14,076 results match your criteria february 2015


Predicting related factors of immunological response to hepatitis B vaccine in hemodialysis patients based on integration of decision tree classification and logistic regression.

Hum Vaccin Immunother 2021 May 14:1-7. Epub 2021 May 14.

Chinese Preventive Medicine Association, Beijing, China.

The non/hypo-response rate of the hepatitis B vaccine among hemodialysis (HD) patients is still high, it is of great significance to explore the influencing factors and their relationships. To study the related factors and their relationships using logistic regression model and Chi-squared Automatic Interaction Detection (CHAID) decision tree model. A randomized controlled trial was conducted between February 2014 and May 2015 in China. Read More

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Factors Predisposing to Survival After Resuscitation for Sudden Cardiac Arrest.

J Am Coll Cardiol 2021 May;77(19):2353-2362

Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California-San Francisco, San Francisco, California, USA. Electronic address:

Background: In the POST SCD study, the authors autopsied all World Health Organization (WHO)-defined sudden cardiac deaths (SCDs) and found that only 56% had an arrhythmic cause; resuscitated sudden cardiac arrests (SCAs) were excluded because they did not die suddenly. They hypothesized that causes underlying resuscitated SCAs would be similarly heterogeneous.

Objectives: The aim of this study was to determine the causes and outcomes of resuscitated SCAs. Read More

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Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital.

JAMA Netw Open 2021 May 3;4(5):e219820. Epub 2021 May 3.

Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina.

Importance: Penicillin allergies are frequently mislabeled, which may contribute to use of less-preferred alternative antibiotics.

Objective: To evaluate a pharmacist-led allergy assessment program's association with antimicrobial use and clinical outcomes.

Design, Setting, And Participants: A pharmacist-led allergy assessment program was launched in 2 phases (June 1, 2015, and November 2, 2016) at a single-center tertiary referral hospital. Read More

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Clinical Features and Management of Stenotrophomonas Maltophilia Keratitis.

Ophthalmol Ther 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology, Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju, Republic of Korea.

Introduction: Stenotrophomonas maltophilia keratitis is an uncommon infectious disease of the cornea. The clinical features, antibiotic susceptibility, and clinical outcomes of S. maltophilia keratitis were investigated in this study. Read More

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Evaluating the Impact of Provider Type and Patient Diagnosis on Patient No-Shows to Vascular Clinic.

WMJ 2021 Apr;120(1):41-44

Department of Surgery, Michael E. DeBakey VA Medical Center, Houston, Texas.

Background: No-shows are a source of burden that lead to wasted resources. While prior research has established that many patient-level affect impact no-show rates, the impact of referring provider-level factors, in particular the type of referring provider-and specific diagnosis are still largely unknown.

Materials And Methods: Retrospective chart review examining new patient consults scheduled for outpatient vascular surgery clinic from August 1, 2014 through February 28, 2015 was conducted. Read More

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Methodological considerations in the assessment of direct and indirect costs of back pain: A systematic scoping review.

PLoS One 2021 11;16(5):e0251406. Epub 2021 May 11.

Health Economics Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, England, United Kingdom.

Background: Back pain is a common and costly health problem worldwide. There is yet a lack of consistent methodologies to estimate the economic burden of back pain to society.

Objective: To systematically evaluate the methodologies used in the published cost of illness (COI) literature for estimating the direct and indirect costs attributed to back pain, and to present a summary of the estimated cost burden. Read More

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First report of a ' Phytoplasma aurantifolia'-related strain (16SrII-V) associated with phyllody, virescence, and shoot proliferation of sweet William () in Taiwan.

Plant Dis 2021 May 11. Epub 2021 May 11.

National Chung Hsing University, 34916, Department of Plant Pathology, Taichung, Taiwan.

The sweet William () is an ornamental belonging to the Caryophyllaceae family; the species produces clusters of flowers that comes in various colors and is grown commonly as garden plants (Lim 2014). In February 2021, sweet Williams showing symptoms typical of phytoplasma diseases were found in a garden located in Wufeng District, Taichung, Taiwan (24°04'37.6"N 120°43'20. Read More

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Drug sellers' knowledge and practices, and client perspectives after an intervention to improve the quality of safe abortion care outside of formal clinics in Nigeria.

BMJ Sex Reprod Health 2021 May 10. Epub 2021 May 10.

Abuja, Nigeria.

Background: In Nigeria, where abortion is legally restricted, individuals seek medication abortion drugs, including misoprostol, directly from pharmacies or drug sellers. However, knowledge of drug sellers or patent medicine vendors (PMVs) dispensation practices and women's experience with self-management is limited and research suggests poor quality of services. This study assesses the knowledge and practices of PMVs and women's experiences after a harm reduction intervention to improve the provision of medication abortion using misoprostol. Read More

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The epidemiology of amoebiasis in Thi-Qar province, Iraq (2015-2020): Differentiation of Entamoeba histolytica/Entamoeba dispar using nested PCR and real-time PCR.

Epidemiol Health 2021 May 6:e2021034. Epub 2021 May 6.

Bint Al-Huda Maternity and Children Teaching Hospital, Thi-Qar Health Office, Nasiriyah 64001, Iraq.

Objectives: The objective was to evaluate the present status of amoebiasis in Thi-Qar province, south of Iraq. As well a determination of Entamoeba histolytica and Entamoeba dispar prevalence with nested and real time PCR.

Methods: Epidemiological data was taken from public health department/ Thi-Qar Health Office (2015-2020). Read More

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Preeclampsia Prevalence, Risk Factors, and Pregnancy Outcomes in Sweden and China.

JAMA Netw Open 2021 May 3;4(5):e218401. Epub 2021 May 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Importance: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. Within-country studies have reported racial differences in the presentation and outcome, but little is known about differences between countries.

Objective: To compare preeclampsia prevalence, risk factors, and pregnancy outcomes between the Swedish and Chinese populations. Read More

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Molecular epidemiology, natural history and long-term outcomes of multi-drug resistant Enterobacterales colonization and infections among solid organ transplant recipients.

Clin Infect Dis 2021 May 10. Epub 2021 May 10.

University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Multidrug-resistant Enterobacterales (MDR-E), including carbapenem-resistant and third-generation cephalosporin-resistant Enterobacterales (CRE, CefR-E), are major pathogens following solid organ transplantation (SOT).

Methods: We prospectively studied patients who underwent lung, liver and small bowel transplant from February 2015-March 2017. Weekly peri-rectal swabs (up to 100 days post-transplant) were cultured for MDR-E. Read More

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Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.

JAMA Neurol 2021 May 10. Epub 2021 May 10.

Department of Neurology, University of California, Irvine, Irvine.

Importance: N-glycan branching modulates cell surface receptor availability, and its deficiency in mice promotes inflammatory demyelination, reduced myelination, and neurodegeneration. N-acetylglucosamine (GlcNAc) is a rate-limiting substrate for N-glycan branching, but, to our knowledge, endogenous serum levels in patients with multiple sclerosis (MS) are unknown.

Objective: To investigate a marker of endogenous serum GlcNAc levels in patients with MS. Read More

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IgG4-Related Disease With Tuberculosis: A Case Report and Retrospective Review of Patients in a Single Center.

Front Immunol 2021 21;12:652985. Epub 2021 Apr 21.

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.

Background: IgG4-related disease (IgG4-RD) is a recently recognized systemic fibro-inflammatory disease of unknown cause involving many organs including pancreas, salivary glands, and lymph nodes. Chronic tuberculosis (TB) infection has been reported in IgG4-RD, but the prevalence of TB infection has not been evaluated in IgG4-RD.

Methods: Characterization of a patient with IgG4-RD by physical examination, laboratory tests, magnetic resonance imaging (MRI) and histological examination. Read More

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Bibliometric Analysis of Global Research Trends on Ultrasound Microbubble: A Quickly Developing Field.

Front Pharmacol 2021 22;12:646626. Epub 2021 Apr 22.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Microbubbles are widely used as highly effective contrast agents to improve the diagnostic capability of ultrasound imaging. Mounting evidence suggests that ultrasound coupled with microbubbles has promising therapeutic applications in cancer, cardiovascular, and neurological disorders by acting as gene or drug carriers. The aim of this study was to identify the scientific output and activity related to ultrasound microbubble through bibliometric approaches. Read More

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Bacterial Flora in the Sphenoid Sinus Changes with Perioperative Prophylactic Antibiotic Administration.

Neurol Med Chir (Tokyo) 2021 May 8. Epub 2021 May 8.

Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical School.

The complications of endonasal transsphenoidal surgery (ETSS) include meningitis and sinusitis, and these complications are troublesome. Some reports have investigated the type of bacteria and the susceptibility of sphenoid sinus mucosal flora to drugs. However, most specimens can be collected after perioperative antibiotic administration. Read More

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[Clinical Features of Neuromyelitis Optica Spectrum Disorders with Connective Tissue Diseases].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):159-165

Department of Neurology,The Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian 362000,China.

Objective To investigate the clinical features of neuromyelitis optica spectrum disorders(NMOSD)with connective tissue diseases(CTD). Methods Clinical data of 16 NMOSD-CTD patients and 54 NMOSD patients admitted to the Second Affiliated Hospital of Fujian Medical University from January 2015 to February 2020 were collected.The initial symptom,intracranial lesion,spinal cord lesion,laboratory examination and treatment response were compared between the two groups. Read More

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Red blood cell distribution width is associated with frailty in older inpatients in China: Sex differences in a cross-sectional study.

Exp Gerontol 2021 May 6;150:111392. Epub 2021 May 6.

Department of Nursing, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Aims: Although some studies have investigated an association between inflammatory marker and frailty, little is known about the relationship of red blood cell volume distribution width (RDW) and frailty. This study aimed to determine whether there were sex-specific associations of RDW and frailty among older hospitalized patients.

Methods: A cross-sectional study was conducted in a comprehensive tertiary hospital in mainland China between February 2015 and November 2017. Read More

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Securing a sustainable and fit-for-purpose UK health and care workforce.

Lancet 2021 May 6. Epub 2021 May 6.

Department of Health Policy, London School of Economics and Political Science, London, UK.

Approximately 13% of the total UK workforce is employed in the health and care sector. Despite substantial workforce planning efforts, the effectiveness of this planning has been criticised. Education, training, and workforce plans have typically considered each health-care profession in isolation and have not adequately responded to changing health and care needs. Read More

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Combination anti-PD1 and ipilimumab therapy in patients with advanced melanoma and pre-existing autoimmune disorders.

J Immunother Cancer 2021 May;9(5)

Department of Medical Oncology, Westmead and Blacktown Hospital, New South Wales, New South Wales, Australia

Background: Clinical trials of immunotherapy have excluded patients with pre-existing autoimmune disease. While the safety and efficacy of single agent ipilimumab and anti-PD1 antibodies in patients with autoimmune disease has been examined in retrospective studies, no data are available for combination therapy which has significantly higher toxicity risk. We sought to establish the safety and efficacy of combination immunotherapy for patients with advanced melanoma and pre-existing autoimmune diseases. Read More

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Education With Therapeutic Alliance Did Not Influence the Improvement of Symptoms of Patients With Chronic Low Back Pain and Low Risk of Poor Prognosis Compared to Education Without Therapeutic Alliance: A Randomized Controlled Trial.

J Orthop Sports Phys Ther 2021 May 7:1-26. Epub 2021 May 7.

Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.

Objectives: To assess the effectiveness of an educational intervention with or without the addition of the therapeutic alliance in patients with nonspecific chronic low back pain (LBP) and low risk of poor prognosis.

Design: Randomized controlled trial. Randomization was performed using random generated numbers. Read More

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Comparison of Treatments for Cocaine Use Disorder Among Adults: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 May 3;4(5):e218049. Epub 2021 May 3.

Department of Neurosurgery, Stanford University, Stanford, California.

Importance: In the US and the United Kingdom, cocaine use is the second leading cause of illicit drug overdose death. Psychosocial treatments for cocaine use disorder are limited, and no pharmacotherapy is approved for use in the US or Europe.

Objective: To compare treatments for active cocaine use among adults. Read More

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Association of Risk Factors With Patient-Reported Voice and Speech Symptoms Among Long-term Survivors of Oropharyngeal Cancer.

JAMA Otolaryngol Head Neck Surg 2021 May 6. Epub 2021 May 6.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Voice and speech production are critical physiological functions that affect quality of life and may deteriorate substantially after oropharyngeal cancer (OPC) treatment. There is limited knowledge about risk factors associated with voice and speech outcomes among survivors of OPC.

Objective: To identify the risk factors of voice and speech symptoms among long-term survivors of OPC. Read More

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Association of Rare Genetic Variants and Early-Onset Atrial Fibrillation in Ethnic Minority Individuals.

JAMA Cardiol 2021 May 5. Epub 2021 May 5.

Department of Medicine, University of Illinois at Chicago.

Importance: Although rare variants in cardiac ion channels, transcription factors, and myocardial structural proteins are associated with early-onset atrial fibrillation (AF) in White individuals of European descent, it remains unclear whether genetic variation also contributes to the cause of AF in those of minority ethnicity.

Objectives: To assess the prevalence of rare and novel pathogenic variants in candidate genes in ethnic minority probands with early-onset AF and determine genotype-phenotype associations.

Design, Setting, And Participants: In this cohort, family-based study, probands of African and Hispanic descent with early-onset AF (defined as AF occurring in individuals aged ≤66 years) prospectively enrolled in a clinical and genetic biorepository underwent sequencing of 60 candidate genes. Read More

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Prevalence of Frailty and Associations with Oral Anticoagulant Prescribing in Atrial Fibrillation.

J Gen Intern Med 2021 May 4. Epub 2021 May 4.

Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Frailty is often cited as a factor influencing oral anticoagulation (OAC) prescription in patients with non-valvular atrial fibrillation (NVAF). We sought to determine the prevalence of frailty and its association with OAC prescription in older veterans with NVAF.

Methods: We used ICD-9 codes in Veterans Affairs (VA) records and Medicare claims data to identify patients with NVAF and CHADSVASC ≥2 receiving care between February 2010 and September 2015. Read More

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Resilience and related factors as predictors of relapse risk in patients with substance use disorder: a cross-sectional study.

Subst Abuse Treat Prev Policy 2021 May 4;16(1):40. Epub 2021 May 4.

Department of Nursing, Faculty of Human Health Sciences, Niimi University, Niimi, Japan.

Background: Resilience, referring to the inherent ability to naturally recover in the face of adverse conditions, is an essential concept in discussions of substance use disorder (SUD) recovery. This study's objective was to shed light on resilience and related factors that affect relapse risk in patients with SUDs.

Method: Fifty-two patients with SUDs were given a self-administrated questionnaire from February to April 2015 consisting of question items for sociodemographic characteristics, relapse risk (Stimulant Relapse Risk Scale), and resilience (Bidimensional Resilience Scale). Read More

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Distribution of Pathogen Resources by the National Culture Collection for Pathogens in South Korea from 2015 to 2019.

Biopreserv Biobank 2021 May 4. Epub 2021 May 4.

Division of Pathogen Resource Management, Center for Public Vaccine Development and Support, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, South Korea.

The National Culture Collection for Pathogens (NCCP) in the Korea Disease Control and Prevention Agency (KDCA) is in charge of the collection, quality control, and commercialization of pathogens and of information on pathogens that cause infectious diseases, and distributes them to be utilized for promoting public health and the health care industry. Since the NCCP Task Force was established in 2009 and the law for collection, management, and exploitation of pathogen resources became effective in 2017, NCCP has been responsible for the deposition, registration, and preservation of pathogen resources. Herein, we provide information on the recent status of pathogen resource distribution over the past 5 years and pathogen resources that are available for distribution presently. Read More

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A severity-of-illness score in patients with tuberculosis requiring intensive care.

S Afr Med J 2021 Mar 2;111(3):245-249. Epub 2021 Mar 2.

Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

Background: We previously retrospectively validated a 6-point severity-of-illness score aimed at identifying patients at risk of dying of tuberculosis (TB) in the intensive care unit (ICU). Parameters included septic shock, HIV infection with a CD4 count <200 cells/µL, renal dysfunction, a ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (P/F) <200 mmHg, a chest radiograph demonstrating diffuse parenchymal infiltrates, and no TB treatment on admission.

Objectives: To prospectively validate the severity-of-illness scoring system in patients with TB requiring intensive care, and to refine and simplify the score in order to expand its clinical utility. Read More

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Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.

Med Gas Res 2021 Jul-Sep;11(3):104-109

Faculty of Environment and Information Studies, Keio University, Fujisawa, Japan.

Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology is needed to further mitigate IMRT-induced bone marrow damage. Molecular hydrogen (H) was recently reported as a preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) and peroxynitrite (ONOO). Read More

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Optimal Timing of Endoscopic Intervention After Extracorporeal Shock-Wave Lithotripsy in the Treatment of Chronic Calcified Pancreatitis.

Pancreas 2021 Apr;50(4):633-638

Department of Gastroenterology, the Second People's Hospital of Karamay, Karamay, Xinjiang Uygur Autonomous Region, China.

Objectives: The interval between extracorporeal shock-wave lithotripsy (ESWL) and endoscopic retrograde cholangiopancreatography (ERCP) may cause differences in cannulation and stone removal. This study was to investigate the optimal timing of ERCP after ESWL.

Methods: Patients with chronic calcified pancreatitis, who underwent ESWL and subsequent ERCP in Changhai Hospital from February 2012 to February 2015, were retrospectively analyzed. Read More

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