855,791 results match your criteria features gca

Comparison of Maternal and Neonatal Subspecialty Care Provision by Hospital.

Am J Perinatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts.

Objective:  The aim of the study is to determine the relationship between a hospital's provision of subspecialty neonatal and maternal care. Specifically, we sought to understand where women with high-risk maternal conditions received intrapartum care and estimate the potential transfer burden for those with maternal high-risk conditions delivering at hospitals without subspecialty maternal care.

Study Design:  This is a descriptive study using data from 2015 State Inpatient Databases and the American Hospital Association Annual Survey. Read More

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Dynamic evolution of hyperuniformity in a driven dissipative colloidal system.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

UNAM-National Nanotechnology Research Center & Institute of Materials Science and Nanotechnology, Bilkent Universitesi, UNAM-National Nanotechnology Research Center & Institute of Materials Science and Nanotechnology, Bilkent University, Ankara, 06800, Turkey, Ankara, 06800, TURKEY.

Hyperuniformity is evolving to become a unifying concept that can help classify and characterize equilibrium and nonequilibrium states of matter. Therefore, understanding the extent of hyperuniformity in dissipative systems is critical. Here, we study the dynamic evolution of hyperuniformity in a driven dissipative colloidal system. Read More

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Silicene/ZnI2 van der Waals heterostructure: tunable structural and electronic properties.

Nanotechnology 2021 Apr 20. Epub 2021 Apr 20.

School of Electrical Engineering and Computer Science, University of Ottawa Faculty of Engineering, 25 Templeton St., Ottawa, Ontario, K1N 6N5, CANADA.

By utilizing ab initio density functional theory, the structural and electronic properties of novel silicene/ZnI2 heterobilayers (HBLs) were investigated. Constructing HBLs with ZnI¬2 in different stacking configurations leads to direct bandgap opening of silicene at K point, which ranges from 138.2 meV to 201. Read More

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A novel method to reduce false alarms in ECG diagnostic systems: capture and quantification of noisy signals.

Physiol Meas 2021 Apr 20. Epub 2021 Apr 20.

Soochow University, Suzhou, 215006, CHINA.

Objective: Muscle artifacts (MA) and electrode motion artifacts (EMA) in electrocardiogram (ECG) signals lead to a large number of false alarms from cardiac diagnostic systems. To reduce false alarms, it is necessary to improve the performance of the diagnostic algorithm in noisy environments by removing excessively noisy signals. However, existing methods focus on signal quality assessment and contain too many artificial features. Read More

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Snow White and the Seven Dwarfs: a fairytale for endocrinologists.

Endocr Connect 2021 Apr 1. Epub 2021 Apr 1.

S Livadas, Endocrine Unit, Athens Medical Centre, Athens, 10563, Greece.

'Snow White and the Seven Dwarfs', a fairytale that is widely known across the Western world, was originally written by the Brothers Grimm, and published in 1812. Though each dwarf was first given an individual name in the 1912 Broadway play by the same title, in Walt Disney's 1937 film 'Snow White and the Seven Dwarfs', they were renamed, and their names have become household words. As it is well known, myths, fables, and fairytales, though appearing to be merely children's tales about made-up and magical beings and places, have, more often than not, originated from real facts. Read More

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SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.

Neoplasia 2021 Apr 17;23(5):473-487. Epub 2021 Apr 17.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland. Electronic address:

Diagnosis of salivary gland neoplasms is often challenging due to their high morphological diversity and overlaps. Several recurrent molecular alterations have been described recently, which can serve as powerful diagnostic tools and potential therapeutic targets (e.g. Read More

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Left axillary lymphadenopathy as initial presentation of metastatic prostate cancer: A rare case report.

Int J Surg Case Rep 2021 Apr 15;82:105889. Epub 2021 Apr 15.

Faculty of Medicine, Kilimanjaro Christian Medical University College, Box 2240, Moshi, Tanzania; Department of Urology, Kilimanjaro Christian Medical Centre, Box 3010, Moshi, Tanzania.

Introduction And Importance: Advanced prostate cancer often presents with lower urinary tract symptoms together with features of cancer on digital rectal examination. The commonest sites of metastasis include bone, liver and lungs. Metastasis to axillary lymph nodes is extremely unusual particularly as initial presentation of the disease. Read More

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Non-rigid image registration using a modified fuzzy feature-based inference system for 3D cardiac motion estimation.

Comput Methods Programs Biomed 2021 Apr 6;205:106085. Epub 2021 Apr 6.

Laboratory on Cardiovascular Imaging and Dynamics, Department of Cardiovascular Sciences, KU Leuven, Belgium.

Background And Objective: Non-rigid image registration is a well-established method for estimating cardiac motion on 3D echocardiographic images. However, such images have relatively poor spatio-temporal resolution making registration challenging. Some of the main challenges are extracting features relevant to the registration problem and defining a suitable geometrical transformation to be applied. Read More

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Design and application of nanoparticles as vaccine adjuvants against human corona virus infection.

J Inorg Biochem 2021 Mar 29;219:111454. Epub 2021 Mar 29.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China; GBA National Institute for Nanotechnology Innovation, Guangdong 510700, PR China; Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing 100021, PR China. Electronic address:

In recent years, some viruses have caused a grave crisis to global public health, especially the human coronavirus. A truly effective vaccine is therefore urgently needed. Vaccines should generally have two features: delivering antigens and modulating immunity. Read More

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The importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws: Study of 276 cases.

J Stomatol Oral Maxillofac Surg 2021 Apr 17. Epub 2021 Apr 17.

Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey.

Purpose: Benign fibro-osseous lesions (BFOLs) are heterogeneous intraosseous dis- ease processes sharing overlapping histopathologic features and demonstrate a wide range of biological behavior. The aim of this study is to highlight the importance of clinical and radiological findings for the definitive histopathologic diagnosis of benign fibro-osseous lesions of the jaws.

Materials And Methods: This is a cross-sectional retrospective study evaluating the three main groups of BFOLs: Cemento-osseous dysplasia, ossifying fibroma, and fibrous dysplasia. Read More

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Defining the risk profile of women with stage 1 hypertension: A time to event analysis.

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

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Should return to pivoting sport be avoided for the secondary prevention of osteoarthritis after anterior cruciate ligament reconstruction? A prospective cohort study with MRI, radiographic and symptomatic outcomes.

Osteoarthritis Cartilage 2021 Apr 17. Epub 2021 Apr 17.

La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Australia. Electronic address:

Objective: To evaluate if returning to pivoting sport following anterior cruciate ligament reconstruction (ACLR) is associated with longitudinal structural and symptomatic osteoarthritis outcomes.

Design: Eighty-one adults aged 18-50 years were followed prospectively 1- to 5-years post-ACLR. Return to pivoting sport was assessed at 1-, 3- and 5-years. Read More

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The bullies are the leaders of the next generation: inherited aminergic neurotransmitter system changes in socially dominant zebrafish, Danio rerio.

Behav Brain Res 2021 Apr 17:113309. Epub 2021 Apr 17.

Department of Anatomy, POB 63, 00014, University of Helsinki, Helsinki, Finland.

We studied the social hierarchy in zebrafish and assessed differences in neurotransmitters and behavior in the F1 generation offspring of dominant and subordinate zebrafish (Danio rerio). We used behavioral assays to study locomotion, ability to complete cognitive tasks, social interaction and aggression. To study the neurochemical changes, we applied quantitative polymerase chain reaction, high pressure liquid chromatography and immunohistochemistry. Read More

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Clinical and Morphological Features of Necrobiosis Lipoidica.

J Am Acad Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology, Mayo Clinic Arizona, 13400 East Shea Blvd, Scottsdale, AZ 85259. Electronic address:

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Identification of a novel calcium activated potassium channel from Leishmania donovani and in silico predictions of its antigenic features.

Acta Trop 2021 Apr 17:105922. Epub 2021 Apr 17.

Department of Biotechnology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Mohali160062, Punjab, India. Electronic address:

Visceral Leishmaniasis is a major neglected tropical disease with increasing incidences of drug resistance. This has led to the search for a suitable drug target for chemotherapeutic intervention. Potassium channels are a family of membrane proteins which play a vital role in homeostasis and any perturbation in them alters cell survival which makes them an attractive target. Read More

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General characteristics, features of cultivation and antibiotic resistance representatives of mycobacterium fortuitum group representatives (review of literature).

Klin Lab Diagn 2021 Apr;66(4):223-228

Samara State Medical University.

Recently, more and more scientific works have been devoted to non-tuberculous mycobacteria, both by domestic and foreign researchers. One of the main reasons for this is the increase in patients with immunosuppression of various origins, improvement of the quality of laboratory and instrumental diagnostics of mycobacteriosis. This article focuses on the representatives of the M. Read More

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Secondary CoQ deficiency, bioenergetics unbalance in disease and aging.

Biofactors 2021 Apr 20. Epub 2021 Apr 20.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC-JA, Sevilla, Spain.

Coenzyme Q (CoQ ) deficiency is a rare disease characterized by a decreased accumulation of CoQ in cell membranes. Considering that CoQ synthesis and most of its functions are carried out in mitochondria, CoQ deficiency cases are usually considered a mitochondrial disease. A relevant feature of CoQ deficiency is that it is the only mitochondrial disease with a successful therapy available, the CoQ supplementation. Read More

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Morphological and scanning electron microscopic study of the gonadal arterioles in the Tibetan sheep.

Anat Histol Embryol 2021 Apr 20. Epub 2021 Apr 20.

College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.

This research aimed at revealing the structural features of Tibetan sheep's testicular and ovarian vasculature and providing theoretical basis for Tibetan sheep's physiological adaptability in plateau and low-oxygen environments. Through scanning electron microscopy, corrosion casts of the feature of the gonad arterioles were observed and analysed. The results of this study found that centrifugal arteries, centrifugal and centripetal arterioles were distributed in a 'dendritic' fashion in the testis lobule, the ovarian arteries and arterioles, which had a spiral shape. Read More

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Variation in the seventh lumbar vertebra and the lumbosacral junction morphometry associated with the sacrocaudal fusion in greyhounds.

Anat Histol Embryol 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Vic., Australia.

The lumbosacral joint is where the 7th lumbar vertebra (L.7) articulates within the sacrum. It is a clinically important area in the dog because of its relatively large range of motion. Read More

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Patients with early-onset primary Sjögren's syndrome have distinctive clinical manifestations and circulating lymphocyte profiles.

Rheumatology (Oxford) 2021 Apr 20. Epub 2021 Apr 20.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Beijing, 100730, China.

Objectives: To further investigate the clinical characteristics and circulating lymphocyte profiles of patients with early-onset primary Sjögren's syndrome (pSS).

Method: Data of 333 patients with pSS were analyzed retrospectively. Early onset was defined as a pSS diagnosis at an age of 35 years or younger. Read More

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Thyroid immune-related adverse events following immune checkpoint inhibitor treatment.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical presentation can be variable. This study sought to define thyroid irAEs following immune checkpoint inhibitor (ICI) treatment and describe their clinical and biochemical associations. Read More

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Characteristics and sources of atmospheric pollutants in typical inland cities in arid regions of central Asia: A case study of Urumqi city.

PLoS One 2021 20;16(4):e0249563. Epub 2021 Apr 20.

School of Environmental and Geographical Sciences, Shanghai Normal University, Shanghai, China.

The arid zone of central Asia secluded inland and has the typical features of the atmosphere. Human activities have had a significant impact on the air quality in this region. Urumqi is a key city in the core area of the Silk Road and an important economic center in Northwestern China. Read More

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Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae.

PLoS Genet 2021 Apr 20;17(4):e1009538. Epub 2021 Apr 20.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release. However, stop codon readthrough can occur when a near-cognate tRNA outcompetes eRF1 in decoding the stop codon, resulting in the continuation of the elongation phase of protein synthesis. At the end of a conventional mRNA coding region, readthrough allows translation into the mRNA 3'-UTR. Read More

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Pathological and Immunohistochemical Characteristics of Granuloma and Lymphatics in Cheilitis Granulomatosa.

Am J Dermatopathol 2021 Apr 19. Epub 2021 Apr 19.

Assistant Professor, Department of Dermatology and STD, Jawaharlal Institute of Post-graduate Medical Education and Research, Puducherry, India; Attending Dermatologist, Department of Dermatology, Da Nang Hospital of Dermatology and Venereology, Da Nang, Vietnam; Post-graduate Year, Department of Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Associate Professor, Department of Medicine, MacKay Medical College, New Taipei City, Taiwan; and Senior Attending Physician, Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Abstract: Cheilitis granulomatosa (CG) is an idiopathic, rare, and chronic granulomatous disorder involving the lips. We characterized the pathological and immunohistopathological findings of these granulomas and their relationship with the lymphatic vessels. Pathologically confirmed cases of primary CG from 2001 to 2016 were collected. Read More

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Malignant Transformation of Giant Cell Tumor of Bone 7 years After Initial Surgery: A Case Report and Literature Review.

JBJS Case Connect 2021 Apr 20;11(2). Epub 2021 Apr 20.

Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Japan.

Case: A 64-year-old man with a history of giant cell tumor of bone (GCTB) in the fibula 7 years earlier developed a recurrence with histologic features of osteosarcoma. Both the primary GCTB and the secondary osteosarcoma were found to have the H3F3A gene mutation. Despite immediate above-the-knee amputation, the patient died of respiratory failure because of lung metastases 3 months later. Read More

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Robust Estimation of Upscaling Factor on Double JPEG Compressed Images.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

As one of the most important topics in image forensics, resampling detection has developed rapidly in recent years. However, the robustness to JPEG compression is still challenging for most classical spectrum-based methods, since JPEG compression severely degrades the image contents and introduces block artifacts in the boundary of the compression grid. In this article, we propose a method to estimate the upscaling factors on double JPEG compressed images in the presence of image upscaling between the two compressions. Read More

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Saliency-Based Multilabel Linear Discriminant Analysis.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

Linear discriminant analysis (LDA) is a classical statistical machine-learning method, which aims to find a linear data transformation increasing class discrimination in an optimal discriminant subspace. Traditional LDA sets assumptions related to the Gaussian class distributions and single-label data annotations. In this article, we propose a new variant of LDA to be used in multilabel classification tasks for dimensionality reduction on original data to enhance the subsequent performance of any multilabel classifier. Read More

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KenDTI: an ensemble model based on network integration and CNN for drug-target interaction prediction.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 20;PP. Epub 2021 Apr 20.

The identification of drug-target interactions (DTIs) is an essential step in the process of drug discovery. As experimental validation suffers from high cost and low success rate, various computational models have been exploited to infer potential DTIs. The performance of DTI prediction depends heavily on the features extracted from drugs and target proteins. Read More

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-Analysis of the Multi-Omics Data Identified the Ataxia Telangiectasia Mutated Gene as a Potential Biomarker of Breast Invasive Carcinoma.

Genet Test Mol Biomarkers 2021 Apr;25(4):263-275

Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

The elevated global burden of the breast invasive carcinoma (BRIC) and lack of appropriate biomarkers for its early detection and treatment requires extensive investigation to enhance understanding regarding BRIC associated molecular alterations. Ataxia telangiectasia mutated () is a multifunctional tumor suppressor gene, which participates in the DNA damage response pathway and cellular checkpoint activation. Several studies have reported the reduction of expression as a reliable biomarker of BRIC. Read More

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