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2D confinement freestanding graphene oxide composite membranes with enriched oxygen vacancies for enhanced organic contaminants removal via peroxymonosulfate activation.

J Hazard Mater 2021 May 8;417:126028. Epub 2021 May 8.

Institute of Green Chemistry and Chemical Technology, Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Introducing membrane filtration into advanced oxidation processes to decrease energy and cost consumption has been considered as a promising direction in environmental remediation. In this work, we firstly developed a kind of novel lawn-like FeO@CoFe@nitrogen-doped reduced graphene oxide@carbon nanotube composites (FeCo@GCTs) through in-situ pyrolysis of self-assembly of Prussian blue analogues and GO, followed through a vacuum-assisted filtration strategy to fabricate 2D confinement freestanding GO composite membrane. Electrochemical analysis and H-TPR revealed the superiority of FeCo@GCTs as ideal electron acceptor, and this unique lawn-like structure concentrated active sites with a confined space and enriched oxygen vacancies that realized 98. Read More

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A new evaluation framework for nature-based solutions (NBS) projects based on the application of performance questions and indicators approach.

Sci Total Environ 2021 May 7;787:147615. Epub 2021 May 7.

GEMMA-Group of Environmental Engineering and Microbiology, Department of Civil and Environmental Engineering, Universitat Politècnica de Catalunya-BarcelonaTech, c/ Jordi Girona 1-3, Building D1, E-08034 Barcelona, Spain. Electronic address:

One of the key features of nature-based solutions (NBSs) is their high effectiveness and economic and resource efficiency in solving problems compared to traditional grey interventions. These aspects, however, have so far attracted little attention in the literature but should be considered, as the evaluation of NBS projects before implementation provides an opportunity to use them as practical tools. This paper aims to present a new evaluation framework of NBS projects (at the stage of solution selection) based on the application of performance questions and the indicators approach. Read More

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Exposure to legacy and novel perfluoroalkyl substance disturbs the metabolic homeostasis in pregnant women and fetuses: A metabolome-wide association study.

Environ Int 2021 May 12;156:106627. Epub 2021 May 12.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, People's Republic of China.

Background: Perfluoroalkyl substances (PFASs) exist extensively and several of these have been verified to be toxic. Prenatal exposure to PFASs has attracted much attention. Metabolome-wide association analyses can be used to explore the toxicity mechanisms of PFASs by identifying associated biomarkers. Read More

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Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity.

DNA Repair (Amst) 2021 May 9;103:103130. Epub 2021 May 9.

Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

The bacterial SOS response to DNA damage induces an error-prone repair program that is mutagenic. In Escherichia coli, SOS-induced mutations are caused by the translesion synthesis (TLS) activity of two error-prone polymerases (EPPs), Pol IV and Pol V. The mutational footprint of the EPPs is confounded by both DNA damage and repair, as mutations are targeted to DNA lesions via TLS and corrected by the mismatch repair (MMR) system. Read More

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Exposures and associations with clinical phenotypes in hypersensitivity pneumonitis: A scoping review.

Respir Med 2021 May 6;184:106444. Epub 2021 May 6.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: https://twitter.com/KerriBerriKerri.

Antigen identification is important for establishing a confident diagnosis of hypersensitivity pneumonitis (HP). There are no systematically curated lists of HP-associated exposures that inform clinical relevance or disease phenotype. We sought to systematically identify all reported causes of HP in the literature and evaluate their clinical relevance. Read More

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Response of European grayling, Thymallus thymallus, to multiple stressors in hydropeaking rivers.

J Environ Manage 2021 May 12;292:112737. Epub 2021 May 12.

Institute of Hydrobiology and Aquatic Ecosystem Management, University of Natural Resources and Life Sciences, Vienna, Austria.

Rivers of the large Alpine valleys constitute iconic ecosystems that are highly threatened by multiple anthropogenic stressors. This stressor mix, however, makes it difficult to develop and refine conservation and restoration strategies. It is, therefore, urgent to acquire more detailed knowledge on the consequences and interactions of prevalent stressors on fish populations, in particular, on indicator species such as the European grayling Thymallus thymallus. Read More

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Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site.

Parkinsonism Relat Disord 2021 May 12;87:70-74. Epub 2021 May 12.

IRCCS Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

Background: Adult-onset focal dystonia can spread to involve one, or less frequently, two additional body regions. Spread of focal dystonia to a third body site is not fully characterized.

Materials And Methods: We retrospectively analyzed data from the Italian Dystonia Registry, enrolling patients with segmental/multifocal dystonia involving at least two parts of the body or more. Read More

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The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database.

Oral Oncol 2021 May 12;118:105330. Epub 2021 May 12.

Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: The number of elderly patients with oral squamous cell carcinoma (OCSCC) is increasing as the elderly population increases. Unfortunately, evidence to guide the management of these patients is lacking.

Methods: Patients with OCSCC identified from the National Cancer Database (NCDB) were stratified into age-based cohorts. Read More

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Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth.

Am J Obstet Gynecol MFM 2021 May 12:100393. Epub 2021 May 12.

Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC; Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC.

Background: There is an increased awareness regarding the association between exposure to environmental contaminants and adverse pregnancy outcomes including preterm birth. Whether an individual's metabolic profile can be utilized during pregnancy to differentiate the subset of patients who are ultimately destined to deliver preterm remains uncertain but could have significant clinical implications.

Objective: We sought to objectively quantify metabolomic profiles of patients at high risk for preterm birth by evaluating mid-trimester maternal plasma, and to measure whether endogenous metabolites and exogenous environmental substances differ among those who ultimately deliver preterm compared to those who deliver at term. Read More

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Deep Recurrent Model for Individualized Prediction of Alzheimer's Disease Progression.

Neuroimage 2021 May 12:118143. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea.

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developing AD in its earliest time. While many of the previous works considered cross-sectional analysis, more recent studies have focused on the diagnosis and prognosis of AD with longitudinal or time series data in a way of disease progression modeling. Read More

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Proteomic insights into protostane triterpene biosynthesis regulatory mechanism after MeJA treatment in Alisma orientale (Sam.) Juz.

Biochim Biophys Acta Proteins Proteom 2021 May 12:140671. Epub 2021 May 12.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Protostane triterpenes in Alisma orientale (Sam.) Juz. have unique structural features with distinct pharmacological activities. Read More

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Phylogeny and evolutionary history of the amniote egg.

J Morphol 2021 May 15. Epub 2021 May 15.

Department of Biology, Trinity College, Hartford, CT, USA.

We review morphological features of the amniote egg and embryos in a comparative phylogenetic framework, including all major clades of extant vertebrates. We discuss 40 characters that are relevant for an analysis of the evolutionary history of the vertebrate egg. Special attention is given to the morphology of the cellular yolk sac, the eggshell and extraembryonic membranes. Read More

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Value of Dynamic Contrast-Enhanced (DCE) MRI in Predicting Response to Foam Sclerotherapy of Venous Malformations.

J Magn Reson Imaging 2021 May 15. Epub 2021 May 15.

Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.

Background: Preoperative imaging assessment of venous malformations (VMs) and prediction of foam sclerotherapy efficacy might be achievable by DCE-MRI but elaborate quantitive analysis was absent.

Purpose: To evaluate the value of DCE-MRI in predicting the effectiveness of foam sclerotherapy in VMs.

Study Type: Retrospective. Read More

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The hunt for a yet unknown: Common molecular signature in some genetically monomorphic enterobacteria.

J Basic Microbiol 2021 May 15. Epub 2021 May 15.

Distributed Information Centre for Bioinformatics, Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Calcutta, West Bengal, India.

Mark Achtman introduced the term "genetically monomorphic bacteria" (GM bacteria) for some human and plant pathogens. They displayed a great uniformity in terms of their "genetic" properties. This "uniformity" poses a challenge to microbiologists. Read More

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The significance of synovial biopsy in the diagnostic workup of the low-grade periprosthetic joint infection of shoulder arthroplasty.

Arch Orthop Trauma Surg 2021 May 15. Epub 2021 May 15.

Department of Joint Replacement, Orthopaedic Clinic Markgröningen, Kurt-Lindemann-Weg 10, 71706, Markgröningen, Germany.

Introduction: A common reason for painful shoulder arthroplasties and revision surgery is a low-grade periprosthetic joint infection (PJI). Diagnosing a low-grade infection is, however, a major diagnostic challenge. This applies even more to the shoulder, which differs from other large joints in terms of clinical features and microbiological spectrum. Read More

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Can MRI differentiate surrounding vertebral invasion from reactive inflammatory changes in superior sulcus tumor?

Eur Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, Paris, France.

Objectives: Vertebral invasion is a key prognostic factor and a critical aspect of surgical planning for superior sulcus tumors. This study aims to further evaluate MRI features of vertebral invasion in order to distinguish it from reactive inflammatory changes.

Methods: Between 2000 and 2016, a retrospective study was performed at a single institution. Read More

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A Real-World Analysis of Patients with Untreated Metastatic Epidermal Growth Factor Receptor (EGFR)-Mutated Lung Adenocarcinoma Receiving First-Line Erlotinib and Bevacizumab Combination Therapy.

Oncol Ther 2021 May 15. Epub 2021 May 15.

Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, No. 5, Fuxing 1st Rd., Guishan Dist., Taoyuan City, 333005, Taiwan.

Introduction: The clinical features of patients with metastatic epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma receiving first-line therapy based on erlotinib combined with bevacizumab are unclear. Here, we sought to analyze the clinical features of this patient group.

Methods: Data were analyzed for the period from January 2015 to August 2019 for 49 patients with metastatic EGFR-mutated lung adenocarcinoma receiving first-line erlotinib-and-bevacizumab combination therapy from the Linkou and Kaohsiung Chang Gung Memorial Hospitals. Read More

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Comparative genomics analysis of Pediococcus acidilactici species.

J Microbiol 2021 May 15. Epub 2021 May 15.

BGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China.

Pediococcus acidilactici is a reliable bacteriocin producer and a promising probiotic species with wide application in the food and health industry. However, the underlying genetic features of this species have not been analyzed. In this study, we performed a comprehensive comparative genomic analysis of 41 P. Read More

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Effect of continuous positive airway pressure on albuminuria in patients with obstructive sleep apnea: a meta-analysis.

Sleep Breath 2021 May 15. Epub 2021 May 15.

Department of Obstetrics & Gynecology, Nanri Branch of the First Hospital of Putian City, Putian, Fujian, China.

Purpose: A relationship between albuminuria and obstructive sleep apnea (OSA) has been documented in previous studies. Nevertheless, the impact of continuous positive airway pressure (CPAP) treatment on albuminuria in subjects with OSA is debated. This meta-analysis was carried out to investigate whether or not CPAP treatment affected urinary albumin-to-creatinine ratio (UACR) in subjects with OSA. Read More

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Assessment of Bioanalytical Method Validation Data Utilizing Heteroscedastic Seven-Point Linear Calibration Curves by EZSTATSG1 Customized Microsoft Excel Template.

J Anal Toxicol 2021 May 15. Epub 2021 May 15.

The School of Science, Technology, and Mathematics, Ohio Northern University, 525 South Main Street, Ada, Ohio 45810, USA.

Bioanalytical methods developed in accredited forensic toxicology laboratories need to be validated according to the ISO/IEC 17025 standards to demonstrate that a method is fit for the intended use. The evaluation of the validation data can be a time-consuming process without a streamlined procedure on a common platform or the aid of a specific software package. The objective of this work was to develop a Microsoft (MS) Excel (Redmond, WA, USA) template, which can rapidly generate all the required numerical and statistical validation results of a quantitative bioanalytical assay with minimal data entry, and to provide documented traceability of the validation data directly to the instrument raw data. Read More

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A convolution based computational approach towards DNA N6-methyladenine site identification and motif extraction in rice genome.

Sci Rep 2021 May 14;11(1):10357. Epub 2021 May 14.

United International University, Dhaka, Bangladesh.

DNA N6-methylation (6mA) in Adenine nucleotide is a post replication modification responsible for many biological functions. Automated and accurate computational methods can help to identify 6mA sites in long genomes saving significant time and money. Our study develops a convolutional neural network (CNN) based tool i6mA-CNN capable of identifying 6mA sites in the rice genome. Read More

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Differential features of chronic cough according to etiology and the simple decision tree for predicting causes.

Sci Rep 2021 May 14;11(1):10326. Epub 2021 May 14.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.

Finding etiology of chronic cough is an essential part of treatment. Although guidelines include many laboratory tests for diagnosis, these are not possible in many primary care centers. We aimed to identify the characteristics and the differences associated with its cause to develop a clinical prediction model. Read More

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Natural language processing methods are sensitive to sub-clinical linguistic differences in schizophrenia spectrum disorders.

NPJ Schizophr 2021 May 14;7(1):25. Epub 2021 May 14.

Linguistics Data Consortium, 3600 Market St, Suite 810, Philadelphia, PA, USA.

Computerized natural language processing (NLP) allows for objective and sensitive detection of speech disturbance, a hallmark of schizophrenia spectrum disorders (SSD). We explored several methods for characterizing speech changes in SSD (n = 20) compared to healthy control (HC) participants (n = 11) and approached linguistic phenotyping on three levels: individual words, parts-of-speech (POS), and sentence-level coherence. NLP features were compared with a clinical gold standard, the Scale for the Assessment of Thought, Language and Communication (TLC). Read More

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Silica-copper catalyst interfaces enable carbon-carbon coupling towards ethylene electrosynthesis.

Nat Commun 2021 May 14;12(1):2808. Epub 2021 May 14.

Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.

Membrane electrode assembly (MEA) electrolyzers offer a means to scale up CO-to-ethylene electroconversion using renewable electricity and close the anthropogenic carbon cycle. To date, excessive CO coverage at the catalyst surface with limited active sites in MEA systems interferes with the carbon-carbon coupling reaction, diminishing ethylene production. With the aid of density functional theory calculations and spectroscopic analysis, here we report an oxide modulation strategy in which we introduce silica on Cu to create active Cu-SiO interface sites, decreasing the formation energies of OCOH* and OCCOH*-key intermediates along the pathway to ethylene formation. Read More

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A spatial model of YAP/TAZ signaling reveals how stiffness, dimensionality, and shape contribute to emergent outcomes.

Proc Natl Acad Sci U S A 2021 May 14;118(20). Epub 2021 May 14.

Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA 92093

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on translocation from the cytoplasm to the nucleus in response to diverse physical cues. Substrate stiffness, substrate dimensionality, and cell shape are all input signals for YAP/TAZ, and through this pathway, regulate critical cellular functions and tissue homeostasis. Yet, the relative contributions of each biophysical signal and the mechanisms by which they synergistically regulate YAP/TAZ in realistic tissue microenvironments that provide multiplexed input signals remain unclear. Read More

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Metagenomic analysis reveals the shared and distinct features of the soil resistome across tundra, temperate prairie, and tropical ecosystems.

Microbiome 2021 May 14;9(1):108. Epub 2021 May 14.

Interdisciplinary Research Center for Soil Microbial Ecology and Land Sustainable Productivity in Dry Areas, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Background: Soil is an important reservoir of antibiotic resistance genes (ARGs), but their potential risk in different ecosystems as well as response to anthropogenic land use change is unknown. We used a metagenomic approach and datasets with well-characterized metadata to investigate ARG types and amounts in soil DNA of three native ecosystems: Alaskan tundra, US Midwestern prairie, and Amazon rainforest, as well as the effect of conversion of the latter two to agriculture and pasture, respectively.

Results: High diversity (242 ARG subtypes) and abundance (0. Read More

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Surface-enhanced Raman spectroscopy for analysis of PCR products of viral RNA of hepatitis C patients.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 5;259:119908. Epub 2021 May 5.

PCR Laboratory, PINUM Hospital, Faisalabad, Pakistan.

In the current study, for a qualitative and quantitative study of Polymerase Chain Reaction (PCR) products of viral RNA of Hepatitis C virus (HCV) infection, surface-enhanced Raman spectroscopy (SERS) methodology has been developed. SERS was used to identify the spectral features associated with the PCR products of viral RNA of Hepatitis C in various samples of HCV-infected patients with predetermined viral loads. The measurements for SERS were performed on 30 samples of PCR products, which included three PCR products of RNA of healthy individuals, six negative controls, and twenty-one HCV positive samples of varying viral loads (VLs) using Silver nanoparticles (Ag NPs) as a SERS substrates. Read More

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Differentiation of inflammatory from degenerative changes in the sacroiliac joints by machine learning supported texture analysis.

Eur J Radiol 2021 May 11;140:109755. Epub 2021 May 11.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.

Purpose: To compare the diagnostic performance of texture analysis (TA) against visual qualitative assessment in the differentiation of spondyloarthritis (SpA) from degenerative changes in the sacroiliac joints (SIJ).

Method: Ninety patients referred for suspected inflammatory lower back pain from the rheumatology department were retrospectively included at our university hospital institution. MRI at 3 T of the lumbar spine and SIJ was performed with oblique coronal T1-weighted (w), fluid-sensitive fat-saturated (fs) TIRM and fsT1w intravenously contrast-enhanced (CE) images. Read More

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Integrating multi-omics data through deep learning for accurate cancer prognosis prediction.

Comput Biol Med 2021 May 9;134:104481. Epub 2021 May 9.

School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, 510000, China; Key Laboratory of Machine Intelligence and Advanced Computing (MOE), Sun Yat-sen University, Guangzhou, 510000, China. Electronic address:

Background: Genomic information is nowadays widely used for precise cancer treatments. Since the individual type of omics data only represents a single view that suffers from data noise and bias, multiple types of omics data are required for accurate cancer prognosis prediction. However, it is challenging to effectively integrate multi-omics data due to the large number of redundant variables but relatively small sample size. Read More

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Mismatch Repair Status Correlates With Survival in Young Adults With Metastatic Colorectal Cancer.

J Surg Res 2021 May 11;266:104-112. Epub 2021 May 11.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa. Electronic address:

Background: Young adults with metastatic colorectal cancer (mCRC) may have higher rates of deficient mismatch repair (dMMR) than older patients. This study sought to assess patterns of MMR-testing and survival among young adult mCRC patients in the National Cancer Database (NCDB), hypothesizing that dMMR correlates with worse survival than in MMR-proficient (pMMR) patients.

Methods: Stage-IV colorectal cancers were identified in NCDB (2010-2016). Read More

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