7,571 results match your criteria february july


Health-related quality of life, workability, and return to work of patients after liver transplantation.

Langenbecks Arch Surg 2021 May 6. Epub 2021 May 6.

Transplant Center Graz, Graz, Austria.

Background: Health-related quality of life (HrQoL) and workability are related parameters to measure success of therapy. Both have been insufficiently explored in patients after liver transplantation (LT). Particularly little is known about patients' attitude to return to work, employment status before LT, and how frequently there is any employment at any time after LT. Read More

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Association of Risk Factors With Patient-Reported Voice and Speech Symptoms Among Long-term Survivors of Oropharyngeal Cancer.

JAMA Otolaryngol Head Neck Surg 2021 May 6. Epub 2021 May 6.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Voice and speech production are critical physiological functions that affect quality of life and may deteriorate substantially after oropharyngeal cancer (OPC) treatment. There is limited knowledge about risk factors associated with voice and speech outcomes among survivors of OPC.

Objective: To identify the risk factors of voice and speech symptoms among long-term survivors of OPC. Read More

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Negative pressure wound therapy does not decrease postoperative wound complications in patients undergoing mastectomy and flap fixation.

Sci Rep 2021 May 5;11(1):9620. Epub 2021 May 5.

Department of Surgery, Zuyderland Medical Center, Postbus 5500, 6130 MB, Sittard, The Netherlands.

Patients and breast cancer surgeons are frequently confronted with wound complications after mastectomy. Negative pressure wound therapy (NPWT) is a promising technique for preventing wound complications after skin closure in elective surgery. However, a clinical study evaluating postoperative complications following the use of NPWT, focusing solely on closed incisions in patients undergoing mastectomy, has yet to be performed. Read More

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Association of Rare Genetic Variants and Early-Onset Atrial Fibrillation in Ethnic Minority Individuals.

JAMA Cardiol 2021 May 5. Epub 2021 May 5.

Department of Medicine, University of Illinois at Chicago.

Importance: Although rare variants in cardiac ion channels, transcription factors, and myocardial structural proteins are associated with early-onset atrial fibrillation (AF) in White individuals of European descent, it remains unclear whether genetic variation also contributes to the cause of AF in those of minority ethnicity.

Objectives: To assess the prevalence of rare and novel pathogenic variants in candidate genes in ethnic minority probands with early-onset AF and determine genotype-phenotype associations.

Design, Setting, And Participants: In this cohort, family-based study, probands of African and Hispanic descent with early-onset AF (defined as AF occurring in individuals aged ≤66 years) prospectively enrolled in a clinical and genetic biorepository underwent sequencing of 60 candidate genes. Read More

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α2-Adrenergic Agonists or Stimulants for Preschool-Age Children With Attention-Deficit/Hyperactivity Disorder.

JAMA 2021 May 4. Epub 2021 May 4.

Perelman School of Medicine at University of Pennsylvania.

Importance: Attention-deficit/hyperactivity disorder (ADHD) is diagnosed in approximately 2.4% of preschool-age children. Stimulants are recommended as first-line medication treatment. Read More

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A severity-of-illness score in patients with tuberculosis requiring intensive care.

S Afr Med J 2021 Mar 2;111(3):245-249. Epub 2021 Mar 2.

Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

Background: We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of tuberculosis (TB) in the intensive care unit (ICU). Parameters included septic shock, HIV infection with a CD4 count <200 cells/µL, renal dysfunction, a ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (P/F) <200 mmHg, a chest radiograph demonstrating diffuse parenchymal infiltrates, and no TB treatment on admission.

Objectives: To prospectively validate the severity-of-illness scoring system in patients with TB requiring intensive care, and to refine and simplify the score in order to expand its clinical utility. Read More

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Human Papillomavirus, Related Diseases, and Vaccination: Knowledge and Awareness Among Health Care Students and Professionals in Nepal.

J Cancer Educ 2021 May 3. Epub 2021 May 3.

Department of Epidemiology, School of Public Health, University of Alabama At Birmingham, 1665 University Blvd, Birmingham, AL, 35294-0022, USA.

Human papillomavirus (HPV) is a common sexually transmitted disease worldwide. While burden of HPV-associated cancers and mortality is higher in low-income countries, there is limited data about knowledge of it among health care students and professionals. We assessed awareness and knowledge of HPV, its related diseases, and HPV vaccine among 333 participants, composed of 146 medical students (MSs) and professionals (MPs) and 187 nursing students (NSs) and professionals (NPs) using a 40-question survey between July 2018 and February 2019. Read More

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Association Between Income Inequality and County-Level COVID-19 Cases and Deaths in the US.

JAMA Netw Open 2021 05 3;4(5):e218799. Epub 2021 May 3.

Department of Epidemiology and Population Health, Stanford University, Stanford, California.

Importance: Socioeconomically marginalized communities have been disproportionately affected by the COVID-19 pandemic. Income inequality may be a risk factor for SARS-CoV-2 infection and death from COVID-19.

Objective: To evaluate the association between county-level income inequality and COVID-19 cases and deaths from March 2020 through February 2021 in bimonthly time epochs. Read More

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An Initiative to Improve Timely Glucocorticoid Tapering in Vasculitis.

J Clin Rheumatol 2021 Apr 27. Epub 2021 Apr 27.

From the Lupus and Vasculitis Clinic, Division of Rheumatology, McGill University Health Centre, Montreal, Quebec Division of Rheumatology, Vancouver General Hospital, Vancouver, British Columbia Division of Rheumatology, Sunnybrook Health Sciences Centre Vasculitis Clinic, Division of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background/objective: High-dose glucocorticoids (GCs) are required in the initial treatment of systemic vasculitis. However, slow or delayed tapering can lead to unnecessary GC exposure and toxicity. In this quality improvement initiative, we aimed to increase appropriate GC tapering among newly referred patients awaiting specialty consultation at a tertiary vasculitis clinic. Read More

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Comparison of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Biopsy Device for Lymphadenopathy.

Gastroenterol Res Pract 2021 15;2021:6640862. Epub 2021 Apr 15.

Department of Gastroenterology, Saitama Medical University International Medical Center, Japan.

Background: Accurate diagnosis of benign and malignant lymphadenopathy is important for determining the appropriate treatment and prognosis. This study evaluated the diagnostic accuracy and usefulness of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a conventional needle compared to endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) with a Franseen needle for diagnosing lymphadenopathy.

Methods: Patients who underwent EUS-FNA or EUS-FNB for mediastinal or abdominal lymphadenopathy between July 2013 and August 2020 were enrolled in the study. Read More

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The impact of helicopter emergency medical services and craniocervical traction on the early reduction of cervical spine dislocation in a rural area of Japan.

J Orthop Sci 2021 Apr 28. Epub 2021 Apr 28.

The Department of Orthopaedic Surgery, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Background: Several studies have shown an association between achieving decompression of the spinal cord within a few hours and neurological recovery, even in patients with complete paralysis due to cervical spine dislocation. This study aimed to clarify the impact of helicopter emergency medical services (HEMSs) and craniocervical traction on the rapid reduction of lower cervical spine dislocation in rural Japan.

Methods: The success rate of and factors inhibiting closed reduction, the time from injury to reduction and the functional prognosis of lower cervical spine dislocations treated between July 2012 and February 2020 were retrospectively analysed. Read More

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A six-week healthy eating intervention with family engagement improves food knowledge and preferences but not dietary diversity among urban preschool children in Sri Lanka.

Public Health Nutr 2021 Apr 30:1-22. Epub 2021 Apr 30.

Public Health, School of Medicine, Griffith University, Gold Coast, QLD 4222,

Objective: To evaluate the effectiveness of a multicomponent intervention (MCI) on children's dietary diversity and its impact pathway components of children's food knowledge and healthy food preferences.

Design: A six-week cluster randomised controlled trial with a MCI consisting of child nutrition education plus family engagement, through parental nutrition education, meal preparation and tasting was compared with two groups: single component intervention (SCI) of child nutrition education, and control, conducted during February to July 2018. Preschool centres were randomly assigned to one of the three arms. Read More

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Childbirth Care among SARS-CoV-2 Positive Women in Italy.

Int J Environ Res Public Health 2021 04 16;18(8). Epub 2021 Apr 16.

Servizio Assistenza Territoriale, Direzione Generale Cura Della Persona, Salute e Welfare, Emilia-Romagna Region, 40127 Bologna, Italy.

The new coronavirus emergency spread to Italy when little was known about the infection's impact on mothers and newborns. This study aims to describe the extent to which clinical practice has protected childbirth physiology and preserved the mother-child bond during the first wave of the pandemic in Italy. A national population-based prospective cohort study was performed enrolling women with confirmed SARS-CoV-2 infection admitted for childbirth to any Italian hospital from 25 February to 31 July 2020. Read More

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Contemporary Neoadjuvant Therapies for High-Risk Melanoma: A Systematic Review.

Cancers (Basel) 2021 Apr 15;13(8). Epub 2021 Apr 15.

Division of General Surgery, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.

Despite advances in adjuvant immuno- and targeted therapies, the risk of relapse for stage III melanoma remains high. With 43 active entries on clinicaltrials.gov (8 July 2020), there is a surge of interest in the role of contemporary therapies in the neoadjuvant setting. Read More

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Modeling the Potential Future Distribution of Anthrax Outbreaks under Multiple Climate Change Scenarios for Kenya.

Int J Environ Res Public Health 2021 Apr 15;18(8). Epub 2021 Apr 15.

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL 32611, USA.

The climate is changing, and such changes are projected to cause global increase in the prevalence and geographic ranges of infectious diseases such as anthrax. There is limited knowledge in the tropics with regards to expected impacts of climate change on anthrax outbreaks. We determined the future distribution of anthrax in Kenya with representative concentration pathways (RCP) 4. Read More

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A Mars Environment Chamber Coupled with Multiple In Situ Spectral Sensors for Mars Exploration.

Sensors (Basel) 2021 Apr 4;21(7). Epub 2021 Apr 4.

Shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment, School of Space Science and Physics, Institute of Space Sciences, Shandong University, Weihai 264209, China.

Laboratory simulation is the only feasible way to achieve Martian environmental conditions on Earth, establishing a key link between the laboratory and Mars exploration. The mineral phases of some Martian surface materials (especially hydrated minerals), as well as their spectral features, are closely related to environmental conditions. Therefore, Martian environment simulation is necessary for Martian mineral detection and analysis. Read More

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Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria.

Int J Environ Res Public Health 2021 04 5;18(7). Epub 2021 Apr 5.

Danube Hospital, A-1220 Vienna, Austria.

The COVID 19 pandemic represents a major stress factor for non-infected pregnant women. Although maternal stress during pregnancy increases the risk of preterm birth and intrauterine growth restriction, an increasing number of studies yielded no negative effects of COVID 19 lockdowns on pregnancy outcome. The present study focused on pregnancy outcome during the first COVID 19 lockdown phase in Austria. Read More

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Efficacy and Safety of Niraparib as Maintenance Treatment in Patients with Extensive-Stage Small Cell Lung Cancer after First-Line Chemotherapy: A Randomized, Double-Blind, Phase 3 Study.

J Thorac Oncol 2021 Apr 26. Epub 2021 Apr 26.

The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Introduction: ZL-2306-005 is a randomized, double-blind, multicenter phase 3 study evaluating the efficacy and safety of niraparib, a poly(ADP-ribose) polymerase inhibitor, as first-line maintenance therapy in Chinese patients with platinum-responsive, extensive-stage small cell lung cancer (ES-SCLC).

Methods: Patients with complete/partial response (CR/PR) to standardized, platinum-based first-line chemotherapy were randomized 2:1 to receive niraparib or placebo (300 mg [baseline body weight ≥77 kg, platelet count ≥150,000/μL] or 200 mg) once daily until progression or unacceptable toxicity. Primary endpoints were progression-free survival (PFS) (blinded independent central review, BICR) and overall survival (OS) (sample size planned: 591 patients). Read More

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Perinatal outcomes of the antenatally diagnosed omphalocele cases: a single tertiary center experience.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Department of Obstetrics and Gynecology, Çukurova University, School of Medicine, Adana, Turkey.

Objectives: To evaluate the perinatal outcomes of antenatally diagnosed omphalocele cases.

Material And Methods: This was a retrospective study conducted between July 2014 and February 2020 at the prenatal diagnosis center of a university clinic. Gestational week of diagnosis, associated anomalies, karyotype analysis results, complications during pregnancy, termination/delivery characteristics, and postnatal results were evaluated. Read More

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Development of an Emergency Department-Based Intervention to Expand Access to Medications for Opioid Use Disorder in a Medicaid Nonexpansion Setting: Protocol for Engagement and Community Collaboration.

JMIR Res Protoc 2021 Apr 29;10(4):e18734. Epub 2021 Apr 29.

Department of Emergency Medicine, Vanderbilt University, Nashville, TN, United States.

Background: The opioid epidemic has disproportionately impacted areas in the Appalachian region of the United States. Characterized by persistent Medicaid nonexpansion, higher poverty rates, and health care access challenges, populations residing in these areas of the United States have experienced higher opioid overdose death rates than those in other parts of the country. Jefferson County, Alabama, located in Southern Appalachia, has been especially affected, with overdose rates over 2 times greater than the statewide average (48. Read More

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Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial.

Trials 2021 Apr 28;22(1):309. Epub 2021 Apr 28.

Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Objectives: The aim of this trial is to evaluate the antiviral efficacy, clinical efficacy, and safety of nelfinavir in patients with asymptomatic and mild COVID-19.

Trial Design: The study is designed as a multicenter, open-label, blinded outcome assessment, parallel group, investigator-initiated, exploratory, randomized (1:1 ratio) controlled clinical trial.

Participants: Asymptomatic and mild COVID-19 patients will be enrolled in 10 university and teaching hospitals in Japan. Read More

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Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19.

Arterioscler Thromb Vasc Biol 2021 Apr 29:ATVBAHA120315698. Epub 2021 Apr 29.

Department of Cardiology and Angiology, University Hospital Tuebingen, Eberhard Karls University Tuebingen, Germany. (C.L., A.-K.R., S.G., Á.P.-U., P.J., A.A., T.H., K.-P.K., T.C., D.R., M.P.G., K.A.L.M.).

Objective: Patients with coronary artery disease (CAD) are at increased risk for cardiac death and respiratory failure following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Platelets are crucially involved in pathogenesis of CAD and might also contribute to pathophysiology of SARS-CoV-2 infection. Approach and Results: We enrolled a cohort of 122 participants from February 2020 to July 2020 including 55 patients with preexisting CAD and acute SARS-CoV-2 infection (CAD-SARS-CoV-2), 28 patients with CAD and without SARS-CoV-2 (CAD-SARS-CoV-2), and 39 healthy controls. Read More

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Equivalent outcomes with minimally invasive and sternotomy mitral valve repair for degenerative mitral valve disease.

J Card Surg 2021 Apr 28. Epub 2021 Apr 28.

Department of Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.

Background: Debate continues in regard to the optimal surgical approach to the mitral valve for degenerative disease.

Methods: Between February 2004 and July 2015, 363 patients underwent mitral valve repair for degenerative mitral valve disease via either sternotomy (sternotomy, n = 109) or small right anterior thoracotomy (minimally invasive, n = 259). Survival, need for mitral valve reoperation, and progression of mitral regurgitation more than two grades were compared between cohorts using time-based statistical methods and inverse probability weighting. Read More

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The association between white matter changes and development of malignant middle cerebral artery infarction: A case-control study.

Medicine (Baltimore) 2021 Apr;100(17):e25751

Department of Neurology.

Abstract: Disrupted blood-brain barrier (BBB) in patients with ischemic stroke plays a critical role in malignant middle cerebral artery infarction (MMI) development.Cerebral white matter changes (WMC), particularly in the deep subcortical area or in severe one, may be also underlain by disrupted BBB. It is unclear whether the presence of WMC with potential premorbid disruption of BBB makes patients susceptible to MMI. Read More

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Changes in decision-making process for life-sustaining treatment in patients with advanced cancer after the life-sustaining treatment decisions-making act.

BMC Palliat Care 2021 Apr 27;20(1):63. Epub 2021 Apr 27.

Division of Hematology-Oncology, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, 877, Bangeojinsunhwando-ro, Dong-gu, 44033, Ulsan, Republic of Korea.

Background: Cancer is a leading cause of death in Korea. To protect the autonomy and dignity of terminally ill patients, the Life-Sustaining Treatment Decision-Making Act (LST-Act) came into full effect in Korea in February 2018. However, it is unclear whether the LST-Act influences decision- making process for life-sustaining treatment (LST) for terminally ill cancer patients. Read More

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Implementing capnography to help improve patient safety during procedural sedation: quality improvement in a high-volume gastroenterology department.

Eur J Gastroenterol Hepatol 2021 Apr 19. Epub 2021 Apr 19.

aDepartment of Gastroenterology and Hepatology, UZ Leuven, Belgium bCoreva Scientific, Königswinter, Germany cDepartment of Pneumology dDepartment of Pediatrics, UZ Leuven, Belgium eMedasense Biometrics, Raman Gat fAt the time of writing at Medtronic, Jerusalem, Israel.

Objective: Respiratory compromise is a major cause of adverse events during procedural sedation; continuous monitoring is vital for identifying and halting decompensation. We performed a quality improvement investigation to assess patient safety during procedural sedation in gastroenterology and the impact of implementing capnography monitoring.

Patients And Methods: Sedation-related adverse events and interventions were prospectively recorded during the endoscopic procedure and in recovery. Read More

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[DNM1L gene variant caused encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1: three cases report and literature review].

Zhonghua Er Ke Za Zhi 2021 May;59(5):400-406

Department of Pediatrics, Hunan Intellectual and Developmental Disabilities Research Center, Xiangya Hospital of Central South University, Changsha 410008, China.

To investigate the clinical characteristics of R403C variant in DNM1L gene caused encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 (EMPF1). The clinical data of three patients, who carried R403C variant in the DNM1L gene, diagnosed at Xiangya Hospital from February 2018 to February 2020 were retrospectively summarized. Literature reviewing was performed by taking "DNM1L" or "encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1" as keywords for searching in online Mendelian inheritance in man (OMIM), PubMed, China national knowledge infrastructure (CNKI), and Wanfang data knowledge service platform up to July 2020. Read More

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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform.

J Vis Exp 2021 Apr 12(170). Epub 2021 Apr 12.

Department of Nephrology and internal intensive Care, Charité Universitätsmedizin Berlin;

The MACCS (Medical Assistant for Chronic Care Service) platform enables secure sharing of key medical information between patients after kidney transplantation and physicians. Patients provide information such as vital signs, well-being, and medication intake via smartphone apps. The information is transferred directly into a database and electronic health record at the kidney transplant center, which is used for routine patient care and research. Read More

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A Web-Based Lifestyle Intervention Aimed at Improving Cognition in Patients With Cancer Returning to Work in an Outpatient Setting: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2021 Apr 26;10(4):e22670. Epub 2021 Apr 26.

Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: A high percentage of patients with cancer experience cognitive impairment after cancer treatment, resulting in a decreased health-related quality of life and difficulty returning to work. Consequently, there is a need for effective treatment options to improve cognitive functioning in these patients. In a healthy aging population, multidomain web-based lifestyle interventions have been found to be effective in preventing cognitive decline and improving cognitive functioning. Read More

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Betalactam hypersensitivity: the importance of delabeling in primary care.

Br J Clin Pharmacol 2021 Apr 25. Epub 2021 Apr 25.

Department of Pharmacology, University Hospital of Fattouma Bourguiba Monastir, Tunisia.

The aim of the present study was to assess the outcomes of an allergy work up of patients with a penicillin allergy label by primary care.

Patients And Methods: An allergy work up was performed on adult patients with a history of a penicillin allergy seen by primary medical care in Monastir (Tunisia) between July 2016 and February 2018. Patients with negative skin tests (ST) were challenged with amoxicillin. Read More

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