7,548 results match your criteria fecal microbiome


Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes.

Curr Diab Rep 2018 Oct 18;18(12):129. Epub 2018 Oct 18.

Department of Pathology & Immunology, Baylor College of Medicine and Texas Children's Hospital, 6621 Fannin Street, Houston, TX, 77030, USA.

Purpose Of Review: Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gastrointestinal Neuropathies: New Insights and Emerging Therapies.

Gastroenterol Clin North Am 2018 Dec 28;47(4):877-894. Epub 2018 Sep 28.

Neurogastroenterology and Motility Unit, Department of Pediatric Gastroenterology, Great Ormond Street Hospital, London WC1N 3JH, UK; Stem Cells and Regenerative Medicine, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

The bewildering complexity of the enteric nervous system makes it susceptible to develop a wide array of motility disorders, collectively called enteric neuropathies. These gastrointestinal conditions are among the most challenging to manage, mainly given poor characterization of their etiopathophysiology and outcomes. Not surprisingly, therefore, targeted or curative therapies for enteric neuropathies are lacking and management is largely symptomatic. Read More

View Article
December 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fecal source identification using random forest.

Microbiome 2018 Oct 18;6(1):185. Epub 2018 Oct 18.

School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Background: Clostridiales and Bacteroidales are uniquely adapted to the gut environment and have co-evolved with their hosts resulting in convergent microbiome patterns within mammalian species. As a result, members of Clostridiales and Bacteroidales are particularly suitable for identifying sources of fecal contamination in environmental samples. However, a comprehensive evaluation of their predictive power and development of computational approaches is lacking. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants.

Clin Infect Dis 2018 Oct 16. Epub 2018 Oct 16.

Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.

Background: Gut dysbiosis has been suggested as a major risk factor for the development of late-onset sepsis (LOS), a main cause of mortality and morbidity in preterm infants. We aimed to assess specific signatures of the gut microbiome including metabolic profiles in preterm infants <34 weeks of gestation preceding LOS.

Methods: In a single center cohort fecal samples of preterm infants were prospectively collected during the period of highest vulnerability for LOS (day 7, 14, 21 of life). Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gut microbiota and obesity: An opportunity to alter obesity through Fecal Microbiota Transplant (FMT).

Diabetes Obes Metab 2018 Oct 17. Epub 2018 Oct 17.

University of Cincinnati College of Medicine, Cincinnati, OH.

Obesity is a global pandemic with immense health consequences for individuals and societies. Multiple factors including environmental influences and genetic predispositions are known to influence the development of obesity. Despite an increasing understanding of the factors driving the obesity episdemic, therapeutic interventions to prevent or reverse obesity are limited in their impact. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

The Safety of Fecal Microbiota Transplantation for Crohn's Disease: Findings from A Long-Term Study.

Adv Ther 2018 Oct 16. Epub 2018 Oct 16.

Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Introduction: Fecal microbiota transplantation (FMT) has been used as a potential treatment option for Crohn's disease (CD). However, there is still lack of safety and efficacy evidence based on large samples of CD undergoing FMT. This study aimed to evaluate the risk factors of adverse event (AE) in the long term and the efficacy of FMT in the short term for patients with CD. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Alterations of Gut Microbiome in the Patients With Severe Fever With Thrombocytopenia Syndrome.

Front Microbiol 2018 1;9:2315. Epub 2018 Oct 1.

Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus, and the number of SFTS cases increased year by year in China. Previous studies had indicated that gut microbiome closely associated with human health and diseases, including infection diseases, liver diseases, gastrointestinal diseases and metabolic diseases. The aim of this study is to investigate the alterations and involvements of gut microbial in SFTS patients. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Response of Gut Microbiota to Dietary Fiber and Metabolic Interaction With SCFAs in Piglets.

Front Microbiol 2018 28;9:2344. Epub 2018 Sep 28.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Dietary fiber (DF) is increasingly thought to regulate diversity of piglet gut microbiota to alleviate weaning stress in piglets. This study was conducted to investigate the effects of DF on growth performance of piglets and composition of their gut microbiota, as well as the interaction between gut microbiota and short-chain fatty acids (SCFAs) in piglets. A total of 840 piglets were allocated to three dietary treatments consisting of a control group (CG), an alfalfa meal group (AG), and a commodity concentrated fiber group (OG) in a 30-day feeding trial. Read More

View Article
September 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Precise Fecal Microbiome of the Herbivorous Tibetan Antelope Inhabiting High-Altitude Alpine Plateau.

Front Microbiol 2018 28;9:2321. Epub 2018 Sep 28.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

The metataxonomic approach combining 16S rRNA gene amplicon sequencing using the PacBio Technology with the application of the operational phylogenetic unit (OPU) approach, has been used to analyze the fecal microbial composition of the high-altitude and herbivorous Tibetan antelopes. The fecal samples of the antelope were collected in Hoh Xil National Nature Reserve, at an altitude over 4500 m, the largest depopulated zone in Qinghai-Tibetan Plateau, China, where non-native animals or humans may experience life-threatening acute mountain sickness. In total, 104 antelope fecal samples were enrolled in this study, and were clustered into 61,258 operational taxonomic units (OTUs) at an identity of 98. Read More

View Article
September 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Altered Gut Microbiota Composition in Subjects Infected With .

Front Microbiol 2018 28;9:2292. Epub 2018 Sep 28.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.

Clonorchiasis is an infectious disease caused by helminths of (). The adult parasite mainly inhabits the bile duct and gall bladder, and results in various complications to the hepatobiliary system. The amount of bile secreted into the intestine is reduced in cases of infection, which may alter the pH of the gut and decrease the amount of surfactant protein D released from the gallbladder. Read More

View Article
September 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Tong-Xie-Yao-Fang Regulates 5-HT Level in Diarrhea Predominant Irritable Bowel Syndrome Through Gut Microbiota Modulation.

Front Pharmacol 2018 28;9:1110. Epub 2018 Sep 28.

Preparation Department, Tianjin Second People's Hospital, Tianjin, China.

Tong-Xie-Yao-Fang (TXYF) has been widely used for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) in traditional Chinese medicine. However, its mechanism of action in the treatment of IBS-D remains to be fully understood. Recent reports have shown that species in the gut can induce production in the colon, which then contributes to IBS-D. Read More

View Article
September 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection in Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine at Mount Sinai, New York.

Objectives: Recurrent Clostridium difficile infection (RCDI) increases morbidity and mortality in patients with inflammatory bowel disease (IBD). Fecal microbiota transplant (FMT) is known to be very effective for RCDI in non-IBD patients with cure rates up to 91%. The same success rates of FMT have not been reported in IBD patients with RCDI, and the data in pediatrics is limited. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury.

mSystems 2018 Sep-Oct;3(5). Epub 2018 Oct 9.

Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Science, Zhejiang University, Zhejiang, People's Republic of China.

Fecal microbiota transplantation (FMT) is one of the most effective ways to regulate the gut microbiota. Here, we investigated the effect of exogenous fecal microbiota on gut function from the perspective of analysis of the mucosal proteomes in a piglet model. A total of 289 differentially expressed proteins were annotated with 4,068 gene ontology (GO) function entries in the intestinal mucosa, and the levels of autophagy-related proteins in the forkhead box O (FoxO) signaling pathway were increased whereas the levels of proteins related to inflammation response were decreased in the recipient. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

An exploratory study on the effect of daily fruits and vegetable juice on human gut microbiota.

Food Sci Biotechnol 2018 Oct 17;27(5):1377-1386. Epub 2018 May 17.

Institute of MD Healthcare, Seoul, South Korea.

In order to evaluate the effect of daily consumption of fruit and vegetable juice on the human intestinal microbial community, we compared changes in the gut microbiota and extracellular vesicles in human feces and bowel, and skin symptoms at the baseline and 3 weeks post juice consumption of 22 participants. After 3 weeks of juice consumption, a significant increase in the richness of microbiota (α-diversity,  < 0.05) was observed. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study.

Front Immunol 2018 25;9:2195. Epub 2018 Sep 25.

Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Patients with steroid refractory gastrointestinal (GI) tract graft- vs.-host disease (GvHD) face a poor prognosis and limited therapeutic options. To accurately assess the efficacy and safety of fecal microbiota transplantation (FMT) in treating steroid refractory GI tract GvHD, we conducted a pilot study involving eight patients. Read More

View Article
September 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease.

Authors:
Tao Zuo Siew C Ng

Front Microbiol 2018 25;9:2247. Epub 2018 Sep 25.

Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.

In the twenty first century, the changing epidemiology of inflammatory bowel disease (IBD) globally with increasing disease incidence across many countries relates to the altered gut microbiota, due to a combinatorial effect of environmental factors, human immune responses and genetics. IBD is a gastrointestinal disease associated with a gut microbial dysbiosis, including an expansion of facultative anaerobic bacteria of the family Enterobacteriaceae. Advances in high-throughput sequencing enable us to entangle the gut microbiota in human health and IBD beyond the gut bacterial microbiota, expanding insights into the mycobiota, virobiota and helminthes. Read More

View Article
September 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress.

Front Psychiatry 2018 27;9:454. Epub 2018 Sep 27.

Laboratory for Microbiome Sciences, Institute of Biomedical Sciences, Shanxi University, Taiyuan, China.

Depression has been correlated with metabolic disorders, and the gut microbiota and its metabolites have been reported to be key factors affecting metabolic disorders. Several metabolites generated by the gut microbiota have been reported to exert antidepressant-like effects, including the short chain fatty acid (SCFA) butyrate. However, recent work has suggested that the abundance of butyrate is not significantly changed in neither human nor experimental animals with depression, and butyrate has been reported to decrease upon the administration of prebiotics with antidepressant-like effects. Read More

View Article
September 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility.

J Cell Physiol 2018 Oct 14. Epub 2018 Oct 14.

Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Osaka, Japan.

Organ-organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common in patients with renal failure. The aim of this study was to elucidate the relationship between gastrointestinal motility and gastrointestinal symptoms in chronic kidney disease. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Broccoli consumption affects the human gastrointestinal microbiota.

J Nutr Biochem 2018 Sep 21;63:27-34. Epub 2018 Sep 21.

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, 449 Bevier Hall, 905 S. Goodwin Ave, Urbana, IL, 61801, United States; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 260 Bevier Hall, 905 S. Goodwin Ave, Urbana, IL, 61801, United States. Electronic address:

The human gastrointestinal microbiota is increasingly linked to health outcomes; however, our understanding of how specific foods alter the microbiota is limited. Cruciferous vegetables such as broccoli are a good source of dietary fiber and phytonutrients, including glucosinolates, which can be metabolized by gastrointestinal microbes. This study aimed to determine the impact of broccoli consumption on the gastrointestinal microbiota of healthy adults. Read More

View Article
September 2018
8 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Comparison of intestinal expression of the apical sodium-dependent bile acid transporter between dogs with and without chronic inflammatory enteropathy.

J Vet Intern Med 2018 Oct 12. Epub 2018 Oct 12.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas.

Background: Intestinal absorption of bile acids is mediated by the apical sodium-dependent bile acid transporter (ASBT). Fecal bile acid dysmetabolism has been reported in dogs with chronic inflammatory enteropathy (CIE).

Objective: Characterization of ASBT distribution along the intestinal tract of control dogs and comparison to dogs with CIE. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Microcapsule of sweet orange essential oil changes gut microbiota in diet-induced obese rats.

Biochem Biophys Res Commun 2018 Oct 9. Epub 2018 Oct 9.

College of Forestry and Life Science, Chongqing University of Arts and Sciences, Chongqing, 402160, China.

Obesity is associated with the changes in gut microbiota. The aim of present study was to investigate the effects of sweet orange essential oil (SOEO) microcapsules on body weight and gut microbiota in obese rats induced by high-fat diet. By analyzing the body weight, fat rate and the sequence of cloned microbial small-subunit ribosomal RNA genes (16S rDNA) in rats fecal samples, we found that SOEO microcapsules decreased the body weight and increased the relative abundance of Bifidobacterium (genus-level) in gut microbiota. Read More

View Article
October 2018
3 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Microbiota and Derived Parameters in Fecal Samples of Infants with Non-IgE Cow's Milk Protein Allergy under a Restricted Diet.

Nutrients 2018 Oct 11;10(10). Epub 2018 Oct 11.

Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA)-Consejo Superior de Investigaciones Científicas (CSIC), 33300 Villaviciosa, Spain.

Cow's milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice.

Inflamm Bowel Dis 2018 Oct;24(11):2394-2403

Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Human and mouse studies implicate the inflammasome in the pathogenesis of inflammatory bowel diseases, though the effects in mice are variable. The noncanonical inflammasome activator caspase-11 (Casp11) reportedly attenuates acute dextran sodium sulfate (DSS) colitis in mice. However, the effects of Casp11 on chronic experimental colitis and factors that influence the impact of Casp11 on acute DSS colitis are unknown. Read More

View Article
October 2018
3 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Effects of the intake of white wheat bread added with garlic and resistant starch: action on calcium bioavailability and metabolic parameters of growing Wistar rats.

Food Funct 2018 Oct 12. Epub 2018 Oct 12.

Departamento de Nutrición y Bromatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Buenos Aires, Argentina.

Wheat bread is a widely consumed food and is suitable for the introduction of functional ingredients. The aim of this work was to study the effects of bread with garlic and resistant starch as a fiber source on physiological, metabolic, and functional parameters using an in vivo Wistar rat model. Rats were fed with three diets: a control diet prepared according to the American Institute of Nutrition (C), and two semisynthetic diets containing wheat bread (B) and wheat bread with garlic, resistant starch and calcium citrate (BGR). Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice.

World J Gastroenterol 2018 Oct;24(37):4254-4262

Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.

Aim: To investigate the effects of VSL#3 on tumor formation, and fecal and intestinal mucosal microbiota in azoxymethane/dextran sulfate sodium (AOM/DSS) induced mice model.

Methods: C57BL/6 mice were administered AOM/DSS to develop the ulcerative colitis (UC) carcinogenesis model. Mice were treated with 5-ASA (75 mg/kg/d), VSL#3 (1. Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome.

World J Gastroenterol 2018 Oct;24(37):4217-4223

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary T2N 2T9, Canada.

The brain-gut axis serves as the bidirectional connection between the gut microbiome, the intestinal barrier and the immune system that might be relevant for the pathophysiology of inflammatory demyelinating diseases. People with multiple sclerosis have been shown to have an altered microbiome, increased intestinal permeability and changes in bile acid metabolism. Experimental evidence suggests that these changes can lead to profound alterations of peripheral and central nervous system immune regulation. Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota.

Int J Mol Sci 2018 Oct 10;19(10). Epub 2018 Oct 10.

DSM Nutritional Products Ltd., R&D Human Nutrition and Health, 4002 Basel, Switzerland.

Recently, the concept of prebiotics has been revisited to expand beyond non-digestible oligosaccharides, and the requirements for selective stimulation were extended to include microbial groups other than, and additional to, bifidobacteria and lactobacilli. Here, the gut microbiota-modulating effects of well-known and novel prebiotics were studied. An fermentation screening platform (i-screen) was inoculated with adult fecal microbiota, exposed to different dietary fibers that had a range of concentrations (inulin, alpha-linked galacto-oligosaccharides (alpha-GOS), beta-linked GOS, xylo-oligosaccharides (XOS) from corn cobs and high-fiber sugar cane, and beta-glucan from oats), and compared to a positive fructo-oligosaccharide (FOS) control and a negative control (no fiber addition). Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

The microbiome and antibiotic resistance in integrated fishfarm water: Implications of environmental public health.

Sci Total Environ 2019 Feb 29;649:1491-1501. Epub 2018 Aug 29.

College of Public Health, Division of Environmental Health Sciences, The Ohio State University, Columbus, OH 43210, USA; Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Aquaculture, the production of farm-raised fish, is a major industry that employs and feeds millions of individuals across the globe, but which may also be a nexus of emerging public health threats. This study examined potential health risks associated with integrated aquaculture operations by with One Health approach using a suite of tools to study water contamination sources, pathogens, antibiotic resistant bacteria, and bacterial community in the water from fishponds. Water samples from 27 fishponds across 9 villages were collected in Jiangmen City, China. Read More

View Article
February 2019
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Extended persistence of general and cattle-associated fecal indicators in marine and freshwater environment.

Sci Total Environ 2019 Feb 9;650(Pt 1):1292-1302. Epub 2018 Sep 9.

National Risk Management Research Laboratory, Office of Research and Development, United States Environmental Protection Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45268, United States.

Fecal contamination of recreational waters with cattle manure can pose a risk to public health due to the potential presence of various zoonotic pathogens. Fecal indicator bacteria (FIB) have a long history of use in the assessment of recreational water quality, but FIB quantification provides no information about pollution sources. Microbial source tracking (MST) markers have been developed in response to a need to identify pollution sources, yet factors that influence their decay in ambient waters are often poorly understood. Read More

View Article
February 2019
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course.

Cell Host Microbe 2018 Oct;24(4):600-610.e4

The Broad Institute of MIT and Harvard, Infectious Disease and Microbiome, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is challenging as many patients exhibit incomplete responses to treatment. As part of the PROTECT (Predicting Response to Standardized Colitis Therapy) Study, we evaluated the role of the gut microbiome in disease course for 405 pediatric, new-onset, treatment-naive UC patients. Patients were monitored for 1 year upon treatment initiation, and microbial taxonomic composition was analyzed from fecal samples and rectal biopsies. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria.

Eur J Nutr 2018 Oct 10. Epub 2018 Oct 10.

Toronto General Hospital, University Health Network, 585 University Avenue, 9-973, Toronto, ON, M5G 2C4, Canada.

Non-alcoholic fatty-liver disease (NAFLD) is now considered one of the leading causes of liver disease worldwide and is associated with metabolic syndrome and obesity. There are several factors contributing to the disease state. Recent research suggests that the intestinal microbiota (IM) and bacterial products may play a role through several mechanisms which include increased energy uptake, intestinal permeability and chronic inflammation. Read More

View Article
October 2018
3 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Alterations in the diversity and composition of mice gut microbiota by lytic or temperate gut phage treatment.

Appl Microbiol Biotechnol 2018 Oct 9. Epub 2018 Oct 9.

Institute of Food Safety and Nutrition, Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Jiangsu Academy of Agricultural Sciences, No. 50 Zhongling Street, Xuanwu Area, Nanjing, 210014, China.

Phages, the most abundant species in the mammalian gut, have numerous advantages as biocontrol agent over antibiotics. In this study, mice were orally treated with the lytic gut phage PA13076 (group B), the temperate phage BP96115 (group C), no phage (group A), or streptomycin (group D) over 31 days. At the end of the experiment, fecal microbiota diversity and composition was determined and compared using high-throughput sequencing of the V3-V4 hyper-variable region of the 16S rRNA gene and virus-like particles (VLPs) were quantified in feces. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Protocol for Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 13;2018:8941340. Epub 2018 Sep 13.

Department of Pharmacology, Anhui Medical University, Hefei, Anhui Province, China.

Background: Fecal microbiota transplantation (FMT) is an emerging treatment approach for inflammatory bowel disease (IBD). The donor selection, the separation of fecal bacteria, the frequency of FMT, the way of infusion, the long-term safety, and efficacy are still uncertain.

Aim: To further study the efficacy and safety and protocol of FMT for IBD. Read More

View Article
September 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects.

J Nutr Metab 2018 13;2018:7497260. Epub 2018 Sep 13.

Pharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USA.

Background: Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem.

Objectives: An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation.

Results: After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes ( < 0. Read More

View Article
September 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Isolation and Characterization of subsp. BCBR-583 for Probiotic Applications in Fermented Foods.

J Microbiol Biotechnol 2018 Oct 3. Epub 2018 Oct 3.

Department of Food Science and Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, South Korea.

Recent human gut microbiome studies have supported that the genus is one of the most beneficial bacteria for human intestinal health. To develop a new probiotic strain for functional food applications, fourteen fecal samples were collected from healthy Koreans and a strain BCBR-583 was newly selected and isolated from a 25-year-old Korean woman's fecal sample using the selective medium for . Subsequent fructose-6-phosphate phosphoketolase (F6PPK) test and 16S rRNA gene sequencing analysis of the strain BCBR-583 confirmed that it belongs to subsp. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Microbiota and Phage Therapy: Future Challenges in Medicine.

Med Sci (Basel) 2018 Oct 5;6(4). Epub 2018 Oct 5.

Cochin Institute-INSERM U1016, University Paris Descartes, Development, Reproduction and Cancer, Cochin Hospital, Paris, 75014, France.

An imbalance of bacterial quantity and quality of gut microbiota has been linked to several pathologies. New strategies of microbiota manipulation have been developed such as fecal microbiota transplantation (FMT); the use of pre/probiotics; an appropriate diet; and phage therapy. The presence of bacteriophages has been largely underestimated and their presence is a relevant component for the microbiome equilibrium. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fecal Microbiota Transplantation for the Management of Clostridium difficile Infection.

Surg Infect (Larchmt) 2018 Oct 9. Epub 2018 Oct 9.

Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago , Chicago, Illinois.

The clinical burden of Clostridium difficile infection (CDI) continues to grow. Despite the multitude of treatment options that have been developed and tested to combat the morbidity and death associated with CDI, recurrence remains common. As such, treatment modalities such as fecal microbiota transplantation (FMT) have become studied increasingly; FMT serves to transplant stool from carefully selected healthy subjects into C. Read More

View Article
October 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Risks Related to High-Dosage Recombinant Antimicrobial Peptide Microcin J25 in Mice Model: Intestinal Microbiota, Intestinal Barrier Function and Immune Regulation.

J Agric Food Chem 2018 Oct 9. Epub 2018 Oct 9.

Antimicrobial peptide (AMP) can be a promising alternative in various domains. However, the further risk information is required. In this study, mice were orally administrated different dosages of recombinant AMP microcin J25 (4. Read More

View Article
October 2018
2 Reads
2.91 Impact Factor
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Clostridioides difficile.

Trends Microbiol 2018 Oct 5. Epub 2018 Oct 5.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Clostridioides difficile is a spore-forming, anaerobic, intestinal pathogen that causes severe diarrhea that can lead to death. In 2011, C. difficile infected ∼500000 people in the USA and killed ∼29000 people. Read More

View Article
October 2018
4 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gut Microbiota and Body Weight in School-Aged Children: The KOALA Birth Cohort Study.

Obesity (Silver Spring) 2018 Oct 8. Epub 2018 Oct 8.

Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands.

Objective: This study aimed to examine the intestinal microbiota composition of school-aged children in association with (over)weight.

Methods: The fecal microbiota composition of 295 children was analyzed using the Human Intestinal Tract Chip. Anthropometric outcomes (overweight [BMI  ≥  85th percentile], age- and sex-standardized BMI and weight z scores) were measured at 6 to 7 years of age, and elastic net was used to select genus-like bacterial groups related to all anthropometric outcomes. Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

[Analysis of structural features of gut microbiota in two-kidney-one-clip hypertensive rats based on high-throughput sequencing technology].

Zhonghua Xin Xue Guan Bing Za Zhi 2018 Sep;46(9):706-712

Graduate School of Baotou Medical College, Baotou 014060, China.

To characterize the gut microbial community structure of two-kidney-one-clip (2K1C) hypertensive rats, provide new evidences for prevention and treatment of hypertension. Adult male SD rats were divided into 2K1C hypertensive model group and sham operation group (8 each). Blood pressure was recorded by tail-cuff technique weekly for 4 weeks. Read More

View Article
September 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Effect of Synbiotic and Probiotic Supplementation on Serum Levels of Endothelial Cell Adhesion Molecules in Hemodialysis Patients: a Randomized Control Study.

Probiotics Antimicrob Proteins 2018 Oct 6. Epub 2018 Oct 6.

Department of Biostatistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The aim of this study was to investigate the effect of synbiotic and probiotic supplementation on serum vascular dysfunction and necrosis markers in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled trial, 75 HD patients were randomly assigned to either the synbiotic or probiotic or placebo group. The patients in the synbiotic group received 15 g of prebiotics and 5 g probiotic powder containing Lactobacillus acidophilus strain T16 (IBRC-M10785), Bifidobacterium bifidum strain BIA-6, Bifidobacterium lactis strain BIA-6, Bifidobacterium longum strain LAF-5 (2. Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gut Microbiota Imbalance Can Be Associated with Non-malabsorptive Small Bowel Shortening Regardless of Blind Loop.

Obes Surg 2018 Oct 6. Epub 2018 Oct 6.

Department of Surgery and Experimental Research Laboratory, Federal University of Sao Paulo, Sao Paulo, Brazil.

Introduction: Some traditional bariatric surgery procedures may lead to functional gut shortening, which may unsettle the fine-tuned gastrointestinal physiology and affect gut microbiota balance.

Purpose: Evaluate the gut microbiota behavior in rat models facing gut shortening due to intestinal bypass.

Materials And Methods: Wistar rats (n = 17) were randomly distributed in three groups: (1) sham group (n = 5); (2) blind loop group (n = 6); and (3) resection group (n = 6). Read More

View Article
October 2018
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Diabetes progression and alterations in gut bacterial translocation: prevention by diet supplementation with human milk in NOD mice.

J Nutr Biochem 2018 Oct 4;62:108-122. Epub 2018 Oct 4.

Université Lille et CHU de Lille Laboratoire de Virologie EA3610, F-59037 Lille, France.

Impaired intestinal barrier function occurs before type 1 diabetes (T1D) onset with a possible contribution of microbial translocation. Breastfeeding is associated with enhanced mucosal intestinal integrity and T1D protection. Our aim was to study the potential of human milk (HM) to prevent diabetes onset and modulate the translocation of gut bacteria susceptible to breastfeeding or associated to diabetes onset. Read More

View Article
October 2018
4 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.

Surg Obes Relat Dis 2018 Aug 29. Epub 2018 Aug 29.

University of Michigan, Department of Surgery, Ann Arbor, Michigan. Electronic address:

Background: One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.

Objectives: To examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model. Read More

View Article
August 2018
1 Read
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice.

Biochim Biophys Acta Mol Basis Dis 2018 Oct 4;1864(12):3746-3758. Epub 2018 Oct 4.

Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA. Electronic address:

Phosphatase and tensin homolog (Pten) antagonizes PI3K-Akt signaling; therefore, Pten impairment causes tumorigenesis. However, the correlation between Pten deficiency and colon cancer has remained elusive due to numerous opposite observations. To study this correlation, we examined whether Pten deficiency in intestinal epithelial cells (IECs) induces tumorigenesis. Read More

View Article
October 2018
1 Read
4.88 Impact Factor
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Altered composition of the gut microbiome in patients with drug-resistant epilepsy.

Epilepsy Res 2018 Nov 24;147:102-107. Epub 2018 Sep 24.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Objective: The relationship between the gut microbiota and the central nervous system has been gradually recognized while whether microbiome plays a role in the pathogenesis of drug-resistant epilepsy is still unknown. The aim of our work was to explore whether dysbiosis is involved in the mechanism of drug-resistant epilepsy.

Methods: Patients with epilepsy attending West China Hospital of Sichuan University were enrolled from March to May 2017. Read More

View Article
November 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Gut dysbiosis is associated with the reduced exercise capacity of elderly patients with hypertension.

Hypertens Res 2018 Oct 5. Epub 2018 Oct 5.

Wenzhou Medical University, 325035, Wenzhou, Zhejiang, China.

Hypertension is a global health issue, and a reduced exercise capacity is unavoidable for older people. According to recent clinical studies, the intestinal microbiota play a crucial role in the pathogenesis of many human diseases. We investigated whether specific alterations in the gut microbiota contribute to the reduced exercise capacity of elderly patients with hypertension. Read More

View Article
October 2018
3 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

A low abundance of Bifidobacterium but not Lactobacillius in the feces of Chinese children with wheezing diseases.

Medicine (Baltimore) 2018 Oct;97(40):e12745

Department of Pediatrics, The Second People's Hospital of Changzhou, Affiliate Hospital of NanJing Medical University.

Background: The intestinal microbiota is linked with allergic reaction diseases. However, the difference in the fecal microbiota composition between sensitized wheezy and nonsensitized subjects in Chinese children remains unknown. The aim of this study was to quantitate the amounts of fecal microbiota in wheezy children, and to explore the correlation between fecal microbiota and serum Th1/Th2/Th17-type cytokines and total IgE in these patients. Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.

Fecal microbiota transplantation for patients with irritable bowel syndrome: A meta-analysis protocol.

Medicine (Baltimore) 2018 Oct;97(40):e12661

Nanjing University of Chinese Medicine, Nanjing, China.

Irritable bowel syndrome (IBS) is a common functional bowel disease characterized by chronic or recurrent abdominal pain, bloating, constipation, and diarrhea. Many patients with IBS have a poor quality of life due to abdominal discomfort, diarrhea, constipation, and the presence of other diseases. At present, intestinal motility inhibitors, adsorbents, astringents, intestinal mucosal protective agents, and antidepressants have been combined to treat IBS, but the treatment process is long, which results in a large economic burden to patients. Read More

View Article
October 2018
2 Reads
iconPDF
Still can't find the full text of the article? Sign up to send a request to the authors directly.