48,039 results match your criteria favorable outcome


Semicircular Lipoatrophy: A Case Series With Follow-up of 76 Patients in Madrid and a Proposed Classification.

Actas Dermosifiliogr 2021 Jun 8. Epub 2021 Jun 8.

Servicio de ITS/Dermatología. Sección de Especialidades Médicas, Organismo Autónomo Madrid Salud, Ayuntamiento de Madrid, Madrid, España. Electronic address:

Background And Objective: The clinical presentations of semicircular lipoatrophy (SL) vary, and diagnostic criteria are unclear. Several etiopathogenic factors, including occupational environmental ones, have been suggested. We aimed to describe a cluster of cases of suspected SL that started to appear in May 2008 among employees of the city council of Madrid, Spain. Read More

View Article and Full-Text PDF

Acute Gluteal Compartment Syndrome with Nonclassical Symptoms: A Case Report on an Easily Missed Diagnosis.

JBJS Case Connect 2021 Jun 11;11(2). Epub 2021 Jun 11.

Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois.

Case: A 34-year-old man presented to the emergency department with rhabdomyolysis, acute kidney injury, and pain in the gluteal region after falling asleep on his side after heroin and alcohol use. On examination, he had swollen gluteal compartment musculature; however, he tolerated full passive range of motion with minimal pain. Intercompartmental pressure measured >110 mm Hg; therefore, emergent fasciotomy of the gluteal compartment musculature was performed. Read More

View Article and Full-Text PDF

End-to-End Automatic Morphological Classification of Intracranial Pressure Pulse Waveforms Using Deep Learning.

IEEE J Biomed Health Inform 2021 Jun 11;PP. Epub 2021 Jun 11.

Objective: Mean intracranial pressure (ICP) is commonly used in the management of patients with intracranial pathologies. However, the shape of the ICP signal over a single cardiac cycle, called ICP pulse waveform, also contains information on the state of the craniospinal space. In this study we aimed to propose an end-to-end approach to classification of ICP waveforms and assess its potential clinical applicability. Read More

View Article and Full-Text PDF

Overall and event-free survival of childhood lymphoma in Greece: analysis of harmonized clinical data over a 24-year active registration period.

Leuk Lymphoma 2021 Jun 11:1-13. Epub 2021 Jun 11.

Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

We assessed event-free (EFS) and overall (OS) survival in 676 incident cases of childhood Hodgkin (HL) and non-Hodgkin (NHL) lymphoma actively registered in Greece (1996-2019). HL-OS was 96% and NHL-OS 85%, whereas HL-EFS was 86% and NHL-EFS was 81%, notably similar to the respective OS rates (HL: 95%, NHL: 85%) in developed countries. For HL, older age at diagnosis, high maternal education and close proximity to treatment centers were linked to remarkably favorable outcomes. Read More

View Article and Full-Text PDF

Long-term cognitive and academic outcomes among pediatric brain tumor survivors treated with proton versus photon radiotherapy.

Pediatr Blood Cancer 2021 Jun 11:e29125. Epub 2021 Jun 11.

Department of Pediatrics, Section of Psychology, Baylor College of Medicine, Houston, Texas, USA.

Background: Proton radiotherapy (PRT) may be associated with less neurocognitive risk than photon RT (XRT) for pediatric brain tumor survivors. We compared neurocognitive and academic outcomes in long-term survivors treated with XRT versus PRT.

Methods: Survivors underwent neurocognitive evaluation >1 year after craniospinal (CSI) or focal PRT or XRT. Read More

View Article and Full-Text PDF

Cruroplasty added to laparoscopic sleeve gastrectomy; does it decrease postoperative incidence of de-novo acid reflux?: A randomised controlled trial.

Ann Med Surg (Lond) 2021 Jun 21;66:102415. Epub 2021 May 21.

Department of General Surgery, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.

Background: Laparoscopic sleeve gastrectomy(LSG) is the most popular bariatric surgery worldwide. Postoperative de-novo acid reflux is one of the major common complications of the procedure. Different additive anti-reflux surgical techniques have been tried to decrease the complication although no favorable outcome is obtained. Read More

View Article and Full-Text PDF

The Prognostic Value of the Acute Phase Systemic Immune-Inflammation Index in Patients With Intracerebral Hemorrhage.

Front Neurol 2021 25;12:628557. Epub 2021 May 25.

Neurosurgery Department of West China Hospital, Sichuan University, Chengdu, China.

The systemic immune-inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH). Patients with primary spontaneous ICH were enrolled. Read More

View Article and Full-Text PDF

Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML.

Cell Death Discov 2021 Jun 10;7(1):137. Epub 2021 Jun 10.

Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Over the last 50 years, there has been a steady improvement in the treatment outcome of acute myeloid leukemia (AML). However, median survival in the elderly is still poor due to intolerance to intensive chemotherapy and higher numbers of patients with adverse cytogenetics. Fadraciclib (CYC065), a novel cyclin-dependent kinase (CDK) 2/9 inhibitor, has preclinical efficacy in AML. Read More

View Article and Full-Text PDF

Impact of health-related quality of life on repeat protocol biopsy compliance on active surveillance for favorable prostate cancer: results from a prospective cohort in the PRIAS-JAPAN study.

Urol Oncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Objectives: This study aimed to evaluate how health-related quality of life (HRQOL) is related to repeat protocol biopsy compliance.

Materials And Methods: We conducted a retrospective analysis using data from a prospective cohort in the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study between January 2010 and August 2019. We used the Short Form 8 Health Survey (SF-8), as patient-reported outcomes, to assess HRQOL at AS enrollment and the first year of the protocol. Read More

View Article and Full-Text PDF

[Combination of apparent diffusion coefficient and amplitude-integrated electroencephalogram to predict the outcome of comatose patients with severe traumatic brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):609-612

Department of Neurology, Suqian First Hospital, Suqian 223899, Jiangsu, China.

Objective: To examine whether the combination of quantitative regional apparent diffusion coefficient (ADC) and amplitude-integrated electroencephalogram (aEEG) can predict the outcome of comatose patients with severe traumatic brain injury (sTBI).

Methods: A prospective study was conducted. The patients with coma caused by sTBI [Glasgow coma scale (GCS) < 8] admitted to Suqian First Hospital from January 2016 to June 2019 were enrolled. Read More

View Article and Full-Text PDF

Macrophage biomimetic nanocarriers for anti-inflammation and targeted antiviral treatment in COVID-19.

J Nanobiotechnology 2021 Jun 10;19(1):173. Epub 2021 Jun 10.

Center for Infection and Immunity, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, Guangdong, China.

Background: The worldwide pandemic of COVID-19 remains a serious public health menace as the lack of efficacious treatments. Cytokine storm syndrome (CSS) characterized with elevated inflammation and multi-organs failure is closely correlated with the bad outcome of COVID-19. Hence, inhibit the process of CSS by controlling excessive inflammation is considered one of the most promising ways for COVID-19 treatment. Read More

View Article and Full-Text PDF

Midterm outcome of biosynthetic collagen prosthesis for treating aortic and peripheral prosthetic graft infections.

Vascular 2021 Jun 10:17085381211025380. Epub 2021 Jun 10.

Department of Vascular Surgery, 155897Barmherzige Brüder Hospital, Regensburg, Germany.

Objectives: To report the midterm outcomes of treating prosthetic peripheral and aortic graft infections using a biosynthetic collagen prosthesis in a tertiary vascular center.

Methods: A retrospective analysis of all patients with prosthetic peripheral and aortic graft infections who underwent in situ reconstruction using a biosynthetic collagen prosthesis between March 2015 and November 2020 was conducted. Perioperative and midterm outcomes were analyzed. Read More

View Article and Full-Text PDF

Levels of bioactive adrenomedullin in plasma and cerebrospinal fluid in relation to delayed cerebral ischemia in patients after aneurysmal subarachnoid hemorrhage: A prospective observational study.

J Neurol Sci 2021 Jun 5;427:117533. Epub 2021 Jun 5.

Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

Objectives: Adrenomedullin (ADM) has been identified as a promising biomarker of mortality and outcome in sepsis, heart failure and after major surgery. A recently developed assay specific for bioactive adrenomedullin (bio-ADM) has not yet been assessed in aneurysmal subarachnoid hemorrhage (aSAH). The objective of this prospective trial was to assess the time course of bio-ADM after aSAH in relation to the development of delayed cerebral ischemia (DCI) and its association with clinical outcome. Read More

View Article and Full-Text PDF

Aerosolized plus intravenous colistin versus intravenous colistin alone for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria: A retrospective cohort study.

Int J Infect Dis 2021 Jun 7. Epub 2021 Jun 7.

Division of Infectious Diseases, Department of Medicine, King Saud University, Saudi Arabia.

Objective: The purpose of this study was to compare the effectiveness and safety of aerosolized (AER) plus intravenous (IV) colistin to IV colistin alone in patients with nosocomial pneumonia (NP) due to multidrug-resistant (MDR) Gram-negative bacteria.

Method: This was a retrospective cohort study of adults with NP who received IV colistin alone or in combination with adjunctive AER colistin. The primary endpoint was clinical cure at end of therapy. Read More

View Article and Full-Text PDF

Serum and hematologic responses after three cycles of cabazitaxel therapy as predictors of survival in castration-resistant prostate cancer.

Cancer Chemother Pharmacol 2021 Jun 10. Epub 2021 Jun 10.

Department of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: In this study, we investigated the association between the early response of serum and hematological variables and the outcome of cabazitaxel therapy.

Patients And Methods: The medical records of 59 consecutive patients who had previously received docetaxel chemotherapy for the treatment of metastatic castration-resistant prostate cancer (CRPC) and who received cabazitaxel at our hospital between January 2011 and March 2020 were retrospectively reviewed and statistically analyzed.

Results: The median follow-up period after cabazitaxel initiation was 15. Read More

View Article and Full-Text PDF

Communicating Uncertainties About the Effects of Medical Interventions Using Different Display Formats.

Risk Anal 2021 Jun 9. Epub 2021 Jun 9.

Management Division/Centre for Decision Research, Leeds University Business School, Leeds, West Yorkshire, UK.

Communicating uncertainties in scientific evidence is important to accurately reflect scientific knowledge , increase public understanding of uncertainty, and to signal transparency and honesty in reporting. While techniques have been developed to facilitate the communication of uncertainty, many have not been empirically tested, compared for communicating different types of uncertainty, or their effects on different cognitive, trust, and behavioral outcomes have not been evaluated. The present study examined how a point estimate, imprecise estimate, conflicting estimates, or a statement about the lack of evidence about treatment effects, influenced participant's responses to communications about medical evidence. Read More

View Article and Full-Text PDF

Early Exanthema Upon Vemurafenib Plus Cobimetinib Is Associated With a Favorable Treatment Outcome in Metastatic Melanoma: A Retrospective Multicenter DeCOG Study.

Front Oncol 2021 24;11:672172. Epub 2021 May 24.

Department of Dermatology, University Hospital Essen, German Cancer Consortium (DKTK), Essen, Germany.

Background: The combination of BRAF and MEK inhibitors has become standard of care in the treatment of metastatic BRAF V600-mutated melanoma. Clinical factors for an early prediction of tumor response are rare. The present study investigated the association between the development of an early exanthema induced by vemurafenib or vemurafenib plus cobimetinib and therapy outcome. Read More

View Article and Full-Text PDF

Characteristics and outcomes of lung cancers detected on low-dose lung cancer screening CT.

Cancer Epidemiol Biomarkers Prev 2021 Jun 9. Epub 2021 Jun 9.

Department of Radiology, Massachusetts General Hospital

Background: Lung cancer screening(LCS) with low-dose CT(LDCT) was implemented in the United States following National Lung Screening Trial(NLST). The real-world benefits of implementing LCS are yet to be determined with outcome-oriented data. The study objective is to investigate the characteristics and outcomes of screening detected lung cancers. Read More

View Article and Full-Text PDF

FLT3-ITD Allele Frequency Is an Independent Prognostic Factor for Poor Outcome in FLT3-ITD-Positive AML Patients.

Clin Lymphoma Myeloma Leuk 2021 May 11. Epub 2021 May 11.

Clinical Pathology and Oncologic Laboratory Medicine Department, National Cancer Institute, Cairo University, Egypt.

Background: FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a molecular genetic alteration significantly affecting the clinical outcome in patients with acute myeloid leukemia (AML). FLT3-ITD mutations are characterized by variable mutant-to-wild allelic ratios (ARs) and sizes of the duplicated sequences. The size of the inserted sequence may vary from a few to hundreds of nucleotides. Read More

View Article and Full-Text PDF

[Necrotizing Fasciitis of the Right Thigh Caused by Emphysematous Pyelonephritis Due to a Staghorn Stone : A Case Report].

Hinyokika Kiyo 2021 Apr;67(4):147-152

The Department of Urology, Muroran City General Hospital.

We report a rare case of necrotizing fasciitis in the thigh induced by emphysematous pyelonephritis due to a staghorn stone. A 60-year-old female was diagnosed with a staghorn stone in the right kidney at another clinic. We referred her to another hospital for indication of percutaneous nephrolithotripsy. Read More

View Article and Full-Text PDF

Stratification of urothelial bladder carcinoma depending on immunohistochemical expression of GATA3 and CK5/6.

J Immunoassay Immunochem 2021 Jun 9:1-17. Epub 2021 Jun 9.

Pathology Department, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.

Bladder urothelial carcinoma (BUC) has two pathways with distinct molecular features and prognosis, non-muscle invasive (NMI) and muscle invasive (MI) tumors. The aim is to investigate the expression of GATA3 and CK5/6 in BUC with correlation to clinicopathologic parameters, including their impact on survival beside their potential use to stratify cases into prognostic subgroups. This study included 80 cases of BUC stained immunohistochemically by GATA3 and CK5/6. Read More

View Article and Full-Text PDF

Periurethral injection with polyacrylamide after previous TVT surgery.

Int Urogynecol J 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Vestfold Hospital Trust, PO Box 2168, Postterminalen, 3103, Tønsberg, Norway.

Introduction And Hypothesis: The aim of this registry study was to assess the clinical utility of using periurethral bulking with polyacrylamide hydrogel in women with stress urinary incontinence (SUI) after previous midurethral sling surgery.

Methods: The study period was 2007 through 2019. Using data from the Norwegian Female Incontinence Registry we included 57 women who had received Bulkamid® because of insufficient improvement or recurrent SUI after previous retropubic TVT surgery. Read More

View Article and Full-Text PDF

[Percutaneous implantation of an aortic prosthetic valve on a degenerated mitral bioprosthesis. Report of one case].

Rev Med Chil 2021 Jan;149(1):137-141

Instituto Cardiovascular, Hospital Clínico San Carlos, Madrid, España.

Reintervention of a mitral degenerated bioprosthesis has a high surgical risk, especially in elderly patients with multiple comorbidities. We report a 74 years old female with two previous cardiac surgical procedures and a new structural mitral bioprosthesis deterioration with severe mitral regurgitation. Considering her high-surgical risk, a fully percutaneous treatment was performed with a balloon-expandable aortic valve in mitral position (valve-in-valve) through a transseptal approach with a favorable outcome. Read More

View Article and Full-Text PDF
January 2021

An Intervention to Improve Medication Adherence in People With Heart Disease (Text4HeartII): Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 Jun 9;9(6):e24952. Epub 2021 Jun 9.

National Institute for Health Innovation, University of Auckland, Auckland, New Zealand.

Background: Mobile health technologies have the potential to improve the reach and delivery of interventions for promoting long-term secondary prevention of coronary heart disease.

Objective: This study aims to determine the effectiveness of an SMS text messaging intervention (Text4HeartII) for improving adherence to medication and lifestyle changes over and above usual care in people with coronary heart disease at 24 and 52 weeks.

Methods: A two-arm, parallel, randomized controlled trial was conducted in New Zealand. Read More

View Article and Full-Text PDF

The role of oligohydramnios and fetal growth restriction in adverse pregnancy outcomes in preeclamptic patients.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Bursa Yüksek İhtisas Training and Research Hospital Department of Gynecology and Obstetrics, Bursa, Turkey.

Objectives: We aimed to compare perinatal outcomes of oligohydramnios or fetal growth restriction with normal amniotic fluid index and fetal growth in preeclampsia and to compare the outcomes of only oligohydramnios, only fetal growth restriction and oligohydramnios with fetal growth restriction preeclamptic groups.

Material And Methods: A total of 743 preeclamptic patients were evaluated between June 2016 and 2020. Patients were divided into two groups: preeclampsia with oligohydramnios or fetal growth restriction (n = 237) and preeclampsia with normal amniotic fluid index and fetal growth (n = 506). Read More

View Article and Full-Text PDF

[Clinical Features and Prognostic Factors of Patients with Multiple Myeloma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):772-780

Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, Jiangsu Province, China,E-mail:

Objective: To summarize the clinical and Laboratory characteristics of patients with multiple myeloma (MM) and analyze the prognostic factors.

Methods: Two hundred MM patients were retrospectively analyzed for the following parameters, including peripheral blood, bone marrow morphology, cytogenetics, clinical staging, and response to the chemotherapy in order to summarize related factors affecting overall survival (OS). The prognostic factors were also analyzed. Read More

View Article and Full-Text PDF

Neoadjuvant lenvatinib for inoperable thyroid cancer: A case report and literature review.

Cancer Rep (Hoboken) 2021 Jun 8:e1466. Epub 2021 Jun 8.

Department of Otorhinolaryngology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Background: Poorly differentiated thyroid cancer (PDTC) is now classified as a separate thyroid tumor entity. It has male predominance and poor prognosis compared to differentiated TC.

Case: We report a case of a patient with PDTC who was previously deemed inoperable. Read More

View Article and Full-Text PDF

Outcomes and Nephrotoxicity Associated with Vancomycin Treatment in Patients 80 Years and Older.

Clin Interv Aging 2021 1;16:1023-1035. Epub 2021 Jun 1.

Department of Internal Medicine and Geriatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Purpose: This retrospective observational study investigated the efficacy and safety of vancomycin to treat patients aged 80 years and older. In particular, the associations between vancomycin trough concentration (VTC) and treatment outcomes or nephrotoxicity were explored.

Patients And Methods: Patients aged ≥80 years had received ≥3 vancomycin treatments and ≥1 detection of VTC. Read More

View Article and Full-Text PDF

COVID-19 related multisystem inflammatory syndrome in children (MIS-C): a case series from a tertiary care pediatric hospital in Qatar.

BMC Pediatr 2021 06 8;21(1):267. Epub 2021 Jun 8.

Sidra Medicine, PO BOX 26999, Doha, Qatar.

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of coronavirus disease 2019 (COVID-19) in children, which is increasingly being reported worldwide. Here we report the first case series of 7 children diagnosed with MIS-C in Qatar.

Methods: Clinical features and outcomes of COVID-19 positive patients admitted to Sidra Medicine, Qatar from June to October 2020, who met the WHO case definition for MIS-C were reviewed. Read More

View Article and Full-Text PDF

A Study to Assess and Improve Adherence to Iron Chelation Therapy in Transfusion-Dependent Thalassemia Patients.

Hemoglobin 2021 Jun 8:1-7. Epub 2021 Jun 8.

Department of Pediatrics, Faculty of Medicine, Clinical Research for Holistic Management in Pediatric Hematology and Oncology, Chulalongkorn University, Bangkok, Thailand.

Transfusion-dependent thalassemia (TDT) patients require regular blood transfusions. The unavoidable consequence is iron overload. Iron chelation therapy is the mainstay of treatment, of which the favorable outcome depends mainly on adherence level. Read More

View Article and Full-Text PDF