450,576 results match your criteria female mice

Nerve excitability and neuropathic pain is reduced by BET protein inhibition after spared nerve injury.

J Pain 2021 Jun 19. Epub 2021 Jun 19.

Institute of Neurosciences, Dept. Cell Biology, Physiology and Immunology, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

Neuropathic pain is a common disability produced by enhanced neuronal excitability after nervous system injury. The pathophysiological changes that underlie the generation and maintenance of neuropathic pain require modifications of transcriptional programs. In particular, there is an induction of pro-inflammatory neuromodulators levels, and changes in the expression of ion channels and other factors intervening in the determination of the membrane potential in neuronal cells. Read More

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Long-term melatonin treatment attenuates body weight gain with aging in female mice.

J Endocrinol 2021 Jun 1. Epub 2021 Jun 1.

N Sugino, Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine Graduate School of Medicine, Ube, Japan.

Women usually experience body weight gain with aging, which can put them at risk for many chronic diseases. Previous studies indicated that melatonin treatment attenuates body weight gain and abdominal fat deposition in several male animals. However, it is unclear whether melatonin affects female animals in the same way. Read More

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Altered germline cyst formation and oogenesis in Tex14 mutant mice.

Biol Open 2021 Jun 22;10(6). Epub 2021 Jun 22.

Buck Institute for Research on Aging, 94949, Novato, CA, USA.

During oocyte differentiation in mouse fetal ovaries, sister germ cells are connected by intercellular bridges, forming germline cysts. Within the cyst, primary oocytes form via gaining cytoplasm and organelles from sister germ cells through germ cell connectivity. To uncover the role of intercellular bridges in oocyte differentiation, we analyzed mutant female mice lacking testis-expressed 14 (TEX14), a protein involved in intercellular bridge formation and stabilization. Read More

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Mice born to mothers with gravida traumatic brain injury have distorted brain circuitry and altered immune responses.

J Neurotrauma 2021 Jun 22. Epub 2021 Jun 22.

Barrow Neurological Institute, 115467, Translational Neurotrauma Research Program, Phoenix, Arizona, United States.

Intimate partner violence (IPV) increases risk of traumatic brain injury (TBI). Physical assaults increase in frequency and intensity during pregnancy. The consequences of TBI during pregnancy (gravida TBI; gTBI) on offspring development is unknown, for which stress and inflammation during pregnancy worsen fetal developmental outcomes. Read More

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Effects of Three-Dimensional Sodium Alginate Scaffold on Maturation and Developmental Gene Expressions in Fresh and Vitrified Preantral Follicles of Mice.

Int J Fertil Steril 2021 Jul 22;15(3):167-177. Epub 2021 Jun 22.

Anatomy Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Prior to chemotherapy interventions, i maturation (IVM) of folliclesthrough vitrification can be used to help young people conserve their fertility. The aim of s tudy was to inves tigate effect of sodium alginat scaffold on follicles development and improvement of the culture medium.

Materials And Methods: This experimental study was conducted on immature female BALB/c mice (12-14 days). Read More

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Paternal exposure to microcystin-LR induces fetal growth restriction partially through inhibiting cell proliferation and vascular development in placental labyrinth.

Environ Sci Pollut Res Int 2021 Jun 21. Epub 2021 Jun 21.

Department of Toxicology & Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China.

Microcystin-leucine arginine (MC-LR) has reproductive and developmental toxicities. Previous studies indicated that gestational exposure to MC-LR induced fetal growth restriction in mice. The aim of this study was to further evaluate the effect of paternal MC-LR exposure before mating on fetal development. Read More

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Differences in the reaction of hyperlipidemia on different endothelial progenitor cells based on sex.

Biomed Rep 2021 Aug 7;15(2):64. Epub 2021 Jun 7.

Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.

The sex of a patient can affect the outcomes of several cardiovascular diseases, and men generally tend to experience earlier episodes of cardiovascular diseases compared with women. The progression of atherosclerosis during hyperlipidemia can be induced by reactive oxygen species (ROS) and oxidized-low-density lipoprotein (ox-LDL). By contrast, bone marrow (BM)-derived endothelial progenitor cells (EPCs) have been reported to serve a protective role against atherosclerosis. Read More

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Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus.

J Neuroinflammation 2021 Jun 21;18(1):140. Epub 2021 Jun 21.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, 92521, USA.

Background: Obesity is characterized by a systemic inflammation and hypothalamic neuroinflammation. Systemic inflammation is caused by macrophages that infiltrate obese adipose tissues. We previously demonstrated that high-fat diet (HFD)-fed male mice exhibited peripheral macrophage infiltration into the hypothalamus, in addition to activation of resident microglia. Read More

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Alcohol consumption preferentially activates a subset of pro-opiomelanocortin (POMC) producing neurons targeting the amygdala.

Neuropharmacology 2021 Jun 18:108674. Epub 2021 Jun 18.

Department of Psychology, Arizona State University, Tempe, Arizona, 85281, USA.

Background: Alcohol abuse is a worldwide public health concern and leads to an estimated 90,000 alcohol-related deaths in the United States annually. Alcohol may promote its euphoric and motivational effects, in part, by activating the endogenous opioid system. Pro-opiomelanocortin (POMC) producing neurons located within the arcuate nucleus (ArcN) of the hypothalamus make up one circuit of the endogenous opioid system, and heavily projects to reward-related brain areas such as the amygdala, nucleus accumbens (NAc) and ventral tegmental area (VTA). Read More

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Exposure to fruit-flavoring during adolescence increases nicotine consumption and promotes dose escalation.

Neuropharmacology 2021 Jun 18:108672. Epub 2021 Jun 18.

Department of Psychiatry; Pharmacology Graduate Group; Neuroscience Graduate Group; School of Arts and Sciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104. Electronic address:

The rise of e-cigarette popularity has sparked interest in the role of palatable flavors on nicotine use. Despite growing evidence that sweet flavorants enhance nicotine reward, their influence on nicotine consumption has not been studied extensively. In addition, the impact that flavored nicotine use in adolescence could have on nicotine reward and dependence in adulthood remains unclear. Read More

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Kappa opioid receptor modulation of endometriosis pain in mice.

Neuropharmacology 2021 Jun 18:108677. Epub 2021 Jun 18.

Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra. Barcelona, Spain; IMIM (Hospital Del Mar Medical Research Institute), Barcelona, Spain. Electronic address:

The kappa opioid receptor is a constituent of the endogenous opioid analgesia system widely expressed in somatosensory nervous pathways and also in endometrial tissues. This work investigates the possible involvement of kappa opioid receptor on the nociceptive, behavioral and histopathological manifestations of endometriosis in a murine model. Female mice receiving endometrial implants develop a persistent mechanical hypersensitivity in the pelvic area that is stronger during the estrus phase of the estrous cycle. Read More

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Effect of a High-calorie Diet and Constant Light Exposure on Female Reproduction, Metabolism and Immune Inflammation: A Comparative Study of Different Mouse Models.

Am J Reprod Immunol 2021 Jun 21:e13479. Epub 2021 Jun 21.

Department of Gynecology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, 200011, China.

Problem: Excess caloric intake and irregular circadian rhythm could severely impair female reproductive, metabolic and immune function. However, the similarities and differences between their individual and combined effects and mechanisms have not been fully elucidated. Due to limitations and confounding factors in clinical research, we used these two kinds of unhealthy factors to intervene the mice singly or in combination to explore their effects on individuals. Read More

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Protective role of vitamin E in testicular development of mice exposed to valproic acid.

Andrologia 2021 Jun 21:e14140. Epub 2021 Jun 21.

Center of Biotechnology on Reproduction (CEBIOR-BIOREN), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.

Valproic acid (VPA) is a teratogenic antiepileptic, causing alterations in oxidative stress in prenatal development, being altered the development of the male reproductive system. The purpose of this study was to determine the protective effect of vitamin E (VE) on the testicular development in embryos, foetuses and pubertal mice exposed to VPA, VPA+VE and only VE. Sixty pregnant adult female mice were used, to which they were administered 600 mg/kg of VPA (VPA groups), 600 mg/kg of VPA and 200 IU of VE (VPA+VE groups), 200 IU VE (VE groups) and 0. Read More

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In vivo toxicities of the hospital effluent in Mahdia Tunisia.

J Water Health 2021 Jun;19(3):499-511

Research Unit of Analysis and Process Applied to the Environment (APAE UR17ES32), Higher Institute of Applied Sciences and Technology of Mahdia, University of Monastir, Mahdia 5100, Tunisia E-mail:

Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via biochemical and histopathological determinations. Read More

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The role of medial prefrontal cortex projections to locus ceruleus in mediating the sex differences in behavior in mice with inflammatory pain.

FASEB J 2021 Jul;35(7):e21747

Center for the Neurobiology of Stress Resilience and Psychiatric Disorders, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

We tested the hypothesis that the cognitive impairment associated with inflammatory pain may result from dysregulation of the top-down control of locus ceruleus's (LC) activity by the medial prefrontal cortex (mPFC). Injection of complete Freund's adjuvant (CFA) served as a model for inflammatory pain. The CFA injection decreased the thermal thresholds in both sexes but only the male mice showed increased anxiety-like behavior and diminished cognition, while the females were not affected. Read More

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A murine Staphylococcus aureus fracture-related infection model characterised by fracture non-union, staphylococcal abscess communities and myeloid-derived suppressor cells.

Eur Cell Mater 2021 Jun 21;41:774-792. Epub 2021 Jun 21.

AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos,

A fracture-related infection (FRI) is a serious complication that can occur after surgical fixation of bone fractures. Affected patients may encounter delayed healing and functional limitations. Although it is well established that Staphylococcus aureus (S. Read More

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Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice.

Front Cell Dev Biol 2021 4;9:669732. Epub 2021 Jun 4.

Joint International Research Laboratory of Reproduction and Development, Chongqing Medical University, Chongqing, China.

The association between the accumulation of synthetic chemicals with estrogenic activity and risks to oogenesis has become a growing concern. This study indicates that estrogen exposure can affect homologous recombination in early oogenesis and influence the reproductive potential and lifespan of female offspring. We conducted this study in developing mouse ovaries using two different models: oral doses administered to the mother, and fetal ovary cultures. Read More

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Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice.

Front Behav Neurosci 2021 3;15:678102. Epub 2021 Jun 3.

Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, United States.

Deaths related to opioid use have skyrocketed in the United States, leading to a public health epidemic. Research has shown that both biological (genes) and environmental (stress) precursors are linked to opioid use. In particular, stress during adolescence-a critical period of frontal lobe development-influences the likelihood of abusing drugs. Read More

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Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression.

Biomed Pharmacother 2021 Jun 17:111533. Epub 2021 Jun 17.

Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

Ovarian cancer (OC) is one of the most common gynecologic malignancies with poor survival rate, and Iberin is a member of isothiocyanate family with anti-tumor activity. However, the role of Iberin in OC development has not been reported yet. In this study, A2780 and OVCAR-3 cells were treated with gradient concentrations of Iberin to investigate the effect of Iberin on OC in vitro. Read More

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Serotonin involvement in okadaic acid-induced diarrhoea in vivo.

Arch Toxicol 2021 Jun 20. Epub 2021 Jun 20.

Departamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002, Lugo, Spain.

The consumption of contaminated shellfish with okadaic acid (OA) group of toxins leads to diarrhoeic shellfish poisoning (DSP) characterized by a set of symptoms including nausea, vomiting and diarrhoea. These phycotoxins are Ser/Thr phosphatase inhibitors, which produce hyperphosphorylation in cellular proteins. However, this inhibition does not fully explain the symptomatology reported and other targets could be relevant to the toxicity. Read More

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J Nutr Biochem 2021 Jun 17:108805. Epub 2021 Jun 17.

Laboratorio de Fisiología de la Preñez y el Parto, Centro de Estudios Farmacológicos y Botánicos (CEFyBO-UBA/CONICET). Paraguay 2155, Piso 16, C1121ABG. Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.

Maternal overnutrition negatively impacts the offspring's health leading to an increased risk of developing chronic diseases or metabolic syndrome in adulthood. What we eat affects the endocannabinoid system (eCS) activity, which in turn modulates lipogenesis and fatty acids utilization in hepatic, muscle, and adipose tissues. This study aimed to evaluate the transgenerational effect of maternal obesity on cannabinoid receptor 1 knock-out (CB1 KO) animals in combination with a postnatal obesogenic diet on the development of metabolic disturbances on their offspring. Read More

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Olanzapine leads to nonalcoholic fatty liver disease through the apolipoprotein A5 pathway.

Biomed Pharmacother 2021 Jun 17;141:111803. Epub 2021 Jun 17.

Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

The antipsychotic drug olanzapine was reported to induce nonalcoholic fatty liver disease (NAFLD), whereas the underlying mechanism remains incompletely understood. This study investigated whether apolipoprotein A5 (apoA5) and sortilin, two interactive factors involved in NAFLD pathogenesis, are implicated in olanzapine-induced NAFLD. In our study, at week 8, olanzapine treatment successfully induced hepatic steatosis in female C57 BL/6 J mice, which was independent of body weight gain. Read More

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The effect of sex on the mouse lens transcriptome.

Exp Eye Res 2021 Jun 16:108676. Epub 2021 Jun 16.

Department of Biological Sciences University of Delaware, Newark, DE, 19716, USA. Electronic address:

The transcriptome of mammalian tissues differs between males and females, and these differences can change across the lifespan, likely regulating known sexual dimorphisms in disease prevalence and severity. Cataract, the most prevalent disease of the ocular lens, occurs at similar rates in young individuals, but its incidence is elevated in older women compared to men of the same age. However, the influence of sex on the lens transcriptome was unknown. Read More

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Erxian Decoction, a famous Chinese medicine formula, ameliorate depression-like behavior in perimenopausal mice.

Endocr Metab Immune Disord Drug Targets 2021 Jun 17. Epub 2021 Jun 17.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, China.

Aims: The present study was performed in order to find out the anti-depression effect of Erxian Decoction in perimenopausal mice.

Background: Erxian Decoction (EXD) has been used in folk medicine for the treatment of perimenopausal syndrome, but it has not been researched on perimenopausal depression.

Objective: The present study aimed to evaluate the effect of extraction of Erxian Decoction on perimenopausal depressive mice. Read More

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Chimeric virus-like particles of universal antigen epitopes of coronavirus and phage Qβ coat protein trigger the production of neutralizing antibodies.

Curr Top Med Chem 2021 Jun 18. Epub 2021 Jun 18.

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; b Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs, Henan Agricultural University, Zhengzhou 450046, China.

Background: Virus-like particles (VLPs) are non-genetic multimeric nanoparticles synthesized through in vitro or in vivo self-assembly of one or more viral structural proteins. Immunogenicity and safety of VLPs make them ideal candidates for vaccine development and efficient nanocarriers for foreign antigens or adjuvants to activate the immune system.

Aims: The present study aimed to design and synthesize a chimeric VLP vaccine of the phage Qbeta (Qβ) coat protein presenting the universal epitope of the coronavirus. Read More

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Inhibition of cow's milk allergy development in mice by oral delivery of β-lactoglobulin derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing.

Clin Exp Allergy 2021 Jun 17. Epub 2021 Jun 17.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Background: 2-4% Of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolyzed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Read More

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Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice.

Sci Rep 2021 Jun 18;11(1):12890. Epub 2021 Jun 18.

Department of Cell Systems & Anatomy, University of Texas Health San Antonio, 7703 Floyd Curl Dr., San Antonio, TX, 78229, USA.

Degeneration and death of motor neurons in Amyotrophic Lateral Sclerosis (ALS) are associated with increased lipid peroxidation. Lipid peroxidation is the driver of ferroptosis, an iron-dependent oxidative mode of cell death. However, the importance of ferroptosis in motor neuron degeneration of ALS remains unclear. Read More

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Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station.

NPJ Microgravity 2021 Jun 18;7(1):23. Epub 2021 Jun 18.

Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA.

Sixteen-week-old female C57BL/6J mice were sacrificed aboard the International Space Station after 37 days of flight (RR-1 mission) and frozen carcasses returned to Earth. RNA was isolated from interscapular brown adipose tissue (BAT) and gonadal white adipose tissue (WAT). Spaceflight resulted in differential expression of genes in BAT consistent with increased non-shivering thermogenesis and differential expression of genes in WAT consistent with increased glucose uptake and metabolism, adipogenesis, and β-oxidation. Read More

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Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway.

Nutr Metab (Lond) 2021 Jun 18;18(1):63. Epub 2021 Jun 18.

Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China, 200040.

Objectives: The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy. In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway.

Methods: The estradiol levels of hyperuricemia/gout patients and healthy controls were compared, and a hyperuricemia mouse model was used to observe the urate-lowering effect of estradiol and the changes in ABCG2 expression in the kidney and intestine. Read More

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Deletion of SIRT3 inhibits osteoclastogenesis and alleviates aging or estrogen deficiency-induced bone loss in female mice.

Bone 2021 Jun 15:116061. Epub 2021 Jun 15.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Orthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China. Electronic address:

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