11,651 results match your criteria fecal microbiome


Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production.

Pharmacol Res 2020 May 30:104978. Epub 2020 May 30.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Emerging evidence implicates gut microbiota have an important role in ulcerative colitis (UC). Previous study indicated that Evodiamine (EVO) can alleviate colitis through downregulating inflammatory pathways. However, specific relationship between EVO-treated colitis relief and regulation of gut microbiota is still unclear. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104978DOI Listing

Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass.

Aging (Albany NY) 2020 Jun 2;12. Epub 2020 Jun 2.

Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

As a critical factor involved in the maintenance of physiological homeostasis, the gut microbiota (GM) reportedly plays a key role in bone development. To date, the association between the GM and steroid deficiency-induced osteoporosis remains poorly understood. Forty female Sprague Dawley rats were divided into an ovariectomy (OVX) or control group. Read More

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http://dx.doi.org/10.18632/aging.103290DOI Listing

Beneficial effects of lactitol on the composition of gut microbiota in constipated patients.

J Dig Dis 2020 Jun 1. Epub 2020 Jun 1.

Departement of Gastroenterology, Key Laboratory of Gut Microbiota Translational Medicine Research, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Aim: To explore the changes in microbial composition and the corresponding impact after lactitol treatment in constipated patients.

Methods: Twenty-nine consecutive outpatients diagnosed with chronic constipation from three centers were recruited. The enrolled patients were stratified based on their diabetes history. Read More

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http://dx.doi.org/10.1111/1751-2980.12912DOI Listing

Metagenomic analysis identified microbiome alterations and pathological association between intestinal microbiota and polycystic ovary syndrome.

Fertil Steril 2020 Jun;113(6):1286-1298.e4

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China. Electronic address:

Objective: To identify different microbial species in women with polycystic ovary syndrome (PCOS) and reveal a possible relationship between gut dysbiosis and pathological changes.

Design: Cross-sectional study.

Setting: Academic institution. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.01.027DOI Listing

Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug-Resistant Gram-Negative Bacteria in Patients in a Long-Term Care Facility: A Pilot Study.

Nutrients 2020 May 28;12(6). Epub 2020 May 28.

Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Residents in long-term care facilities (LTCFs) are frequently colonized by multidrug-resistant Gram-negative bacteria, putting them at risk for subsequent infections. We aimed to evaluate the effect of the multispecies probiotic Omnibiotic10AAD on the intestinal and inguinal skin colonization of patients by multidrug-resistant Gram-negative bacteria in LTCFs. Patients colonized by multidrug-resistant Gram-negative bacteria received a 12 week oral course of Omnibiotic10AAD. Read More

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http://dx.doi.org/10.3390/nu12061586DOI Listing

The Effect of Maternal Antibiotic Use in Sows on Intestinal Development in Offspring.

J Anim Sci 2020 Jun 1. Epub 2020 Jun 1.

Wageningen Livestock Research, Wageningen, The Netherlands.

The objective of this study is to investigate the effect of a maternal antibiotic administration during the last week of gestation on the early life intestinal development in neonatal piglets. Colonization of the gut with bacteria starts during birth and plays a major role in the intestinal and immunological development of the intestine. We demonstrate that maternal interventions induced changes in the sows (n=6 to 8 per treatment) fecal microbiota diversity around birth (P<0. Read More

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http://dx.doi.org/10.1093/jas/skaa181DOI Listing

Effects of Dietary Fat Profile on Gut Microbiota in Valproate Animal Model of Autism.

Front Med (Lausanne) 2020 12;7:151. Epub 2020 May 12.

Department of Developmental Pediatrics, The Second Hospital of Jilin University, Changchun, China.

Autism spectrum disorder (ASD) is a developmental disability which may cause significant social, communication, and behavioral challenges. Besides certain essential symptoms, a lot of ASD individuals also suffer the comorbidity of gut microbiota dysbiosis, which possibly causes a variety of gastrointestinal (GI) difficulties. Interestingly, evidence has indicated that behavioral output may be modulated through the communication between the central nervous system and gut microbiota via the gut-brain axis. Read More

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http://dx.doi.org/10.3389/fmed.2020.00151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235405PMC

Rewiring of Microbiota Networks in Erosive Inflammation of the Stomach and Small Bowel.

Front Bioeng Biotechnol 2020 13;8:299. Epub 2020 May 13.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

The development of non-invasive, inexpensive, and effective early diagnosis tests for gastric and small-bowel lesions is an urgent requirement. The introduction of magnetically guided capsule endoscopy (MGCE) has aided examination of the small bowel for diagnoses. However, the distribution of the fecal microbiome in abnormal erosions of the stomach and small bowel remains unclear. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237573PMC

Changes in Intestinal Flora and Metabolites in Neonates With Breast Milk Jaundice.

Front Pediatr 2020 12;8:177. Epub 2020 May 12.

Department of Neonatal Intensive Care Unit, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Breast milk jaundice (BMJ) is the first cause of neonatal jaundice; however, its underlying mechanism is yet to be deciphered. We conducted a study to investigate intestinal flora in neonates with BMJ and used metabolomics to decipher the possible mechanisms by which intestinal flora induces jaundice. Microbiota collected from the feces of BMJ patients and jaundice-free breastfeeding newborns was used for 16S rRNA sequencing. Read More

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http://dx.doi.org/10.3389/fped.2020.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235331PMC

The Effect of Fibers With Different Degrees of Polymerization on Human Gut Bacteria.

Front Microbiol 2020 15;11:819. Epub 2020 May 15.

Laboratory of Biomanufacturing and Food Engineering, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.

Human gut bacteria contribute significantly to human health and several studies have evaluated the effects of dietary fibers on human gut bacterial ecology. However, the relationship between different degrees of fiber polymerization and human gut bacteria is unknown. Here, we analyzed three fiber substrates with different degrees of polymerization, namely carboxymethylcellulose, β-glucans, and galactooligosaccharides. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242623PMC

Folic acid attenuates high-fat diet-induced steatohepatitis deacetylase SIRT1-dependent restoration of PPARα.

World J Gastroenterol 2020 May;26(18):2203-2220

Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Background: Folic acid has been shown to improve non-alcoholic steatohepatitis (NASH), but its roles in hepatic lipid metabolism, hepatic one-carbon metabolism, and gut microbiota are still unknown.

Aim: To demonstrate the role of folic acid in lipid metabolism and gut microbiota in NASH.

Methods: Twenty-four Sprague-Dawley rats were assigned into three groups: Chow diet, high-fat diet (HFD), and HFD with folic acid administration. Read More

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http://dx.doi.org/10.3748/wjg.v26.i18.2203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235203PMC

Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease.

Neurogastroenterol Motil 2020 May 31:e13914. Epub 2020 May 31.

Department of Surgery, Oncology and Gastroenterology (DISCOG), University Hospital of Padua, Padua, Italy.

Background: Butyrate has shown anti-inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic-delivery formulation of butyrate on the fecal microbiota of patients with inflammatory bowel diseases (IBDs).

Methods: In this double-blind, placebo-controlled, pilot study, 49 IBD patients (n = 19 Crohn's disease, CD and n = 30 ulcerative colitis, UC) were randomized to oral administration of microencapsulated-sodium-butyrate (BLM) or placebo for 2 months, in addition to conventional therapy. Read More

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http://dx.doi.org/10.1111/nmo.13914DOI Listing

Diet, nutrients and the microbiome.

Prog Mol Biol Transl Sci 2020 25;171:237-263. Epub 2020 Apr 25.

Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, United States.

Although there is associative evidence linking fecal microbiome profile to health and disease, many studies have not considered the confounding effects of dietary intake. Consuming food provides fermentable substrate which sustains the microbial ecosystem that resides with most abundance in the colon. Western, Mediterranean and vegetarian dietary patterns have a role in modulating the gut microbiota, as do trending restrictive diets such the paleolithic and ketogenic. Read More

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http://dx.doi.org/10.1016/bs.pmbts.2020.04.006DOI Listing

The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin, Bifidobacterium longum and fecal microbiota transplantation.

Environ Pollut 2020 Apr 23;265(Pt A):114651. Epub 2020 Apr 23.

School of Medicine, Nankai University, Tianjin, 300071, China. Electronic address:

The usages of antibiotics in treating the pathogenic infections could alter the gut microbiome and associated resistome, causing long term adverse impact on human health. In this study, mice were treated with human-simulated regimen 25.0 mg kg of amoxicillin for seven days, and their gut microbiota and resistome were characterized using the 16S rRNA amplicons sequencing and the high-throughput qPCR, respectively. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114651DOI Listing

A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow's milk allergy - Comparison to the single parameter guinea pig model.

Toxicol Lett 2020 May 27. Epub 2020 May 27.

Danone Nutricia Research, Utrecht, the Netherlands.

Introduction: This 4-center study is part of a project to validate a food allergy murine model for safety testing of hydrolyzed infant formulas.

Aim: The aim of the current multi-center experiment was to evaluate the residual allergenicity of three partial hydrolyzed whey proteins (pWH) in a multiple-parameter cow's milk allergy murine model and to compare to the classically used guinea pig model. Previous work showed differences in the magnitude of the allergic response to whey between centers. Read More

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http://dx.doi.org/10.1016/j.toxlet.2020.05.020DOI Listing

Dysbiosis of Gut Microbiota and Short-Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes.

JPEN J Parenter Enteral Nutr 2020 May 30. Epub 2020 May 30.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The intestinal microbiota and its metabolites have been reported to play an important role in stroke. Gut microbiota-originating short-chain fatty acids (SCFAs) modulate brain functions directly or indirectly through immune, endocrine, vagal, and other humoral pathways. However, relatively few investigations have evaluated the gut microbiome and SCFAs spectrum or their potential associations with stroke outcomes in acute ischemic stroke (AIS) patients with different stroke severities. Read More

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http://dx.doi.org/10.1002/jpen.1861DOI Listing

Application of a Faecalibacterium 16S rDNA genetic marker for species identification of dog fecal waste.

Environ Sci Pollut Res Int 2020 May 29. Epub 2020 May 29.

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510000, China.

A dog-associated 16S rDNA genetic marker (ED-1) was designed to detect dog fecal contamination in water through a comparative bioinformatics analysis of Faecalibacterium sequences. For the dog fecal samples, ED-1 had 100% specificity, a high positive rate (89% in dog feces and 92.3% in dog fecal-contaminated water samples), and a low detection limit (10 copies/100 mL) in dog-contaminated water samples. Read More

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http://dx.doi.org/10.1007/s11356-020-09369-wDOI Listing

Station and train surface microbiomes of Mexico City's metro (subway/underground).

Sci Rep 2020 May 29;10(1):8798. Epub 2020 May 29.

Departamento de Ciencias Naturales. Unidad Cuajimalpa, Universidad Autónoma Metropolitana, Ciudad de México, México.

The metro is one of the more representative urban transportation systems of Mexico City, and it transports approximately 4.5 million commuters every day. Large crowds promote the exchange of microbes between humans. Read More

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http://dx.doi.org/10.1038/s41598-020-65643-4DOI Listing

Fecal bacteria can predict the efficacy of rifaximin in patients with diarrhea-predominant irritable bowel syndrome.

Pharmacol Res 2020 May 26:104936. Epub 2020 May 26.

Division ofGastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Objective: Rifaximin for treating diarrhea-predominant irritable bowel syndrome (IBS-D) by regulating intestinal microbiota has been studied and recommended. In this study, we tried to investigate the effect of rifaximin on different components of intestinal microbiota and explore which component of gut microbiota can predict the efficacy of rifaximin in IBS-D.

Methods: Healthy controls (HC) and IBS-D patients meeting the Rome III criteria were recruited, and IBS-D patients were orally administered 400 mg rifaximin three times daily for 2 weeks. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104936DOI Listing

Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria.

Inflamm Bowel Dis 2020 May 29. Epub 2020 May 29.

Department of Genetics, UNC at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: The intestinal microbiota play a key role in the onset, progression, and recurrence of Crohn disease (CD). Most microbiome studies assay fecal material, which does not provide region-specific information on mucosally adherent bacteria that directly interact with host systems. Changes in luminal oxygen have been proposed as a contributor to CD dybiosis. Read More

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http://dx.doi.org/10.1093/ibd/izaa103DOI Listing

How do I establish a stool bank for fecal microbiota transplantation within the blood- and tissue transplant service?

Transfusion 2020 May 28. Epub 2020 May 28.

Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

Worldwide, there is a rising demand for thoroughly screened, high-quality fecal microbiota transplantation (FMT) products that can be obtained at a reasonable cost. In the light of this evolving therapeutic area of the intestinal microbiota, both private and public stool banks have emerged. However, some of the larger difficulties when establishing stool banks are caused by the absence of or international disagreement on regulation and legislative formalities. Read More

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http://dx.doi.org/10.1111/trf.15816DOI Listing

Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study.

Breast Cancer Res Treat 2020 May 28. Epub 2020 May 28.

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: To investigate the association between gut microbiome with breast tumor characteristics (receptor status, stage and grade) and known breast cancer risk factors.

Methods: In a pilot cross-sectional study of 37 incident breast cancer patients, fecal samples collected prior to chemotherapy were analyzed by 16S ribosomal RNA (rRNA) gene-based sequencing protocol. Alpha diversity and specific taxa by tumor characteristics and breast cancer risk factors were tested by Wilcoxon rank sum test, and by differential abundance analysis, using a zero-inflated negative binomial regression model with adjustment for total counts, age and race/ethnicity. Read More

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http://dx.doi.org/10.1007/s10549-020-05702-6DOI Listing

Supplementation with Sea Vegetables and Exerts Metabolic Benefits in Diet-Induced Obesity in Mice.

Curr Dev Nutr 2020 May 8;4(5):nzaa072. Epub 2020 Apr 8.

Department of Food Science and Technology, College of Agricultural Sciences, Oregon State University, Corvallis, OR, USA.

Background: Sea vegetables are rich sources of nutrients as well as bioactive components that are linked to metabolic health improvement. Algal polysaccharides improve satiety and modulate gut microbiota while proteins, peptides, and phenolic fractions exert anti-inflammatory, antioxidant, and antidiabetic effects.

Objective: We tested the hypothesis that dietary supplementation with either Pacific dulse (, red algae) or wakame (, brown algae) could remediate metabolic complications in high-fat diet-induced obesity. Read More

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http://dx.doi.org/10.1093/cdn/nzaa072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245532PMC

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances.

Transl Psychiatry 2020 May 28;10(1):170. Epub 2020 May 28.

Affective Disorders Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

The relationships between depression and gut microbiota, particularly those involving the immune system, have become a major focus of recent research. Here, we analyzed changes in gut microbiota and their sulfur metabolites in the feces of a depression rat model using the modified 14-day social defeat stress (SDS) paradigm. Our results showed that SDS increased fecal Lactobacillus reuteri in correlation with ergothioneine levels at around day 11, which continued for at least 1 month following SDS administration. Read More

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http://dx.doi.org/10.1038/s41398-020-0855-1DOI Listing

16S rRNA Gene Amplicon Sequence Data from Feces of Five Species of Wild Animals in Japan.

Microbiol Resour Announc 2020 May 28;9(22). Epub 2020 May 28.

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

We report 16S rRNA amplicon sequence data from feces from 58 wild boars, 60 feral raccoons, 9 wild Japanese badgers, 21 wild masked palm civets, and 8 wild raccoon dogs in Japan. The predominant bacterial taxa in the fecal microbiota were similar in part but varied among the animal species. Read More

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http://dx.doi.org/10.1128/MRA.00368-20DOI Listing

16S rRNA Gene Amplicon Sequence Data from Feces of Wild Deer (Cervus nippon) in Japan.

Microbiol Resour Announc 2020 May 28;9(22). Epub 2020 May 28.

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

We report 16S rRNA amplicon sequence data from feces of 109 wild deer in Japan. The dominant bacterial taxa in fecal microbiota of wild deer hunted between village and mountainous areas and those living on Miyajima Island and in Nara Park were similar but differed in abundance. Read More

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http://dx.doi.org/10.1128/MRA.00346-20DOI Listing

Complete Genome Sequence of Bifidobacterium longum Strain Jih1, Isolated from Human Feces.

Microbiol Resour Announc 2020 May 28;9(22). Epub 2020 May 28.

Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan

We report the complete genome sequence of strain Jih1, isolated from human feces. The assembled genome comprised one circular chromosome of 2.37 Mb. Read More

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http://dx.doi.org/10.1128/MRA.00319-20DOI Listing

Oxygen as a key parameter in in vitro dynamic and multi-compartment models to improve microbiome studies of the small intestine?

Food Res Int 2020 Jul 25;133:109127. Epub 2020 Feb 25.

Food Quality Management, Food Science Department, FARAH, University of Liège, Avenue de Cureghem 10, B-4000 Liège, Belgium. Electronic address:

In vitro digestion and fermentation models are frequently used for human and animal research purposes. Different dynamic and multi-compartment models exist, but none have been validated with representative microbiota in the distal parts of the small intestine. We recently developed a dynamic and multi-compartment piglet model introducing microbiota in an ileum bioreactor. Read More

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http://dx.doi.org/10.1016/j.foodres.2020.109127DOI Listing

Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria.

Microbiome 2020 May 28;8(1):74. Epub 2020 May 28.

State Key Laboratory of Experimental Hematology, Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Gut microbiome alterations are closely related to human health and linked to a variety of diseases. Although great efforts have been made to understand the risk factors for multiple myeloma (MM), little is known about the role of the gut microbiome and alterations of its metabolic functions in the development of MM.

Results: Here, in a cohort of newly diagnosed patients with MM and healthy controls (HCs), significant differences in metagenomic composition were discovered, for the first time, with higher bacterial diversity in MM. Read More

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http://dx.doi.org/10.1186/s40168-020-00854-5DOI Listing

The Role of the Microbiome in Food Allergy: A Review.

Children (Basel) 2020 May 26;7(6). Epub 2020 May 26.

Baylor College of Medicine, Section of Pediatric Immunology, Allergy and Retrovirology, Houston, TX 77030 USA.

Food allergies are common and estimated to affect 8% of children and 11% of adults in the United States. They pose a significant burden-physical, economic and social-to those affected. There is currently no available cure for food allergies. Read More

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http://dx.doi.org/10.3390/children7060050DOI Listing

Human Milk Oligosaccharide Supplementation Affects Intestinal Barrier Function and Microbial Composition in the Gastrointestinal Tract of Young Sprague Dawley Rats.

Nutrients 2020 May 25;12(5). Epub 2020 May 25.

Faculty of Kinesiology, University of Calgary, 2500 University Drive NW, Calgary, AB T2N 1N4, Canada.

Human milk oligosaccharides (HMOs) are chief maternal milk constituents that feed the intestinal microbiota and drive maturation of the infant gut. Our objective was to determine whether supplementing individual HMOs to a weanling diet alters growth and gut health in rats. Healthy three-week-old Sprague Dawley rat pups were randomized to control, 2'--fucosyllactose (2'FL)- and 3'sialyllactose (3'SL)-fortified diets alone or in combination at physiological doses for eight weeks. Read More

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http://dx.doi.org/10.3390/nu12051532DOI Listing

Exploring the mechanism underlying the cardioprotective effect of shexiang baoxin pill on acute myocardial infarction rats by comprehensive metabolomics.

J Ethnopharmacol 2020 May 25;259:113001. Epub 2020 May 25.

Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Ethnopharmacological Relevance: Shexiang Baoxin Pill (SBP) is a commercial Chinese medicine included in the Chinese Pharmacopoeia with well-established cardiovascular protect effect in clinic. However, the mechanism of SBP underlying protective effect on cardiovascular disease has not been clearly elucidated yet.

Aim Of The Study: We aimed to investigate the underlying protective mechanisms of SBP on an acute myocardial infarction (AMI) rat model by using comprehensive metabolomics. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113001DOI Listing

Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review.

Clin Transl Gastroenterol 2020 Feb;11(2):e00126

Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands.

Objectives: To summarize the literature on the influence of exercise on the gut microbiota of healthy adults.

Methods: A systematic and comprehensive search in electronic database, including SciELO, Scopus, PubMed, and Web of Science up to July 5, 2019. Eligibility criterion was original studies conducted on healthy humans including exercise interventions or interventions involving any type of physical activity. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145029PMC
February 2020

Horizontal Gene Transfer of Antibiotic Resistance from Acinetobacter baylyi to Escherichia coli on Lettuce and Subsequent Antibiotic Resistance Transmission to the Gut Microbiome.

mSphere 2020 May 27;5(3). Epub 2020 May 27.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

Agricultural use of antibiotics is recognized by the U.S. Centers for Disease Control and Prevention as a major contributor to antibiotic-resistant infections. Read More

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http://dx.doi.org/10.1128/mSphere.00329-20DOI Listing

Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.

Crit Care 2020 May 27;24(1):268. Epub 2020 May 27.

Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1 Friendship Road, Yuzhong District, Chongqing, 400016, China.

Background: The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown.

Methods: In this work, an antibiotic cocktail was used to eliminate the intestinal microbiota of conventional-housed (CNV) C57/BL6 mice, and then both antibiotic-treated (ABX) mice and CNV mice were intravenously infected with Candida albicans to investigate their differential responses to infection. Read More

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http://dx.doi.org/10.1186/s13054-020-02977-5DOI Listing

High-altitude Tibetan fermented milk ameliorated cognitive dysfunction by modified gut microbiota in Alzheimer's disease transgenic mice.

Food Funct 2020 May 27. Epub 2020 May 27.

Research Center for High Altitude Medicine, Qinghai University, Key Laboratory for Application of High Altitude Medicine in Qinghai Province, Xining, China. and Qinghai University Affiliated Hospital, Xining, China.

Alzheimer's disease (AD) is a complex neurodegenerative disease that is regarded as a growing global challenge. Accumulating evidence linking gut microbiota with AD has become intriguing. The purpose of this study was to investigate how Tibetan fermented milk affected memory impairment in amyloid precursor protein (APP)/presenilin-1 (PS1) mice, using APP/PS1 transgenic mice as examples. Read More

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http://dx.doi.org/10.1039/c9fo03007gDOI Listing

Compositional and Functional Changes in the Gut Microbiota in Irritable Bowel Syndrome Patients.

Gut Liver 2020 May 29. Epub 2020 May 29.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background/aims: This study aimed to characterize the changes in the gut microbiota of irritable bowel syndrome (IBS) patients and to investigate the consequent alterations in bacterial functions.

Methods: We performed 16S rRNA metagenomic sequencing and a phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analyses using fecal samples from control (n=12) and diarrhea-dominant IBS patients (n=7).

Results: The samples were clustered by the principal coordinates analysis depending on the presence of IBS (p=0. Read More

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http://dx.doi.org/10.5009/gnl19379DOI Listing
May 2020
1.494 Impact Factor

Immune Profiling To Predict Outcome of Clostridioides difficile Infection.

mBio 2020 May 26;11(3). Epub 2020 May 26.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

There is a pressing need for biomarker-based models to predict mortality from and recurrence of infection (CDI). Risk stratification would enable targeted interventions such as fecal microbiota transplant, antitoxin antibodies, and colectomy for those at highest risk. Because severity of CDI is associated with the immune response, we immune profiled patients at the time of diagnosis. Read More

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http://dx.doi.org/10.1128/mBio.00905-20DOI Listing

The Gut Microbiota Communities of Wild Arboreal and Ground-Feeding Tropical Primates Are Affected Differently by Habitat Disturbance.

mSystems 2020 May 26;5(3). Epub 2020 May 26.

Department of Biodiversity and Molecular Ecology, Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy.

Human exploitation and destruction of tropical resources are currently threatening innumerable wild animal species, altering natural ecosystems and thus, food resources, with profound effects on gut microbiota. Given their conservation status and the importance to tropical ecosystems, wild nonhuman primates make excellent models to investigate the effect of human disturbance on the diversity of host-associated microbiota. Previous investigations have revealed a loss of fecal bacterial diversity in primates living in degraded compared to intact forests. Read More

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http://dx.doi.org/10.1128/mSystems.00061-20DOI Listing

Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota.

J Clin Med 2020 May 23;9(5). Epub 2020 May 23.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 04514, Korea.

The gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians remain unclear. Here, we examined the associations between gut microbial diversity and taxonomic compositions with both apolipoproteins and lipid markers in a large number of Korean patients. Read More

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http://dx.doi.org/10.3390/jcm9051589DOI Listing

Investigation of the Impacts of Antibiotic Exposure on the Diversity of the Gut Microbiota in Chicks.

Animals (Basel) 2020 May 21;10(5). Epub 2020 May 21.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

The dynamic microbiota in chickens can be affected by exposure to antibiotics, which may alter the composition and substrate availability of functional pathways. Here, 120 Jing Hong chicks at 30 days of age were randomly divided into four treatments totaling seven experimental groups: control chicks not exposed to antibiotics; and chicks exposed to enrofloxacin, diclazuril, and their mixture at 1:1 for 14 days and then not exposed for a withdrawal period of 15 days. Fecal samples were collected from the 7 groups at 8 time-points (exposure to 4 antibiotics and 4 withdrawal periods) to perform in-depth 16S rRNA sequencing of the gut microbiota. Read More

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http://dx.doi.org/10.3390/ani10050896DOI Listing

Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients.

Evid Based Complement Alternat Med 2020 11;2020:5859023. Epub 2020 May 11.

Department of Colo-Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

Background: Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and the rectum. Recently, some studies have shown that microorganisms in the gut play important roles in many chronic diseases such as UC.

Methods: To study the candidate viruses and bacteria involved in UC and to investigate the therapeutic mechanism of Quyushengxin formula (QYSX) in UC patients, metagenomic sequencing was performed on the feces from healthy donors and UC patients before and after QYSX treatment. Read More

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http://dx.doi.org/10.1155/2020/5859023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240791PMC

The novel peptides ICRD and LCGEC screened from tuna roe show antioxidative activity via Keap1/Nrf2-ARE pathway regulation and gut microbiota modulation.

Food Chem 2020 May 20;327:127094. Epub 2020 May 20.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China; School of Marine Science, Ningbo University, Ningbo, China. Electronic address:

In this study, a high-throughput strategy combined with MALDI TOF/TOF-MS and Discovery Studio 2017 was developed to screen peptides with certain functions from hydrolysate. Two dominant peptides, Ile-Cys-Arg-Asp (ICRD) and Leu-Cys-Gly-Glu-Cys (LCGEC), were predicted to have antioxidant activity by Discovery Studio 2017. Then the activity in vitro of peptides had been confirmed via DPPH assay. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127094DOI Listing

Indonesian children fecal microbiome from birth until weaning was different from microbiomes of their mothers.

Gut Microbes 2020 May 26:1-19. Epub 2020 May 26.

Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore.

Gastrointestinal (GI) microbiota play an important role in human health and wellbeing and the first wave of gut microbes arrives mostly through vertical transmission from mother to child. This study has undertaken to understand the microbiota profile of healthy Southeast Asian mother-infant pairs. Here, we examined the fecal, vaginal and breast milk microbiota of Indonesian mothers and the fecal microbiota of their children from less than 1 month to 48 months old. Read More

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http://dx.doi.org/10.1080/19490976.2020.1761240DOI Listing

Therapeutic methods of gut microbiota modification in colorectal cancer management - fecal microbiota transplantation, prebiotics, probiotics, and synbiotics.

Gut Microbes 2020 May 26:1-13. Epub 2020 May 26.

Department of Surgical Oncology, Medical University of Gdansk , Gdańsk, Poland.

The link between gut microbiota and the development of colorectal cancer has been investigated. An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis multiple mechanisms, including inflammation, activation of carcinogens, and tumorigenic pathways as well as damaging host DNA. Several therapeutic methods are available with which to alter the composition and the activity of gut microbiota, such as administration of prebiotics, probiotics, and synbiotics; these can confer various benefits for colorectal cancer patients. Read More

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http://dx.doi.org/10.1080/19490976.2020.1764309DOI Listing

Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet.

Aging (Albany NY) 2020 May 25;12. Epub 2020 May 25.

Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.

Type 2 resistant starch (RS2) is a fermentable dietary fiber conferring health benefits. We investigated the effects of RS2 on host, gut microbiota, and metabolites in aged mice on high-fat diet. In eighteen-month old mice randomly assigned to control, high-fat (HF), or high-fat+20% RS2 (HFRS) diet for 16 weeks, RS2 reversed the weight gain and hepatic steatosis induced by high-fat diet. Read More

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http://dx.doi.org/10.18632/aging.103187DOI Listing

Angiotensin (1-7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats.

Geroscience 2020 May 26. Epub 2020 May 26.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

To (1) investigate the efficacy of multiple doses of an orally delivered probiotic bacteria Lactobacillus paracasei (LP) modified to express angiotensin (1-7) (LP-A) in altering physiologic parameters relevant to the gut-brain axis in older rats and to (2) compare this strategy with subcutaneous delivery of synthetic Ang(1-7) peptide on circulating Ang(1-7) concentrations and these gut-brain axis parameters. Male 24-month-old F344BN rats received oral gavage of LP-A, or subcutaneous injection of Ang(1-7) for 0×, 1×, 3×, or 7×/week over 4 weeks. Circulating RAS analytes, inflammatory cytokines, and tryptophan and its downstream metabolites were measured by ELISA, electrochemiluminescence, and LC-MS respectively. Read More

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http://dx.doi.org/10.1007/s11357-020-00196-yDOI Listing

In vivo metabolic profiles of Panax notoginseng saponins mediated by gut microbiota in rats.

J Agric Food Chem 2020 May 25. Epub 2020 May 25.

Panax notoginseng saponins (PNS) are the major health-beneficial components of P. notoginseng with very low oral bioavailability, which could be bio-transformed by gut microbiota in vitro. However, in vivo biotransformation of PNS mediated by gut microbiota is not well-known. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c01857DOI Listing

Comparative assessment of gut microbial composition and function in patients with Graves' disease and Graves' orbitopathy.

J Endocrinol Invest 2020 May 24. Epub 2020 May 24.

Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.

Background: A previous study indicated that gut microbiota changed notably in Graves' orbitopathy (GO) patients as compared to controls. However, the characteristics of intestinal bacteria in Graves' disease (GD) and GO are unclear.

Objective: The present study aimed to identify specific intestinal bacteria of GD and GO, respectively. Read More

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http://dx.doi.org/10.1007/s40618-020-01298-2DOI Listing

Bacterial Mucosa-associated Microbiome in Inflamed and Proximal Noninflamed Ileum of Patients With Crohn's Disease.

Inflamm Bowel Dis 2020 May 25. Epub 2020 May 25.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Background: Microbiota is most likely essential in the pathogenesis of Crohn's disease (CD). Fecal diversion after ileocecal resection (ICR) protects against CD recurrence, whereas infusion of fecal content triggers inflammation. After ICR, the majority of patients experience endoscopic recurrence in the neoterminal ileum, and the ileal microbiome is of particular interest. Read More

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http://dx.doi.org/10.1093/ibd/izaa107DOI Listing