Curr Med Chem 2021 Apr 19. Epub 2021 Apr 19.
Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, Marseille, F-13009, France. CNRS, UMR7258, Marseille, F-13009, France. Institut Paoli-Calmettes, Marseille, F-13009, France. Aix-Marseille University, UM 105, F-13284, Marseille. France.
Background: Despite continued efforts to develop new treatments, there is an urgent need to discover new drug leads to treat tumours exhibiting primary or secondary resistance to exiting drugs. Cell cultures derived from patient-derived orthotopic xenografts are promising pre-clinical models to better predict drug response in cancer recurrence.
Objective: The aim of the study was to investigate the relationship between the physiochemical properties of drugs and their in vitro potency as well as identifying chemical scaffolds biased towards selectivity or promiscuity of such drugs. Read More