66,349 results match your criteria female sterility

Oocyte cryopreservation versus ovarian tissue cryopreservation for adult female oncofertility patients: a cost-effectiveness study.

J Assist Reprod Genet 2021 May 11. Epub 2021 May 11.

Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, Duke Fertility Center, Duke University, 200 Trent Drive (Baker House 236), Durham, NC, 27713, USA.

Purpose: In December 2019, the American Society for Reproductive Medicine designated ovarian tissue cryopreservation (OTC) as no longer experimental and an alternative to oocyte cryopreservation (OC) for women receiving gonadotoxic therapy. Anticipating increased use of OTC, we compare the cost-effectiveness of OC versus OTC for fertility preservation in oncofertility patients.

Methods: A cost-effectiveness model to compare OC versus OTC was built from a payer perspective. Read More

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Pathways and factors regulated by bone marrow-derived stem cells in human ovarian tissue.

Fertil Steril 2021 May 8. Epub 2021 May 8.

Fundación Instituto Valenciano de Infertilidad (IVI), Valencia, Spain; Grupo de Investigación en Medicina Reproductiva, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain; IVI-RMA Valencia, Valencia, Spain. Electronic address:

Objective: To describe molecular and paracrine signaling changes produced by human bone marrow-derived stem cells (BMDSC) in human ovarian cortex.

Design: Experimental study.

Setting: University hospital research laboratories. Read More

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Reproductive outcomes in individuals with chromosomal reciprocal translocations.

Genet Med 2021 May 10. Epub 2021 May 10.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Patients with reciprocal balanced translocations (RBT) have a risk for recurrent pregnancy losses (RPL), affected child, and infertility. Currently, genetic counseling is based on karyotypes found among the products of conception (POC), although factors influencing the success of assisted reproductive technologies (ART) in RBT couples are not established.

Methods: Cytogenetic results from 261 POC and offspring of the parents (113 women and 90 men) with RBT were evaluated. Read More

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Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre.

BMC Res Notes 2021 May 10;14(1):177. Epub 2021 May 10.

Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Objective: To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population.

Results: This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Read More

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The comprehensive variant and phenotypic spectrum of TUBB8 in female infertility.

J Assist Reprod Genet 2021 May 10. Epub 2021 May 10.

Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, 410008, China.

Purpose: TUBB8 is a gene that is frequently analysed in the genetic diagnosis of female infertility; 102 variants of this gene have been identified. However, the evaluation of its pathogenicity and the resulting phenotypes vary. Here, we aimed to identify novel TUBB8 variants as well as to summarize the reported variants and phenotypes in order for them to be included in genetic counselling analyses. Read More

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Predictive Factors for Live Birth in Fresh Fertilization/Intracytoplasmic Sperm Injection Treatment in Poor Ovarian Reserve Patients Classified by the POSEIDON Criteria.

Front Endocrinol (Lausanne) 2021 12;12:630832. Epub 2021 Apr 12.

Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

The mechanisms underlying poor ovarian response (POR) in assisted reproductive technology remain unclear, there is no consensus on the management of poor responders, the POSEIDON stratification classifies infertility patients into "expected" or "unexpected" groups to provide a more nuanced picture of POR, but few researchers have discussed the independent predictive factors (smoothed plots and the threshold effect) for live birth in POR patients classified by the new criteria. We conducted a retrospective cohort study using clinical data from 6,580 POR patients classified by the POSEIDON criteria in the First Affiliated Hospital of Zhengzhou University, and explored the live birth based on the results before and after the threshold inflection point of each independent influencing factor. Among 6,580 poor ovarian reserve patients classified by the POSEIDON criteria, 1,549 (23. Read More

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The potential role of assisted oocyte activation in the management of a POSEIDON group 3 patient with fertilization failure: A case report and literature review.

Taiwan J Obstet Gynecol 2021 May;60(3):567-569

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. Electronic address:

Objective: Assisted oocyte activation combined with ICSI (ICSI-AOA) has been reported to improve fertilization outcomes of couples with oocyte activation deficiency (OAD). Although there's no sufficient evidence to support ICSI-AOA as routine use, it might be beneficial for POSEIDON group 3 patients with suspected oocyte-related OAD.

Case Report: A 29-year-old female presented with a history of primary infertility for two years. Read More

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[Effects of Vitrification with Self-made Carriers and Slow Programmed Freezing on Ovarian Tissue of Sheep].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):193-198

Infertility Center,Qilu Hospital of Shandong University,Jinan 250012,China.

Objective To investigate the effects of self-made carriers on the cryopreservation of ovarian tissue of sheep. Methods Thirty-two ovaries were randomly assigned to fresh group,programmed freezing group,self-made carrier I vitrification group,and self-made carrier Ⅱ vitrification group.The morphology,proliferation,apoptosis,and estrogen level of the ovarian tissue in each group were observed. Read More

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A homozygous missense mutation in TBPL2 is associated with oocyte maturation arrest and degeneration.

Clin Genet 2021 May 9. Epub 2021 May 9.

Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

The genetic causes in most of patients with oocyte maturation arrest remain largely unknown. In this study, we identified a homozygous missense mutation in TBPL2 (TATA box binding protein like 2) in two infertile sisters with oocyte maturation arrest and degeneration from a consanguineous family by whole-exome sequencing. The TBPL2 mutation is rare and pathogenic, and impaired the transcription initiation function of the protein. Read More

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WNT4 balances development versus disease in gynecologic tissues and women's health.

Endocrinology 2021 May 8. Epub 2021 May 8.

Dept. of Pathology, University of Colorado Anschutz Medical Campus.

The WNT family of proteins are crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in development of the female phenotype in the fetus, and in the maintenance of Müllerian and reproductive tissues. WNT4 dysfunction or dysregulation can drive sex reversal syndromes, highlighting the key role of WNT4 in sex determination. Read More

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Acute abdomen: Unusual presentation of Herlyn-Werner Wunderlich syndrome.

Int J Surg Case Rep 2021 Apr 27;82:105911. Epub 2021 Apr 27.

Department of Surgery, Samlaniya Medical Complex, P.O. Box 12, Manama, Bahrain.

Introduction And Importance: The presentation of an acute abdomen has a wide range of differentials. Developmental anomalies are rarely considered as part of the clinical reasoning process due to it being a mimicker of other commoner diseases. The importance of considering such anomalies and recognizing them early is essential in order to prevent complications, such as infertility. Read More

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Fertility Knowledge and Awareness Practices.

Nurs Womens Health 2021 May 4. Epub 2021 May 4.

Objective: To synthesize the literature on fertility knowledge and fertility awareness among women seeking pregnancy.

Data Sources: The search terms "fertility awareness OR fertility knowledge AND women AND subfertile OR infertile OR seeking pregnancy OR trying to conceive OR pre-conception OR conception NOT contraception NOT birth control" were used via CINAHL, PubMed, and Web of Science. Primary research studies were considered in the search parameters. Read More

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The experiences of women with breast cancer who undergo fertility preservation.

Hum Reprod Open 2021 29;2021(2):hoab018. Epub 2021 Apr 29.

Department of Development and Regeneration, Research Foundation-Flanders, University of Leuven, Leuven, Belgium.

Study Question: How do women, who have just been diagnosed with breast cancer, experience oocyte or embryo banking?

Summary Answer: Fertility preservation was a challenging yet welcome way to take action when confronted with breast cancer.

What Is Known Already: Fertility preservation for women with breast cancer is a way to safeguard future chances of having children. Women who have just been diagnosed with breast cancer report stress, as do women who have to undergo IVF treatment. Read More

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Melatonin: Multi-Target Mechanism Against Diminished Ovarian Reserve Based on Network Pharmacology.

Front Endocrinol (Lausanne) 2021 19;12:630504. Epub 2021 Apr 19.

Department of Traditional Chinese Medical Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Background: Diminished ovarian reserve (DOR) significantly increases the risk of female infertility and contributes to reproductive technology failure. Recently, the role of melatonin in improving ovarian reserve (OR) has attracted widespread attention. However, details on the pharmacological targets and mechanisms of melatonin-improved OR remain unclear. Read More

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The Inferto-Sex Syndrome (ISS): sexual dysfunction in fertility care setting and assisted reproduction.

J Endocrinol Invest 2021 May 6. Epub 2021 May 6.

Chair of Endocrinology and Medical Sexology (ENDOSEX), Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 1, E Tower South. Floor 4, Room E413, 00133, Rome, Italy.

Purpose: Infertility represents a peculiar social burden affecting more than 15% of couples, provoking it a real threat to the general quality of life and to the sexual health. The medicalization (diagnosis, therapy and follow up) of the lack of fertility is frequently a challenge in term of personal and couple's involvement. In particular, while the Assisted Reproductive Technology (ART) has allowed many infertile couples to achieve pregnancy, the therapeutic process faced by the couple bears a strong psychological stress that can affect the couple's quality of life, relationship and sexuality. Read More

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Effect of bisphenol A on alterations of ICAM-1 and HLA-G genes expression and DNA methylation profiles in cumulus cells of infertile women with poor response to ovarian stimulation.

Sci Rep 2021 May 5;11(1):9595. Epub 2021 May 5.

Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.

This study aimed to investigate the relationship between follicular fluid Bisphenol A (BPA) concentrations with alterations of ICAM-1 and HLA-G genes and proteins expression as well as methylation profiles in the cumulus cells of poor ovarian response (POR) women based on their healthy lifestyle habit. Eighty women under the age of 35 were divided into two groups: 1-POR without using plastic containers (n = 40) and 2-POR with using plastic containers (n = 40). The ICAM-1 and HLA-G genes and protein expressions were examined by the quantitative PCR and western blotting technique. Read More

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Chemoprotective Effect of Syringic Acid on Cyclophosphamide Induced Ovarian Damage via Inflammatory Pathway.

J Oleo Sci 2021 ;70(5):675-683

Department of Gynecology, Affiliated Hospital of Hebei University.

Cyclophosphamide (CP) is very well-known anticancer drug and commonly used against various cancers. CP therapy is related to female ovarian cancer and causes female infertility. The ovarian cancer associated with the increase oxidative stress and inflammatory reaction. Read More

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January 2021

Abortion and Infertility.

Gregory K Pike

Issues Law Med 2020 ;35(2):173-195

Senior Research Fellow, Bios Centre, London. Bachelor of Sciences with Honors in Physiology; Doctor of Philosophy.

The purpose of this article is to examine one potential factor that might negatively impact female fertility, namely induced abortion. While there appears to be a general consensus that there is no association between abortion and infertility, amongst the publications that do exist there is nevertheless evidence to the contrary. Moreover, given the variety of reasonable grounds for a link, and the insufficient attention to the subject by researchers, a re-examination of the field is warranted. Read More

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January 2020

Impact of gamma radiation dose on sterility and quality parameters of Anastrepha fraterculus (Diptera: Tephritidae).

An Acad Bras Cienc 2021 30;93(2):e20190249. Epub 2021 Apr 30.

Programa de Pós-Graduação em Fitossanidade, Universidade Federal de Pelotas, Av. Eliseu Maciel, s/n, 96010-900 Pelotas, RS, Brazil.

Anastrepha fraterculus (Wiedemann, 1830) (Diptera: Tephritidae) is a major fruit pest, which is basicaly controlled using insecticides, which represents a risk to beneficial arthropods, human health and food contamination. The sterile insect technique (SIT) is a potential alternative tool for the management of this pest, however, only conflicting data is found regarding the optimal dose to achieve sterility. Thus, this study evaluated the effect of gamma radiation doses (0, 40, 50, 60 and 70 Gy) on male and female reproductive sterility, gonads morphometry, emergence, flight ability, and longevity under nutritional stress of A. Read More

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Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women.

Environ Int 2021 May 1;155:106589. Epub 2021 May 1.

Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing follicles. The quantity and quality of the follicles decline with age, thereby eventually leading to menopause. Read More

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Functional differences of Toll-like receptor 4 in osteogenesis, adipogenesis and chondrogenesis in human bone marrow-derived mesenchymal stem cells.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Multipotent human bone marrow-derived mesenchymal stem cells (hMSCs) are promising candidates for bone and cartilage regeneration. Toll-like receptor 4 (TLR4) is expressed by hMSCs and is a receptor for both exogenous and endogenous danger signals. TLRs have been shown to possess functional differences based on the species (human or mouse) they are isolated from therefore, the effects of knockdown of TLR4 were evaluated in humans during the differentiation of MSCs into bone, fat and chondrocyte cells in vitro. Read More

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Methods of Ovarian Tissue Cryopreservation: Is Vitrification Superior to Slow Freezing?-Ovarian Tissue Freezing Methods.

Reprod Sci 2021 May 3. Epub 2021 May 3.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL, USA.

After cancer treatment, female survivors often develop ovarian insufficiency or failure. Oocyte and embryo freezing are well-established fertility preservation options, but cannot be applied in pre-pubescent girls, in women with hormone-sensitive malignancies, or when gonadotoxic treatment cannot be delayed. Although ovarian tissue cryopreservation (OTC) has been used to restore fertility and endocrine function, the relative efficacy of its two major protocols, slow freezing and vitrification, remains controversial. Read More

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Effects of moderate intensity endurance training and high-intensity interval training on the reproductive parameters of wistar rats overfed in infancy.

Chin J Physiol 2021 Mar-Apr;64(2):106-114

Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development of obesity, cardiovascular diseases, and diabetes in the long term. In addition to metabolic changes during adulthood, overweight/obesity may influence reproductive function. Human and animal studies suggest that lifestyle changes through exercise and/or controlled diet result in improved semen quality in obese individuals. Read More

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Risk of embryo aneuploidy is affected by the increase in sperm DNA damage in recurrent implantation failure patients under ICSI-CGH array cycles.

Hum Fertil (Camb) 2021 May 3:1-9. Epub 2021 May 3.

Department of Anatomical Sciences, Iran University of Medical Science, Tehran, Iran.

This study investigates the relationship between sperm DNA damage in recurrent implantation failure (RIF) patients treated with comparative genomic hybridisation array-intracytoplasmic sperm injection (CGH array-ICSI) cycles and embryo aneuploidy screening. Forty-two RIF couples were selected. Sperm DFI was measured using TUNEL by flow cytometry. Read More

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Differences in Family Planning and Fertility Among Female and Male Gynecologic Oncologists.

Womens Health Rep (New Rochelle) 2021 8;2(1):78-84. Epub 2021 Apr 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.

The objective of the study was to compare family planning and infertility among female and male gynecologic oncologists in the United States This cross-sectional multiple choice survey was administered to the Society of Gynecologic Oncology gynecologic oncologists. The survey collected information on demographics and practice, family planning, and fertility and infertility experiences. Chi-square and Fisher's exact tests were used to compare experiences by gender. Read More

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Laughs and Jokes in Assisted Reproductive Technologies: Quantitative and Qualitative Analysis of Video-Recorded Doctor-Couple Visits.

Front Psychol 2021 14;12:648333. Epub 2021 Apr 14.

Department of Health Science, University of Milan, Milan, Italy.

To explore the characteristics of the use of laughs and jokes during doctor-couple assisted reproductive technology (ART) visits. 75 videotaped doctor-couple ART visits were analyzed and transcribed in order to: (1) quantify laugh and jokes, describing the contribution of doctors and couples and identifying the timing of appearance; (2) explore the topic of laughs and jokes with qualitative thematic analysis. On average, each visit contained 17. Read More

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Circadian rhythm-associated Rev-erbα modulates polarization of decidual acrophage via PI3K/Akt signaling pathway.

Am J Reprod Immunol 2021 May 2:e13436. Epub 2021 May 2.

NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200090, China.

Problem: Circadian rhythms are involved not only in the repair and regeneration of the immune system, but may also be associated with regulation of inflammation and immune responses. Rev-erbα could constitute a link between immunity and circadian rhythms since it is a transcription factor that regulates circadian rhythms and has functions in multiple physiological and pathological processes. Decidual macrophages (dMφs) play crucial roles in immune balance at the maternal-fetal interface, and abnormal macrophage polarization is related to adverse pregnancy outcomes, such as infertility, recurrent spontaneous abortion and preterm labor. Read More

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Contact, moral foundations or knowledge? What predicts attitudes towards women who undergo IVF.

BMC Pregnancy Childbirth 2021 May 1;21(1):346. Epub 2021 May 1.

School of Arts and Humanities, Edith Cowan University, Perth, Western Australia.

Background: The willingness to try in vitro fertilization (IVF) as an infertility treatment, as well as its psychosocial consequences for couples, may be influenced by how they perceive the attitudes of general public towards this procedure. The focus of the current study was to identify predictors of attitudes towards mothers who underwent IVF to conceive a child. Three predictors were derived from attitude components: contact with someone who had undergone IVF (behavior), moral foundations (emotions), and the level of knowledge (cognition) about IVF. Read More

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[Becoming a father in the face of symbolic wounds in filiation: a case of male infertility].

Monique Jaoul

Soins Pediatr Pueric 2021 Mar-Apr;42(319):22-26. Epub 2021 Jan 23.

Service d'aide médicale à la procréation, Centre hospitalier de Poissy-Saint-Germain, rue du Champ-Gaillard, 78300 Poissy, France. Electronic address:

With the intention of having a child and the subsequent question of filiation, "becoming a mother" as well as "becoming a father" always involve a risk. In both men and women, the plan to have a child or to become pregnant can lead to the revival of unresolved conflicts that can question the very organisation of their being. Sterility then comes as a defence against the risk of collapse. Read More

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Systematic Review of Black Cohosh () for Management of Polycystic Ovary Syndrome-Related Infertility.

J Pharm Pract 2021 Apr 29:8971900211012244. Epub 2021 Apr 29.

Department of Pharmacy Practice, Drug Information Center, D'Youville School of Pharmacy, Buffalo, NY, USA.

Polycystic ovary syndrome (PCOS) is a common cause of female infertility. To conduct a systematic review assessing the efficacy and safety of black cohosh for ovulation-induction through hormone regulation and increased endometrial thickness to improve pregnancy rates in women with PCOS-related infertility. Preferred Reporting Items for Systematic Reviews and Meta-Analyses was used. Read More

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