57,716 results match your criteria female offspring


Evaluation of the influence of diet supplementation with conjugated linoleic acid isomers on elemental composition in the cardio-oncological nutritional programming rat' model.

J Trace Elem Med Biol 2021 Jul 7;68:126816. Epub 2021 Jul 7.

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

Background: The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer.

Methods: Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). Read More

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Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring.

Bone 2021 Jul 27:116133. Epub 2021 Jul 27.

Department of Orthopedic Surgery; Department of Advanced Therapy for Musculoskeletal Disorders II; Department of Musculoskeletal Reconstruction and Regeneration Surgery; Department of Orthopedic Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Electronic address:

Changes in bone metabolism occur in mothers during pregnancy or lactation that may decrease bone mass and result in fragility fractures after partum. However, use of drugs during pregnancy or lactation to counteract these effects is often prohibited or strongly discouraged. Therefore, approaches to protect mothers from fragility fractures have not been established. Read More

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Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan.

Drug Res (Stuttg) 2021 Jul 29. Epub 2021 Jul 29.

Sechenov University, Moscow, Russia.

Objective: Study of embryotoxicity, teratogenicity and reproductive toxicity of the new drug Lipophtalocyan in rats.

Material And Methods: Studies were conducted on 210 non-inbred female rats and 105 non-inbred male rats. The drug was administered daily via i. Read More

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Distant hybridization and gynogenesis between Nile tilapia Oreochromis niloticus and Jaguar cichlid Parachromis managuensis.

Anim Reprod Sci 2021 Jul 16;232:106806. Epub 2021 Jul 16.

Pearl River Fisheries Research Institute, Chinese Academy of Fisheries Science, Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation, Ministry of Agriculture, Guangzhou, Guangdong, China.

To investigate the distant hybridization and gynogenesis between Nile tilapia Oreochromis niloticus and Jaguar cichlid Parachromis managuensis, reciprocal crossing was first performed between the two species. No offspring, however, were viable when there were these hybridizations. Gynogenesis was induced in O. Read More

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Maternal exposure to sodium ρ-perfluorous nonenoxybenzene sulfonate during pregnancy and lactation disrupts intestinal barrier and may cause obstacles to the nutrient transport and metabolism in F0 and F1 generations of mice.

Sci Total Environ 2021 Jul 1;794:148775. Epub 2021 Jul 1.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address:

Sodium ρ-perfluorous nonenoxybenzene sulfonate (OBS), a novel kind of perfluoroalkyl and polyfluoroalkyl compound, has been widely detected in the environment. The toxicity of OBS to living organisms has become a public concern. A growing body of research showed that maternal exposure to environmental pollutants caused intestinal and metabolic diseases that could be conserved across offspring. Read More

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The association between personalities, alternative breeding strategies, and reproductive success in dunnocks.

J Evol Biol 2021 Jul 27. Epub 2021 Jul 27.

Department of Zoology, University of Otago, 340 Great King Street, Dunedin, 9016, New Zealand.

Although consistent between-individual differences in behaviour (i.e. animal personality) are ubiquitous in natural populations, relatively few studies have examined how personalities influence the formation of social relationships. Read More

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Are you my mummy? Long-term olfactory memory of mother's body odour by offspring in the domestic cat.

Anim Cogn 2021 Jul 26. Epub 2021 Jul 26.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Longevity of odour memories, particularly those acquired during early development, has been documented in a wide range of taxa. Here, we report that kittens of the domestic cat retained a memory into adult life of their mother´s body odour experienced before weaning. Kittens from 15 litters were tested when permanently separated from their mother at weaning on postnatal week 8, and tested again when 4 and 6 months and over 1 year of age. Read More

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Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring.

eNeuro 2021 Jul 26. Epub 2021 Jul 26.

Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211 USA

Opioid drugs are increasingly being prescribed to pregnant women. Such compounds can also bind and activate opioid receptors in the fetal brain, which could lead to long term brain and behavioral disruptions. We hypothesized that maternal treatment with oxycodone (OXY), the primary opioid at the center of the current crisis, leads to later neurobehavioral disorders and gene expression changes in the hypothalamus and hippocampus of resulting offspring. Read More

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Caste development and sex ratio of the Ryukyu drywood termite Neotermes sugioi and its potential mechanisms.

Sci Rep 2021 Jul 22;11(1):15037. Epub 2021 Jul 22.

Field Science Education and Research Center, Hokkaido Forest Research Station, Kyoto University, 553 Tawa, Shibecha-cho, Kawakami-gun, Hokkaido, 088-2339, Japan.

Sex allocation is one of the most studied traits in evolutionary biology because its theoretical predictions match the empirical data. Here, using the Ryukyu dry-wood termite Neotermes sugioi, we investigated several factors that could bias the sex allocation in three populations (Okinawa, Ishigaki/Iriomote, and Yonaguni). Our survey showed that there were more queen-only colonies than king-only colonies in these populations, suggesting a longer lifespan of the queens than that of the kings. Read More

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Placental insufficiency induces a sexually dimorphic response in the expression of cardiac growth and metabolic signalling molecules upon exposure to a postnatal western diet in guinea pigs.

J Dev Orig Health Dis 2021 Jul 26:1-13. Epub 2021 Jul 26.

Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

There is a strong relationship between low birth weight (LBW) and an increased risk of developing cardiovascular disease (CVD). In postnatal life, LBW offspring are becoming more commonly exposed to the additional independent CVD risk factors, such as an obesogenic diet. However, how an already detrimentally programmed LBW myocardium responds to a secondary insult, such as an obesogenic diet (western diet; WD), during postnatal life is ill defined. Read More

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Podocyte endowment and the impact of adult body size on kidney health.

Am J Physiol Renal Physiol 2021 07 26. Epub 2021 Jul 26.

Stem Cells and Development Program, Monash Biomedicine Discovery Institute and the Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

Low birth weight is a risk factor for chronic kidney disease (CKD), while adult podocyte depletion is a key event in the pathogenesis of glomerulosclerosis. However, whether low birth weight due to poor maternal nutrition is associated with low podocyte endowment and glomerulosclerosis in later life is not known. Female Sprague-Dawley rats were fed a normal (NPD, 20%) or low (LPD, 8%) protein diet from 3 weeks before mating until postnatal day 21 (PN21), when kidneys from some male offspring were taken for quantitation of podocyte number and density in whole glomeruli using immunolabeling, tissue clearing and confocal microscopy. Read More

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Sperm length divergence as a potential prezygotic barrier in a passerine hybrid zone.

Ecol Evol 2021 Jul 16;11(14):9489-9497. Epub 2021 Jun 16.

Natural History Museum University of Oslo Oslo Norway.

The saltmarsh sparrow and Nelson's sparrow differ in ecological niche, mating behavior, and plumage, but they hybridize where their breeding distributions overlap. In this advanced hybrid zone, past interbreeding and current backcrossing result in substantial genomic introgression in both directions, although few hybrids are currently produced in most locations. However, because both species are nonterritorial and have only brief male-female interactions, it is difficult to determine to what extent assortative mating explains the low frequency of hybrid offspring. Read More

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Maternal High-Fat Diet Exposure During Gestation and Lactation Affects Intestinal Development in Suckling Rats.

Front Physiol 2021 8;12:693150. Epub 2021 Jul 8.

Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.

Maternal health and diet influence metabolic status and play a crucial role in the development of metabolic function in offspring and their susceptibility to metabolic diseases in adulthood. The pathogenesis of various metabolic disorders is often associated with impairment in intestinal structure and function. Thus, the aim of the current study was to determine the effects of maternal exposure to a high fat diet (HFD), during gestation and lactation, on small intestinal growth and maturation in rat pups at 21 days old. Read More

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Effect of a single cold stress exposure on the reproductive behavior of male Acheta domesticus crickets.

J Insect Physiol 2021 Jul 21:104287. Epub 2021 Jul 21.

Department of Biology, 258 Pearson Hall, Miami University, Oxford, OH 45056, USA. Electronic address:

Cold stress is an important abiotic factor that can impact insect physiology, behavior, and overall fitness. Upon exposure to cold temperature, many insects enter a reversible state of immobility called chill coma. If the cold stress is brief and mild enough, insects can recover and regain full mobility upon return to warmer temperatures. Read More

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Associations of Body Mass Index and Waist Circumference in Young Adulthood with Later Life Incident Diabetes.

J Clin Endocrinol Metab 2021 Jul 24. Epub 2021 Jul 24.

Division of General Medicine; Columbia University, New York, NY, USA.

Context: The independent contribution of young adult exposure to overweight and obesity to later life incident diabetes is not well studied.

Objective: To assess the associations of exposures to elevated body mass index (BMI) and waist circumference (WC) in young adulthood (ages 18 to 39 years) with incident diabetes later in life (≥40 years).

Design: Pooled data from six US prospective cohorts (ARIC, CARDIA, CHS, Framingham Offspring, Health ABC, MESA). Read More

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Cardiovascular and Cerebrovascular Implications of Growth Restriction: Mechanisms and Potential Treatments.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, Australia.

Fetal growth restriction (FGR) is a common complication of pregnancy, resulting in a fetus that fails to reach its genetically determined growth potential. Whilst the fetal cardiovascular response to acute hypoxia is well established, the fetal defence to chronic hypoxia is not well understood due to experiment constraints. Growth restriction results primarily from reduced oxygen and nutrient supply to the developing fetus, resulting in chronic hypoxia. Read More

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Perinatal High-Fat Diet Influences Ozone-Induced Responses on Pulmonary Oxidant Status and the Molecular Control of Mitophagy in Female Rat Offspring.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 Maastricht, The Netherlands.

Previous research has shown that a perinatal obesogenic, high-fat diet (HFD) is able to exacerbate ozone-induced adverse effects on lung function, injury, and inflammation in offspring, and it has been suggested that mitochondrial dysfunction is implicated herein. The aim of this study was to investigate whether a perinatal obesogenic HFD affects ozone-induced changes in offspring pulmonary oxidant status and the molecular control of mitochondrial function. For this purpose, female Long-Evans rats were fed a control diet or HFD before and during gestation, and during lactation, after which the offspring were acutely exposed to filtered air or ozone at a young-adult age (forty days). Read More

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In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up Growth and Dysmetabolism in the Adult Rat Liver.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, 1151 Richmond Street, London, ON N6A 5C1, Canada.

The rates of gestational cannabis use have increased despite limited evidence for its safety in fetal life. Recent animal studies demonstrate that prenatal exposure to Δ9-tetrahydrocannabinol (Δ9-THC, the psychoactive component of cannabis) promotes intrauterine growth restriction (IUGR), culminating in postnatal metabolic deficits. Given IUGR is associated with impaired hepatic function, we hypothesized that Δ9-THC offspring would exhibit hepatic dyslipidemia. Read More

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Paeoniflorin ameliorates oxidase stress in Glutamate-stimulated SY5Y and prenatally stressed female offspring through Nrf2/HO-1 signaling pathway.

J Affect Disord 2021 Jul 17;294:189-199. Epub 2021 Jul 17.

Biomedicine Key Laboratory of Shaanxi Province, school of pharmacy, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China. Electronic address:

Background: Prenatal stress (PS) can cause brain retardation, reduce the learning and memory ability of the offspring and significantly increase the incidence of depression in offspring. Paeoniflorin (PF), a kind of monoterpenoid glycoside, is one of the main active ingredients of Chinese Medicine Paeonia lactiflora Pall, has anti-inflammation and potential neuroprotective effects. However, few reports have shown that the neuroprotective effects of PF are exerted through ameliorating Glutamate toxicity in vivo and in vitro. Read More

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Sex differences in the impact of parental obesity on offspring cardiac SIRT3 expression, mitochondrial efficiency and diastolic function early in life.

Am J Physiol Heart Circ Physiol 2021 07 23. Epub 2021 Jul 23.

Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, MS, United States.

Previous studies suggest that parental obesity may adversely impact long-term metabolic health of the offspring. We tested the hypothesis that parental (paternal + maternal) obesity impairs cardiac function in the offspring early in life. Within 1-3 days after weaning, offspring from obese rats fed a high fat diet (HFD-Offs) and age-matched offspring from lean rats (ND-Offs) were submitted to echocardiography and cardiac catheterization for assessment of pressure-volume relationships. Read More

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Chronic stress and poor sleeping habits are associated with self-reported IBS and poor psychological well-being in the general population.

BMC Res Notes 2021 Jul 22;14(1):280. Epub 2021 Jul 22.

Department of Internal Medicine, Lund University, Skåne University Hospital, Jan Waldenström Street 15, Floor 5, 20502, Malmö, Sweden.

Objective: The present population-based study aimed to examine the association of chronic stress and sleeping difficulties with self-reported irritable bowel syndrome (IBS), gastrointestinal (GI) symptoms past 2 weeks, and psychological well-being.

Results: The Malmö Offspring Study included subjects from the general population to complete a questionnaire regarding sociodemographic factors, lifestyle factors, and medical health. Experience of chronic stress during the past or past 5 years was reported. Read More

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Genetic mapping of novel modifiers for Apc induced intestinal polyps' development using the genetic architecture power of the collaborative cross mice.

BMC Genomics 2021 Jul 22;22(1):566. Epub 2021 Jul 22.

Department of Clinical Microbiology & Immunology, Sackler Faculty of Medicine, Ramat Aviv, 69978, Tel-Aviv, Israel.

Background: Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850, which is designated Apc (Multiple intestinal neoplasia), develop intestinal adenomas. Read More

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Perinatal SSRI exposure disrupts G protein-coupled receptor BAI3 in developing dentate gyrus and adult emotional behavior: relevance to psychiatric disorders.

Neuroscience 2021 Jul 19. Epub 2021 Jul 19.

School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. Electronic address:

Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed to pregnant women suffering with depression, although the long-term impact of these medications on exposed offspring are poorly understood. Perinatal SSRI exposure alters human offspring's neurodevelopment and increases risk for psychiatric illness in later life. Rodent studies suggest that perinatal SSRI-induced behavioral abnormalities are driven by changes in the serotonin system as well as epigenetic and transcriptomic changes in the developing hippocampus. Read More

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Male microchimerism in females: a quantitative study of twin pedigrees to investigate mechanisms.

Hum Reprod 2021 Jul 19. Epub 2021 Jul 19.

Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

Study Question: Does having a male co-twin, older brothers, or sons lead to an increased probability of persistent male microchimerism in female members of twin pedigrees?

Summary Answer: The presence of a male co-twin did not increase risk of male microchimerism and the prevalence of male microchimerism was not explained by having male offspring or by having an older brother.

What Is Known Already: Microchimerism describes the presence of cells within an organism that originate from another zygote and is commonly described as resulting from pregnancy in placental mammals. It is associated with diseases with a female predilection including autoimmune diseases and pregnancy-related complications. Read More

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Maternal and neonatal canine cortisol measurement in multiple matrices during the perinatal period: A pilot study.

PLoS One 2021 22;16(7):e0254842. Epub 2021 Jul 22.

Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.

Stress exposure during perinatal period may lead to maternal cortisol increase that negatively affects the offspring development. In recent years, the interest on non-invasive sampling methods to measure cortisol as a marker of stress is increasing in both humans and animals. Indeed, discomfort due to blood collection may compromise the diagnostic outcome, mainly in uncooperative patients. Read More

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Transgenerational evidence of increases in dopamine D2 receptor sensitivity in rodents: Impact on sensorimotor gating, the behavioral response to nicotine and BDNF.

J Psychopharmacol 2021 Jul 22:2698811211033927. Epub 2021 Jul 22.

James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA.

Background/aims: Neonatal quinpirole (NQ) treatment to rats increases dopamine D (DAD) receptor sensitivity in adult animals. We investigated if increased DAD sensitivity would be passed to the next (F1) generation, and if these animals demonstrated sensorimotor gating deficits and enhanced behavioral responses to nicotine.

Methods: Male and female rats were intraperitoneal (IP) administered quinpirole (1 mg/kg) or saline (NS) from postnatal day (P)1-21. Read More

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Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model.

Mol Psychiatry 2021 Jul 21. Epub 2021 Jul 21.

Department of Internal Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA.

Immunoglobulin G (IgG) autoantibodies reactive to fetal brain proteins in mothers of children with ASD have been described by several groups. To understand their pathologic significance, we developed a mouse model of maternal autoantibody related ASD (MAR-ASD) utilizing the peptide epitopes from human autoantibody reactivity patterns. Male and female offspring prenatally exposed to the salient maternal autoantibodies displayed robust deficits in social interactions and increased repetitive self-grooming behaviors as juveniles and adults. Read More

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The effect of temperature on host patch exploitation by an egg parasitoid.

PLoS One 2021 21;16(7):e0254750. Epub 2021 Jul 21.

Département de sciences biologiques, Institut de recherche en biologie végétale, Université de Montréal, Montréal, Québec, Canada.

The effect of temperature during host patch exploitation by parasitoids remains poorly understood, despite its importance on female reproductive success. Under laboratory conditions, we explored the behaviour of Anaphes listronoti, an egg parasitoid of the carrot weevil, Listronotus oregonensis, when foraging on a host patch at five temperatures. Temperature had a strong effect on the female tendency to exploit the patch: A. Read More

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Cardiometabolic consequences of maternal hyperandrogenemia in male offspring.

Physiol Rep 2021 Jul;9(14):e14941

Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA.

Polycystic ovary syndrome (PCOS) in women is characterized by hyperandrogenemia, obesity, and oligo- or anovulation. In addition, women with PCOS are often obese, with insulin resistance, hyperlipidemia, and elevated blood pressure. The cardiometabolic consequences for the male offspring of maternal hyperandrogenemia are unclear. Read More

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Early-life social experience affects offspring DNA methylation and later life stress phenotype.

Nat Commun 2021 07 20;12(1):4398. Epub 2021 Jul 20.

Department of Epidemiology and Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Denver, Aurora, CO, USA.

Studies in rodents and captive primates suggest that the early-life social environment affects future phenotype, potentially through alterations to DNA methylation. Little is known of these associations in wild animals. In a wild population of spotted hyenas, we test the hypothesis that maternal care during the first year of life and social connectedness during two periods of early development leads to differences in DNA methylation and fecal glucocorticoid metabolites (fGCMs) later in life. Read More

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