4,737 results match your criteria feeding difficulties


Tongue movements and teat compression during bottle feeding: A pilot study of a quantitative ultrasound approach.

Early Hum Dev 2021 May 30;159:105399. Epub 2021 May 30.

Radboud university medical center, Department of Rehabilitation, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

Nutritive sucking is a complex process, essential to proper growth and development. The complexity of this oral sensorimotor activity includes movements of the tongue and jaw. Tongue movements during nutritive sucking can only be visualized with instrumented methods such as ultrasound. Read More

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Expanding the clinical phenotype and genetic spectrum of PURA-related neurodevelopmental disorders.

Brain Dev 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: PURA-related neurodevelopmental disorders (PURA-NDDs) include 5q31.3 deletion syndrome and PURA syndrome. PURA-NDDs are characterized by neonatal hypotonia, moderate to severe global developmental delay/intellectual disability (GDD/ID), facial dysmorphism, epileptic seizures, nonepileptic movement disorders, and ophthalmological problems. Read More

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Further Delineation of the Clinical and Pathologic Features of HIKESHI-Related Hypomyelinating Leukodystrophy.

Pediatr Neurol 2021 May 14;121:11-19. Epub 2021 May 14.

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: A recurrent homozygous missense variant, c.160G>C;p.(Val54Leu) in HIKESHI, was found to cause a hypomyelinating leukodystrophy with high frequency in the Ashkenazi Jewish population. Read More

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Pharyngo-esophageal motility reflex mechanisms in the human neonate: Importance of integrative cross-systems physiology.

Am J Physiol Gastrointest Liver Physiol 2021 Jun 9. Epub 2021 Jun 9.

Innovative Infant Feeding Disorders Research Program, Center for Perinatal Research, Divisions of Neonatology, Pediatric Gastroenterology and Nutrition, Department of Pediatrics at The Ohio State University College of Medicine, grid.240344.5Nationwide Children's Hospital, Columbus, Ohio.

Swallowing is a critical function for survival and development in human neonates, and requires cross-system coordination between neurologic, airway, and digestive motility systems. Development of pharyngo-esophageal motility is influenced by intra- and extra-uterine development, pregnancy complications, and neonatal comorbidities. Primary role of these motility reflex mechanisms is to maintain aerodigestive homeostasis under basal and adaptive biologic conditions including oral feeding, gastroesophageal reflux, and sleep. Read More

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Does ankyloglossia interfere with breastfeeding in newborns? A cross-sectional study.

J Clin Transl Res 2021 Apr 6;7(2):263-269. Epub 2021 Apr 6.

Dental School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background And Aim: Ankyloglossia is a congenital anomaly that can affect breastfeeding. The aim was to evaluate the prevalence of ankyloglossia in newborns and breastfeeding difficulties reported by mothers; assess possible factors that may interfere with breastfeeding.

Methods: A cross-sectional study was conducted with 391 pairs of mothers/newborns at a university hospital. Read More

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[Analysis of the clinical perinatal characteristics of 226 patients with Prader-Willi syndrome in China].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):466-470

Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To enhance the early recognition of Prader-Willi syndrome by summarizing the clinical characteristics of Prader-Willi syndrome (PWS) during perinatal period. Through a nationwide cross-sectional study in the Department of Pediatrics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,226 children diagnosed as PWS by molecular genetics were recruited from September 2019 to March 2020. Clinical data including fetuses Age, birth weight, fetal movement, fetal position, amniotic fluid, mode of bith, crying, muscle tension, feeding, and cryptorchidism were collected to analyze the clinical characteristics of Chinese PWS patients in the perinatal period, and according to the mode of birty, birth weight and genotypes to perform subgroup analysis. Read More

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[Clinical and genetic studies on 76 patients with hydrocephalus caused by methylmalonic acidemia combined with homocysteinuria].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):459-465

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To analyze the clinical features, genetic characteristics, treatment and follow-up results of patients with hydrocephalus caused by methylmalonic acidemia combined with homocysteinuria, and to discuss the optimal strategies for assessing and treating such patients. From January 1998 to December 2020, 76 patients with hydrocephalus due to methylmalonic acidemia combined with homocysteinuria in the Department of Pediatrics in 11 hospitals including Peking University First Hospital were diagnosed by biochemical, genetic analysis and brain imaging examination. The patients were divided into operation-group and non-operation-group according to whether they underwent ventriculoperitoneal shunt. Read More

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A Self-criticism of Diagnostic and Therapeutic Decision Making in Children Admitted With Acute Lower Respiratory Infection at a Single Pediatric Emergency Department.

Pediatr Emerg Care 2021 Jun 7. Epub 2021 Jun 7.

From the Division of Pediatric Emergency, Ankara City Hospital Division of Pediatrics, Ankara City Hospital, University of Health Sciences Division of Pediatric Radiology, Ankara City Hospital Division of Pediatric Allergy and Immunology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.

Objectives: Acute bronchiolitis and community-acquired pneumonia are the most common acute lower respiratory infections (LRIs) leading to emergency admission and hospitalization in children. The aim of this study is to investigate clinical, laboratory, and radiology findings; diagnostic and therapeutic decisions; and the relationships between them in patients younger than 2 years of age, hospitalized for LRI.

Methods: Patients hospitalized for acute LRI (aged 28 days to 24 months) between November 1, 2017, and March 31, 2018, at a referral hospital were included. Read More

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PICU Follow-Up Clinic: Patient and Family Outcomes 2 Months After Discharge.

Pediatr Crit Care Med 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada. CHU Sainte-Justine Research Center, Montréal, QC, Canada. Department of Psychology, Université de Montréal, Montréal, QC, Canada.

Objectives: Hospitalization in a PICU is a life-altering experience for children and their families. Yet, little is known about the well-being of these children after their discharge. We are describing the outcome of PICU survivors at a PICU clinic 2 months after discharge. Read More

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Congenital epulis of the newborn, criteria for the approach. Case report

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):212-215. Epub 2020 Apr 13.

Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica del Noreste, Departamento de Fisiología Celular y Genética. Monterrey, Nuevo León, México.

Background: The newborn congenital epulis or granular cell tumor is a benign tumor that appears in the oral cavity of newborns with more frequency in the gingiva of the alveolar crest of the maxilla at the level of the incisive and canine area, predominantly in the female sex. It is of diagnostic importance since it can interfere with feeding, swallowing and via area, putting the health of the newborn at risk. It usually involutes spontaneously and in case of surgical treatment there are no reports of recurrence. Read More

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Accurate Tumor Segmentation via Octave Convolution Neural Network.

Front Med (Lausanne) 2021 19;8:653913. Epub 2021 May 19.

The State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, China.

Three-dimensional (3D) liver tumor segmentation from Computed Tomography (CT) images is a prerequisite for computer-aided diagnosis, treatment planning, and monitoring of liver cancer. Despite many years of research, 3D liver tumor segmentation remains a challenging task. In this paper, we propose an effective and efficient method for tumor segmentation in liver CT images using encoder-decoder based octave convolution networks. Read More

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Tube placement using 'IRIS': A pilot assessment of its utility and safety.

Intensive Crit Care Nurs 2021 May 31:103077. Epub 2021 May 31.

Department of Anaesthetics, Level 3, Gate 38, Brunel Building, Southmead Hospital Bristol, BS105NB, United Kingdom. Electronic address:

Introduction: Most critically ill patients have a feeding tube placed blindly, but 0.5% result in a major lung complication because misplacement is only detected at the end of procedure. Real-time guided tube placement may pre-empt such complications. Read More

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A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis.

Eur J Hum Genet 2021 Jun 1. Epub 2021 Jun 1.

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

The genetic etiology of intellectual disability remains elusive in almost half of all affected individuals. Within the Solve-RD consortium, systematic re-analysis of whole exome sequencing (WES) data from unresolved cases with (syndromic) intellectual disability (n = 1,472 probands) was performed. This re-analysis included variant calling of mitochondrial DNA (mtDNA) variants, although mtDNA is not specifically targeted in WES. Read More

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Nutrition Considerations in Neonatal Extracorporeal Life Support.

Neoreviews 2021 Jun;22(6):e382-e391

Department of Pediatrics, Medical University of South Carolina, Charleston, SC.

Extracorporeal life support (ECLS) is a life-saving therapy, but neonates who require ECLS have unique nutritional needs and require aggressive, early nutritional support. These critically ill neonates are at increased risk for long-term feeding difficulties, malnutrition, and growth failure with associated increased morbidity and mortality. Unfortunately, few studies specific to this population exist. Read More

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Co-Occurrence and Clustering of Sedentary Behaviors, Diet, Sugar-Sweetened Beverages, and Alcohol Intake among Adolescents and Adults: The Latin American Nutrition and Health Study (ELANS).

Nutrients 2021 May 26;13(6). Epub 2021 May 26.

Center for Excellence in Nutrition and Feeding Difficulties, PENSI Institute, Sabará Children's Hospital, São Paulo 05076-040, Brazil.

Poor diet, sedentary behaviors, sugar-sweetened beverages (SSB) and alcohol intake seem to co-exist in complex ways that are not well understood. The aim of this study was to provide an understanding of the extent to which unhealthy behaviors cluster in eight Latin America countries. A secondary aim was to identify socio-demographic characteristics associated with these behaviors by country. Read More

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Focusing on Autism Spectrum Disorder in Xia-Gibbs Syndrome: Description of a Female with High Functioning Autism and Literature Review.

Children (Basel) 2021 May 26;8(6). Epub 2021 May 26.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, 56128 Calambrone, Italy.

Background: Xia-Gibbs syndrome (XGS) is a rare disorder caused by de novo mutations in the AT-Hook DNA binding motif Containing 1 () gene, which is characterised by a wide spectrum of clinical manifestations, including global developmental delay, intellectual disability, structural abnormalities of the brain, global hypotonia, feeding problems, sleep difficulties and apnoea, facial dysmorphisms, and short stature.

Methods: Here, we report on a girl patient who shows a peculiar cognitive and behavioural profile including high-functioning autism spectrum disorder (ASD) without intellectual disability and provide information on her developmental trajectory with the aim of expanding knowledge of the XGS clinical spectrum. On the basis of the current clinical case and the literature review, we also attempt to deepen understanding of behavioural and psychiatric manifestations associated with XGS. Read More

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Food Sources of Shortfall Nutrients among Latin Americans: Results from the Latin American Study of Health and Nutrition (ELANS).

Int J Environ Res Public Health 2021 05 7;18(9). Epub 2021 May 7.

Center for Excellence in Nutrition and Feeding Difficulties, Sabará Children's Hospital, PENSI Institute, São Paulo 012228-200, Brazil.

Increased consumption of energy-dense, nutrient-poor foods can lead to inadequate intakes of shortfall nutrients, including vitamin A, D, C, and E, dietary folate, calcium, iron, magnesium, potassium, and fiber. The objective was to examine the prevalence of inadequate intake of shortfall nutrients and identify food sources of shortfall nutrients in eight Latin American countries. Data from ELANS, a multi-country, population-based study of 9218 adolescents and adults were used. Read More

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Accessing local support online: Mothers' experiences of local Breastfeeding Support Facebook groups.

Matern Child Nutr 2021 Jun 1:e13227. Epub 2021 Jun 1.

Department of Public Health, Policy and Social Sciences, Swansea University, Swansea, UK.

The importance of support to breastfeeding success is well established, as are the difficulties many mothers face in accessing the support they need. With the majority of UK mothers now accessing social media for support, Breastfeeding Support Facebook (BSF) groups have increased exponentially. BSF groups vary in type (local or national/international) and in moderation-overseen by breastfeeding mothers and by midwives or trained lactation specialists. Read More

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A Comparison of Weight Gain Following Mandibular Distraction Osteogenesis and Tongue-Lip Adhesion in the Treatment of Robin Sequence.

J Craniofac Surg 2021 May 25. Epub 2021 May 25.

Cleft Center Amsterdam, Amsterdam UMC, Division of Plastic and Reconstructive Surgery, Location AMC, Meibergdreef Cleft Center Amsterdam, Amsterdam UMC, Division of Plastic and Reconstructive Surgery, Location VUmc, Ziekenhuisgebouw, De Boelelaan Department of Pediatrics, Amsterdam UMC, Location AMC, Meibergdreef Department of Pediatrics, Amsterdam UMC, Location VUmc, Ziekenhuisgebouw, De Boelelaan, Amsterdam, The Netherlands.

Abstract: Obstructive respiratory stress and feeding difficulties in infants with Robin sequence (RS) may result in poor weight gain or loss. Following failure of conservative treatment, surgical options include mandibular distraction osteogenesis (MDO) and tongue-lip adhesion (TLA). Whilst both techniques have demonstrated to improve airway patency and feeding behavior, an advantage of either in restoring weight growth remains unknown. Read More

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Modern Mandibular Distraction Applications in Hemifacial Microsomia.

Clin Plast Surg 2021 Jul 8;48(3):375-389. Epub 2021 May 8.

Division of Plastic Surgery, Department of Surgery, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19014, USA. Electronic address:

Phenotypic severity dictates the timing and type of surgical intervention required. Mandibular distraction in children without respiratory and feeding difficulties remains controversial with regard to long-term mandibular growth outcomes and reducing surgical burden. Early mandibular distraction does not obviate secondary orthognathic surgery at skeletal maturity; it provides improved functional, aesthetic, and psychosocial outcomes, at least in the short term. Read More

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Expanding the spectrum of endocrinopathies identified in Schaaf-Yang syndrome - A case report and review of the literature.

Eur J Med Genet 2021 May 27;64(8):104252. Epub 2021 May 27.

Department of Pediatrics, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel; Pediatric Endocrinology Unit, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel; The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Schaaf-Yang syndrome is a genetic disorder caused by mutations in the paternal allele of the MAGEL2 gene. Developmental delay, feeding difficulties, joint contractures and a high prevalence of autism spectrum disorders are characteristic of the syndrome. Endocrine abnormalities include mostly various pituitary hormonal deficiencies, presenting as hypoglycemia in 48% of reported cases. Read More

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Duration of breast feeding and attention-deficit/hyperactivity disorder in United States preschool-aged children.

Res Dev Disabil 2021 May 26;115:103995. Epub 2021 May 26.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, United States. Electronic address:

Background: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by difficulties sustaining attention and controlling hyperactivity and impulsive behavior. Population-based studies concerning the association between breast-feeding duration and ADHD among preschool-aged children in the United States (U.S. Read More

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Unilateral Choanal Atresia Presenting With Congenital Respiratory Distress and Recurrent Cyanotic Episodes.

Ear Nose Throat J 2021 May 28:1455613211020978. Epub 2021 May 28.

Pediatric Otorhinolaryngology Unit, 36739Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Congenital unilateral choanal atresia (CA) is not considered an emergent condition and should not cause respiratory distress in the newborn. Therefore, surgical repair of unilateral CA is usually delayed. This description of a newborn with congenital unilateral CA that caused significant respiratory distress, recurrent cyanotic episodes, and severe feeding difficulties highlights an exception to that rule. Read More

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Novel Compound Heterozygous Pathogenic Variants in Cause Isolated Sulfite Oxidase Deficiency in a Chinese Han Family.

Front Genet 2021 7;12:607085. Epub 2021 May 7.

Shaanxi Institute for Pediatric Diseases, Xi'an Children's Hospital, Xi'an, China.

Aim: To explore the clinical imaging, laboratory and genetic characteristics of a newborn boy with isolated sulfite oxidase deficiency (ISOD) in a Chinese mainland cohort.

Methods: Homocysteine and uric acid in plasma and cysteine and total homocysteine in the blood spot were assessed in a Chinese newborn patient with progressive encephalopathy, tonic seizures, abnormal muscle tone, and feeding difficulties. Whole exome sequencing and Sanger sequencing facilitated an accurate diagnosis. Read More

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Oral and Swallowing Abilities Tool (OrSAT) for Type 1 SMA Patients: Development of a New Module.

J Neuromuscul Dis 2021 May 19. Epub 2021 May 19.

Pediatric Neurology Unit and Centro Clinico Nemo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

We describe the development of a new tool specifically designed to record oral abilities, swallowing and, more generally, feeding in young type 1 SMA patients, to be used during the first 24 months of life.The tool is composed by a checklist and a separate section summarizing the functional abilities into levels of feeding/swallowing impairment. The checklist includes 12 questions assessing aspects thought to be clinically meaningful for a type 1 SMA population and developmentally appropriate for infants during the first months of life. Read More

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Fumaric acid production using alternate fermentation mode by immobilized Rhizopus oryzae-a greener production strategy.

Chemosphere 2021 May 13;281:130858. Epub 2021 May 13.

INRS-ETE, Université Du Québec, 490, Rue de La Couronne, Québec, G1K 9A9, Canada.

The current work investigates the impact of using immobilized Rhizopus oryzae NRRL 1526 for bioproduction of fumaric acid using agro-industrial residues as feedstock. This use of agro-industrial residues, a renewable feedstock, for the production of bio-based platform chemical makes the process cost-competitive as well as greener by preventing the release of assimilable organic carbon to the environment, thereby reducing the generation of greenhouse gases. Immobilization of R. Read More

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A neonate with molybdenum cofactor deficiency type B.

Transl Pediatr 2021 Apr;10(4):1039-1044

Department of Neonatology, The Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.

Molybdenum cofactor deficiency (MoCD) is an autosomal recessive disease which leads to a combined deficiency of molybdenum cofactor dependent enzymes. There are four different genes in molybdenum cofactor biosynthesis, , , , . The patients with MOCS2 homozygous mutation who onset in the neonatal period always have severe seizures, feeding difficulties, progressive neurological deterioration. Read More

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Intraoperative Identification of the Shunt Point of Spinal Arteriovenous Malformations by a Selective Arterial Injection of Saline to Subtract Signals of Indocyanine Green: Technical Note.

World Neurosurg 2021 May 15;151:132-137. Epub 2021 May 15.

Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Background: It is crucial to identify a shunt point for spinal arteriovenous malformation (AVM) treatment. For this purpose, some intraoperative supports have been reported-intravenous injection of indocyanine green (ICG), selective arterial injection of ICG, and selective arterial injection of saline with a high frame rate digital camera. However, there are difficulties in accurately identifying the shunt point, especially if the lesion has multiple feeders. Read More

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Rational Design of Novel Therapies for Pantothenate Kinase-Associated Neurodegeneration.

Mov Disord 2021 May 18. Epub 2021 May 18.

Departments of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.

Background: This review highlights the recent scientific advances that have enabled rational design of novel clinical trials for pantothenate kinase-associated neurodegeneration (PKAN), a rare autosomal recessive neurogenetic disorder associated with progressive neurodegenerative changes and functional impairment. PKAN is caused by genetic variants in the PANK2 gene that result in dysfunction in pantothenate kinase 2 (PANK2) enzyme activity, with consequent disruption of coenzyme A (CoA) synthesis, and subsequent accumulation of brain iron. The clinical phenotype is varied and may include dystonia, rigidity, bradykinesia, postural instability, spasticity, loss of ambulation and ability to communicate, feeding difficulties, psychiatric issues, and cognitive and visual impairment. Read More

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Sedatives for opioid withdrawal in newborn infants.

Cochrane Database Syst Rev 2021 05 18;5:CD002053. Epub 2021 May 18.

Department of Neonatal Medicine, RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, Australia.

Background: Neonatal abstinence syndrome (NAS) due to opioid withdrawal may result in disruption of the mother-infant relationship, sleep-wake abnormalities, feeding difficulties, weight loss, seizures and neurodevelopmental problems.

Objectives: To assess the effectiveness and safety of using a sedative versus control (placebo, usual treatment or non-pharmacological treatment) for NAS due to withdrawal from opioids and determine which type of sedative is most effective and safe for NAS due to withdrawal from opioids.

Search Methods: We ran an updated search on 17 September 2020 in CENTRAL via CRS Web and MEDLINE via Ovid. Read More

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