2,353 results match your criteria features osteosarcoma

Machine learning-based CT radiomics features for the prediction of pulmonary metastasis in osteosarcoma.

Br J Radiol 2021 Jun 11:20201391. Epub 2021 Jun 11.

Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo and Department of Orthopedic surgery, University of Missouri health Care, Columbia, Missouri.

Objective: This study aims to build machine learning-based CT radiomic features to predict patients developing metastasis after osteosarcoma diagnosis.

Methods And Materials: This retrospective study has included 81 patients with a histopathological diagnosis of osteosarcoma. The entire dataset was divided randomly into training (60%) and test sets (40%). Read More

View Article and Full-Text PDF

MicroRNA-340-5p inhibits the malignant phenotypes of osteosarcoma by directly targeting NRF2 and deactivating the PI3K/AKT pathway.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3661-3669

Department of Pediatrics, Yantai Maternity and Child Care Hospital, Yantaishan Hospital, Yantai, China.

Objective: The aim of the study was to examine the effects and potential mechanisms of miR-340-5p in Osteosarcoma (OS) progression.

Patients And Methods: qRT-PCR was applied to detect expressions of miR-340-5p and NRF2 mRNA. MTT and transwell assay were carried out to determine the roles of miR-340-5p in OS cells viability, invasion and migration. Read More

View Article and Full-Text PDF

Cyclin-dependent kinase 7 (CDK7) is an emerging prognostic biomarker and therapeutic target in osteosarcoma.

Ther Adv Musculoskelet Dis 2021 18;13:1759720X21995069. Epub 2021 Feb 18.

Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. South, Los Angeles, CA 90095, USA.

Background: Overexpression of cyclin-dependent kinase 7 (CDK7) is a well-known pathogenic feature of various malignancies and a sign of a more dismal prognosis. As relatively little is known about CDK7 in osteosarcoma, we elected to evaluate its expression, prognostic value, and function.

Methods: We began by analyzing the publicly available data sets on CDK7 expression, including RNA sequencing data from the and the . Read More

View Article and Full-Text PDF
February 2021

Skull Base Primary Ewing Sarcoma: A Radiological Experience of a Rare Disease in an Atypical Location.

Am J Case Rep 2021 Jun 5;22:e930384. Epub 2021 Jun 5.

Department of Radiology, School of Medical Sciences, University of Science Malaysia, Kota Bharu, Malaysia.

BACKGROUND Ewing sarcoma and primitive neuroectodermal tumor are rare tumors grouped under the spectrum of the Ewing sarcoma family of tumors. These highly malignant tumors involve the bones and commonly occur in children. Ewing sarcoma of the skull bone accounts for only 1% of all Ewing sarcomas, with primary skull base Ewing sarcoma occurring in less than 1% of cases. Read More

View Article and Full-Text PDF

Preliminary Radiogenomic Evidence for the Prediction of Metastasis and Chemotherapy Response in Pediatric Patients with Osteosarcoma Using F-FDF PET/CT, and .

Cancers (Basel) 2021 May 28;13(11). Epub 2021 May 28.

Radiological & Medico-Oncological Sciences, University of Science & Technology, Seoul 34113, Korea.

Chemotherapy response and metastasis prediction play important roles in the treatment of pediatric osteosarcoma, which is prone to metastasis and has a high mortality rate. This study aimed to estimate the prediction model using gene expression and image texture features. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) images of 52 pediatric osteosarcoma patients were used to estimate the machine learning algorithm. Read More

View Article and Full-Text PDF

Radiopacity endowed magnetic nanocomposite with hyperthermia andmineralization potential: a combinatorial therapeutic system for osteosarcoma.

Biomed Mater 2021 May 28;16(4). Epub 2021 May 28.

Department of Polymer Science and Rubber Technology, Cochin University of Science and Technology, Kochi 682022, India.

The development of clinically advanced multifaceted therapeutic materials for osteosarcoma is at the forefront of cancer research. Accordingly, this work presents the design of a multifunctional magnetic nanocomposite composed of maghemite, strontium doped hydroxyapatite and silica nanoparticles prospectively holding indispensable therapeutic features such as magnetic hyperthermia,biomineralization, sustained drug release and intrinsic radiopacity for the treatment of osteosarcoma. The optimal composition has been identified by sequentially modulating the ratio of precursors of the magnetic nanocomposite synthesized by sol-gel technique. Read More

View Article and Full-Text PDF

Pathology of pleomorphic/undifferentiated and dedifferentiated bone neoplasms.

Semin Diagn Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology and Laboratory Medicine, Division of Bone and Soft tissue, University of Miami, Sylvester Comprehensive Cancer Center, and Jackson Memorial Hospitals, Miami, FL, USA. Electronic address:

Primary malignant bone tumors are uncommon and their accurate classification requires careful correlation of clinical, radiological, and pathologic findings. It is a heterogeneous group of tumors with a wide spectrum of morphology and their biological potential can be of low- or high-grade, depending on their risk for developing metastases. Over the past several decades, the classification of bone sarcomas has remained largely constant. Read More

View Article and Full-Text PDF

Up-regulation of pro-angiogenic molecules and events does not relate with an angiogenic switch in metastatic osteosarcoma cells but to cell survival features.

Apoptosis 2021 May 22. Epub 2021 May 22.

Remodeling Processes and Cellular Niches Laboratory, Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB) - CONICET - Hospital Italiano Buenos Aires (HIBA), Instituto Universitario del Hospital Italiano (IUHI), Potosí 4240, C1199ACL, CABA, Argentina.

Osteosarcoma (OS) is the most frequent malignant bone tumor, affecting predominantly children. Metastases represent a major clinical challenge and an estimated 80% would present undetectable micrometastases at diagnosis. The identification of metastatic traits and molecules would impact in micrometastasis management. Read More

View Article and Full-Text PDF

Research models and mesenchymal/epithelial plasticity of osteosarcoma.

Cell Biosci 2021 May 22;11(1):94. Epub 2021 May 22.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

Most osteosarcomas (OSs) develop from mesenchymal cells at the bone with abnormal growth in young patients. OS has an annual incidence of 3.4 per million people and a 60-70% 5-year surviving rate. Read More

View Article and Full-Text PDF

Ewing Sarcoma Misdiagnosed as a Traumatic Hematoma: A Case from Family Practice.

Am J Case Rep 2021 May 22;22:e931843. Epub 2021 May 22.

Department of Family and Community Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

BACKGROUND Timely diagnosis of cancers is crucial, as delays can adversely affect a patient's outcome and experience. Since soft tissue hematoma is a common clinical condition following trauma, soft tissue tumors can be misdiagnosed as hematomas due to the similar clinical features. CASE REPORT A 13-year-old girl presented with a gradually expanding swelling in the left arm that developed following minor trauma. Read More

View Article and Full-Text PDF

Low-grade osteosarcoma is predominant in gnathic osteosarcomas: A report of seven cases of osteosarcoma of the jaw.

Clin Exp Dent Res 2021 May 19. Epub 2021 May 19.

Division of Diagnostic Pathology, Keio University Hospital, Tokyo, Japan.

Objective: Primary osteosarcoma of the jaw bones is very rare, and histological features of gnathic osteosarcoma remain obscure. The purpose of this study was to describe the clinicopathological features of gnathic osteosarcoma.

Materials And Methods: Seven cases of gnathic osteosarcoma from Japan diagnosed during the period between 2000 and 2016 were examined retrospectively. Read More

View Article and Full-Text PDF

Primary and radiation induced skull base osteosarcoma: a systematic review of clinical features and treatment outcomes.

J Neurooncol 2021 May 17. Epub 2021 May 17.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA.

Purpose: We aim to systematically review and summarize the demographics, clinical features, management strategies, and clinical outcomes of primary and radiation-induced skull-base osteosarcoma (SBO).

Methods: PubMed, Scopus, and Cochrane databases were used to identify relevant articles. Papers including SBO cases and sufficient clinical outcome data were included. Read More

View Article and Full-Text PDF

Correlation between Prognostic Factors and the Histopathological Response to Neoadjuvant Chemotherapy in Osteosarcoma: A Retrospective Study.

Int J Surg Oncol 2021 26;2021:8843325. Epub 2021 Apr 26.

Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: Multimodality treatment, incorporating neoadjuvant chemotherapy and adjuvant chemotherapy, is the standard management plan for osteosarcoma that increases the overall survival (OS) rate. However, data regarding prognostic factors affecting the histopathological response following neoadjuvant chemotherapy is limited. We retrospectively reviewed patients diagnosed with osteosarcoma in our center between 2008 and 2018. Read More

View Article and Full-Text PDF

Osteosarcoma (osteogenic sarcoma) of the jaws presenting in general dental practice - a series of four cases.

Br Dent J 2021 May 14;230(9):583-586. Epub 2021 May 14.

Professor of Oral and Maxillofacial Surgery, Trinity College Dublin, Dublin 2, Ireland.

Introduction Osteosarcoma is the most common primary malignant bone tumour, usually arising in the long bones, with occurrence in the head and neck accounting for 8% of all osteosarcomas. Clinical features include swelling, pain, facial dysesthesia and abnormal mobility of teeth. Treatment consists of a combination of surgery, radiotherapy and chemotherapy. Read More

View Article and Full-Text PDF

The diagnosis of pulmonary metastases on chest computed tomography in primary bone sarcoma and musculoskeletal soft tissue sarcoma.

Br J Radiol 2021 May 21:20210088. Epub 2021 May 21.

UCL Cancer Institute, 72 Huntley St, WC1E 6DD, London, UK.

The lungs are the commonest site of metastasis for primary high-grade bone and soft tissue sarcoma, but current guidelines on the management of pulmonary nodules do not specifically cater for this group of patients. The current article reviews the literature from the past 20 years that has reported the CT features of pulmonary metastases in the setting of known primary bone and soft tissue sarcoma, with emphasis on osteosarcoma, chondrosarcoma, and trunk and extremity soft tissue sarcoma, the aim being to aid radiologists who report chest CT of musculoskeletal sarcoma patients in deciding which lesions should be considered metastatic, which lesions are indeterminate and require follow-up, and which lesions are of no concern. Read More

View Article and Full-Text PDF

Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase.

Biosci Rep 2021 May 10. Epub 2021 May 10.

Harbin Medical University Cancer Hospital, Harbin, China.

Aim: Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis.

Methods: GSK3β expressions in clinical osteosarcoma tissues with or without metastasis were examined by immunohistochemical staining. Read More

View Article and Full-Text PDF

Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery.

Front Oncol 2021 22;11:673494. Epub 2021 Apr 22.

Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Extraskeletal osteosarcoma is an uncommon and high-grade soft tissue malignancy. The incidence is even lower when the lung and pulmonary artery are the primary site. The purpose of this report is to present the radiological features of this neoplasm in a 52-year-old man. Read More

View Article and Full-Text PDF

Gene Expression Classifier Reveals Prognostic Osteosarcoma Microenvironment Molecular Subtypes.

Front Immunol 2021 20;12:623762. Epub 2021 Apr 20.

Department of Musculoskeletal Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Osteosarcoma (OSA) is the most common bone malignancy and displays high heterogeneity of molecular phenotypes. This study aimed to characterize the molecular features of OSA by developing a classification system based on the gene expression profile of the tumor microenvironment. Integrative analysis was performed using specimens and clinical information for OSA patients from the TARGET program. Read More

View Article and Full-Text PDF

Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value.

J Orthop Surg Res 2021 May 5;16(1):294. Epub 2021 May 5.

Department of Orthopedics, Haian Hospital of Traditional Chinese Medicine, 55 Ninghai Middle Road, Haian, Nantong, Jiangsu Province, 226600, People's Republic of China.

Background: Osteosarcoma is a disease with high mortality in children and adolescents, and metastasis is one of the important clinical features of osteosarcoma. N6-Methyladenosine (m6A) is the most abundant methylation modification in mRNA, which is regulated by m6A regulators. It is reported that it is related to the occurrence and development of tumors. Read More

View Article and Full-Text PDF

Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases.

Breast Cancer 2021 May 3. Epub 2021 May 3.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Aims: Metaplastic breast cancer (MBC) comprises a heterogeneous group of tumors, of which MBC with osseous differentiation (MBC-OD) is extremely rare that only few cases have been reported. This study aimed to present the clinicopathologic and molecular features of MBC-OD.

Methods: We collected 6 cases of MBC-OD from five different centers and described its clinicopathologic and molecular characteristics based on the next-generation sequencing. Read More

View Article and Full-Text PDF

Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review.

Eur J Pharmacol 2021 Aug 30;904:174131. Epub 2021 Apr 30.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

The safe development of nanotechnology and usage of nanoparticles (NPs) require the cellular toxicity examination of these NPs. Systematic studies are necessary to collect related data and comparison of the physicochemical features of NPs and their effects on cellular viability on model systems. In the present study, we systematically reviewed original studies, which investigated the cytotoxic effects and apoptosis of free NPs (loaded with doxorubicin (Dox)/or methotrexate (MTX)) via in vitro models. Read More

View Article and Full-Text PDF

Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers.

Am J Physiol Cell Physiol 2021 Apr 21. Epub 2021 Apr 21.

Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan.

Cells adapt to applied cyclic stretch (CS) to circumvent chronic activation of proinflammatory signaling. Currently, the molecular mechanism of the selective disassembly of actin stress fibers (SFs) in the stretch direction, which occurs at the early stage of the cellular response to CS, remains controversial. Here we suggest that the mechanosensitive behavior of myosin II, a major cross-linker of SFs, primarily contributes to the directional disassembly of the actomyosin complex SFs in bovine vascular smooth muscle cells and human U2OS osteosarcoma cells. Read More

View Article and Full-Text PDF

Malignant Transformation of Giant Cell Tumor of Bone 7 years After Initial Surgery: A Case Report and Literature Review.

JBJS Case Connect 2021 04 20;11(2). Epub 2021 Apr 20.

Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Japan.

Case: A 64-year-old man with a history of giant cell tumor of bone (GCTB) in the fibula 7 years earlier developed a recurrence with histologic features of osteosarcoma. Both the primary GCTB and the secondary osteosarcoma were found to have the H3F3A gene mutation. Despite immediate above-the-knee amputation, the patient died of respiratory failure because of lung metastases 3 months later. Read More

View Article and Full-Text PDF

Characterizing the relationship between the chemical structures of drugs and their activities on primary cultures of pediatric solid tumors.

Curr Med Chem 2021 Apr 19. Epub 2021 Apr 19.

Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, Marseille, F-13009, France. CNRS, UMR7258, Marseille, F-13009, France. Institut Paoli-Calmettes, Marseille, F-13009, France. Aix-Marseille University, UM 105, F-13284, Marseille. France.

Background: Despite continued efforts to develop new treatments, there is an urgent need to discover new drug leads to treat tumours exhibiting primary or secondary resistance to exiting drugs. Cell cultures derived from patient-derived orthotopic xenografts are promising pre-clinical models to better predict drug response in cancer recurrence.

Objective: The aim of the study was to investigate the relationship between the physiochemical properties of drugs and their in vitro potency as well as identifying chemical scaffolds biased towards selectivity or promiscuity of such drugs. Read More

View Article and Full-Text PDF

Protuberant fibro-osseous lesion of the temporal bone: report of four cases and review of the literature.

Int J Oral Maxillofac Surg 2021 Apr 14. Epub 2021 Apr 14.

Service de Chirurgie Maxillo-faciale et Chirurgie Plastique, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Université de Paris, Paris, France.

'Bullough lesions', also referred to as protuberant fibro-osseous lesions (PFOL), are rare temporal bone lesions initially described in 1999. Since only 12 cases have been reported, several key issues, such as their origin and recommended management strategies, remain unresolved. This article reports the largest cohort included in the literature to date, comprising four patients with PFOL. Read More

View Article and Full-Text PDF

Atypical pulmonary metastases in children: the spectrum of radiologic findings.

Pediatr Radiol 2021 Apr 13. Epub 2021 Apr 13.

Pediatric Radiology Unit, Ruth Rappaport Children's Hospital, 8 HaAliya HaShniya Street, 3109601, Haifa, Israel.

Pulmonary nodules present a diagnostic challenge when they appear as atypical metastases in pediatric oncology patients. Chest computed tomography (CT) is the primary imaging modality for assessing lung nodules. In pediatric populations, Wilms tumor and osteosarcoma are the cancers most likely to produce pulmonary metastasis, both typical and atypical. Read More

View Article and Full-Text PDF

MRI-based radiomics signature for pretreatment prediction of pathological response to neoadjuvant chemotherapy in osteosarcoma: a multicenter study.

Eur Radiol 2021 Mar 30. Epub 2021 Mar 30.

Department of Radiology, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics. Guangdong Province), 183 Zhongshan Da Dao Xi, Guangzhou, 510630, Guangdong, China.

Objective: To develop and validate a radiomics signature based on magnetic resonance imaging (MRI) from multicenter datasets for preoperative prediction of pathologic response to neoadjuvant chemotherapy (NAC) in patients with osteosarcoma.

Methods: We retrospectively enrolled 102 patients with histologically confirmed osteosarcoma who received chemotherapy before treatment from 4 hospitals (68 in the primary cohort and 34 in the external validation cohort). Quantitative imaging features were extracted from contrast-enhanced fat-suppressed T1-weighted images (CE FS T1WI). Read More

View Article and Full-Text PDF

Development and Validation of a Hypoxia-Associated Prognostic Signature Related to Osteosarcoma Metastasis and Immune Infiltration.

Front Cell Dev Biol 2021 18;9:633607. Epub 2021 Mar 18.

Department of Orthopedics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Increasing evidence has shown that hypoxia microenvironment relates to tumor initiation and progression. However, no studies focus on the application of hypoxia-associated genes in predicting osteosarcoma patients' prognosis. This research aims to identify the hypoxia-associated genes related to osteosarcoma metastasis and construct a gene signature to predict osteosarcoma prognosis. Read More

View Article and Full-Text PDF

Prediction of neoadjuvant chemotherapy response in high-grade osteosarcoma: added value of non-tumorous bone radiomics using CT images.

Quant Imaging Med Surg 2021 Apr;11(4):1184-1195

Nuclear & Radiological Engineering and Medical Physics Programs, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Background: This study aimed to determine the impact of including radiomics analysis of non-tumorous bone region of interest in improving the performance of pathological response prediction to chemotherapy in high-grade osteosarcomas (HOS), compared to radiomics analysis of tumor region alone.

Methods: This retrospective study included 157 patients diagnosed with HOS between November 2013 and November 2017 (age range, 5-44 years; mean age, 16.99 ±7. Read More

View Article and Full-Text PDF

Tideglusib suppresses stem-cell-like features and progression of osteosarcoma by inhibiting GSK-3β/NOTCH1 signaling.

Biochem Biophys Res Commun 2021 May 1;554:206-213. Epub 2021 Apr 1.

Department of Oncology, The First Affiliated Hospital of Henan University of Chinese Medicine, 19 Renmin Road, Zhengzhou, 450000, China. Electronic address:

Osteosarcoma is the most common primary bone tumor in children, teenagers and adolescents. Cancer stem cells (CSCs) have the function to self-renew and keep the phenotype of tumor, causing clinical treatment failure. Therefore, developing effective therapies to inhibit osteosarcoma progression is urgently necessary. Read More

View Article and Full-Text PDF