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Levodopa-Induced Dyskinesia in Parkinson Disease Specifically Associates With Dopaminergic Depletion in Sensorimotor-Related Functional Subregions of the Striatum.

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid Unidad de Medicina Nuclear, Hospital Universitario Virgen del Rocío Departamento de Psicología Experimental, Facultad de Psicología, Universidad de Sevilla, Sevilla, Spain.

Purpose: To determine whether the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) specifically relates to dopaminergic depletion in sensorimotor-related subregions of the striatum.

Methods: Our primary study sample consisted of 185 locally recruited PD patients, of which 73 (40%) developed LID. Retrospective 123I-FP-CIT SPECT data were used to quantify the specific dopamine transporter (DAT) binding ratio within distinct functionally defined striatal subregions related to limbic, executive, and sensorimotor systems. Read More

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Microglia activated by microbial neuraminidase contributes to ependymal cell death.

Fluids Barriers CNS 2021 Mar 23;18(1):15. Epub 2021 Mar 23.

Laboratorio de Fisiología Animal, Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga-IBIMA, Campus de Teatinos, 29071, Málaga, Spain.

The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. Here we demonstrate that activated microglia participates in ependymal cell death. Read More

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Optimizing cardiovascular imaging in Staphylococcus aureus endocarditis.

Echocardiography 2021 Mar 11. Epub 2021 Mar 11.

Department of Infectious Disease, Ochsner Clinic Foundation, New Orleans, LA, USA.

Introduction: The shift toward value-based health care drives physicians to examine opportunities to optimize use of healthcare resources. There is discordance between providers' use of cardiovascular imaging (CVI) in assessing patients for infective endocarditis (IE) with Staphylococcus aureus bacteremia (SAB). An evidence-based algorithm was created to minimize variation of CVI use. Read More

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Characterization of macular choroid in normal-tension glaucoma: a swept-source optical coherence tomography study.

Acta Ophthalmol 2021 Mar 6. Epub 2021 Mar 6.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.

Purpose: To investigate the features of the small-to-medium (choriocapillaris and Sattler's layer) and large (Haller's layer) sized vessel layers of the macular choroid in normal-tension glaucoma (NTG) patients using swept-source optical coherence tomography (SS-OCT).

Methods: We conducted an observational cross-sectional study in 234 NTG eyes from 134 patients, and 203 normal eyes from 109 non-glaucomatous control subjects. We used Image J to segment the choroidal layer and then a Python script to measure the average macular choroidal thickness (MCT) and choroidal vascular index (CVI) of two vessel layers at five different locations. Read More

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Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces.

Diagnostics (Basel) 2021 Feb 24;11(3). Epub 2021 Feb 24.

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania 'Luigi Vanvitelli', via Pansini 5, 80131 Naples, Italy.

Cystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this retrospective cross-sectional study and divided into two groups based on the presence (17 eyes) or absence (16 eyes) of CSs. Read More

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February 2021

Psychometric evaluation of the Arabic version of the higher education inventory scale for nursing students.

BMC Psychiatry 2021 Feb 6;21(1):77. Epub 2021 Feb 6.

Princess Salma Faculty of Nursing, Al-al-Bayt University, P.O. Box: 130049, Al-Mafraq, 25113, Jordan.

Background: Studies in the literature have relied on a single instrument to assess stress levels and sources among nursing students in Jordan and in other Arab countries. Thus, there is a need to develop Arabic versions of psychometrically validated instruments for evaluating a wider range of aspects related to stress and stressors. The Higher Education Stress Inventory (HESI) is an instrument used to assess various aspects of stress and stressors related to higher education in different educational settings and among different student populations. Read More

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February 2021

Development and content validity evaluation of a candidate instrument to assess image quality in digital mammography: A mixed-method study.

Eur J Radiol 2021 Jan 2;134:109464. Epub 2020 Dec 2.

Dutch Expert Centre for Screening (LRCB), Wijchenseweg 101, 6538 SW, Nijmegen, the Netherlands; Department for Health Evidence, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA, Nijmegen, the Netherlands. Electronic address:

Purpose: To develop a candidate instrument to assess image quality in digital mammography, by identifying clinically relevant features in images that are affected by lower image quality.

Methods: Interviews with fifteen expert breast radiologists from five countries were conducted and analysed by using adapted directed content analysis. During these interviews, 45 mammographic cases, containing 44 lesions (30 cancers, 14 benign findings), and 5 normal cases, were shown with varying image quality. Read More

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January 2021

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study.

Nutrients 2020 Nov 17;12(11). Epub 2020 Nov 17.

Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.

Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Read More

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November 2020

Development of a Manual on the Technique of Applying the Unna Boot in Patients With Venous Leg Ulcers.

Wounds 2021 Jan 14;33(1):28-33. Epub 2020 Jul 14.

Division of Plastic Surgery, Department of Surgery, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Introduction: Providing adequate care for people with venous leg ulcers (VLUs) can be a challenge. Numerous publications have discussed the importance of compression therapies on the treatment of VLUs, but few have described the necessary materials and techniques for applying the Unna boot, contributing to the underutilization of this therapy. The use of manuals is one of the strategies in the training of health professionals. Read More

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January 2021

Integrating genetic and clinical data to predict impulse control disorders in Parkinson's disease.

Eur J Neurol 2021 Feb 9;28(2):459-468. Epub 2020 Nov 9.

Movement Disorders Unit, Department of Neurology and Clinical Neurophysiology/Institute of Biomedicine of Seville, University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.

Background And Purpose: Impulse control disorders (ICDs) are frequent in Parkinson's disease (PD), with associated clinical and genetic risk factors. This study was aimed at analyzing the clinical features and the genetic background that underlie ICDs in PD.

Methods: We included 353 patients with PD in this study (58. Read More

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February 2021

Biomarkers for central serous chorioretinopathy.

Ther Adv Ophthalmol 2020 Jan-Dec;12:2515841420950846. Epub 2020 Aug 24.

Faculty-Clinician, UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213, USA.

Central serous chorioretinopathy (CSCR) is a common chorioretinal disease characterized by serous retinal detachment that most commonly involves the macular region. Although the natural history of the acute form shows a self-limiting course, a significant number of patients suffer from recurrent episodes leading to chronic disease, often leaving patients with residual visual impairment. Visual morbidity is often worsened by a delay in the diagnosis due to the incorrect understanding of the particular biomarkers of the disease. Read More

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A New Contrast Sensitivity Test for Pediatric Patients: Feasibility and Inter-Examiner Reliability in Ocular Disorders and Cerebral Visual Impairment.

Transl Vis Sci Technol 2020 08 20;9(9):30. Epub 2020 Aug 20.

New England College of Optometry, Boston, MA, USA.

Purpose: Assess feasibility and interexaminer reliability of a new test of contrast sensitivity (CS) for pediatric populations.

Methods: The Double Happy (DH) measures CS using a method similar to the Teller Acuity Cards. The schematic DH face is 16 degrees in diameter with features of 0. Read More

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Choroidal vascularity index and choriocapillary changes in retinal vein occlusions.

Graefes Arch Clin Exp Ophthalmol 2020 Nov 29;258(11):2389-2397. Epub 2020 Aug 29.

Edward Harkness Institute of Ophthalmology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.

Purpose: To evaluate the changes in the choroidal structure in the setting of retinal vein occlusion (RVO).

Methods: Changes in the structure of the choroid were studied in sixty-four eyes with unilateral central or branch RVO using optical coherence tomography (OCT) with enhanced depth imaging and OCT-angiography (OCT-A). Choroidal vascularity index (CVI), Haller layer/choroidal thickness (H/C) ratio, and choriocapillaris flow density were used to compare the structural characteristics of the choroid with fellow eyes and the eyes of thirty-four age-, gender-, and systemic co-morbidity-matched controls. Read More

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November 2020

Choroidal Vascularity Index in young Choroideremia patients.

Retina 2020 Aug 18. Epub 2020 Aug 18.

Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Purpose: To evaluate choroidal features in young patients affected by Choroideremia.

Methods: Young CHM patients and controls were recruited at the Eye Clinic in Florence. High resolution choroidal imaging was obtained using swept source - OCT with long OCT scans (12x9 mm OCT scans). Read More

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Chronic Venous Insufficiency as a Predisposing Factor for Basal Cell Carcinoma on Legs.

Ann Vasc Surg 2020 Oct 16;68:185-191. Epub 2020 May 16.

Department of Pathology, Medical School, Unicamp, Campinas, SP, Brazil. Electronic address:

Background: The main risk factor associated with basal cell carcinomas (BCCs) is believed to be exposure to ultraviolet radiation (UVR). In the case of lower limb BCC, the frequency is higher in women, possibly because of greater exposure of the leg to UVR. Chronic venous insufficiency (CVI), also more common in women, may have some association with leg BCCs. Read More

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October 2020

Analysis of choroidal morphology and comparison of imaging findings of subtypes of polypoidal choroidal vasculopathy: a new classification system.

Int J Ophthalmol 2020 18;13(5):731-736. Epub 2020 May 18.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

Aim: To classify polypoidal choroidal vasculopathy (PCV) into 2 subtypes based on the subfoveal choroidal thickness (SFCT) and to further evaluate their multimodal image features.

Methods: A retrospective observational case series study. Sixty-four eyes of 64 patients with PCV were enrolled and classified into 2 groups based on SFCT (thick-choroid group/thin-choroid group). Read More

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A comparative study of the choroidal vascularity indexes in the fellow eyes of patients with pachychoroid neovasculopathy and central serous chorioretinopathy by binarization method.

Graefes Arch Clin Exp Ophthalmol 2020 Aug 15;258(8):1649-1654. Epub 2020 May 15.

Department of Ophthalmology, Ankara University School of Medicine, Vehbi Koç Eye Hospital, Mamak Street, Dikimevi, Ankara, Turkey.

Purpose: To evaluate the choroidal vascularity index (CVI) in the fellow eyes of patients with pachychoroid neovasculopathy (PCN) and central serous chorioretinopathy (CSC).

Methods: Fifty-eight asymptomatic fellow eyes from 58 patients diagnosed with PCN or CSC and 26 eyes from 26 healthy participants were included. The total choroidal area (CA), luminal area (LA), and stromal area (SA) were measured with ImageJ software and Niblack threshold method. Read More

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Choroidal Anatomic Alterations After Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: A Multicenter Study.

Am J Ophthalmol 2020 09 28;217:104-113. Epub 2020 Apr 28.

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California, Los Angeles, California, USA; Greater Los Angeles VA Healthcare Center, Los Angeles, California, USA. Electronic address:

Purpose: To study the early anatomic choroidal alterations in eyes with chronic central serous chorioretinopathy (CSCR) undergoing photodynamic therapy (PDT).

Design: Multicenter retrospective cohort study.

Methods: A total of 77 patients and 81 eyes with chronic CSCR treated with PDT and 64 untreated fellow eyes were evaluated. Read More

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September 2020

The inter-relationships between cerebral visual impairment, autism and intellectual disability.

Neurosci Biobehav Rev 2020 07 13;114:201-210. Epub 2020 Apr 13.

Department of Vision Science, Glasgow Caledonian University, Glasgow, UK.

From birth, vision guides our movement, facilitates social interaction and accords recognition and understanding of the environment. In children, vision underpins development of these skills, and is crucial for typical development. Deficits in visual processing may lead to impairment of cognitive, motor, and social development, placing children at risk of developing features of autism. Read More

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Cerebral visual impairment captured with a structured history inventory in extremely preterm born children aged 6.5 years.

J AAPOS 2020 02 12;24(1):28.e1-28.e8. Epub 2020 Feb 12.

Department of Psychology, University of Bologna, Italy.

Purpose: To investigate whether a questionnaire can identify cerebral visual impairment (CVI) in a group of 6.5-year-old children born extremely preterm (EPT) as accurately as direct assessments.

Methods: This prospective population-based study included 120 children born before 27 weeks' gestational age (66 males; mean, 25. Read More

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February 2020

Geometry of the Poincaré plot can segregate the two arms of autonomic nervous system - A hypothesis.

Med Hypotheses 2020 May 20;138:109574. Epub 2020 Jan 20.

Dept. of Physiology, Calcutta Medical College, 88, College Street, Calcutta 700073, India. Electronic address:

Autonomic Nervous System (ANS) operates to achieve the optimum physiological functioning and maintains homeostasis in a tonic and continuous manner. Evaluation of ANS profile is crucial in assessing autonomic dysfunction. Conventional ANS evaluation procedures fail to capture minute dynamic alterations of ANS activities. Read More

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Determining minimum set of features for diabetes mobile apps.

J Diabetes Metab Disord 2019 Dec 27;18(2):333-340. Epub 2019 Jun 27.

4Department of Health Education and Health Promotion, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Interest in mobile health applications (apps) for diabetes self-care is growing. Mobile health is a promising new treatment modality for diabetes, though few smartphone apps have been designed based on a proper study and prioritization. The aim of this study was to determine a minimum set of features for diabetes mobile apps. Read More

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December 2019

Evaluation of the Choroid in Eyes With Retinitis Pigmentosa and Cystoid Macular Edema.

Invest Ophthalmol Vis Sci 2019 12;60(15):5000-5006

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States.

Purpose: To study the anatomical choroidal features associated with the presence of cystoid macular edema (CME) in eyes with retinitis pigmentosa (RP).

Methods: A total of 159 eyes (from 159 patients) with a diagnosis of RP were enrolled in this retrospective cross-sectional case-control study and divided into two groups based on the presence (67 eyes) or absence (92 eyes) of CME. Retinal and choroidal features were evaluated on spectral domain optical coherence tomography including central macular thickness (CMT) and subfoveal choroidal thickness (CT). Read More

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December 2019

A questionnaire to assess women's perception of respectful maternity care (WP-RMC): Development and psychometric properties.

Midwifery 2020 Jan 5;80:102573. Epub 2019 Nov 5.

Independent scholar, Rotterdam, the Netherlands.

Objective: To develop and assess the psychometric properties of Women's Perspection-Respectful Maternity Care (WP-RMC) Questionnaire.

Design: An exploratory sequential mixed method study was carried out from March to August 2018 in Tehran, Iran. The questionaire items were generated from the literature review and qualitatatve study. Read More

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January 2020

A web-based clinical pedagogy program to enhance registered nurse preceptors' teaching competencies - An innovative process of development and pilot program evaluation.

Nurse Educ Today 2020 Jan 18;84:104215. Epub 2019 Oct 18.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Level 2, Clinical Research Centre, Block MD 11,10 Medical Drive, 117597, Singapore. Electronic address:

Background: Registered Nurse Preceptors guide students to integrate theory into practice, assess clinical competencies, and enhance problem-solving skills. Researches have indicated that the teaching competencies of nurse preceptors can be transferred to students' clinical learning.

Objectives: The aims of the study are to develop a web-based clinical pedagogy (WCP) program for Registered Nurse Preceptors and conduct pilot program evaluation. Read More

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January 2020

A Study of Risk Factors of Chronic Venous Insufficiency and its Association with Features Suggestive of Preceding or Present Deep Venous Thrombosis.

Indian J Dermatol 2019 Sep-Oct;64(5):366-371

Department of Dermatology, Jaslok Hospital, Mumbai, Maharashtra, India.

Background: Deep venous thrombosis (DVT), even though resolved, may damage the valves and may lead to chronic venous insufficiency (CVI). We designed the present study to examine the thrombotic markers or other ultrasound features in the absence of active thrombosis in patients presenting with features suggestive of CVI.

Materials And Methods: It was a cross-sectional study of 50 DVT patients. Read More

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September 2019

An integrated coastal vulnerability approach to small islands: The Azores case.

Sci Total Environ 2019 Nov 3;690:1218-1227. Epub 2019 Jul 3.

MARE - Centro de Ciências do Mar e do Ambiente, Faculdade de Ciências e Tecnologia, Universidade dos Açores, Rua da Mãe de Deus, 9501-855 Ponta Delgada, Açores, Portugal. Electronic address:

Coastal development in small islands needs adapting to climate and ecosystem changes in the Anthropocene era. Understanding variability of coastal vulnerability along the entire coastline informs coastal planning and management at an island-wide scale as some coastal stretches are more appropriate for big-scale development, while others require additional coastal protection and/or ecosystem conservation. To date, few researches focused on developing macro-scale coastal vulnerability index at an island or archipelagic-scale. Read More

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November 2019

A wearable approach for intraoperative physiological stress monitoring of multiple cooperative surgeons.

Int J Med Inform 2019 09 31;129:60-68. Epub 2019 May 31.

Institute for Systems Engineering and Computers - Technology and Science (INESC TEC), Porto, Portugal; Faculty of Engineering, University of Porto, Portugal.

It is known that excessive levels of occupational stress affect professionals' technical and non-technical skills and surgeons are no exception. However, very few studies address this problem in neurosurgeons. A system for monitoring cardiovascular strain and autonomic imbalance during intracranial aneurysm procedures is proposed in order to obtain overall cardiac measures from those procedures. Read More

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September 2019

Application of neuroendoscopic surgical techniques in the assessment and treatment of cerebral ventricular infection.

Neural Regen Res 2019 Dec;14(12):2095-2103

Department of Neurosurgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Cerebral ventricular infection (CVI) is one of the most dangerous complications in neurosurgery because of its high mortality and disability rates. Few studies have examined the application of neuroendoscopic surgical techniques (NESTs) to assess and treat CVI. This multicenter, retrospective study was conducted using clinical data of 32 patients with CVI who were assessed and treated by NESTs in China. Read More

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December 2019

CDKL5 deficiency disorder: Relationship between genotype, epilepsy, cortical visual impairment, and development.

Epilepsia 2019 08 16;60(8):1733-1742. Epub 2019 Jul 16.

Children's Hospital Colorado, Aurora, Colorado.

Objective: The cyclin-dependent kinase like 5 (CDKL5) gene is a known cause of early onset developmental and epileptic encephalopathy, also known as CDKL5 deficiency disorder (CDD). We sought to (1) provide a description of seizure types in patients with CDD, (2) provide an assessment of the frequency of seizure-free periods and cortical visual impairment (CVI), (3) correlate these features with genotype and gender, and (4) correlate these features with developmental milestones.

Methods: This is a cohort study of patients with CDD. Read More

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