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Clinical and cytopathological features of suspected thyroglossal duct cysts and neoplasms arising from them: A large series from a referral cancer center.

Cancer Cytopathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Thyroglossal duct cysts (TGDCs) are the most common congenital midline cystic lesions in the neck, and they are often evaluated by fine-needle aspiration. Recognizing the cytomorphologic features of TGDCs and their mimics is important for clinical management.

Methods: This study examined the clinical, radiological, and cytopathological features of 86 ultrasonography-guided fine-needle aspiration (US-FNA) specimens from clinically suspected TGDCs or malignancies arising from TGDCs and correlated the findings with surgical follow-up and/or imaging studies. Read More

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September 2021

Solitary chondrosarcoma of the right ring finger: A case report.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Department of Orthopaedic Surgery, Nippon Medical School.

We present a case of solitary chondrosarcoma arising from the proximal phalanx of the ring finger in an elderly man. The chondrosarcoma developed over a period of 14 years, during which the phalanx became progressively more deformed. Several radiographic investigations were carried out, but the patient declined further suggested diagnostic examinations (computed tomography, magnetic resonance imaging, biopsy). Read More

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September 2021

Outcomes of Management of Sinonasal Malignancies at a Dedicated Cancer Institution: A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):115-120. Epub 2021 Jul 24.

Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

Introduction: Sinonasal malignancies (SNMs) are a rare and heterogeneous group of cancers with an incidence of 3%-5% of all head-and-neck tumours. The aim of the present study was to identify the characteristic features of SNMs and to analyze the treatment outcomes and the prognostic factors affecting it.

Materials And Methods: A retrospective review of patients with SNM treated at a dedicated cancer center of Pakistan between 2004 and 2018 was carried out. Read More

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Xanthogranulomatous Pyelonephritis: A Narrative Review with Current Perspectives on Diagnostic Imaging and Management, Including Interventional Radiology Techniques.

Int J Nephrol Renovasc Dis 2021 7;14:359-369. Epub 2021 Sep 7.

Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Waterford City, X91 DWX0, Ireland.

Xanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". Read More

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September 2021

Formation and functionalization of Ge-nanoparticles in ZnO.

Nanotechnology 2021 Sep 13. Epub 2021 Sep 13.

Department of Physics, Center for Materials Science and Nanotechnology, University of Oslo, PO Box 1048 - Blindern, Blindern, N-0316 Oslo 3, Oslo, NO-0316, NORWAY.

Semiconductor nanocrystals are often proposed as a viable route to improve solar energy conversion in photovoltaics and photoelectrochemical systems. Embedding the nanocrystals in, e.g. Read More

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September 2021

Complex Fibroadenoma with Pronounced Squamous Metaplasia: A Rare Case Report, Differential Diagnostic Considerations, and Associated Breast Cancer Risk.

Int J Surg Pathol 2021 Sep 13:10668969211035842. Epub 2021 Sep 13.

12280Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA.

Squamous metaplasia of the breast is a rare and unusual finding. A number of benign and malignant differential entities exist when squamous cells are present in a breast lesion. Our patient was found to have pronounced squamous metaplasia and keratin cysts arising in a complex fibroadenoma. Read More

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September 2021

A Diagnostic Strategy via Multiresolution Synchrosqueezing Transform on Obsessive Compulsive Disorder.

Int J Neural Syst 2021 Sep 9:2150044. Epub 2021 Sep 9.

Electrical and Electronics Engineering Department, Izmir University of Economics, 35330 Izmir, Turkey.

This research presents a new method for detecting obsessive-compulsive disorder (OCD) based on time-frequency analysis of multi-channel electroencephalogram (EEG) signals using the multi-variate synchrosqueezing transform (MSST). With the evolution of multi-channel sensor implementations, the employment of multi-channel techniques for the extraction of features arising from multi-channel dependency and mono-channel characteristics has become common. MSST has recently been proposed as a method for modeling the combined oscillatory mechanisms of multi-channel signals. Read More

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September 2021

Osteochondroma Arising from the Thyroid Cartilage: A Case Report and Literature Review.

Case Rep Otolaryngol 2021 2;2021:8286012. Epub 2021 Sep 2.

University of California, Department of Head and Neck Surgery, Los Angeles, CA, USA.

Introduction: Osteochondromas are relatively common benign bone tumors often located at the metaphyseal ends of long bones; however, they are rare in the head and neck region. The objective of this study is to present a case of an osteochondroma arising from the thyroid cartilage causing insidious dysphonia and to present a literature review.

Methods: The medical record of a patient treated for osteochondroma of the thyroid cartilage was reviewed. Read More

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September 2021

Sclerosing Polycystic Adenoma of Salivary Glands: A Novel Neoplasm Characterized by PI3K-AKT Pathway Alterations-New Insights Into a Challenging Entity.

Am J Surg Pathol 2021 Sep 13. Epub 2021 Sep 13.

Department of Pathology, Charles University, Faculty of Medicine in Plzen Bioptic Laboratory Ltd Molecular and Genetic Laboratory, Bioptic Laboratory Ltd, Plzen The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Králové Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine in Prague, Prague, Charles University and Motol University Hospital, Prague, Czech Republic Department of Histopathology, Division of Clinical Medicine, University of Surrey, Royal Surrey County Hospital, Guildford, Surrey, UK Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Comprehensive Cancer Center (CCC) Erlangen-EMN, Erlangen, Germany Department of Pathology, CHU Gui de Chauliac, Montpellier, France Department of Pathology, National University Health System, Singapore, Singapore Department of Pathology, Research Institute GROW, Maastricht University Medical Center, Maastricht, The Netherlands Department of Anatomic Histopathology and Cytogenetics, Department of Laboratory Medicine, Niguarda Cancer Center, Milan, Italy Medical Laboratory CSD, Kyiv, Ukraine Institute of Biomedicine, Pathology, University of Turku, and Turku University Hospital, Turku, Finland.

Sclerosing polycystic adenoma (SPA) is a rare salivary gland neoplasm originally thought to represent a non-neoplastic lesion. Recently we have encountered an index case of apocrine intraductal carcinoma of parotid gland of 62-year-old man with invasive salivary duct carcinoma component arising from SPA, a combination of tumor entities that has never been published so far. Here, we further explore the nature of SPA by evaluating 36 cases that were identified from the authors' consultation files. Read More

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September 2021

Basal cell carcinoma-not always the 'good guy': Case report of a life-threatening basosquamous carcinoma and review of the literature.

Exp Ther Med 2021 Oct 10;22(4):1158. Epub 2021 Aug 10.

Department of Urology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Cutaneous basosquamous carcinoma is a variant of basal cell carcinoma that is characterized by histopathological features of both basal and squamous cell carcinoma. Due to its local invasiveness, high frequency of recurrence, and its metastatic potential, it is considered to be one of the most aggressive subtypes of basal cell carcinoma. We present the case of an 81-year-old male who was admitted to the hospital with incessant hemorrhage arising from a cutaneous tumor that later proved to be a basosquamous carcinoma. Read More

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October 2021

Sudden death in an adolescent due to undiagnosed classic Hodgkin lymphoma.

J Forensic Sci 2021 Sep 9. Epub 2021 Sep 9.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Few cases of natural sudden death presenting as an undiagnosed lymphoma have been reported in the literature, especially in adolescents. Herein we provide a report of sudden death caused by undiagnosed classic Hodgkin lymphoma (cHL). We describe an 18-year-old female who collapsed after several weeks of weight loss, decreased appetite, and dyspnea. Read More

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September 2021

PD-1 Tcf1 CD8 T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure.

Cell Rep 2021 Sep;36(10):109672

Department of Oncology, University of Lausanne, Lausanne, Switzerland. Electronic address:

Virus-specific PD1 Tcf1 memory-like CD8 T cells (Ts) maintain the CD8 T cell response during chronic viral infection. However, the fate of these cells following cessation of persistent antigen exposure has been unclear. Here, we find that Ts persist upon transfer into antigen-free hosts and form memory following recall stimulation. Read More

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September 2021

Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia.

Front Immunol 2021 19;12:697307. Epub 2021 Aug 19.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

The interplay between T- and B-cell compartments during naïve, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B cell impact on T cell subsets, starting from the thymic selection. Here we investigated characteristics of naïve and effector T cell subsets in XLA patients, revealing prominent alterations in the corresponding T-cell receptor (TCR) repertoires. Read More

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Electrochemical sensor based on Ni-exchanged natural zeolite/carbon black hybrid nanocomposite for determination of vitamin B.

Mikrochim Acta 2021 Sep 6;188(10):323. Epub 2021 Sep 6.

Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059, Krakow, Poland.

The utilization of environmentally friendly nanoporous natural zeolite exchanged with Ni ions (NiZ) and conductive carbon black (CB) in the fabrication of a novel and selective voltammetric sensor of vitamin B (VB) is presented. The used clinoptilolite-rich zeolite material and CB were characterized in terms of morphology and textural properties. The superior properties of Ni-zeolite/carbon black modified glassy carbon electrode (NiZCB-GCE), arising from the synergistic effect of combining the unique features of zeolite and conductive carbon black, were confirmed by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements. Read More

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September 2021

Inter-trial effects in priming of pop-out: Comparison of computational updating models.

PLoS Comput Biol 2021 Sep 3;17(9):e1009332. Epub 2021 Sep 3.

Department of Psychology, Ludwig-Maximilians-Universität München, Munich, Germany.

In visual search tasks, repeating features or the position of the target results in faster response times. Such inter-trial 'priming' effects occur not just for repetitions from the immediately preceding trial but also from trials further back. A paradigm known to produce particularly long-lasting inter-trial effects-of the target-defining feature, target position, and response (feature)-is the 'priming of pop-out' (PoP) paradigm, which typically uses sparse search displays and random swapping across trials of target- and distractor-defining features. Read More

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September 2021

Genomic Profiling of Combined Hepatocellular Cholangiocarcinoma Reveals Genomics Similar to Either Hepatocellular Carcinoma or Cholangiocarcinoma.

JCO Precis Oncol 2021 Aug 19;5. Epub 2021 Aug 19.

Foundation Medicine Inc, Cambridge, MA.

Purpose: Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a rare, aggressive primary liver carcinoma, with morphologic features of both hepatocellular carcinomas (HCC) and liver cholangiocarcinomas (CCA).

Methods: The genomic profiles of 4,975 CCA, 1,470 HCC, and 73 cHCC-CCA cases arising from comprehensive genomic profiling in the course of clinical care were reviewed for genomic alterations (GA), tumor mutational burden, microsatellite instability status, genomic loss of heterozygosity, chromosomal aneuploidy, genomic ancestry, and hepatitis B virus status.

Results: In cHCC-CCA, GA were most common in (65. Read More

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Avoiding bias in self-controlled case series studies of coronavirus disease 2019.

Stat Med 2021 Sep 1. Epub 2021 Sep 1.

School of Mathematics and Statistics, The Open University, Milton Keynes, UK.

Many studies, including self-controlled case series (SCCS) studies, are being undertaken to quantify the risks of complications following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). One such SCCS study, based on all COVID-19 cases arising in Sweden over an 8-month period, has shown that SARS-CoV-2 infection increases the risks of AMI and ischemic stroke. Some features of SARS-CoV-2 infection and COVID-19, present in this study and likely in others, complicate the analysis and may introduce bias. Read More

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September 2021

Approach to Cystic Lesions in the Abdomen and Pelvis, with Radiologic-Pathologic Correlation.

Radiographics 2021 Sep-Oct;41(5):1368-1386

From the Department of Radiology, MedStar Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (J.H.Y., J.A.C., M.A.M.); Pathology and Laboratory Medicine Service, VA Medical Center, Washington, DC (E.E.P.); Department of Pathology, George Washington University School of Medicine and Health Sciences, Washington, DC (E.E.P.); and American Institute for Radiologic Pathology, Silver Spring, Md (M.A.M.).

Cystic lesions found in and around the peritoneal cavity can often be challenging to diagnose owing to significant overlap in imaging appearance between the different entities. When the cystic lesion can be recognized to arise from one of the solid abdominal organs, the differential considerations can be more straightforward; however, many cystic lesions, particularly when large, cannot be clearly associated with one of the solid organs. Cystic lesions arising from the mesentery and peritoneum are less commonly encountered and can be caused by relatively rare entities or by a variant appearance of less-rare entities. Read More

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September 2021

Signatures of Dimensionality and Symmetry in Exciton Band Structure: Consequences for Exciton Dynamics and Transport.

Nano Lett 2021 Aug 31. Epub 2021 Aug 31.

Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot 7610001, Israel.

Exciton dynamics, lifetimes, and scattering are directly related to the exciton dispersion or band structure. Here, we present a general theory for exciton band structure within both and model Hamiltonian approaches. We show that contrary to common assumption, the exciton band structure contains nonanalytical discontinuities-a feature which is impossible to obtain from the electronic band structure alone. Read More

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Congenital Coronary Artery Anomalies and Sudden Cardiac Death.

Pediatr Cardiol 2021 Aug 30. Epub 2021 Aug 30.

Cardiology Unit, ASST Fatebenefratelli Sacco - Luigi Sacco University Hospital, University of Milan, Via G.B. Grassi, 74, 20157, Milan, Italy.

Coronary artery anomalies (CAAs) are a heterogeneous group of rare congenital diseases whose features and pathophysiological mechanisms are extremely variable, ranging from silent anomalies to sudden cardiac death (SCD) in the most severe cases. Although rare, congenital CAAs confer a high risk of myocardial ischemia and SCD, especially in young, previously "healthy" athletes during or immediately after vigorous exertion. Although some high-risk features that may lead to SCD have been identified, specific pathophysiological mechanisms related to SCD still remain poorly understood. Read More

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Clinicopathological analysis of primary carcinoid tumour of the ovary arising in mature cystic teratomas.

J Int Med Res 2021 Aug;49(8):3000605211034666

Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of patients with primary ovarian carcinoid tumours arising in mature cystic teratomas.

Methods: This retrospective case series analysed the data from patients with primary ovarian carcinoid tumours arising in mature cystic teratomas.

Results: The study enrolled four patients. Read More

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Identification and prevalence of potentially therapeutic targetable variants of major cancer driver genes in ampullary cancer patients in India through deep sequencing.

Cancer Genet 2021 Aug 15;258-259:41-48. Epub 2021 Aug 15.

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India.

Ampulla is a complex region located at the confluence of pancreatic and common bile duct and intestinal epithelium. Tumors arising in this region are anatomically and morphologically heterogenous, however they show unique as well as overlapping molecular features. Cancers of both these anatomic sites share morphological as well as genetic profile despite having few unique differences. Read More

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A case of peripancreatic plexiform schwannoma.

Surg Case Rep 2021 Aug 28;7(1):199. Epub 2021 Aug 28.

Department of Surgery, Osaka Saiseikai Nakatsu Hospital, 2-10-39, Shibata, Kita-ku, Osaka, 530-0012, Japan.

Background: Plexiform schwannoma is one of the least common variants of schwannoma, accounting for only 5% of all schwannoma cases. It generally occurs in the skin and subcutaneous tissues and is uncommon in deep soft tissue or viscera. We present an extremely rare case of plexiform schwannoma arising from the peripancreatic plexus. Read More

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Distinctive Supramolecular Features of β-Cyclodextrin Inclusion Complexes with Antidepressants Protriptyline and Maprotiline: A Comprehensive Structural Investigation.

Authors:
Thammarat Aree

Pharmaceuticals (Basel) 2021 Aug 18;14(8). Epub 2021 Aug 18.

Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Depression, a global mental illness, is worsened due to the coronavirus disease 2019 (COVID-2019) pandemic. Tricyclic antidepressants (TCAs) are efficacious for the treatment of depression, even though they have more side effects. Cyclodextrins (CDs) are powerful encapsulating agents for improving molecular stability, water solubility, and lessening the undesired effects of drugs. Read More

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Cutaneous Melanomas Arising during Childhood: An Overview of the Main Entities.

Dermatopathology (Basel) 2021 Aug 1;8(3):301-314. Epub 2021 Aug 1.

Department of Biopathology, Center Léon Bérard, 69008 Lyon, France.

Cutaneous melanomas are exceptional in children and represent a variety of clinical situations, each with a different prognosis. In congenital nevi, the risk of transformation is correlated with the size of the nevus. The most frequent type is lateral transformation, extremely rare before puberty, reminiscent of a superficial spreading melanoma (SSM) ex-nevus. Read More

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ST-GREED: Space-Time Generalized Entropic Differences for Frame Rate Dependent Video Quality Prediction.

IEEE Trans Image Process 2021 1;30:7446-7457. Epub 2021 Sep 1.

We consider the problem of conducting frame rate dependent video quality assessment (VQA) on videos of diverse frame rates, including high frame rate (HFR) videos. More generally, we study how perceptual quality is affected by frame rate, and how frame rate and compression combine to affect perceived quality. We devise an objective VQA model called Space-Time GeneRalized Entropic Difference (GREED) which analyzes the statistics of spatial and temporal band-pass video coefficients. Read More

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September 2021

Does the primary tumour location affect the prognosis of patients with colorectal cancer peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?

World J Surg Oncol 2021 Aug 26;19(1):253. Epub 2021 Aug 26.

Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: The impact of primary tumour location on the prognosis of patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is rarely discussed, and the evidence is still limited.

Methods: Patients with PM arising from CRC treated with CRS and HIPEC at the China National Cancer Center and Huanxing Cancer Hospital between June 2017 and June 2019 were systematically reviewed. Clinical characteristics, pathological features, perioperative parameters, and prognostic data were collected and analysed. Read More

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The Genetics of Myelodysplastic Syndromes: Clinical Relevance.

Genes (Basel) 2021 Jul 27;12(8). Epub 2021 Jul 27.

IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy.

Myelodysplastic syndromes (MDS) are a clonal disease arising from hematopoietic stem cells, that are characterized by ineffective hematopoiesis (leading to peripheral blood cytopenia) and by an increased risk of evolution into acute myeloid leukemia. MDS are driven by a complex combination of genetic mutations that results in heterogeneous clinical phenotype and outcome. Genetic studies have enabled the identification of a set of recurrently mutated genes which are central to the pathogenesis of MDS and can be organized into a limited number of cellular pathways, including RNA splicing (, , , genes), DNA methylation (, , ), transcription regulation (), signal transduction (, ), DNA repair (), chromatin modification (, ), and cohesin complex (). Read More

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Uveal Melanoma Identified as Ocular Mass on Point-of-care Ultrasound.

Clin Pract Cases Emerg Med 2021 Aug;5(3):367-368

University of California, Los Angeles, Department of Emergency Medicine, Los Angeles, California.

Case Presentation: A 41-year-old man presented to the emergency department with five months of progressive monocular vision loss in his right eye, which he described as a gradually descending and enlarging black spot. He had no light perception in his right eye with elevated intraocular pressure and an afferent pupillary defect, while his left eye visual acuity and pupillary exam was normal. Point-of-care ultrasound demonstrated a hyperechoic, pedunculated mass in the posterior chamber of his right eye, consistent with a diagnosis of ocular melanoma. Read More

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p16 Regulates Cellular Senescence in PD-1-Expressing Human T Cells.

Front Immunol 2021 9;12:698565. Epub 2021 Aug 9.

Research Centre, Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada.

T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the development of cellular senescence features both and . This is associated with p16 expression and an impaired cell cycle G1 to S-phase transition in repeatedly stimulated T cells. Read More

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