15,035 results match your criteria features investigations


The Use of Generalizability Theory to Inform Sampling of Educator Language Used With Preschoolers With Autism Spectrum Disorder.

J Speech Lang Hear Res 2021 Apr 13:1-10. Epub 2021 Apr 13.

Department of Educational Psychology, University of Minnesota, Twin Cities, Minneapolis.

Purpose A myriad features can impact the nature, frequency, and length of adult-child interactions important for language learning. Empirical investigations of language learning opportunities for young children with autism spectrum disorder (ASD) provide limited generalizable insight, with inferences more constrained to the sample than is often considered. The aim of this study was to explore a multidimensional understanding of reliability and define optimal measurement procedures for a measurement approach used to examine the language of preschool educators interacting with children with ASD. Read More

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High-Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?

Mov Disord 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Abnormal oscillatory neural activity in the beta-frequency band (13-35 Hz) is thought to play a role in Parkinson's disease (PD); however, increasing evidence points to alterations in high-frequency ranges (>100 Hz) also having pathophysiological relevance.

Objectives: Studies have found that power in subthalamic nucleus (STN) high-frequency oscillations is increased with dopaminergic medication and during voluntary movements, implicating these brain rhythms in normal basal ganglia function. The objective of this study was to investigate whether similar signaling occurs in the internal globus pallidus (GPi), a nucleus increasingly used as a target for deep brain stimulation (DBS) for PD. Read More

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Decoding concurrent representations of pitch and location in auditory working memory.

J Neurosci 2021 Apr 10. Epub 2021 Apr 10.

Institute of Medical Psychology, Medical Faculty, Goethe University, 60528 Frankfurt am Main, Germany

Multivariate analyses of hemodynamic signals serve to identify the storage of specific stimulus contents in working memory. Representations of visual stimuli have been demonstrated both in sensory regions and in higher cortical areas. While previous research has typically focused on the working memory maintenance of a single content feature, it remains unclear whether two separate features of a single object can be decoded concurrently. Read More

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Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review.

Curr Pharm Des 2021 Apr 12. Epub 2021 Apr 12.

Cellular and Molecular Endocrine Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran. Iran.

Bacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as "bacterial nanocellulose OR bacterial cellulose OR BNC" AND "cancer OR carcinoma OR tumor". Read More

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Epigenetic regulation in Alzheimer's disease: is it a potential therapeutic target?

Authors:
Fabio Coppedè

Expert Opin Ther Targets 2021 Apr 12. Epub 2021 Apr 12.

Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Via Roma 55, 56126 Pisa, Italy.

Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. Changes in DNA methylation and post-translational modifications of histone tails are increasingly observed in AD tissues, and likely contribute to disease onset and progression. The reversibility of these epigenetic marks offers the potential for therapeutic interventions. Read More

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Molecular Basis of Class B GPCR Selectivity for the Neuropeptides PACAP and VIP.

Front Mol Biosci 2021 25;8:644644. Epub 2021 Mar 25.

Department of Chemistry, University of Vermont, Burlington, VT, United States.

The related neuropeptides PACAP and VIP, and their shared PAC1, VPAC1 and VPAC2 receptors, regulate a large array of physiological activities in the central and peripheral nervous systems. However, the lack of comparative and molecular mechanistic investigations hinder further understanding of their preferred binding selectivity and function. PACAP and VIP have comparable affinity at the VPAC1 and VPAC2 receptor, but PACAP is 400-1,000 fold more potent than VIP at the PAC1 receptor. Read More

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COVID-19-associated leukocytoclastic vasculitis leading to gangrene and amputation.

IDCases 2021 6;24:e01117. Epub 2021 Apr 6.

Rashid Hospital, Internal Medicine Department, Umm Hurair 2, Dubai, United Arab Emirates.

A 41-year-old male with type 2 diabetes mellitus (T2DM) presented with complaints of recent onset limb weakness, diffuse body rash and fever. Computerized Tomography (CT) scan of the brain did not reveal a stroke but laboratory investigations of the patient portrayed multi-systemic involvement. Naso-pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was taken which resulted as positive. Read More

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The Origin and Molecular Epidemiology of Dengue Fever in Hainan Province, China, 2019.

Front Microbiol 2021 24;12:657966. Epub 2021 Mar 24.

NHC Key Laboratory of Control of Tropical Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China.

There was an outbreak of Dengue fever on September 5, 2019, in Hainan Province, which has not been endemic for 28 years. We aim to describe the clinical and epidemiological features of the 2019 outbreak in Hainan Province and identify the cause. All type 1 Dengue fever cases that occurred in this outbreak of Hainan exhibited mild clinical symptoms. Read More

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Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder.

Brain Behav Immun 2021 Apr 7. Epub 2021 Apr 7.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health; Department of Psychiatry, The University of Melbourne; Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia.

Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (SSD), although their biological underpinnings remain unclear. Despite the existence of hypotheses by which peripheral inflammation may impact brain structure, few studies have examined this relationship in SSD. This study aimed to establish the relationship between peripheral markers of inflammation and brain morphology and determine whether such relationships differed across healthy controls and individuals with first episode psychosis (FEP) and chronic schizophrenia. Read More

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Incidental diagnosis of situs inversus totalis: a perspective from an emergency department attendance.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Emergency Department, Sheikh Shakhbout Medical City, Abu Dhabi, UAE

A 30-year-old man of African origin presented to our emergency department (ED) with subjective fever and abdominal pain which started on the day of attendance. Vital signs and systemical examination were within normal limits. As part of his evaluation in ED, a 12-lead electrocardiogram was performed which showed features consistent with dextrocardia later confirmed on a chest X-ray as well. Read More

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Therapeutic plasma exchange: A potential management strategy for critically ill MIS-C patients in the pediatric intensive care unit.

Transfus Apher Sci 2021 Apr 1:103119. Epub 2021 Apr 1.

Ankara Yıldırım Beyazıt University, Ankara Children's Hospital, Department of Pediatric Surgery, Ankara, Turkey. Electronic address:

This study aimed to evaluate the effectiveness and the role of therapeutic plasma exchange (TPE) in treatment of children with severe MIS-C. In addition, we assessed demographic data, clinical features, laboratory abnormalities, underlying conditions, treatments, and outcomes. Patients with severe MIS-C who were admitted to the pediatric intensive care unit (PICU) between September 01 and October 05, 2020 were included in this observational, descriptive, retrospective study. Read More

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Radiomics in pancreatic neuroendocrine tumors: methodological issues and clinical significance.

Eur J Nucl Med Mol Imaging 2021 Apr 9. Epub 2021 Apr 9.

Vita-Salute San Raffaele University, Via Olgettina 58, Milan, 20132, Italy.

Purpose: To present the state-of-art of radiomics in the context of pancreatic neuroendocrine tumors (PanNETs), with a focus on the methodological and technical approaches used, to support the search of guidelines for optimal applications. Furthermore, an up-to-date overview of the current clinical applications of radiomics in the field of PanNETs is provided.

Methods: Original articles were searched on PubMed and Science Direct with specific keywords. Read More

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study.

Biomed Res Int 2021 23;2021:3582342. Epub 2021 Mar 23.

Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy.

In the field of biology and medicine, one hears often about stem cells and their potential. The dental implant new surfaces, subjected to specific treatments, perform better and allow for quicker healing times and better clinical performance. The purpose of this study is to evaluate from a biological point of view the interaction and cytotoxicity between stem cells derived from dental pulp (DPSCs) and titanium surfaces. Read More

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Automated Online Flow Cytometry Advances Microalgal Ecosystem Management as , High-Temporal Resolution Monitoring Tool.

Front Bioeng Biotechnol 2021 23;9:642671. Epub 2021 Mar 23.

Sustainable Food Processing Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

Microalgae are emerging as a next-generation biotechnological production system in the pharmaceutical, biofuel, and food domain. The economization of microalgal biorefineries remains a main target, where culture contamination and prokaryotic upsurge are main bottlenecks to impair culture stability, reproducibility, and consequently productivity. Automated online flow cytometry (FCM) is gaining momentum as bioprocess optimization tool, as it allows for spatial and temporal landscaping, real-time investigations of rapid microbial processes, and the assessment of intrinsic cell features. Read More

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Optimising Antimicrobial Selection and Duration in the Treatment of Febrile Neutropenia in Children.

Infect Drug Resist 2021 30;14:1283-1293. Epub 2021 Mar 30.

Royal Marsden Hospital and Institute of Cancer Research, Sutton, SM2 5PT, UK.

Febrile neutropenia (FN) is a frequent complication of cancer treatment in children. Owing to the potential for overwhelming bacterial sepsis, the recognition and management of FN requires rapid implementation of evidenced-based management protocols. Treatment paradigms have progressed from hospitalisation with broad spectrum antibiotics for all patients, through to risk adapted approaches to management. Read More

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Osteoperiostitis in children: proposal for a diagnostic algorithm.

Eur J Pediatr 2021 Apr 8. Epub 2021 Apr 8.

Rheumatology Unit, Department of Woman's and Child's Health, University of Padova, Via Giustiniani 3, 35128, Padua, Italy.

Juvenile osteoperiostites (JOP) are a group of inflammatory bone diseases whose differential diagnosis is often difficult. The main conditions are acute osteomyelitis (AOM), chronic non-bacterial osteomyelitis (CNO) and the Goldbloom syndrome (GS). The study was aimed to develop an algorithm to enable an early diagnosis of JOP. Read More

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Preoperative Analysis of CA-I25 and its Relation with Histopathological Study in Ovarian Tumours.

Mymensingh Med J 2021 Apr;30(2):402-409

Dr Towhida Nazneen, Junior Consultant, Department of Obs & Gynae, General Hospital Munshigong, Dhaka, Bangladesh; Email: towhida

Ovarian cancer (OC) is the seventh most common cancer among women in the world. Epithelial OC is the most predominant pathological subtype, with five major histotype. All five subtypes that differ in origination, pathogenesis, molecular alterations, risk factors and prognosis. Read More

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Morphological and molecular characterization of species from Yam ( spp.) in West Africa.

J Nematol 2020 22;52. Epub 2021 Jan 22.

Nematology Research Unit, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, 9000 Gent, Belgium.

The root-lesion nematodes (RLN), spp., are among the major plant-parasitic nematodes affecting yam ( spp.) production in West Africa. Read More

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January 2021

Microsaccades: Empirical Research and Methodological Advances - Introduction to Part 1 of the Thematic Special Issue.

J Eye Mov Res 2020 Jun 19;12(6). Epub 2020 Jun 19.

University of Bern and SciAns GmbH, Iffwil, Switzerland.

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on "Microsaccades: Empirical Research and Methodological Advances" invited authors to submit original research and reviews encompassing measurements and data analyses in fundamental, translational, and applied studies. We present the first volume of this special issue, comprising 14 articles by research teams around the world. Read More

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Can omics deliver temperature resilient ready-to-grow crops?

Crit Rev Biotechnol 2021 Apr 7:1-24. Epub 2021 Apr 7.

Center of Excellence in Genomics & Systems Biology, International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Hyderabad, India.

Plants are extensively well-thought-out as the main source for nourishing natural life on earth. In the natural environment, plants have to face several stresses, mainly heat stress (HS), chilling stress (CS) and freezing stress (FS) due to adverse climate fluctuations. These stresses are considered as a major threat for sustainable agriculture by hindering plant growth and development, causing damage, ultimately leading to yield losses worldwide and counteracting to achieve the goal of "zero hunger" proposed by the Food and Agricultural Organization (FAO) of the United Nations. Read More

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Zinc- and Cadmium meso-Aryl-Isoporphyrins: Non-Aromatic NIR Dyes with Distinct Conformational Features.

Chemistry 2021 Apr 7. Epub 2021 Apr 7.

TU Braunschweig, Institut für Anorganische und Analytische Chemie, Hagenring 30, 38106, Braunschweig, GERMANY.

A series of pyrrolyl and dipyrrinyl isoporphyrins carrying different phenyl and thienyl groups is reported. The compounds are obtained by a one-pot approach in the presence of a template reagent. Thienyl derivatives gave better yields, and were the only subclass to form with sterical hindrance. Read More

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