587,367 results match your criteria fatty acid


Rapid and reversible control of human metabolism by individual sleep states.

Cell Rep 2021 Oct;37(4):109903

Department of Pulmonology, University Hospital Zurich, Zurich 8091, Switzerland. Electronic address:

Sleep is crucial to restore body functions and metabolism across nearly all tissues and cells, and sleep restriction is linked to various metabolic dysfunctions in humans. Using exhaled breath analysis by secondary electrospray ionization high-resolution mass spectrometry, we measured the human exhaled metabolome at 10-s resolution across a night of sleep in combination with conventional polysomnography. Our subsequent analysis of almost 2,000 metabolite features demonstrates rapid, reversible control of major metabolic pathways by the individual vigilance states. Read More

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October 2021

Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.

Cell Rep 2021 Oct;37(4):109898

Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

After demyelinating injury of the central nervous system, resolution of the mounting acute inflammation is crucial for the initiation of a regenerative response. Here, we aim to identify fatty acids and lipid mediators that govern the balance of inflammatory reactions within demyelinating lesions. Using lipidomics, we identify bioactive lipids in the resolution phase of inflammation with markedly elevated levels of n-3 polyunsaturated fatty acids. Read More

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October 2021

Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements.

Cell Rep 2021 Oct;37(4):109900

Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, EH16 4UU, UK. Electronic address:

Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding of the unique biology of this disease, particularly its prenatal origin, has hindered improvement of survival. We perform multiple RNA sequencing experiments on fetal, neonatal, and adult hematopoietic stem and progenitor cells from human and mouse. Read More

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October 2021

β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME.

Cell Rep 2021 Oct;37(4):109883

Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address:

Myeloid-derived suppressor cells (MDSCs) impede antitumor immunity; however, the precise mechanisms that regulate their suppressive function remain unresolved. Identifying these mechanisms could lead to therapeutic interventions to boost cancer immunotherapy efficacy. Here, we reveal that β2 adrenergic receptor (β2-AR) expression on MDSCs increases with tumor growth and that the β2-AR stress pathway drives the immune suppressive activity of MDSCs by altering their metabolism. Read More

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October 2021

Arthritis flares mediated by tissue-resident memory T cells in the joint.

Cell Rep 2021 Oct;37(4):109902

Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

Rheumatoid arthritis is a systemic autoimmune disease, but disease flares typically affect only a subset of joints, distributed in a distinctive pattern for each patient. Pursuing this intriguing pattern, we show that arthritis recurrence is mediated by long-lived synovial resident memory T cells (T). In three murine models, CD8+ cells bearing T markers remain in previously inflamed joints during remission. Read More

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October 2021

Impacts of high-intensity exercise on the metabolomics profile of human skeletal muscle tissue.

Scand J Med Sci Sports 2021 Oct 27. Epub 2021 Oct 27.

Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas (UNICAMP), Campinas, SP, Brazil.

The study aimed to identify and quantify the metabolites profile and metabolic pathways in human muscle tissue engaged during exhaustive high-intensity cycling exercise. Seven healthy physically active men performed a graded exercise test and an exhaustive supramaximal effort at 115% of maximal aerobic power with muscles biopsies performed in rest and immediately after exhaustion for quantifying of muscle metabolites changes by H-NMR spectroscopy. The time until exhaustion (tlim) recorded was 224. Read More

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October 2021

The Comparisons of Fatty Acid Composition in Some Anaerobic Gut Fungi Neocallimastix, Orpinomyces, Piromyces, and Caecomyces.

An Acad Bras Cienc 2021 22;93(4):e20200896. Epub 2021 Oct 22.

Kahramanmaras Sutcu Imam University, Faculty of Agriculture, Department of Animal Science, Avsar Campus, Postal 46000, Avsar Village/Kahramanmaras, Turkey.

The objective of this study were to identify the fatty acid composition for decanoic (C10:0), tridecanoic (C13:0), myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), oleic (C18:1n9c), linoleic (C18:2n6c), arachidic (C20:0), arachidonic (C20:4n6), heneicosanoic (C21:0), erucic (C22:1n9) and Cis-4,7,10,13,16,19-docosahexaenoic (C22:6n3) acids by Neocallimastix, Orpinomyces, Caecomyces and Piromyces species of rumen fungus during in vitro culture. Fatty acid (FA) profi le of anaerobic fungi comprises carbon chains of length ranging from 10 to 22 were analyzed as methyl esters. Analysis of fatty acids was performed using Gas Chromatography-Mass Spectrophotometer (GC-MS). Read More

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October 2021

Reclassification of as nom. nov. and emended description of the genus .

Int J Syst Evol Microbiol 2021 Oct;71(10)

College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, PR China.

was proposed as a novel member of genus in 2016. Some time earlier, has been proposed as a novel species of a novel genus named . When comparing the 16S rRNA gene sequences of type strains NH6-79 and D11M-2, they showed 97. Read More

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October 2021

sp. nov., isolated from the gut of a millipede () from a coconut tree.

Int J Syst Evol Microbiol 2021 Oct;71(10)

Department and Graduate Institute of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.

During an investigation of microbes associated with arthropods living in decaying coconut trees, a isolate, Milli4, was cultured from the digestive tract of the common Asian millipede, . Sequence analysis of 16S rRNA and genes found that Milli4 was closely related but not identical to Esp-1, B13 and CCA1. Whole genome sequencing suggested that this isolate represents a new species, with average nucleotide identity (OrthoANIu) values of around 83. Read More

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October 2021

Proposal of fam. nov. to accommodate the genera and and reclassification of as a later heterotypic synonym of based on whole genome sequence analysis.

Int J Syst Evol Microbiol 2021 Oct;71(10)

Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, PR China.

The genus , affiliated to the class , is an important marine member that produces prodiginines. Currently, its taxonomic assignment to family level is not well presented. Phylogeny of 16S rRNA gene sequences indicated that forms a monophyletic clade with , which is neighboured by of the family and another monophyletic clade of the family . Read More

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October 2021

sp. nov., isolated from the top soil layer on basaltic material in Turkey.

Int J Syst Evol Microbiol 2021 Oct;71(10)

Department of Biology, Faculty of Science and Arts, Ondokuz Mayis University, 55139 Samsun, Turkey.

An actinobacterium, designated 14C53, was isolated from a soil sample on basaltic material from Samsun, Turkey. The growth ranges for NaCl concentration and pH of strain 14C53 were quite limited and the growth temperature range of the strain was 20-37 °C, with an optimum at 28 °C. Phylogenetic analysis of 16S rRNA gene sequences revealed that strain 14C53 was most closely related to A8036 (98. Read More

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October 2021

sp. nov., isolated from the mud in a fermentation cellar used for the production of Chinese strong-flavour liquor.

Int J Syst Evol Microbiol 2021 Oct;71(10)

Luzhou Laojiao Co., Ltd., Luzhou 646000, PR China.

A novel Gram-positive, non-motile, non-flagellated, strictly anaerobic, non-spore-forming and dumbbell-shaped, coccoid- or chain-shaped bacterium, designated strain LZLJ-3, was isolated from a mud fermentation cellar which has been used for the production of Chinese strong-flavour liquor for over 100 years. Strain LZLJ-3 grew at 20-40 °C (optimum, 37 °C), at pH 6.0-8. Read More

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October 2021

Differential effects of early-life and post-weaning galactooligosaccharides intervention on colonic bacterial composition and function in weaning piglets.

Appl Environ Microbiol 2021 Oct 27:AEM0131821. Epub 2021 Oct 27.

National Center for International Research on Animal Gut Nutrition, Laboratory of Gastrointestinal Microbiology, National Experimental Teaching Demonstration Center of Animal Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Recently, we have proved that the early-life galactooligosaccharides (GOS) intervention could improve the colonic function by altering the bacterial composition in the suckling piglets. However, whether the early-life GOS (ELG) intervention could have a long influence of the colonic microbiota, and the ELG and post-weaning GOS (PWG) combined intervention would have an interaction effect on maintaining colonic health in weaning piglets remain to be explored. Thus in this study, we illustrated the differential effect of ELG and PWG intervention on colonic microbiota and colonic function of weaning piglets. Read More

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October 2021

A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain.

Appl Environ Microbiol 2021 Oct 27:AEM0152221. Epub 2021 Oct 27.

Aquatic and Crop Resource Development, National Research Council Canada, Montréal, Canada.

The single putative cutinase-encoding gene from the genome of SRS30216 was cloned and expressed in as a secreted fusion protein, designated YebF-KrCUT, where YebF is the extracellular carrier protein. The 294-amino acid sequence of KrCUT is unique among currently characterized cutinases by having a C-terminal extension that consists of a short (Pro-Thr)-rich linker and a 55-amino-acid region resembling the substrate binding domain of poly(hydroxybutyrate) (PHB) depolymerases. Phylogenetically, KrCUT takes a unique position among known cutinases and cutinase-like proteins of bacterial and fungal origin. Read More

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October 2021

The Impact of Fish Oil Supplementation on Self-Perception of the Voice in Vocal Performers: A Randomized, Single-Blind, Placebo-Controlled Study.

J Speech Lang Hear Res 2021 Oct 27:1-7. Epub 2021 Oct 27.

Department of Human Sciences and Design, Baylor University, Waco, TX.

Purpose Physically active adults have experienced training benefits from fish oil-derived omega-3 fatty acid (FO n3), which may also be of benefit to singers. The purpose of this research study was to determine if self-reported vocal adaptations and body composition changes occur in singers following FO n3 supplementation in conjunction with a singer's normal training regimen. Method Twenty college students, currently enrolled in vocal lessons at a university, were randomized to receive either 3. Read More

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October 2021

High-Fat and Combined High-Fat and Sucrose Diets Promote Cardiac Oxidative Stress Independent of Nox2 Redox Regulation and Obesity in Rats.

Cell Physiol Biochem 2021 Oct;55(5):618-634

Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil,

Background/aims: Oxidative stress is associated with cardiometabolic alterations, and the involvement of excess glucose and fatty acids has been demonstrated in this process. Thus, the aim of this study was to investigate the effects of different hypercaloric diets on cardiac oxidative stress.

Methods: Wistar rats were randomized into four groups: control (C), high-sucrose (HS), high-fat (HF), and high-fat with sucrose (HFS). Read More

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October 2021

ASPEN lipid injectable emulsion safety recommendations part 2: Neonate and pediatric considerations.

Nutr Clin Pract 2021 Oct 27. Epub 2021 Oct 27.

Retired.

Lipid injectable emulsions (ILEs) are complex pharmaceutical formulations intended as a source of energy and fatty acids for parenteral nutrition (PN) therapy. Part 1 of this series addressed issues associated with and safety recommendations pertaining to adult ILE use. Part 2 addresses ILE safety in neonatal and pediatric patients. Read More

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October 2021

Low-Frequency Sonophoresis as an Active Approach to Potentiate the Transdermal Delivery of Agomelatine-Loaded Novasomes: Design, Optimization, and Pharmacokinetic Profiling in Rabbits.

AAPS PharmSciTech 2021 Oct 27;22(8):261. Epub 2021 Oct 27.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The first melatonergic antidepressant drug, agomelatine (AGM), is commonly used for controlling major depressive disorders. AGM suffers low (< 5%) oral bioavailability owing to the hepatic metabolism. The current work investigated the potential of low-frequency sonophoresis on enhancing transdermal delivery of AGM-loaded novasomes and, hence, bioavailability of AGM. Read More

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October 2021

Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor.

J Med Chem 2021 Oct 27. Epub 2021 Oct 27.

Bristol Myers Squibb, Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08544, United States.

Inhibition of TGFβ signaling in concert with a checkpoint blockade has been shown to provide improved and durable antitumor immune response in mouse models. However, on-target adverse cardiovascular effects have limited the clinical use of TGFβ receptor (TGFβR) inhibitors in cancer therapy. To restrict the activity of TGFβR inhibitors to tumor tissues and thereby widen the therapeutic index, a series of tumor-activated prodrugs of a selective small molecule TGFβR1 inhibitor were prepared by appending to a serine protease substrate and a half-life extension fatty acid carbon chain. Read More

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October 2021

Physiological and Metabolite Alterations Associated with Neuronal Signals of during Infections.

ACS Chem Neurosci 2021 Oct 27. Epub 2021 Oct 27.

Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630003, India.

Metabolomic reprogramming plays a crucial role in the activation of several regulatory mechanisms including neuronal responses of the host. In the present study, alterations at physiological and biochemical levels were initially assessed to monitor the impact of the candidate pathogen on the nematode host . The abnormal behavioral responses were observed in infected worms in terms of hyperosmolarity and high viscous chemicals. Read More

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October 2021

Dietary agents in mitigating chemotherapy-related cognitive impairment (chemobrain or chemofog): first review addressing the benefits, gaps, challenges and ways forward.

Food Funct 2021 Oct 27. Epub 2021 Oct 27.

Research Unit, Mangalore Institute of Oncology, Pumpwell, Mangalore, Karnataka 575002, India.

Chemobrain or chemofog is one of the important but less investigated side effects, where the cancer survivors treated with chemotherapy develop long-term cognitive impairments, affecting their quality of life. The biological mechanisms triggering the development of chemobrain are largely unknown. However, a literature study suggests the generation of free radicals, oxidative stress, inflammatory cytokines, epigenetic chromatin remodeling, decreased neurogenesis, secretion of brain-derived neurotropic factor (BDNF), dendritic branching, and neurotransmitter release to be the cumulative contributions to the ailment. Read More

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October 2021

polysaccharide-zinc complex modulates the immune response and alleviates LPS-induced intestinal inflammation inhibiting the TLR4/NF-κB signaling pathway.

Food Funct 2021 Oct 27. Epub 2021 Oct 27.

CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, Hunan 410125, China.

polysaccharide-zinc (EP-Zn), a kind of polysaccharide-zinc complex, has been shown to improve the immune response and reduce the inflammatory factors in weaned piglets. Yet, the molecular mechanism remains unclear. The present study was conducted to investigate the immunomodulating activity and anti-inflammatory mechanism of EP-Zn in mice. Read More

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October 2021

Stearic acid does not overcome -10, -12 CLA-induced milk fat depression in lactating ewes.

Br J Nutr 2021 Oct 27:1-19. Epub 2021 Oct 27.

Department of Animal Production, Santa Catarina State University, Lages, Santa Catarina, 88520-000, Brazil.

The objective of this study was to test the hypothesis that stearic acid supplementation increases milk fat content and overcomes the antilipogenic effects of trans-10, cis-12 conjugated linoleic acid (CLA) in lactating ewes. Twenty-eight Lacaune ewes (36 ± 2 DIM; 70.5 ± 9. Read More

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October 2021

seed oil extracted by pressurized -propane and its effect against biofilms.

Environ Technol 2021 Oct 27:1-47. Epub 2021 Oct 27.

Department of Food Engineering, State University of Maringa, Av. Colombo, 5790, CEP 87020-900, Maringa, Paraná, Brazil.

is often associated worldwide with foodborne illnesses, and the elimination of biofilms formed by this bacterium from industrial surfaces is very challenging. To date, there have been few attempts to investigate plant oils obtained by recent green technologies, applied against biofilms on usual surfaces of the food industry and bacteria isolated from such environment. Therefore, this study evaluated the activity of seed oil (MOSO), extracted with pressurized -propane, against standard and environmental biofilms. Read More

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October 2021

Dietary strategies for gut-derived protein-bound uremic toxins and cardio-metabolic risk factors in chronic kidney disease: A focus on dietary fibers.

Crit Rev Food Sci Nutr 2021 Oct 27:1-15. Epub 2021 Oct 27.

Faculty of Health Sciences, Nutrition and Dietetics Department, Hacettepe University, Ankara, Turkey.

Chronic kidney disease (CKD) is associated with altered composition and function of gut microbiota. The cause of gut dysbiosis in CKD is multifactorial and encompasses the following: uremic state, metabolic acidosis, slow colonic transit, dietary restrictions of plant-based fiber-rich foods, and pharmacological therapies. Dietary restriction of potassium-rich fruits and vegetables, which are common sources of fermentable dietary fibers, inhibits the conversion of dietary fibers to short-chain fatty acids (SCFA), which are the primary nutrient source for the symbiotic gut microbiota. Read More

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October 2021

Screening for neonatal inherited metabolic disorders by tandem mass spectrometry in Guangzhou.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Aug;50(4):463-471

Guangzhou Newborn Screening Center, Guangzhou Women and Children's Medical Center, Guangzhou 510180, China.

To analyze the screening results for inherited metabolic disorders (IMD) in newborns by tandem mass spectrometry (MS/MS) in Guangzhou.A total of 272 117 newborns in Guangzhou from Jan 2015 to Dec 2020 were screened for IMD by MS/MS in Guangzhou Newborn Screening Center. When the primary screening was positive, the newborns and their mothers were recalled. Read More

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Screening and follow-up results of fatty acid oxidative metabolism disorders in 608 818 newborns in Jining, Shandong province.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Aug;50(4):472-480

3. Zhejiang Bosheng Biotechnology Co., Ltd., Hangzhou 310012, China.

To investigate the incidence and gene mutation characteristics of fatty acid oxidative metabolism disorders in Jining area of Shandong province , and to evaluate the therapeutic effect. Blood samples of newborns were collected in Jining of Shandong province between July 14, 2014 and December 31, 2019. Tandem mass spectrometry was used to determine the levels of carnitine and acylcarnitine in the blood to screen for fatty acid oxidative metabolism disorder. Read More

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The diffusible signal factor synthase, RpfF, in Xanthomonas oryzae pv. oryzae is required for the maintenance of membrane integrity and virulence.

Mol Plant Pathol 2021 Oct 26. Epub 2021 Oct 26.

Laboratory of Plant Microbe Interactions, Centre for DNA Fingerprinting and Diagnostics, Uppal, India.

The Xanthomonas group of phytopathogens communicate with a fatty acid-like cell-cell signalling molecule, cis-11-2-methyl-dodecenoic acid, also known as diffusible signal factor (DSF). In the pathogen of rice, Xanthomonas oryzae pv. oryzae, DSF is involved in the regulation of several virulence-associated functions, including production and secretion of several cell wall hydrolysing type II secretion effectors. Read More

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October 2021

Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice.

Diabetes Obes Metab 2021 Oct 27. Epub 2021 Oct 27.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Aims: Glucokinase activators (GKAs) show a hypoglycaemic effect through augmentation of insulin secretion in pancreatic beta-cells and glucose utilization in the liver. The results from some clinical studies of GKAs suggested they show an unsustained hypoglycaemic effect. We investigated how sub-chronic administration of a GKA results in attenuation in the hypoglycaemic effect in a diabetic condition. Read More

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October 2021

In vitro ruminal fermentation, methane production and nutrient degradability as affected by fruit and vegetable pomaces in differing concentrations.

J Anim Physiol Anim Nutr (Berl) 2021 Oct 26. Epub 2021 Oct 26.

Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland.

Pomaces are food industry by-products and may serve as animal feed to increase sustainability of meat and milk production. The aim of the present study was to evaluate fermentation characteristics of dried fruit and vegetable pomaces in a short-term in vitro experiment using the Hohenheim Gas Test. A selection of six fruit (apple, aronia, orange, pomegranate, red, white grape) and three vegetable (beetroot, carrot, tomato) pomaces was tested in three concentrations (150, 300, 500 g kg of dry matter (DM)) as supplement to the basal diet (hay, used as control). Read More

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October 2021