189,551 results match your criteria female tract

No Correlation Between Presenting Symptoms Prior to Suburethral Sling Removal and Explanted Pathology Findings Suggests No Need for Routine Microscopic Pathology Evaluation.

Female Pelvic Med Reconstr Surg 2021 Apr 21. Epub 2021 Apr 21.

From the Department of Urology Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX.

Objectives: We compared explanted midurethral sling (MUS) standard clinical pathology report findings with presenting symptoms before synthetic sling removal (SSR).

Methods: An institutional review board-approved, prospectively maintained database of women who underwent a single SSR for MUS-related complication(s) was retrospectively reviewed for demographics, time interval between MUS placement and SSR, MUS type, and presenting symptoms before SSR. We compared 2 groups, one with MUS-related symptoms, including incontinence, voiding dysfunction, dyspareunia/pain, erosion, exposure, and/or urinary tract infections, and the second group characterized by self-reported symptoms attributed to the mesh material (systemic, autoimmune, or inflammatory disorder-mesh reaction group). Read More

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Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter.

Mol Pharm 2021 Apr 22. Epub 2021 Apr 22.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K.

Intestinal efflux transporters affect the gastrointestinal processing of many drugs but further data on their intestinal expression levels are required. Relative mRNA expression and relative and absolute protein expression data of transporters are commonly measured by real-time polymerase chain reaction (RT-PCR), Western blot and mass spectrometry-based targeted proteomics techniques. All of these methods, however, have their own strengths and limitations, and therefore, validation for optimized quantification methods is needed. Read More

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[Cushing's syndrome with subsequent tertiary adrenocortical insufficiency after simultaneous multiple intra-articular local glucocorticoid treatment : Keep an eye on hormone deficiency conditions requiring treatment after multiple administrations of local steroids].

Z Rheumatol 2021 Apr 22. Epub 2021 Apr 22.

Klinik für Kinder- und Jugendmedizin, Allgemeine Pädiatrie, Universitätsklinikum Münster, Münster, Deutschland.

After simultaneous multiple local treatment with glucocorticoids at 46 sites a 4‑year-old female patient with newly diagnosed polyarticular juvenile idiopathic arthritis (JIA) initially developed Cushing's syndrome followed by a gradual worsening of her condition and finally an acute high fever urinary tract infection. Iatrogenic adrenocortical insufficiency after multiple intra-articular glucocorticoid administration was diagnosed. The possibility of severe systemic glucocorticoid side effects after extensive local treatment should be included in the regular management of JIA patients. Read More

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The role of portoenterostomy in the treatment of patients with multiple bile duct trauma: Case series and review of the literature.

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):362-368

Department of General Surgery, İzmir Katip Çelebi Üniversity, Atatürk Training and Research Hospital, İzmir-Turkey.

Background: Hepaticojejunostomy is a challenging and complex procedure to be administered with the confidence, in conditions which contain a large number of bile duct damaged by benign pathologies or major bile duct trauma.

Methods: Here, our clinical series of portoenterostomy (PE), in which we applied in patients who had aggressive hilar dissection for hilar benign biliary pathologies and major bile duct traumas during laparoscopic cholecystectomies were discussed in the light of the literature. The PE procedure was performed in the presence of three or more bile ducts that could not be merged. Read More

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Are Urogenital Symptoms Caused by Sexually Transmitted Infections and Colonizing Bacteria?

J Low Genit Tract Dis 2021 Apr 22. Epub 2021 Apr 22.

Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

Objective: This study aimed to investigate the prevalence of sexually transmitted infections (STIs) and colonizing bacteria in relation to urogenital symptoms.

Materials And Methods: In this cross-sectional study, patients visiting the STI clinic at Umeå University Hospital were asked for symptoms and condom use. Samples from 759 patients (465 male and 294 female) were analyzed for 4 STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) and 3 colonizing bacteria (Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum). Read More

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HPV infection and bacterial microbiota in the semen from healthy men.

BMC Infect Dis 2021 Apr 21;21(1):373. Epub 2021 Apr 21.

Department of Paediatrics, University of Turku & Turku University Hospital, Turku, Finland.

Background: Aberrant microbiota composition has been linked to disease development at numerous anatomical sites. Microbiota changes in reaction to viral infections, such as human papillomavirus (HPV), have been investigated almost exclusively in the female reproductive tract. However, HPV infection may also affect male health by reducing semen quality and fertility. Read More

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Sperm Bauplan and Function and Underlying Processes of Sperm Formation and Selection.

Physiol Rev 2021 Apr 21. Epub 2021 Apr 21.

Deparment of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales, Spain.

The spermatozoon is a highly differentiated and polarized cell, with two main structures: the head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum, which generates energy and propels the cell; both structures are connected by the neck. The sperm's main aim is to participate in fertilization, thus activating development. Despite this common bauplan and function there is an enormous diversity in structure and performance of sperm cells. Read More

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A Case of Idiopathic Orbital Inflammation in a Seven-Year-Old Child.

Cureus 2021 Mar 16;13(3):e13924. Epub 2021 Mar 16.

Ophthalmology, Bahrain Defence Force Royal Medical Services (BDFRMS), Riffa, BHR.

We present a case of idiopathic orbital inflammation (IOI) in a pediatric patient that was initially diagnosed as orbital cellulitis. A seven-year-old female presented with painful right upper eyelid swelling and ptosis and an upper respiratory tract infection. Ruling out secondary causes that are sight and life-threatening conditions is prudent. Read More

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Brain abscess in a rheumatoid arthritis patient treated with leflunomide - A case presentation and review.

Surg Neurol Int 2021 17;12:97. Epub 2021 Mar 17.

Department of Neurology, Papageorgiou Hospital of Thessaloniki, Periferiaki Odos N. Efkarpia, Thessaloniki, Central Macedonia, Greece.

Background: Immunosuppression is a significant parameter in the pathogenesis of brain abscesses (BA) and it could be the result of severe infections such as acquired immunodeficiency syndrome or drug-induced, by several medications used for systemic autoimmune diseases. Leflunomide is a pyrimidine synthesis inhibitor that affects the proliferation of lymphocytes and is used as a disease-modifying antirheumatic drug. Mild infections, particularly those of the respiratory tract and herpes zoster, are one of its most common adverse effects. Read More

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Regenerative Medicine Approaches in Bioengineering Female Reproductive Tissues.

Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27101, USA.

Diseases, disorders, and dysfunctions of the female reproductive tract tissues can result in either infertility and/or hormonal imbalance. Current treatment options are limited and often do not result in tissue function restoration, requiring alternative therapeutic approaches. Regenerative medicine offers potential new therapies through the bioengineering of female reproductive tissues. Read More

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Circular RNAs: Novel potential regulators in embryogenesis, female infertility, and pregnancy-related diseases.

J Cell Physiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Circular RNAs (circRNAs) are endogenous noncoding RNAs with unique cyclic structures. Although they were previously considered as nonfunctional transcription byproducts, numerous studies have demonstrated that circRNAs regulate gene transcription and expression via different mechanisms. Reproductive health influences the quality of life and affects offspring propagation in women. Read More

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Not Just Uterine Adenocarcinoma-Neoplastic and Non-Neoplastic Masses in Domestic Pet Rabbits (): A Review.

Berit Baum

Vet Pathol 2021 Apr 20:3009858211002190. Epub 2021 Apr 20.

Vet Med Labor GmbH, Kornwestheim, Germany.

With increasing numbers of pet rabbits living out their natural lifespan, rabbit oncology is stepping more and more into the limelight. On the other hand, rabbit tumors are less covered in recent editions of textbooks of veterinary pathology than before. We present 1238 cases with neoplastic and non-neoplastic masses in rabbit tissue, submitted from 2008 to 2019, supplemented by a review of the literature on neoplasms in rabbits. Read More

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Pharmacovigilance-based drug repurposing: The search for inverse signals via OpenVigil identifies putative drugs against viral respiratory infections.

Br J Clin Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein Campus Kiel, Germany.

Aim: Pharmacovigilance data are primarily used to identify adverse drug reactions by screening for disproportionate reporting, i.e. more reports of certain combinations of adverse events and drugs than expected. Read More

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Intraoperative mapping of pre-central motor cortex and subcortex: a proposal for supplemental cortical and novel subcortical maps to Penfield's motor homunculus.

Brain Struct Funct 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.

Penfield's motor homunculus describes a caricaturised yet useful representation of the map of various body parts on the pre-central cortex. We propose a supplemental map of the clinically represented areas of human body in pre-central cortex and a novel subcortical corticospinal tract map. We believe this knowledge is essential for safe surgery in patients with eloquent brain lesions. Read More

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Polish versions of the ICIQ-FLUTS and the ICIQ-FLUTS LF: translation, adaptation, and validation of female-specific instruments for evaluation of lower urinary tract symptoms.

Int Urogynecol J 2021 Apr 19. Epub 2021 Apr 19.

Department of Urology, Jagiellonian University, Medical College, ul. Jakubowskiego 2, 30-688, Krakow, Poland.

Introduction And Hypothesis: Previously, there was no specific questionnaire in the Polish language for overall assessment of lower urinary tract symptoms (LUTS) in women. The aim of this study was to translate, culturally adapt, and validate Polish versions of the International Consultation on Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms (ICIQ-FLUTS and ICIQ-FLUTS LF, short and long forms) for use in clinical practice and research in Poland.

Methods: The original English ICIQ-FLUTS and ICIQ-FLUTS LF were adapted to Polish according to international standards and recommended procedures. Read More

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Correlation between symptoms and imaging findings including pelvic floor ultrasound to improve the symptom-based diagnosis of female urethral diverticulum (CHECK-UD study).

Int Urogynecol J 2021 Apr 19. Epub 2021 Apr 19.

Department of Urology and Pediatric Urology, University Hospital Essen, Essen, Germany.

Introduction And Hypothesis: The objective was to establish a model to predict the presence of a female urethral diverticulum (UD) based on symptoms.

Methods: A prospective CHECK-UD study (check of female urethral diverticulum) was conducted. Female patients presenting with symptoms such as lower urinary tract symptoms (LUTS), postmicturition dribble or urinary incontinence (UI), dyspareunia or pain in the pelvic area, and recurrent urinary tract infection (UTI) treated between 2015 and 2020 were included. Read More

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Urinary retention on an acute geriatric hospitalisation unit: prevalence, risk factors and the role of screening, an observational cohort study.

Eur Geriatr Med 2021 Apr 18. Epub 2021 Apr 18.

Department of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, Box 7003 35, 3000, Leuven, Belgium.

Purpose: Urinary retention (UR) is common in older patients. The aim of this observational cohort study was to measure the prevalence of UR in patients aged ≥ 75 years on admission to an acute geriatric hospitalisation unit and to determine which at risk group would benefit from screening.

Methods: Post-void residual volumes (PVR) were measured within 3 days of admission with an ultrasound bladder scan. Read More

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Urethral clear cell carcinoma - Case report and review of litrature.

Urol Case Rep 2021 Sep 29;38:101659. Epub 2021 Mar 29.

King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Urethral clear cell carcinoma is very rare disease affecting both sexes, however it is mostly described in female urethra. The origin of this cancer is yet to be discovered. We report a 57 years old lady who presented to our clinic with obstructive lower urinary tract symptoms and found to have a urethral diverticulum containing a soft tissue lesion found to be a clear cell carcinoma after excision. Read More

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September 2021

Serum 2-microglobulin may be a viral biomarker by analyzing children with upper respiratory tract infections and exanthem subitum: a retrospective study.

PeerJ 2021 6;9:e11109. Epub 2021 Apr 6.

Department of Pediatrics, Yancheng Third People's Hospital, Yancheng, China.

Background: Due to the lack of effective and feasible viral biomarkers to distinguish viral infection from bacterial infection, children often receive unnecessary antibiotic treatment. To identify serum 2-microglobulin that distinguishes bacterial upper respiratory tract infection from viral upper respiratory tract infection and exanthem subitum in children.

Methods: This retrospective study was conducted from January 1, 2019 to September 30, 2020 in Yancheng Third People's Hospital. Read More

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A 13 year hospital based study on the Trend of Urinary Stone Disease in Uttarakhand, India.

Nepal J Epidemiol 2021 Mar 31;11(1):949-958. Epub 2021 Mar 31.

Department of Community and Family Medicine, All India Institute of Medical Sciences, Mangalagiri, Guntur, Andhra Pradesh, India.

Background: The present retrospective study on urinary stone disease in the Uttarakhand state was necessitated as no study has been done yet.

Methods: A 13 year retrospective study (from 2005 to 2018) was conducted on the urinary stones removed from the patients, admitted at Himalayan Institute of Medical Sciences, Dehradun. The incidence of the disease, site of stones in urinary tract upon diagnosis, composition of removed stones and occurrence of a possible co-relationship between the incidence of the urinary stone disease at different times, age, sex, religion of the patients was investigated. Read More

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Ability of ESWL nomograms to predict stone-free rate in children.

J Pediatr Urol 2021 Mar 29. Epub 2021 Mar 29.

Baskent University Faculty of Medicine, Department of Urology, Ankara, Turkey.

Introduction: We aimed to evaluate whether the pediatric extracorporeal shock wave lithotripsy (ESWL) nomograms can predict stone-free status in children effectively and whether they are applicable to our series. We hypothesize that two current nomograms predicting successful treatment with ESWL in pediatric patients are valid.

Study Design: We evaluated 415 renal units (children <18 years) with eligible data who received ESWL treatment for upper urinary tract stones. Read More

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Incidence of nephrolithiasis after bladder augmentation in people with spina bifida.

J Pediatr Urol 2021 Mar 19. Epub 2021 Mar 19.

Division of Pediatric Urology, Riley Hospital for Children at IU Health, 705 Riley Hospital Dr., Suite 4230, Indianapolis, IN 46202, USA. Electronic address:

Introduction: Risks of nephrolithiasis after bladder augmentation in people with spina bifida (SB) remain unclear. Annual incidence of nephrolithiasis in the general population is 0.01% for 10-14 years old, 0. Read More

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Evolutionary consequences of environmental effects on gamete performance.

Philos Trans R Soc Lond B Biol Sci 2021 Jun 19;376(1826):20200122. Epub 2021 Apr 19.

School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.

Variation in pre- and post-release gamete environments can influence evolutionary processes by altering fertilization outcomes and offspring traits. It is now widely accepted that offspring inherit epigenetic information from both their mothers and fathers. Genetic and epigenetic alterations to eggs and sperm-acquired post-release may also persist post-fertilization with consequences for offspring developmental success and later-life fitness. Read More

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Optimal timing of endoscopic retrograde cholangiopancreatography for acute cholangitis associated with distal malignant biliary obstruction.

BMC Gastroenterol 2021 Apr 17;21(1):175. Epub 2021 Apr 17.

Division of Gastroenterology, Department of Internal Medicine, Liver Research Institute, College of Medicine, Seoul National University Hospital, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Background: There is a lack of studies regarding the optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in patients with cholangitis caused by distal malignant biliary obstruction (MBO). This study aims to investigate the optimal timing of ERCP in patients with acute cholangitis associated with distal MBO with a naïve papilla.

Methods: A total of 421 patients with acute cholangitis, associated with distal MBO, were enrolled for this study. Read More

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Low Rates of Urologic Side Effects Following COVID Vaccination: An Analysis of the FDA Vaccine Adverse Event Reporting System.

Urology 2021 Apr 14. Epub 2021 Apr 14.

Division of Urology, Cedars-Sinai Medical Center, Los Angeles CA. Electronic address:

Objective: To quantify and describe urologic adverse events and symptoms after vaccination with the Pfizer-BioNTech and Moderna COVID-19 vaccines.

Methods And Materials: We queried the FDA Vaccine Adverse Event Reporting System (VAERS) for all reported symptoms following the Pfizer-BioNTech and Moderna vaccines as of February 12th, 2021. All urologic symptoms were isolated and the reported adverse events associated with each symptom were reviewed. Read More

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Spatiotemporal transcriptional dynamics of the cycling mouse oviduct.

Dev Biol 2021 Apr 14. Epub 2021 Apr 14.

Department of Molecular Biosciences, University of Texas at Austin, TX, 78712, USA. Electronic address:

Female fertility in mammals requires iterative remodeling of the entire adult female reproductive tract across the menstrual/estrous cycle. However, while transcriptome dynamics across the estrous cycle have been reported in human and bovine models, no global analysis of gene expression across the estrous cycle has yet been reported for the mouse. Here, we examined the cellular composition and global transcriptional dynamics of the mouse oviduct along the anteroposterior axis and across the estrous cycle. Read More

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Clinical Features of Essential Voice Tremor and Associations with Tremor Severity and Response to Octanoic Acid Treatment.

Laryngoscope 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, SUNY Upstate Medical University, Syracuse, New York, U.S.A.

Objectives/hypothesis: The purpose of this study was to characterize the clinical features, tremor variability, and factors related to octanoic acid (OA) treatment response in essential voice tremor (EVT).

Study Design: Prospective, double blind, placebo-controlled, crossover study with secondary analysis.

Methods: Clinical tremor features in 16 individuals with EVT were comprehensively assessed, and correlations with acoustic tremor severity were determined. Read More

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Altering the microbiome inhibits tumorigenesis in a mouse model of oviductal high-grade serous carcinoma.

Cancer Res 2021 Apr 16. Epub 2021 Apr 16.

Pathology, Internal Medicine, University of Michigan Medical School

Studies have shown bacteria influence the initiation and progression of cancers arising in sites that harbor rich microbial communities, such as the colon. Little is known about the potential for the microbiome to influence tumorigenesis at sites considered sterile, including the upper female genital tract. The recent identification of distinct bacterial signatures associated with ovarian carcinomas suggests microbiota in the gut, vagina, or elsewhere might contribute to ovarian cancer pathogenesis. Read More

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Nationwide surveillance of bacterial pathogens isolated from patients with acute uncomplicated cystitis in 2018: Conducted by the Japanese Research Group for Urinary Tract Infections (JRGU).

J Infect Chemother 2021 Apr 13. Epub 2021 Apr 13.

Department of Urology, Hyogo College of Medicine College Hospital, 1-1 Mukogawa-machi, Nishinomiya, 663-8501, Japan; Japanese Research Group for Urinary Tract Infection (JRGU), 1-1 Mukogawa- Machi, Nishinomiya, 663-8501, Japan.

Introduction: The aim of this study was to monitor the development of drug-resistant bacteria isolated from acute uncomplicated cystitis (AUC) and to evaluate methodology of the survey conducted by collecting only clinical data.

Methods: We enrolled female patients at least 16 years of age diagnosed with AUC in 2018. Patient information including age, menopausal status, and results of bacteriological examination were collected and analyzed regardless of bacterial identification, antimicrobial susceptibility testing or extended-spectrum β-lactamase (ESBL) detection method. Read More

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Hematuria and its repetition after initial control in patients receiving anti-coagulant: A prospective observational study.

Urologia 2021 Apr 16:391560321999965. Epub 2021 Apr 16.

Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Although Gross hematuria in patients receiving anticoagulants is not very common, it is one of the most common reasons of consulting with urologists. It is recommended to investigate urinary tract malignancies but simultaneous approach to anticoagulation and hematuria so as the optimum balance could be attained, is not clearly defined in the literature yet. We aim to answer pitfalls of hematuria management in anticoagulant receiving patients in this manuscript. Read More

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