4,306 results match your criteria fatal road

Trends in Propeller Strike-Induced Mortality in Harbor Seals (Phoca vitulina) of the Salish Sea.

J Wildl Dis 2021 May 12. Epub 2021 May 12.

SeaDoc Society, UC Davis Karen C. Drayer Wildlife Health Center-Orcas Island Office, 942 Deer Harbor Road, Eastsound, Washington 98245, USA.

Documenting human impacts on marine mammals is critical for understanding and mitigating harm. Although propeller strike injuries in small marine mammals are often debilitating and fatal, little is known about the occurrence or demographics of these types of injuries in pinniped populations. Using data of stranded harbor seals (Phoca vitulina) in the Salish Sea from 2002-19, we identified 27 cases of fatal propeller strikes. Read More

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Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections.

J Colloid Interface Sci 2021 Apr 24;599:390-403. Epub 2021 Apr 24.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China. Electronic address:

Bacteria induced wound infection has become fatal healthcare issues needed to be resolved urgently. It is of vital importance to develop multifunctional therapeutic platforms to fight against increased bacterial antibiotic resistance. Herein, a titanium carbide (MXene)/zeolite imidazole framework-8 (ZIF-8)/polylactic acid (PLA) composite membrane (MZ-8/PLA) was fabricated through in-situ growth of ZIF-8 on MXene and the subsequent electrospinning process. Read More

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Clinical characteristics of tumor lysis syndrome in childhood acute lymphoblastic leukemia.

Sci Rep 2021 May 6;11(1):9656. Epub 2021 May 6.

Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Tumor lysis syndrome (TLS) is a common and fatal complication of childhood hematologic malignancies, especially acute lymphoblastic leukemia (ALL). The clinical features, therapeutic regimens, and outcomes of TLS have not been comprehensively analyzed in Chinese children with ALL. A total of 5537 children with ALL were recruited from the Chinese Children's Cancer Group, including 79 diagnosed with TLS. Read More

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Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled trials.

Eur J Clin Pharmacol 2021 May 3. Epub 2021 May 3.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Purpose: Empagliflozin, dapagliflozin, canagliflozin, and ertugliflozin have been shown in randomized controlled trials to improve cardiovascular, metabolic, and renal outcomes in heart failure patients. To date, there has not been any meta-analysis examining the differences in clinical outcomes across different SGLT2 inhibitors in heart failure patients.

Methods: Four electronic databases (PubMed, Embase, Cochrane, SCOPUS) were searched on 13 September 2020 for articles published from 1 January 2000 to 13 September 2020 examining the effect of SGLT2 inhibitors on cardiovascular, renal, and metabolic outcomes in heart failure patients. Read More

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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

J Med Chem 2021 May 3. Epub 2021 May 3.

Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.

In immunoglobulin light-chain (LC) amyloidosis, transient unfolding or unfolding and proteolysis enable aggregation of LC proteins, causing potentially fatal organ damage. A drug that kinetically stabilizes LCs could suppress aggregation; however, LC sequences are variable and have no natural ligands, hindering drug development efforts. We previously identified high-throughput screening hits that bind to a site at the interface between the two variable domains of the LC homodimer. Read More

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Differences in D-dimer blood concentration in atrial fibrillation patients with left atrial thrombus or severe left atrial spontaneous echo contrast.

J Interv Card Electrophysiol 2021 May 3. Epub 2021 May 3.

Department of Cardiology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin Er Road, Shanghai, 200025, China.

Purpose: Severe left atrial spontaneous echo contrast (SLASEC) is considered the prior stage to thrombosis and a high-risk factor for thrombotic events. Studies have suggested an effect of D-dimer blood concentration on exclusion of left atrial thrombus (LAT), but it remains unclear whether D-dimer concentrations differ between atrial fibrillation (AF) patients with SLASEC or LAT.

Methods: Nonvalvular AF patients scheduled to undergo catheter ablation or cardioversion in Shanghai Ruijin Hospital between January 2017 and July 2020 were screened for this prospective study. Read More

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Risk factors for secondary hemophagocytic lymphohistiocytosis in severe coronavirus disease 2019 adult patients.

BMC Infect Dis 2021 Apr 29;21(1):398. Epub 2021 Apr 29.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Rui Jin 2nd road, Shanghai, 200025, China.

Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammatory event and a fatal complication of viral infections. Whether sHLH may also be observed in patients with a cytokine storm induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still uncertain. We aimed to determine the incidence of sHLH in severe COVID-19 patients and evaluate the underlying risk factors. Read More

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Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Eur J Med Chem 2021 Apr 20;220:113431. Epub 2021 Apr 20.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3PQ, UK. Electronic address:

Duchenne muscular dystrophy is a fatal disease with no cure, caused by lack of the cytoskeletal protein dystrophin. Upregulation of utrophin, a dystrophin paralogue, offers a potential therapy independent of mutation type. The failure of first-in-class utrophin modulator ezutromid/SMT C1100 in Phase II clinical trials necessitates development of compounds with better efficacy, physicochemical and ADME properties and/or complementary mechanisms. Read More

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Long-term exposure to road traffic noise and incident myocardial infarction: A Danish Nurse Cohort study.

Environ Epidemiol 2021 Jun 22;5(3):e148. Epub 2021 Apr 22.

Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Evidence of nonauditory health effects of road traffic noise exposure is growing. This prospective cohort study aimed to estimate the association between long-term exposure to road traffic noise above a threshold and incident myocardial infarction (MI) in Denmark.

Methods: In the Danish Nurse Cohort study, we used data of 22,378 women, at recruitment in 1993 and 1999, who reported information on MI risk factors. Read More

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Preventable deaths following road traffic collisions in Botswana: A retrospective review.

Injury 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Bokamoso private hospital, Botswana.

Road traffic collisions (RTC) are a major cause of mortality and morbidity in Botswana. To our knowledge no research has been conducted in Botswana to investigate preventable deaths that occur as a result of RTCs. The aim of this study is to establish the rate of preventable deaths from RTCs in the greater Gaborone area in Botswana. Read More

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Prognostic value of NT-proBNP in patients with chronic coronary syndrome and normal left ventricular systolic function according to glucose status: a prospective cohort study.

Cardiovasc Diabetol 2021 Apr 22;20(1):84. Epub 2021 Apr 22.

State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 BeiLiShi Road, XiCheng District, 100037, Beijing, China.

Background: The prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with coronary artery disease (CAD) with different glucose status has not been established. This study sought to evaluate the significance of NT-proBNP in predicting major adverse cardiovascular events (MACEs) in patients with chronic coronary syndrome (CCS) and normal left-ventricular systolic function (LVSF) according to different glucose status, especially in those with abnormal glucose metabolism.

Methods: A total of 8062 patients with CCS and normal LVSF were consecutively enrolled in this prospective study. Read More

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Associations between dietary patterns and the incidence of total and fatal cardiovascular disease and all-cause mortality in 116,806 individuals from the UK Biobank: a prospective cohort study.

BMC Med 2021 Apr 22;19(1):83. Epub 2021 Apr 22.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: Traditionally, studies investigating diet and health associations have focused on single nutrients. However, key nutrients co-exist in many common foods, and studies focusing solely on individual nutrients may obscure their combined effects on cardiovascular disease (CVD) and all-cause mortality. We aimed to identify food-based dietary patterns which operate through excess energy intake and explain high variability in energy density, free sugars, saturated fat, and fiber intakes and to investigate their association with total and fatal CVD and all-cause mortality. Read More

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Evaluation of a warning system to reduce the risk of casualty crashes at rural junctions in South Australia.

Traffic Inj Prev 2021 Apr 21:1-10. Epub 2021 Apr 21.

Centre for Automotive Safety Research (CASR), The University of Adelaide, Adelaide, Australia.

Objective: This study evaluated the effectiveness and potential safety benefits of a Rural Junction Active Warning System (RJAWS), which uses variable speed limit signs (VSLSs) to temporarily impose a reduced speed limit along the major road when another vehicle is approaching on the minor road or turning into the minor road from the far-side major leg.

Methods: The RJAWS was trialed at 4 3-leg rural junctions between 2-lane roads in South Australia. A quasi-experimental before-after analysis was conducted. Read More

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Amiodarone lung: under recognised but not forgotten.

J R Coll Physicians Edinb 2021 03;51(1):61-64

Mid Yorkshire Hospitals NHS Trust, Aberford Road, Wakefield WF1 4DG, UK, Email:

Amiodarone is a common medication used widely in clinical practice. It is a triiodinated antiarrhythmic associated with a variety of adverse effects both pulmonary and extrapulmonary, the most serious being amiodarone-induced pulmonary toxicity (AIPT) or amiodarone lung. This can present with a variety of clinical syndromes ranging from subacute symptoms to an indolent and a progressive course thus mimicking an alternative diagnosis. Read More

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Pharmaceutical design of a delivery system for the bacteriocin lacticin 3147.

Drug Deliv Transl Res 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland.

Lacticin 3147 is a dual-acting two-peptide bacteriocin which is generally active against Gram-positive bacteria, including Listeria monocytogenes and antimicrobial-resistant bacteria such as Closteroides difficile in the colon. L. monocytogenes infections can cause life-long effects in the elderly and vulnerable and can cause severe complications in pregnant women. Read More

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First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors.

EClinicalMedicine 2021 Apr 30;34:100797. Epub 2021 Mar 30.

Sarah Cannon Research Institute, 1100 Martin L. King Jr. Boulevard, Nashville, TN 37203 United States.

Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.

Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom. Patients with previously-treated advanced metastatic solid tumors and adequate performance status and organ function were eligible. Read More

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Coping with endogeneity and unobserved heterogeneity in real-time clustering critical crash occurrences nested within weather and road surface conditions.

Int J Inj Contr Saf Promot 2021 Apr 19:1-15. Epub 2021 Apr 19.

Department of Civil & Architectural Engineering, University of Wyoming, Laramie, Wyoming, USA.

The knot of endogeneity and unobserved heterogeneity are causes of rendering parameter estimates inconsistent in real-time crash prediction. This study intends to alleviate the potential sources of these issues in detecting critical crashes, involving fatal or incapacitating injuries, versus non-critical crashes through a 402-mile Interstate-80 in Wyoming. Among different types of endogeneity, the problem of errors-in-variables and simultaneity was respectively mitigated by conflating disaggregated real-time traffic observations with aggregated environmental conditions and removing secondary crashes from the dataset. Read More

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Association between serum uric acid levels and cardiovascular events in hospitalized patients with type 2 diabetes.

Prim Care Diabetes 2021 Apr 10. Epub 2021 Apr 10.

Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Aims: This study aimed to determine the association between serum uric acid (UA) levels and cardiovascular events in hospitalized patients with type 2 diabetes mellitus (T2DM).

Methods: A retrospective cohort study was conducted in 2227 hospitalized patients with T2DM. Cox proportional hazards regression was used to assess the association between serum UA and cardiovascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, heart failure, unstable angina, and arrhythmias requiring hospitalization. Read More

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Successful treatment of infantile oxysterol 7α-hydroxylase deficiency with oral chenodeoxycholic acid.

BMC Gastroenterol 2021 Apr 13;21(1):163. Epub 2021 Apr 13.

The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Background: Deficiency of oxysterol 7α-hydroxylase, encoded by CYP7B1, is associated with fatal infantile progressive intrahepatic cholestasis and hereditary spastic paraplegia type 5. Most reported patients with CYP7B1 mutations presenting with liver disease in infancy have died of liver failure. However, it was recently reported that two patients treated with chenodeoxycholic acid survived. Read More

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Severity analysis of road transport accidents of hazardous materials with machine learning.

Traffic Inj Prev 2021 13;22(4):324-329. Epub 2021 Apr 13.

School of Automobile, Chang'an University, Xi'an, China.

Objective: The aim of this study was to explore a suitable method for analyzing road transport accidents that involve hazardous materials and to explore the main factors that influence the occurrence of accidents of varying severity.

Methods: The 2015-2019 reported crash data from the Ministry of Transport of the People's Republic of China were obtained, and road transport crashes involving hazardous materials were extracted as the analysis data. The dataset was classified into three injury severity categories: property damage only (PDO), injured (INJ), and fatal (FAT). Read More

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Rule discovery to identify patterns contributing to overrepresentation and severity of run-off-the-road crashes.

Accid Anal Prev 2021 Jun 10;155:106119. Epub 2021 Apr 10.

University of Naples Federico II, Department of Civil, Architectural and Environmental Engineering, Via Claudio 21, 80125, Naples, Italy. Electronic address:

The main objective of this paper was to analyse the roadway, environmental, and driver-related factors associated with an overrepresentation of frequency and severity of run-off-the-road (ROR) crashes. The data used in this study refer to the 6167 crashes occurred in the section Naples-Candela of A16 motorway, Italy in the period from 2001 to 2011. The analysis was carried out using the rule discovery technique due to its ability of extracting knowledge from large amounts of data previously unknown and indistinguishable by investigating patterns that occur together in a given event. Read More

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In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers.

Genome Med 2021 Apr 12;13(1):57. Epub 2021 Apr 12.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Background: Mutations in the DMD gene encoding dystrophin-a critical structural element in muscle cells-cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing is a promising strategy for permanently curing DMD.

Methods: In this study, we developed a novel strategy for reframing DMD mutations via CRISPR-mediated large-scale excision of exons 46-54. Read More

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Targeted delivery of thrombolytic enzymes.

Young M Kwon

Bioimpacts 2021 29;11(2):85-86. Epub 2020 Oct 29.

Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Nova Southeastern University 3200 S. University Dr. Fort Lauderdale, FL 33328.

Although thrombolytic agents have been used for several decades in the treatment of thromboembolic conditions, there is an unmet need for the development of safer thrombolytic agents. The development of new molecules themselves may not be sufficient. This has sparked a growing interest in the design of novel nanoscale drug carrier systems for the delivery of thrombolytic enzymes in an effort to address its fatal side effects. Read More

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October 2020

Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway.

Cell Death Dis 2021 Apr 7;12(4):380. Epub 2021 Apr 7.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Mei Long Road, Shanghai, 200237, China.

Conjunctival melanoma (CM) is a rare and fatal ocular tumour with poor prognosis. There is an urgent need of effective therapeutic drugs against CM. Here, we reported the discovery of a novel potential therapeutic target for CM. Read More

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Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy.

Sci Rep 2021 Apr 7;11(1):7598. Epub 2021 Apr 7.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Ovarian cancer is highly metastatic, with a high frequency of relapse, and is the most fatal gynecologic malignancy in women worldwide. It is important to elevate the drug susceptibility and cytotoxicity of ovarian cancer cells, thereby eliminating resident cancer cells for more effective therapeutic efficacy. Here, we developed a bispecific antibody (BsAb; mPEG × HER2) that can easily provide HER2 tumor tropism to mPEGylated liposomal doxorubicin (PLD) and further increase the drug accumulation in cancer cells via receptor-mediated endocytosis, and improve the cytotoxicity and therapeutic efficacy of HER2 ovarian tumors. Read More

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Management of arrhythmias in pulmonary hypertension.

J Interv Card Electrophysiol 2021 Apr 5. Epub 2021 Apr 5.

Royal Papworth Hospital, Cambridge Biomedical Campus, Cambridge, CB2 0AY, UK.

Background: Pulmonary hypertension (PH) is a potentially devastating clinical condition with a poor long-term prognosis. Cardiac arrhythmias are frequent in PH, and pulmonary hypertensives are particularly susceptible to the adverse haemodynamic effects of heart rhythm disorders. However, arrhythmia management in PH patients can be more challenging than in the general population due to the particular physiological idiosyncrasies associated with the condition. Read More

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Investigation of factors contributing to injury severity in single vehicle motorcycle crashes in India.

Int J Inj Contr Saf Promot 2021 Apr 6:1-12. Epub 2021 Apr 6.

RBG Lab, Department of Engineering Design, IIT Madras, Chennai, India.

Single-vehicle crashes are of major concern in both developed as well as in Low Middle Income Countries due to the severity of injuries, particularly fatal accidents. In India, a significant proportion of crashes are single-vehicle crashes. The vehicles which are involved in accidents due to causes such as self skidding, hitting stationary objects, trees that are simply contributed by the drivers themselves are referred to as out-of-control single-vehicle crashes. Read More

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A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin.

J Pharmacol Toxicol Methods 2021 Apr 2;109:107057. Epub 2021 Apr 2.

Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom.

Idiopathic pulmonary fibrosis (IPF) is a disease that causes scarring and destruction of lung tissue that is ultimately fatal. There is a need to develop improved treatments for IPF. One problem with identifying novel treatments of IPF is the poor predictability of current preclinical models. Read More

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