188,744 results match your criteria family identified


Spontaneous remission of West syndrome associated with acute infection and fever in five patients.

Epilepsy Res 2021 May 8;174:106663. Epub 2021 May 8.

Department of Neurology, Hospital Materno Infantil Salta, Argentina. Electronic address:

Objective: We analyzed the records of 198 patients with West syndrome (WS) seen at a single pediatric neurology center in Argentina between June 2004 and June 2017. Five patients with infection-related spontaneous remission of the electroclinical manifestations were identified.

Methods: The following parameters were investigated: personal and family history, clinical characteristics of the seizures - mainly spasms - and EEG findings, type of treatment, and outcome. Read More

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Recommendations for Postoperative Surveillance of Pediatric Benign Ovarian Neoplasms.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Electronic address:

Study Objective: Assess postoperative management of pediatric patients with benign ovarian neoplasms to develop recommendations for postoperative care.

Design: A retrospective cohort study.

Setting: Eight pediatric hospitals in the Midwest. Read More

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Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases.

Free Radic Biol Med 2021 May 11. Epub 2021 May 11.

Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens 11635, Greece. Electronic address:

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases. Senescent cells (SC) exhibit a specific senescence-associated secretory phenotype (SASP), mainly characterized by the production of proinflammatory and matrix-degrading molecules. Read More

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Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1.

J Biol Chem 2021 May 11:100772. Epub 2021 May 11.

Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC) - CONICET and Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA Córdoba, Argentina. Electronic address:

TRIM7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1, the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence indicates that TRIM7 plays an important role in cancer development, viral pathogenesis, and atherosclerosis, and thus represents a potential therapeutic target. TRIM family proteins share a multidomain architecture with a conserved N-terminal tripartite motif (TRIM) and a variable C-terminal domain. Read More

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"There may be a problem, but I'm not going because…": examining classes of men and their rationales for not seeking mental health treatment.

J Ment Health 2021 May 14:1-8. Epub 2021 May 14.

Department of Applied Human Sciences, Kansas State University, Manhattan, KS, USA.

Background: Men are less likely than women to seek out mental health treatment, despite men also having mental health struggles.

Aim: We examined typologies of men's reasons for not seeking treatment even though they perceived a need for treatment.

Method: We conducted a latent class analysis using a U. Read More

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The role of TNFRSF11B in development of osteoarthritic cartilage.

Rheumatology (Oxford) 2021 May 14. Epub 2021 May 14.

Dept. of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Dept. Orthopaedics, LUMC.

Objectives: Osteoarthritis (OA) is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously identified with gain-of-function mutation in a family with early-onset OA with chondrocalcinosis, is among the highest upregulated genes in lesioned OA cartilage (RAAK-study). Here, we determined the role of TNFRSF11B overexpression in development of OA. Read More

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Family-centered music therapy-Empowering premature infants and their primary caregivers through music: Results of a pilot study.

PLoS One 2021 14;16(5):e0250071. Epub 2021 May 14.

Department of Neonatology, University Children's Hospital, Heidelberg, Germany.

Background: In Neonatal Intensive Care Units (NICUs) premature infants are exposed to various acoustic, environmental and emotional stressors which have a negative impact on their development and the mental health of their parents. Family-centred music therapy bears the potential to positively influence these stressors. The few existing studies indicate that interactive live-improvised music therapy interventions both reduce parental stress factors and support preterm infants' development. Read More

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Genetic Determinants of Paget's Disease of Bone.

Curr Osteoporos Rep 2021 May 14. Epub 2021 May 14.

Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.

Purpose Of Review: To provide an overview of the role of genes and loci that predispose to Paget's disease of bone and related disorders.

Recent Findings: Studies over the past ten years have seen major advances in knowledge on the role of genetic factors in Paget's disease of bone (PDB). Genome wide association studies have identified six loci that predispose to the disease whereas family based studies have identified a further eight genes that cause PDB. Read More

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HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.

Inflamm Bowel Dis 2021 May 14. Epub 2021 May 14.

State Key Laboratory of Analytical Chemistry for Life Science, School of Life Sciences, Nanjing University, Nanjing, China.

Background: Interleukin-10 (IL-10) is a potent immunoregulatory cytokine that plays a pivotal role in maintaining mucosal immune homeostasis. As a novel synthetic inhibitor of salt-inducible kinases (SIKs), HG-9-91-01 can effectively enhance IL-10 secretion at the cellular level, but its in vivo immunoregulatory effects remain unclear. In this study, we investigated the effects and underlying mechanism of HG-9-91-01 in murine colitis models. Read More

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Endozoicomonadaceae symbiont in gills of Acesta clam encodes genes for essential nutrients and polysaccharide degradation.

FEMS Microbiol Ecol 2021 May 14. Epub 2021 May 14.

Department of Biology, University of Bergen, Norway.

Gammaproteobacteria from the family Endozoicomonadaceae have emerged as widespread associates of dense marine animal communities. Their abundance in coral reefs involves symbiotic relationships and possibly host nutrition. We explored functions encoded in the genome of an uncultured Endozoicomonadaceae 'Candidatus Acestibacter aggregatus' that lives inside gill cells of large Acesta excavata clams in deep-water coral reefs off mid-Norway. Read More

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Cutaneous Leishmaniasis Outbreak Investigation in Hajjah Governorate, Yemen, in 2018: Case-Control Study.

JMIR Public Health Surveill 2021 May 14;7(5):e27442. Epub 2021 May 14.

Department of Public Health, Community Medicine and Family Medicine, Faculty of Medicine, Jordan University of Science & Technology, Amman, Jordan.

Background: Cutaneous leishmaniasis (CL) is endemic in Yemen. About 4440 cases were reported in 2019. On July 23, 2018, a Hajjah governorate surveillance officer notified the Ministry of Public Health and Population about an increase in the number of CL cases in Bani-Oshb, Kuhlan district, Hajjah governorate. Read More

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An App-Based Parenting Program to Promote Healthy Energy Balance-Related Parenting Practices to Prevent Childhood Obesity: Protocol Using the Intervention Mapping Framework.

JMIR Form Res 2021 May 14;5(5):e24802. Epub 2021 May 14.

Behavioural Science Institute, Radboud University, Nijmegen, Netherlands.

Background: The family environment plays an important role in the development of children's energy balance-related behaviors. As a result, parents' energy balance-related parenting practices are important targets of preventive childhood obesity programs. Families with a lower socioeconomic position (SEP) may benefit from participating in such programs but are generally less well reached than families with a higher SEP. Read More

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Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.

Clin Genet 2021 May 14. Epub 2021 May 14.

Reproductive Medicine Centre, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Non-obstructive azoospermia (NOA) is the most severe form of male infertility, and it is primarily associated with genetic defects. We performed whole-exome sequencing of 236 patients with NOA and identified a homozygous pathogenic variant of autophagy-related 4D cysteine peptidase (ATG4D) in two siblings from a consanguineous family and compound heterozygous pathogenic variants of ATG4D in two sporadic cases. The expression of LC3B, a regulator of autophagic activity, was significantly decreased, and the apoptosis rate of spermatogenic cells in testicular tissues was increased. Read More

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Prognostic Prediction Based on Dynamic Contrast-Enhanced MRI and Dynamic Susceptibility Contrast-Enhanced MRI Parameters from Non-Enhancing, T2-High-Signal-Intensity Lesions in Patients with Glioblastoma.

Korean J Radiol 2021 May 4. Epub 2021 May 4.

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Objective: Few attempts have been made to investigate the prognostic value of dynamic contrast-enhanced (DCE) MRI or dynamic susceptibility contrast (DSC) MRI of non-enhancing, T2-high-signal-intensity (T2-HSI) lesions of glioblastoma multiforme (GBM) in newly diagnosed patients. This study aimed to investigate the prognostic values of DCE MRI and DSC MRI parameters from non-enhancing, T2-HSI lesions of GBM.

Materials And Methods: A total of 76 patients with GBM who underwent preoperative DCE MRI and DSC MRI and standard treatment were retrospectively included. Read More

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Efficacy and safety of phytoestrogens in the treatment of perimenopausal and postmenopausal depressive disorders: a systematic review and meta-analysis.

Int J Clin Pract 2021 May 13:e14360. Epub 2021 May 13.

Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, PR China.

Background: Depression is one of the most common and specific symptoms among menopausal women, leading to significant personal, family, and economic burdens. Some studies have shown that phytoestrogens can help relieve symptoms of depression.

Objectives: This systematic review and meta-analysis aims to assess the efficacy and safety of phytoestrogens in treating depression among menopausal women. Read More

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Differences in Access to HIV Services and Risky Sexual Behaviors Among Malawian Women at Social Venues Who Do and Do Not Engage in Sex Work.

AIDS Behav 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC, 27599-7435, USA.

In the high HIV-burden country of Malawi, female sex workers (FSW) are one of the populations most profoundly affected by HIV. The Malawi Priorities for Local AIDS Control Efforts (PLACE) surveyed 1,004 self-identified FSW, 213 other FSW (OFSW), and 130 other high risk women (OHRW) at social venues. Analyses compared the three groups using survey-weighted log binomial regression models. Read More

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Twelve-Month outcomes of a Cluster-Randomized Trial of Home-Based Postpartum Contraceptive Delivery in Southwest Trifinio, Guatemala.

Obstet Gynecol Res 2021 15;4(2):81-89. Epub 2021 Apr 15.

University of Colorado, Anschutz Medical Campus, Aurora, USA.

Design: We executed a cluster-randomized parallel arm pragmatic trial to observe the association of home-based postpartum contraceptive provision, including the contraceptive implant, with three and 12-month contraceptive utilization, satisfaction, and pregnancy rates.

Methods: Eight clusters were randomized to receive either the home-based contraceptive delivery (condoms, pills, injection, implant) during the routine 40-day postpartum visit in addition to routine care, or routine care alone, which included comprehensive contraceptive counseling throughout antepartum care.

Results: 208 women were enrolled in the study, 108 in the intervention clusters and 100 in control clusters. Read More

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The lived experiences of chronic pain among immigrant Indian-Canadian women: A phenomenological analysis.

Can J Pain 2020 Sep 24;4(3):40-50. Epub 2020 Sep 24.

Lawrence S. Bloomberg Faculty of Nursing, Toronto, Ontario, Canada.

: Chronic pain is a growing public health concern affecting 1.5 million people in Canada. In particular, it is a concern among the expanding immigrant population, because immigrant groups report higher pain intensity than non-immigrants. Read More

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September 2020

Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.

Ann Transl Med 2021 Apr;9(8):631

School of Medicine, Southeast University, Nanjing, China.

Background: Lycopene is a naturally occurring carotenoid found in many fruits and vegetables, which has antioxidant effects. Although lycopene's protective effect has been observed on ischemia reperfusion (IR) injury in different organs, the effect of lycopene on Kupffer cells (KCs) has not been clearly elucidated in IR-induced acute hepatic inflammatory injury.

Methods: Mice were administered with either olive oil (10 mL/kg body weight) as the control or lycopene (20 mg/kg body weight) by gavage for 2 weeks before undergoing hepatic IR injury. Read More

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Novel compound heterozygous mutations in the gene cause macular corneal dystrophy in a Han Chinese family.

Ann Transl Med 2021 Apr;9(8):622

Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, China.

Background: Macular corneal dystrophy (MCD), a rare autosomal recessive disorder, is caused by pathogenic mutations in the carbohydrate sulfotransferase 6 gene () and is characterized by bilateral progressive stromal clouding and vision loss. Corneal transplantation is often necessary. This study aimed to identify disease-causing mutations in a Han-Chinese MCD patient. Read More

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How Old Is My Dog? Identification of Rational Age Groupings in Pet Dogs Based Upon Normative Age-Linked Processes.

Authors:
Naomi D Harvey

Front Vet Sci 2021 27;8:643085. Epub 2021 Apr 27.

Canine Behaviour and Research Department, Dogs Trust, London, United Kingdom.

Behavioral development is a lifelong process where cognitive traits such as learning and memory may be expected to take quadratic or linear trajectories. It is common practice for operational purposes to reduce study subjects into chronological categories when conducting research. However, there are no agreed-upon thresholds for this practice, and the lack of standardization may hinder comparison between studies of normative and pathological aging. Read More

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Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs.

Front Cardiovasc Med 2021 27;8:658900. Epub 2021 Apr 27.

Faculty of Medicine, Institute of Neurophysiology, University of Cologne, Cologne, Germany.

The cardiovascular toxicity of anticancer drugs promotes the development of cardiovascular diseases. Therefore, cardiovascular toxicity is an important safety issue that must be considered when developing medications and therapeutic applications to treat cancer. Among anticancer drugs, members of the anthracycline family, such as doxorubicin, daunorubicin and mitoxantrone, are known to cause cardiotoxicity and even heart failure. Read More

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Staging Encystation Progression in Using Encystation-Specific Vesicle Morphology and Associating Molecular Markers.

Front Cell Dev Biol 2021 27;9:662945. Epub 2021 Apr 27.

Department of Biology, University of Washington, Seattle, WA, United States.

Differentiation into environmentally resistant cysts is required for transmission of the ubiquitous intestinal parasite . Encystation in requires the production, processing and transport of Cyst Wall Proteins (CWPs) in developmentally induced, Golgi-like, Encystation Specific Vesicles (ESVs). Progress through this trafficking pathway can be followed by tracking CWP localization over time. Read More

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Adhesive Functions or Pseudogenization of Type Va Autotransporters in Species.

Front Cell Infect Microbiol 2021 27;11:607610. Epub 2021 Apr 27.

Fundación Instituto Leloir (FIL), IIBBA (CONICET-FIL), Buenos Aires, Argentina.

Adhesion to host cells is a key step for successful infection of many bacterial pathogens and may define tropism to different host tissues. To do so, bacteria display adhesins on their surfaces. is an intracellular pathogen capable of proliferating in a wide variety of cell types. Read More

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Genome-wide identification and expression analysis of the trehalose-6-phosphate synthase () gene family in cucumber ( L.).

PeerJ 2021 30;9:e11398. Epub 2021 Apr 30.

College of Horticulture, Gansu Agricultural University, Lanzhou, China.

Trehalose-6-phosphate synthase (TPS) is significant in the growth, development and stress resistance of plants. We identified the cucumber family and its physicochemical properties, domains, gene structures, evolutionary relationships, gene locations, -acting elements, conserved motifs, and expression patterns using bioinformatics. Our results uncovered seven genes in the cucumber genome and named according to their locations in the chromosomes. Read More

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The Sugar Transporter family in wheat (. L): genome-wide identification, classification, and expression profiling during stress in seedlings.

PeerJ 2021 4;9:e11371. Epub 2021 May 4.

College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou, Henan, China.

The sugar transporter protein (STP) plays a crucial role in regulating plant growth and stress tolerance. We performed genome-wide identification and expression analysis of the STP gene family to investigate the STPSs' potential roles in the growth of wheat seedlings under stress. Here, a total of 81 TaSTP genes containing the Sugar_tr conserved motif were identified within the wheat genome. Read More

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Genome-wide identification, classification, and expression analysis of the gene family in pineapple ().

PeerJ 2021 27;9:e11329. Epub 2021 Apr 27.

State Key Lab of Ecological Pest Control for Fujian and Taiwan Crops; Key Lab of Genetics, Breeding and Multiple Utilization of Crops, Ministry of Education; Fujian Provincial Key Lab of Haixia Applied Plant Systems Biology, College of Life Sciences, Fuji, Fuzhou, Fujian, China.

Transcription factors (TFs), such as heat shock transcription factors (HSFs), usually play critical regulatory functions in plant development, growth, and response to environmental cues. However, no HSFs have been characterized in pineapple thus far. Here, we identified 22 genes from the pineapple genome. Read More

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Emotional Aspects of Pediatric Post-Intensive Care Syndrome Following Traumatic Brain Injury.

J Child Adolesc Trauma 2021 Jun 6;14(2):177-187. Epub 2021 Apr 6.

Division of Pediatric Psychology, Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University and Doernbecher Children's Hospital, Portland, OR USA.

Children with traumatic brain injury (TBI) requiring neurocritical care are at risk for neurocognitive, emotional, physical, and psychosocial difficulties, collectively known as Post-Intensive Care Syndrome. Our study assessed parent-reported emotional functioning and identified risk factors for emotional sequelae in the acute recovery phase. Fifty-three children between 5 and 18 years old hospitalized for TBI were assessed 1-month following discharge. Read More

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Bioinformatics and Expression Analysis of IDA-Like Genes Reveal Their Potential Functions in Flower Abscission and Stress Response in Tobacco ( L.).

Front Genet 2021 27;12:670794. Epub 2021 Apr 27.

Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, China.

The inflorescence deficient in abscission-like () genes have been shown to play critical roles in floral organ abscission, lateral root formation and various stress responses in . The gene family has been characterized in a number of plant species, while limited information is available about genes of tobacco. In the current study, 15 NtIDL members were identified in the tobacco genome, and were classified into six groups together with IDL members from other species. Read More

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