115,569 results match your criteria fatigue


Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study.

Eur J Cancer 2021 May 5;151:49-62. Epub 2021 May 5.

Institut Gustave Roussy, Villejuif, France.

Background And Purpose: Combined mTORC1 inhibition with everolimus (EVE) and phosphatidylinositol 3-kinase catalytic subunit p110α blockade with alpelisib (ALP) has demonstrated synergistic efficacy in preclinical models and supports testing the combination of ALP and EVE in the clinical setting. The primary objective was to determine the maximum tolerated dose (MTD)/recommended dose for expansion (RDE) of ALP in combination with EVE and in combination with EVE and exemestane (EXE) and subsequently assess safety, preliminary efficacy and effect of ALP on the pharmacokinetics of EVE and determine the magnitude of the drug-drug interaction.

Patients And Methods: Dose escalation phases were conducted in patients with advanced solid tumours and in postmenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC). Read More

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Validation of the Bath CRPS Body Perception Disturbance Scale.

J Pain 2021 May 5. Epub 2021 May 5.

Department of Psychology, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom; Centre for Pain Research, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom.

The Bath Complex Regional Pain Syndrome Body Perception Disturbance Scale ("B-CRPS-BPDS") measures alterations in body perception. We assessed its internal consistency, known group validity, construct validity, and associations with demographic and clinical characteristics. We also evaluated changes in, and baseline predictors of B-CRPS-BPDS scores at follow-up. Read More

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Cardiopulmonary exercise testing during the COVID-19 pandemic.

Prog Cardiovasc Dis 2021 May 5. Epub 2021 May 5.

Department of Kinesiology and Health Sciences, College of Humanities and Sciences, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

The outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has presented a global public health emergency. Although predominantly a pandemic of acute respiratory disease, corona virus infectious disease-19 (COVID-19) results in multi-organ damage that impairs cardiopulmonary (CP) function and reduces cardiorespiratory fitness. Superimposed on the CP consequences of COVID-19 is a marked reduction in physical activity that exacerbates CP disease (CPD) risk. Read More

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A comprehensive approach to study the resting-state brain network related to creative potential.

Brain Struct Funct 2021 May 7. Epub 2021 May 7.

Aix Marseille Univ, UMR 7291, CNRS, NeuroMarseille, InCIAM, Laboratoire de Neurosciences Cognitives, Centre Saint-Charles-Case B, 3, Place Victor Hugo, 13331, Marseille, France.

Studies related to creativity generally investigate cognition and brain functioning linked to creative achievement. However, this approach does not allow characterization of creative potential. To better define creative potential, we studied cognitive function related to creative processes and the associated brain resting functional connectivity. Read More

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Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial.

J Behav Med 2021 May 7. Epub 2021 May 7.

Moffitt Cancer Center, Tampa, FL, 33612, USA.

MBSR(BC) is known to have a positive impact on psychological and physical symptoms among breast cancer survivors (BCS). The cognitive mechanisms of "how" MBSR(BC) works was addressed in a recent study that found that there was strong consistent evidence that reduced emotional reactivity is a mediator and moderate consistent evidence that mindfulness, rumination, and worry were mediators. The purpose of this study, as part of a larger R01 trial, was to test whether positive effects achieved from the MBSR(BC) program were mediated through changes in increased mindfulness, decreased fear of breast cancer recurrence, and perceived stress. Read More

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A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic.

Sci Rep 2021 May 7;11(1):9784. Epub 2021 May 7.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

The mortality rates of COVID-19 vary across the globe. While some risk factors for poor prognosis of the disease are known, regional differences are suspected. We reviewed the risk factors for critical outcomes of COVID-19 according to the location of the infected patients, from various literature databases from January 1 through June 8, 2020. Read More

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Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals.

Arch Med Res 2021 May 4. Epub 2021 May 4.

Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece. Electronic address:

Post-COVID syndrome also known as long COVID refers to symptoms persisting for more than three weeks after the diagnosis of COVID-19. We reviewed the current evidence on post-COVID syndrome, focusing on its clinical manifestations and addressing the challenges for its management in primary healthcare. The incidence of post-COVID syndrome is estimated at 10-35%, while for hospitalized patients it may reach 85%. Read More

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Does change in barometric pressure per given time at high altitude influence symptoms of acute mountain sickness on Mount Fuji? A pilot study.

J Physiol Anthropol 2021 May 7;40(1). Epub 2021 May 7.

Division of Human Environmental Science, Mount Fuji Research Institute, Kami-yoshida 5597-1, Fujiyoshida, Yamanahsi, 4030005, Japan.

Background: Acute mountain sickness (AMS) is a common, transient condition characterized primarily by headaches, and it can also be associated with fatigue, dizziness, and nausea with vomiting. The symptoms of AMS are most pronounced after the first night spent at a new altitude. At sea level, changes in barometric pressure per given time have been associated with migraine headaches. Read More

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Multiple myeloma and physical activity.

BMC Res Notes 2021 May 7;14(1):171. Epub 2021 May 7.

University College London Behavioural Science and Health, Institute of Epidemiology & Health, 1-19 Torrington Place, London, WC1E 6BT, UK.

Objective: Physical activity has been shown to improve quality of life in cancer patients with some evidence in multiple myeloma. This study aimed to determine myeloma patients' exercise levels, their perception of physical activity, and to explore correlations with quality of life. Myeloma outpatients were invited to complete a number of questionnaires, including the Godin leisure-time exercise questionnaire (GLTEQ) to determine their exercise levels, the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire to assess health related quality of life, and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) questionnaire to assess fatigue. Read More

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A 45-year-old female patient with Sheehan's syndrome presenting with imminent adrenal crisis: a case report.

J Med Case Rep 2021 May 8;15(1):229. Epub 2021 May 8.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Background: Sheehan's syndrome is hypopituitarism due to pituitary gland necrosis resulting from hemorrhagic shock during pregnancy. It is a rare complication with varied manifestations and a considerable delay in diagnosis.

Case Presentation: We describe the case of a 45-year-old Ethiopian woman who presented with generalized fatigue for 18 years which progressed to anorexia, nausea, vomiting, diarrhea, and abdominal pain of 6 years' duration, for which she was treated symptomatically throughout these years. Read More

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A new lesser metatarsophalangeal joint replacement arthroplasty design - in vitro and cadaver studies.

BMC Musculoskelet Disord 2021 May 7;22(1):424. Epub 2021 May 7.

Netcare Sunninghill Hospital, Suite 3A, -2 Level, Westwing, Cnr Nanyuki & Witkoppen Road, Sunninghill, Johannesburg, 2157, South Africa.

Background: Isolated degenerative joint disease and/or Freiberg's infraction of the lesser metatarsophalangeal joint, although not frequent may become debilitating in the younger individual. Currently, once conservative management fails, the mainstay of treatment is debridement and excision-interposition arthroplasty. Replacement arthroplasty has been ineffective in the long term as the joints are subject to severe repetitive fatigue loading over small articulating surfaces through a wide range of motion. Read More

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Fatigue fractures after the COVID-19 quarantine.

Phys Sportsmed 2021 May 7. Epub 2021 May 7.

Department of Radiology, General Hospital of Ningxia Medical University Yinchuan, China.

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Effect of trunk muscles fatigue on plantar pressure distribution in novice runners.

J Biomech 2021 Apr 28;122:110487. Epub 2021 Apr 28.

Department of Sports Biomechanics, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran. Electronic address:

During running, trunk muscles act to sufficiently contribute to the energy generation and transmission of the body parts. Improper function of trunk muscles affects running mechanics adversely and could result in altered lower limb energetics. The aim of this study was to examine the effects of trunk muscles fatigue on plantar pressure distribution in novice runners. Read More

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Fatigue Detection of Pilots' Brain Through Brains Cognitive Map and Multilayer Latent Incremental Learning Model.

IEEE Trans Cybern 2021 May 7;PP. Epub 2021 May 7.

This work proposes a nonparametric prior induced deep sum-logarithmic-multinomial mixture (DSLMM) model to detect pilots' cognitive states through the developed brain power map. DSLMM uses multinormal distribution to infer the latent variable of each neuron in the first layer of the network. These latent variables obeyed a sum-logarithmic distribution that is backpropagated to its observation vector and the number of neurons in the next layer. Read More

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Open-Label, Single-Arm, Multicenter, Phase II Trial of Lenvatinib for the Treatment of Patients With Anaplastic Thyroid Cancer.

J Clin Oncol 2021 May 7:JCO2003093. Epub 2021 May 7.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a poor prognosis and an unmet need for effective treatment, especially for patients without mutations or or fusions. Lenvatinib is US Food and Drug Administration-approved for radioiodine-refractory differentiated thyroid cancer and has previously demonstrated activity in a small study of patients with ATC (n = 17). We aimed to further evaluate lenvatinib in ATC. Read More

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Bereavement Needs of Critical Care Nurses: A Qualitative Study.

Dimens Crit Care Nurs 2021 Mar-Apr 01;40(2):83-91

Background/introduction: Bereavement and grief in critical care nurses remain an understudied phenomenon. As a way of self-protection, nurses may compartmentalize their own feelings and need assistance and support in processing feelings of bereavement. Nurses spend much of their time caring for patients and their family members, while guiding them through the dying process; however, they may not take adequate time to address their own bereavement needs. Read More

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Supervised exercises versus telerehabilitation. Benefits for persons with multiple sclerosis.

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

Department of Ergotherapy, School of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.

Objectives: The purpose of this study was to investigate the effectiveness of structured telerehabilitation on fatigue, health status, quality of life (QoL), and activities of daily living (ADL) and compare the possible effects with structured supervised exercise programs in patients with Multiple Sclerosis.

Materials And Methods: This study was a randomized, single-blind trial. Thirty patients with relapsing-remitting Multiple Sclerosis were included in the study and randomly divided into two groups; structured supervised exercise group (Group 1) and telerehabilitation group (Group 2). Read More

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Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies.

Neuropsychol Rev 2021 May 7. Epub 2021 May 7.

Department of Sport, Health & Exercise Science, University of Hull, Hull, UK.

Fatigue is one of the most debilitating symptoms for people with multiple sclerosis (PwMS). By consolidating a diverse and conflicting evidence-base, this systematic review and meta-analysis aimed to gain new insights into the neurobiology of MS fatigue. MEDLINE, ProQuest, CINAHL, Web of Science databases and grey literature were searched using Medical Subject Headings. Read More

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Skeletal and dentoalveolar contributions during Class II correction with Forsus™ FRD appliances : Quantitative evaluation.

J Orofac Orthop 2021 May 7. Epub 2021 May 7.

Department of Orthodontics and Dentofacial orthopedics, KLE Society's Institute of Dental Sciences, Yeshwanthpur Suburb, Bengaluru, Karnataka, India, pin: 560022.

Purpose: Primary objective of the study is to quantify and evaluate the skeletal and dental contributions during sagittal Class II correction with the Forsus™ fatigue resistant device (FRD; 3M Unitek Corp., Monrovia, CA, USA). Secondary objective is to evaluate the overall vertical, soft tissue and chin-throat relation changes with the Forsus™ appliance. Read More

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Postmarketing Safety Monitoring After Influenza Vaccination Using a Mobile Health App: Prospective Longitudinal Feasibility Study.

JMIR Mhealth Uhealth 2021 May 7;9(5):e26289. Epub 2021 May 7.

PhD Programme Epidemiology, Hannover Biomedical Research School, Hannover Medical School, Hannover, Germany.

Background: For the safety monitoring of vaccinations postlicensure, reports of adverse events after immunization (AEFIs) are crucial. New technologies such as digital mobile apps can be used as an active approach to capture these events. We therefore conducted a feasibility study among recipients of the influenza vaccination using an app for assessment of the reporting of AEFIs. Read More

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The Smartphone App haMSter for Tracking Patient-Reported Outcomes in People With Multiple Sclerosis: Protocol for a Pilot Study.

JMIR Res Protoc 2021 May 7;10(5):e25011. Epub 2021 May 7.

Department of Neurology, Medical University of Vienna, Vienna, Austria.

Background: Treatment and monitoring decisions in people with multiple sclerosis (MS) are based commonly on clinician-reported outcomes. These reflect physical and radiological disease activity and are the most relevant endpoints in clinical trials. Over the past few years, the number of studies evaluating so-called patient-reported outcomes (PROs) has been increasing. Read More

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Clinical Characteristics of 195 Cases of COVID-19 with Gastrointestinal Symptoms COVID-19 with Gastrointestinal Symptoms.

Turk J Gastroenterol 2021 Feb;32(2):148-154

Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.

Background: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), have fever, dry cough, dyspnea, and fatigue. The disease has now become a global pandemic. The purpose of this study was to explore the relationship between COVID-19 and gastrointestinal (GI) symptoms. Read More

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February 2021

Validation of the Finnish version of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and evaluation of the applicability of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) and the Fatigue Scale for Motor and Cognitive Functions (FSMC).

Brain Behav 2021 May 7:e02087. Epub 2021 May 7.

Masku Neurological Rehabilitation Centre, The Finnish Neuro Society, Masku, Finland.

Objectives: Cognitive impairment is frequent in multiple sclerosis (MS) as approximately half of the patients manifest some degree of cognitive impairment. The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) has been designed for brief cognitive evaluation. The purpose of the study was to validate the BICAMS along with the Finnish versions of one self-rating questionnaire each for cognition and fatigue. Read More

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Head pre-cooling improves 5-km time trial performance in male amateur runners in the heat.

Scand J Med Sci Sports 2021 May 7. Epub 2021 May 7.

Sports Training Center (CTE), School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, Brazil.

This study aimed to evaluate the effect of head pre-cooling on the 5-km time trial performance of amateur runners in the heat. In a counterbalanced design, fifteen male amateur runners (22.6 ± 3. Read More

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The effect of the clinical nurses 'compassion levels on tendency to make medical error: A cross-sectional study.

Contemp Nurse 2021 May 7:1-23. Epub 2021 May 7.

Sivas Cumhuriyet University Health Services Application and Research Hospital, Sivas, Turkey.

Background: Compassion is considered as the cornerstone of nursing practices and professionalism. However, a decrease in compassion may increase medical errors and adversely affect patient safety.

Aims: The study was conducted to determine clinical nurses' compassion levels and their tendency to make medical errors, and to find whether their compassion levels affect their tendency to make medical errors. Read More

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Response to first-line treatment predicts progression-free survival benefit of small-cell lung cancer patients treated with anlotinib.

Cancer Med 2021 May 6. Epub 2021 May 6.

Department of Oncology, General Hospital of Chinese PLA, Beijing, China.

Background: Anlotinib significantly extended progression-free survival (PFS) and overall survival (OS) in small-cell lung cancer (SCLC) as third or later line treatment.

Methods: In this study, we retrospectively analyzed the efficacy and safety of anlotinib in the clinical practice and aimed to identify risk factors for predicting the clinical benefit of anlotinib in SCLC patients. 29 SCLC patients treated with anlotinib monotherapy or combination therapy as second or later line treatment were included. Read More

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Neurocognitive and Behavioral Outcomes of Chinese Survivors of Childhood Lymphoblastic Leukemia.

Front Oncol 2021 20;11:655669. Epub 2021 Apr 20.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Background: Increasing attention has been dedicated to investigate modifiable risk factors of late effects in survivors of childhood cancer. This study aims to evaluate neurocognitive and behavioral functioning in a relatively young cohort of survivors of childhood acute lymphoblastic leukemia (ALL) in Hong Kong, and to identify clinical and socio-environmental factors associated with these outcomes.

Methods: This analysis included 152 survivors of childhood ALL who were ≥5 years post-diagnosis (52% male, mean [SD] age 23. Read More

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COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211009385. Epub 2021 Apr 20.

Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2-3 weeks. However, there is increasing evidence that a proportion of COVID-19 patients experience a prolonged convalescence and continue to have symptoms lasting several months after the initial infection. Read More

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The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial.

Clin Kidney J 2021 May 10;14(5):1345-1355. Epub 2020 Sep 10.

School of Health Sciences, Centre for Health, Activity and Rehabilitation Research, Queen Margaret University, Edinburgh, UK.

Background: Exercise interventions designed to improve physical function and reduce sedentary behaviour in haemodialysis (HD) patients might improve exercise capacity, reduce fatigue and lead to improved quality of life (QOL). The PrEscription of intraDialytic exercise to improve quAlity of Life study aimed to evaluate the effectiveness of a 6-month intradialytic exercise programme on QOL and physical function, compared with usual care for patients on HD in the UK.

Methods: We conducted a prospective, pragmatic multicentre randomized controlled trial in 335 HD patients and randomly (1:1) assigned them to either (i) intradialytic exercise training plus usual care maintenance HD or (ii) usual care maintenance HD. Read More

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Patient-reported outcomes from a randomized, double-blind, placebo controlled, phase III study of baricitinib placebo in patients with moderately to severely active rheumatoid arthritis and an inadequate response to methotrexate therapy: results from the RA-BALANCE study.

Ther Adv Musculoskelet Dis 2021 20;13:1759720X211006964. Epub 2021 Apr 20.

Department of Rheumatology and Immunity, Center of Clinical Immunology, Peking University People's Hospital, Xicheng District, Beijing, P.R. China.

Introduction: To assess the effect of baricitinib on patient-reported outcomes (PROs) in patients with moderately to severely active rheumatoid arthritis (RA) who had an inadequate response to methotrexate (MTX).

Methods: This was a 52-week, randomized, double-blind, placebo controlled, phase III study in patients with RA who had an inadequate response to MTX. Patients ( = 290) receiving stable background MTX were randomly assigned (1:1) to receive placebo or baricitinib 4 mg once daily with a primary endpoint at week 12. Read More

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