolution over time of the impact of dialysis on daily activities and quality of life.

Study Design: Observational cohort study.

Setting & Participants: 7,771 HD and PD participants from 6 countries participating in the Peritoneal and Dialysis Outcomes and Practice Patterns Studies (PDOPPS/DOPPS). Read More

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Molecular Evolutionary Insights from PRLR in Mammals.

Gen Comp Endocrinol 2021 Apr 16:113791. Epub 2021 Apr 16.

Laboratório de Evolução Humana e Molecular, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address:

Prolactin (PRL) is a pleiotropic neurohormone secreted by the mammalian pituitary gland into the blood, thus reaching many tissues and organs beyond the brain. PRL binds to its receptor, PRLR, eliciting a molecular signaling cascade. This system modulates essential mammalian behaviors and promotes notable modifications in the reproductive female tissues and organs. Read More

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