8,293 results match your criteria fatal illness

Haemophagocytic lymphohistiocytosis in pregnancy: a pertinent case during the COVID-19 pandemic.

BMJ Case Rep 2021 Sep 17;14(9). Epub 2021 Sep 17.

Maternal Fetal Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania, USA

Haemophagocytic lymphohistiocytosis (HLH) is a rare, often fatal disease, and presents a diagnostic challenge in the pregnant patient. This challenge is particularly relevant during the current COVID-19 pandemic. We present a case of HLH in a pregnant woman presenting with fever predating the COVID-19 pandemic. Read More

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September 2021

Causes and outcome of rhabdomyolysis in patients admitted to medical wards in the Prince of Wales Hospital.

Ann Transl Med 2021 Aug;9(16):1329

Faculty of Medicine, Macau University of Science and Technology, Macau, China.

Background: Rhabdomyolysis with a marked elevation of serum creatine kinase (CK) can be caused by various conditions. Acute kidney injury (AKI) is a potential complication of severe rhabdomyolysis and leads to a rapid increase in serum creatinine.

Methods: This study was performed to identify medical cases diagnosed with rhabdomyolysis and to examine the likely causes. Read More

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Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients.

PLoS Pathog 2021 Sep 16;17(9):e1009804. Epub 2021 Sep 16.

Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Prior studies have demonstrated that immunologic dysfunction underpins severe illness in COVID-19 patients, but have lacked an in-depth analysis of the immunologic drivers of death in the most critically ill patients. We performed immunophenotyping of viral antigen-specific and unconventional T cell responses, neutralizing antibodies, and serum proteins in critically ill patients with SARS-CoV-2 infection, using influenza infection, SARS-CoV-2-convalescent health care workers, and healthy adults as controls. We identify mucosal-associated invariant T (MAIT) cell activation as an independent and significant predictor of death in COVID-19 (HR = 5. Read More

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September 2021

Alterations in the Plasma Proteome Induced by SARS-CoV-2 and MERS-CoV Reveal Biomarkers for Disease Outcomes for COVID-19 Patients.

J Inflamm Res 2021 1;14:4313-4328. Epub 2021 Sep 1.

Immunocompromised Host Research Unit, Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Purpose: This study aimed to understand the pathophysiology of host responses to infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/(COVID-19) and Middle East respiratory syndrome coronavirus (MERS-CoV) and to identify proteins for patient stratification with different grades of illness severity.

Patients And Methods: Peripheral blood samples from 43 patients with different grades of COVID-19, 7 MERS-CoV patients admitted to the ICU, and 10 healthy subjects were analyzed using label-free quantitative liquid chromatography-mass spectrometry (LC-MS).

Results: We identified 193 and 91 proteins that differed significantly between COVID-19 and MERS-CoV sample groups, respectively, and 49 overlapped between datasets. Read More

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September 2021

Certain Listeria monocytogenes plasmids contribute to increased UVC ultraviolet light stress.

FEMS Microbiol Lett 2021 Sep 9. Epub 2021 Sep 9.

Department of Animal Science, Iowa State University, Ames, IA, 50011 USA.

Listeria monocytogenes is the causative agent of the highly fatal foodborne disease listeriosis and can persist in food production environments. Recent research highlights the involvement of L. monocytogenes plasmids in different stress response mechanisms, which contribute to its survival in food production facilities. Read More

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September 2021

Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients.

Front Cell Infect Microbiol 2021 23;11:709893. Epub 2021 Aug 23.

Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.

Highlights: Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome.

Background: Coronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Read More

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September 2021

Atypical bacterial co-infections among patients with COVID-19: A study from India.

J Med Virol 2021 Sep 7. Epub 2021 Sep 7.

Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Emerging evidence shows co-infection with atypical bacteria in coronavirus disease 2019 (COVID-19) patients. Respiratory illness caused by atypical bacteria such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila may show overlapping manifestations and imaging features with COVID-19 causing clinical and laboratory diagnostic issues. We conducted a prospective study to identify co-infections with SARS-CoV-2 and atypical bacteria in an Indian tertiary hospital. Read More

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September 2021

Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease.

Neurosci Bull 2021 Sep 6. Epub 2021 Sep 6.

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

Human genetic prion diseases (gPrDs) are directly associated with mutations and insertions in the PRNP (Prion Protein) gene. We collected and analyzed the data of 218 Chinese gPrD patients identified between Jan 2006 and June 2020. Nineteen different subtypes were identified and gPrDs accounted for 10. Read More

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September 2021

Traumatised, angry, abandoned but some empowered: a national survey of experiences of family caregivers bereaved by motor neurone disease.

Palliat Care Soc Pract 2021 30;15:26323524211038584. Epub 2021 Aug 30.

Public Health Palliative Care Unit, School of Psychology and Public Health, La Trobe University, Bundoora Campus Kingsbury Drive, Melbourne, VIC 3086, Australia.

Background: There are few illnesses as disruptive as motor neurone disease, a fatal neurodegenerative condition, where diagnosis introduces a clinical narrative of inevitable decline through progressive immobilisation into death. Recent evidence suggests that bereaved motor neurone disease family caregivers are more likely to be at moderate or high risk of complicated grief.

Methods: Qualitative data from an anonymous national survey of bereaved motor neurone disease caregivers ( = 393) was examined through thematic analysis to explore the experiences of people who are at low, moderate, and high risk of complicated grief. Read More

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Cardiac surgery for patients with schizophrenia: clinical experience of six patients.

Surg Today 2021 Sep 4. Epub 2021 Sep 4.

Department of Psychiatry, National Hospital Organization Kumamoto Medical Center, 1-5 Ninomaru, Chuou-ku, Kumamoto, 860-0008, Japan.

Purpose: The incidence of schizophrenia in Japan is 0.7%, which is similar to the worldwide incidence. The mortality rate of patients with schizophrenia is reported to be higher than that of the general population, and cardiovascular disease is high among the causes of death. Read More

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September 2021

Crimean-Congo haemorrhagic fever-induced liver injury: A systematic review and meta-analysis.

Int J Clin Pract 2021 Sep 4:e14775. Epub 2021 Sep 4.

Our Lady of Fatima University College of Medicine, Valenzuela City, Philippines.

Background: Crimean-Congo haemorrhagic fever (CCHF) is a fatal acute tick-borne viral infection and substantial emerging global public health threat. This illness has a high case fatality rate of up to 40%. The liver is one of the important target organs of the CCHF virus. Read More

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September 2021

Pathology and Pathogenesis of Lassa Fever: Novel Immunohistochemical Findings in Fatal Cases and Clinico-pathologic Correlation.

Clin Infect Dis 2021 Aug 31. Epub 2021 Aug 31.

Infectious Diseases Pathology Branch, Division of High Consequence Pathogen and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Lassa fever is a zoonotic, acute viral illness first identified in Nigeria in 1969. An estimate shows that the "at risk" seronegative population (in Sierra Leone, Guinea, and Nigeria) may be as high as 59 million, with an annual incidence of all illnesses of three million, and fatalities up to 67,000, demonstrating the serious impact of the disease on the region and global health.

Methods: Histopathologic evaluation, immunohistochemical assay, and electron microscopic examination were performed on postmortem tissue samples from 12 confirmed Lassa fever cases. Read More

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Combating Coronavirus Disease-2019 Outbreak in Long-Term Care Facilities for Frail Older Adults: Preventive Measures and Palliative Care Go Hand-in-Hand.

J Palliat Care 2021 Aug 30:8258597211039364. Epub 2021 Aug 30.

Tuen Mun Hospital, New Territories, Hong Kong.

While the whole population is at risk from infection with the coronavirus, older people-often frail and subject to multimorbidity-are at the highest risk for the severe and fatal disease. Despite strict infection control and social distancing measures, frail adults in long-term care facilities may be at particular risk of transmission of respiratory illness. Treatment decisions are often complex attributed to the heterogeneity of this population with regards to different geriatric domains such as functional status, comorbidity, and poly-pharmacy. Read More

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Fatal sickling-associated microvascular occlusive crisis in a young with sickle cell trait.

Autops Case Rep 2021 20;11:e2021297. Epub 2021 Aug 20.

Armed Forces Medical College, Department of Medicine, Pune, Maharashtra, India.

Sickle cell trait (SCT), a heterozygous state characterized by hemoglobin AS, occurs commonly in sub-Saharan Africa, South America, Central America, India, and the Mediterranean countries. SCT is compatible with a normal lifespan and is not commonly regarded as a cause of morbid illness or death compared to its homozygous counterpart. We describe a case of fatal sickling-associated microvascular crisis, identified on post mortem evaluation in a previously undiagnosed 21-year-old military recruit with sickle cell trait. Read More

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Urban-Rural Dimension of Falls and Associated Risk Factors among Community-Dwelling Older Adults in West Java, Indonesia.

J Aging Res 2021 20;2021:8638170. Epub 2021 Aug 20.

Faculty of Health Sciences, Universitas Respati Indonesia, Jakarta, Indonesia.

Falls are one of the common problems among older adults; it is estimated that 684,000 fatal cases of falls occur every year. Furthermore, falls constitute one of the leading causes of mortality due to accidental injury. This study aims to identify the risk factors for falls in the older adults who live in the community, according to the dimensions of the living area: in urban and rural. Read More

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Severe Pneumonia in Neonates Associated with : Case Report and Review of the Literature.

Pathogens 2021 Aug 15;10(8). Epub 2021 Aug 15.

Department of Hygiene, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

The causative agent of legionellosis is the Gram-negative intracellular bacteria spp. Its clinical presentation varies from a mild febrile illness called Pontiac fever to the severe and possible fatal pneumonia, Legionnaires' disease. Immunocompromised patients, in particular, are affected. Read More

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Reframing anorexia nervosa as a metabo-psychiatric disorder.

Trends Endocrinol Metab 2021 Oct 20;32(10):752-761. Epub 2021 Aug 20.

ACUTE at Denver Health, Denver, CO, USA; Eating Recovery Center, Denver, CO, USA; University of Colorado School of Medicine, Denver, CO, USA.

Anorexia nervosa (AN) is a serious and often fatal illness. Despite decades of research, investigators have failed to adequately advance our understanding of the biological aspects of AN that could inform the development of effective interventions. Genome-wide association studies are revealing the important role of metabolic factors in AN, and studies of the gastrointestinal tract are shedding light on disruptions in enteric microbial communities and anomalies in gut morphology. Read More

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October 2021

Prognostic Value of Immune-Inflammatory Index in PSI IV-V Patients with COVID-19.

Biomed Res Int 2021 16;2021:9987931. Epub 2021 Aug 16.

Department of Anesthesiology and Pain Medicine, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan Province, China.

Objective: Respiratory failure is the leading cause of mortality in COVID-19 patients, characterized by a generalized disbalance of inflammation. The aim of this study was to investigate the relationship between immune-inflammatory index and mortality in PSI IV-V patients with COVID-19.

Methods: We retrospectively reviewed the medical records of COVID-19 patients from Feb. Read More

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Epidemiology of Bleeding in Critically Ill Children.

Front Pediatr 2021 4;9:699991. Epub 2021 Aug 4.

Division of Pediatric Critical Care Medicine, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, United States.

Bleeding can be a severe complication of critical illness, but its true epidemiologic impact on children has seldom been studied. Our objective is to describe the epidemiology of bleeding in critically ill children, using a validated clinical tool, as well as the hemostatic interventions and clinical outcomes associated with bleeding. Prospective observational cohort study. Read More

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Severe combined immunodeficiency: a case series from a paediatric hospital in Kenya.

Pan Afr Med J 2021 20;39:56. Epub 2021 May 20.

Department of Paediatrics, University of Nairobi, Nairobi, Kenya.

Severe Combined Immunodeficiency (SCID) involves the lymphocyte lineage and mimics Human Immunodeficiency Virus (HIV) disease common in our region, making it difficult to diagnose and manage effectively. SCID in East Africa stands underdiagnosed because of lack of awareness and diagnostic resources. A case series of three SCID patients admitted to a Tertiary Paediatric Centre in Kenya between 2016 and 2019. Read More

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September 2021

Immunomodulatory effect of vitamin D on immune response to dengue virus infection.

K Alagarasu

Vitam Horm 2021 12;117:239-252. Epub 2021 Jul 12.

Dengue and Chikungunya Group, ICMR-National Institute of Virology, Pune, Maharashtra, India. Electronic address:

Dengue, an acute febrile illness which in some cases requires hospitalization and occasionally a fatal disease, caused by dengue virus is a potential threat to the public health systems throughout the world. Approved antivirals are not available for treating dengue. Immunomodulators, that can reduce inflammation which if not treated properly results in vascular leakage, are being attempted as therapeutics against severe dengue. Read More

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The effect of depressive symptoms on pain in a substance-using population with persistent pain: a cross-sectional cohort study.

BMC Psychiatry 2021 08 20;21(1):416. Epub 2021 Aug 20.

British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada.

Background: In light of the ongoing opioid overdose crisis, there is an urgent need for research on the impacts of mental health among people presenting with concurrent pain and substance use. This study examined the effect of depressive symptoms on pain severity and functional interference among people who use drugs (PWUD) during a community-wide overdose crisis.

Methods: From December 1st 2016 to December 31st 2018, 288 participants in two cohort studies of PWUD in Vancouver, Canada completed interviewer-administered questionnaires that included the Brief Pain Inventory and PROMIS Emotional Distress-Depression instruments. Read More

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Autoantibodies neutralizing type I IFNs are present in 4% of uninfected individuals over 70 years old and account for 20% of COVID-19 deaths.

Sci Immunol 2021 08;6(62)

Joint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France; International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6. Read More

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Sudden cardiac death in a young boy with multisystemic inflammatory syndrome in children (MISC).

BMJ Case Rep 2021 Aug 19;14(8). Epub 2021 Aug 19.

Columbia Asia Referral Hospital Yeshwanthpur, Bangalore, Karnataka, India.

A previously healthy 12-year-old boy presented to the emergency department on the seventh day of illness with classical symptoms of postinflammatory multisystemic syndrome in children temporally associated with SARS-CoV-2 (fever, vomiting, loose stools and rashes all over the body) with COVID-19 seropositivity, high inflammatory markers and elevated cardiac enzymes with cardiogenic shock with multiple organ dysfunction syndrome. After having improved over the first 48 hours following intravenous immunoglobulin and pulsed steroids, this young boy developed sudden cardiac arrest and died. No reversible cause could be identified at the time of resuscitation. Read More

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Non-O1/non-O139 vibrios - occurrence not only in Europe in recent years.

Epidemiol Mikrobiol Imunol 2021 ;70(2):131-138

Non-O1/non-O139 vibrios refer to all vibrios except toxin producing Vibrio cholerae serogroups O1 and O139. The prevalence of illness caused by non-O1/non-O139 vibrios steadily increases all over the world in the last 20 years, which is very probably related to global warming. These infections are reported year-round from tropical and subtropical climate zones, but they were also detected in the mild climate zone of the United States of America and Europe. Read More

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Independent Risk Factors for the Dynamic Development of COVID-19: A Retrospective Study.

Int J Gen Med 2021 10;14:4349-4367. Epub 2021 Aug 10.

Department of Respiratory and Critical Care Medicine, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710038, People's Republic of China.

Objective: To identify the risk factors for predicting the dynamic progression of COVID-19.

Methods: A total of 2321 eligible patients were included in this study from February 4 to April 15, 2020. Two illness conditions, including mild/moderate (M/M) subtype to severe/critical (S/C) and S/C to fatality, were classified. Read More

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Diagnosis of dengue fever in a patient with early pregnancy loss.

BMJ Case Rep 2021 Aug 17;14(8). Epub 2021 Aug 17.

Obstetrics, Gynecology, & Reproductive Sciences, Yale-New Haven Hospital, New Haven, Connecticut, USA.

Dengue is a mosquito-borne virus that causes an influenza-like illness ranging in severity from asymptomatic to fatal. Dengue in pregnancy has been associated with adverse outcomes including miscarriage, preterm birth and fetal and neonatal death. We present the case of a multiparous woman who presented at 9 weeks' gestation with vaginal bleeding and abdominal cramping after a 1 month stay in Mexico. Read More

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[Clinical Guidelines for Cancer Chemotherapy under COVID-19 in the World].

Gan To Kagaku Ryoho 2021 Aug;48(8):992-995

Dept. of Medical Oncology, Nippon Medical School Musashikosugi Hospital.

A risk of COVID-19 infection for cancer patients is reported slightly high compared with general citizens. Among patients with cancer and COVID-19, severe illness and mortality is slightly high and associated with general risk factors and risk factors unique to patients with cancer. Cancer therapy should not be stopped or postponed under COVID-19 because cancer will be fatal disease if delaying or stopping cancer treatment. Read More

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Background of fatal pulmonary embolism: an analysis of all diagnosed fatal pulmonary embolism in 2015-2018 from Hospital District of Helsinki and Uusimaa.

J Thromb Thrombolysis 2021 Aug 16. Epub 2021 Aug 16.

Heart and Lung Center, Helsinki University and Helsinki University Hospital, Stenbäckinkatu 9, Lumivaarantie 23A, 02140, Espoo, Helsinki, Finland.

Pulmonary embolism (PE) mortality has decreased in the last decades but acute PE is still associated with significant fatality. Specific information on fatal PE patients could guide how to efficiently improve PE management but to date this information has been scarce. All the individuals with PE defined as an immediate or underlying cause of death were collected from the death certificate archive of the Hospital District of Helsinki and Uusimaa, Finland, including approximately 1. Read More

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No difference in biomarkers of ischemic heart injury and heart failure in patients with COVID-19 who received treatment with chloroquine phosphate and those who did not.

PLoS One 2021 16;16(8):e0256035. Epub 2021 Aug 16.

Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Chloroquine was promoted as a COVID-19 therapeutic early in the pandemic. Most countries have since discontinued the use of chloroquine due to lack of evidence of any benefit and the risk of severe adverse events. The primary aim of this study was to examine if administering chloroquine during COVID-19 imposed an increased risk of ischemic heart injury or heart failure. Read More

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