J Hypertens 2021 Jul 19. Epub 2021 Jul 19.
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia Department of Twin Research, Kings College London, London, UK Genos Glycoscience Research Laboratory, Zagreb, Croatia Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health German Center for Diabetes Research (DZD) Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health LMU Munich, IBE-Chair of Epidemiology, Neuherberg, Germany Department of Public Health, University of Split, School of Medicine, Split, Croatia NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London Academic Rheumatology Clinical Sciences Building, Nottingham City Hospital, University of Nottingham, Nottingham University of Glasgow, Glasgow, Scotland, UK.
Objectives: Glycosylation of immunoglobulin G (IgG) is an important regulator of the immune system and has been implicated in prevalent hypertension.The aim of this study is to investigate whether the IgG glycome begins to change prior to hypertension diagnosis by analysing the IgG glycome composition in a large population-based female cohort with two independent replication samples.
Methods: We included 989 unrelated cases with incident hypertension and 1628 controls from the TwinsUK cohort (mean follow-up time of 6. Read More