74,351 results match your criteria falls

Associations between polypharmacy and physical performance measures in older adults.

Arch Gerontol Geriatr 2021 Oct 9;98:104553. Epub 2021 Oct 9.

Department of Internal Medicine, Division of Geriatrics, Istanbul Medical School, Istanbul University, Capa, 34390, Istanbul, Turkey.

Objectives: A preserved ambulation is one of the keypoints for functionality and polypharmacy, a common problem in older adults, is associated with worse functional status. Our aim was to examine the associations of polypharmacy with certain physical performance measures used to evaluate ambulation.

Methods: This retrospective, cross-sectional study was conducted in a geriatric outpatient clinic. Read More

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October 2021

Potentially Inappropriate Prescribing for Prostatic Hyperplasia in Older Persons.

J Am Med Dir Assoc 2021 Oct 12. Epub 2021 Oct 12.

Department of Geriatric Medicine, CHU Amiens-Picardie, Amiens, France.

Objectives: In the context of improved medication management of older patients, we wished to evaluate the overprescription of potentially inappropriate drugs (α1-blockers and 5α-reductase inhibitors [5-ARI]) for benign prostate hyperplasia (BPH). These drugs are considered by geriatricians to increase the risk of falls and pharmacodynamic interactions, but these properties have not yet been proven.

Design: This was a descriptive study of drug prescriptions in a geriatric academic center. Read More

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October 2021

The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif.

PLoS One 2021 15;16(10):e0256070. Epub 2021 Oct 15.

Diamond Light Source, Harwell Science & Innovation Campus, Didcot, Oxfordshire, United Kingdom.

Nontypeable Haemophilus influenzae (NTHi) is a significant pathogen in respiratory disease and otitis media. Important for NTHi survival, colonization and persistence in vivo is the Sap (sensitivity to antimicrobial peptides) ABC transporter system. Current models propose a direct role for Sap in heme and antimicrobial peptide (AMP) transport. Read More

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October 2021

Generating non-uniformly correlated twisted sources.

Opt Lett 2021 Oct;46(20):5100-5103

The inverse method of proving the twistability of cross-spectral density (CSD) inevitably falls into spontaneous difficulties. Based on a nonnegative self-consistent design guideline for generating genuine CSDs introduced by Gori and Santarsiero, we demonstrate a feasible way for twisting partially coherent sources by sticking a Schell-model function to CSDs, which also determines the upper bound of the twisting strength. Analysis shows that the degree of coherence of a new class of twisted pseudo-Gaussian Schell-model beam is neither shift invariant nor shift-circular symmetric. Read More

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October 2021

Factors associated with Emergency Medical Dispatcher request and residents' inappropriate transfers from Nursing Homes to Emergency Department.

Eur Geriatr Med 2021 Oct 15. Epub 2021 Oct 15.

INSERM, U1295, F-31073, Toulouse, France.

Purpose: In the last decades, the amount of emergency department (ED) transfers of nursing home (NH) residents has disproportionally increased in western countries. The main role of emergency medical dispatcher (EMD) among this population is to refer residents to EDs in the most appropriate way. The aim of this study was to assess risk factors of inappropriate transfers from NH to ED after EMD request. Read More

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October 2021

Orthostatic hypotension and health outcomes: an umbrella review of observational studies.

Eur Geriatr Med 2019 Dec 7;10(6):863-870. Epub 2019 Nov 7.

Primary Care Department Azienda USL Toscana Sud Est, 58100, Grosseto, Italy.

Purpose: Orthostatic hypotension (OH) is associated with older age and many negative clinical outcomes in geriatric practice. We aimed to capture the breadth of outcomes that have been associated with the presence of OH and systematically assess the quality, strength and credibility of these associations using an umbrella review with integrated meta-analyses.

Methods: We systematically searched several major databases from their commencements through to 16th May 2019 for meta-analyses of observational studies of OH and any health-related outcome. Read More

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December 2019

Sarcopenia and health-related outcomes: an umbrella review of observational studies.

Eur Geriatr Med 2019 Dec 6;10(6):853-862. Epub 2019 Sep 6.

National Research Council, Neuroscience Institute, Aging Branch Via Giustiniani, 2, Padua, Italy.

Background: The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology. Read More

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December 2019

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Eur Geriatr Med 2019 Apr;10(2):275-283

Department of Elderly Medicine, Brighton and Sussex University Hospitals NHS Trust, Sussex, UK.

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. Read More

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Self-reported insomnia symptom, sleep duration and the risk of recurrent falls among older men and women.

Eur Geriatr Med 2019 Apr 23;10(2):303-312. Epub 2019 Jan 23.

Geriatric Section, Department of Medicine, Morehouse School of Medicine, 720 Westview Drive, SW, Atlanta, GA, 30310-1495, USA.

Background/objectives: Previous studies have reported conflicting results on the association between sleep disturbance and recurrent falls. The objective of the current study was to examine the risk of recurrent falls among community-dwelling older adults who reported one or more insomnia symptoms along with normal, short and long sleep durations in comparison with those who reported no insomnia symptom and normal sleep duration.

Design: Secondary data analysis of a prospective cohort study. Read More

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Body shape, fear of falling, physical performance, and falls among individuals aged 55 years and above.

Eur Geriatr Med 2019 Oct 29;10(5):801-808. Epub 2019 Jul 29.

Ageing and Age-Associated Disorders Research Group, University of Malaya, Kuala Lumpur, Malaysia.

Purpose: To evaluate the relationship between waist-to-hip ratio (WHR) and fall-related outcomes in community-dwelling individuals aged 55 and above.

Methods: Cross-sectional data obtained from the first wave of the Malaysian Elders Longitudinal Research (MELoR) study were utilized for this study. Participants aged 55 years and over were recruited using simple random sampling from the electoral rolls of three local parliamentary constituencies. Read More

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October 2019

Wheat respiratory O2 consumption falls with night warming alongside greater respiratory CO2 loss and reduced biomass.

J Exp Bot 2021 Oct 15. Epub 2021 Oct 15.

ARC Centre of Excellence in Plant Energy Biology, Division of Plant Sciences, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.

Warming nights are correlated with declining wheat growth and yield. A key determinant of plant biomass, respiration consumes O2 as it produces ATP and releases CO2 and is typically reduced under warming to maintain metabolic efficiency. We compared the response of respiratory O2 and CO2 flux to multiple night and day warming treatments in wheat leaves and roots, using one commercial (Mace) and one breeding cultivar grown in controlled environments. Read More

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October 2021

Onychomycosis: Rapid Evidence Review.

Am Fam Physician 2021 Oct;104(4):359-367

The Clinics of North Texas, LLP, Wichita Falls, TX, USA.

Onychomycosis is a chronic fungal infection of the fingernail or toenail bed leading to brittle, discolored, and thickened nails. Onychomycosis is not just a cosmetic problem. Untreated onychomycosis can cause pain, discomfort, and physical impairment, negatively impacting quality of life. Read More

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October 2021

FallSkip device is a useful tool for fall risk assessment in sarcopenic older community people.

Int J Older People Nurs 2021 Oct 14:e12431. Epub 2021 Oct 14.

Instituto de Biomecánica de Valencia, Universitat Politècnica de València, Valencia, Spain.

Purpose: Fall prevention is a major health concern for the ageing population. Sarcopenia is considered a risk factor for falls. Some instruments, such as Time Up and Go (TUG), are used for screening risk. Read More

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October 2021

Sarcopenia, frailty and type 2 diabetes mellitus (Review).

Mol Med Rep 2021 Dec 15;24(6). Epub 2021 Oct 15.

The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan.

Skeletal muscle is the largest and most energy‑consuming organ in the human body, which plays an important role in energy metabolism and glucose uptake. There is a notable decrease in glucose uptake in the skeletal muscle of patients with type 2 diabetes mellitus (DM). Endurance exercise can reduce hyperglycemia and improve insulin resistance in patients with type 2 DM. Read More

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December 2021

Past the tipping point: a qualitative study of the views and experiences of men with haemophilia regarding mobility, balance, and falls.

Disabil Rehabil 2021 Oct 15:1-9. Epub 2021 Oct 15.

Physiotherapy Research Unit, Nuffield Orthopaedic Centre, Oxford University Hospital NHS Foundation Trust, UK.

Purpose: The life expectancy of people with haemophilia is increasing due to improved medical care. This improvement is accompanied by the co-morbidities of ageing, which include musculoskeletal degeneration and the associated effect on proprioception and balance. This study aims to explore the views and everyday experiences of those living with haemophilia regarding this. Read More

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October 2021

Stewarding Access to Care: Where We've Been and Where We're Going.

Matthew Tierney

J Am Psychiatr Nurses Assoc 2021 Sep-Oct;27(5):415-417

Matthew Tierney, MS, CNS, ANP, PMHNP, CARN-AP, FAAN, American Psychiatric Nurses Association, Falls Church, VA, USA.

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October 2021

The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects.

Front Cell Dev Biol 2021 28;9:735374. Epub 2021 Sep 28.

Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.

Sarcopenia is an age-related disease in which muscle mass, strength and function may decline with age or can be secondary to cachexia or malnutrition and can lead to weakness, falls and even death. With the increase in life expectancy, sarcopenia has become a major threat to the health of the elderly. Currently, our understanding of bone-muscle interactions is not limited to their mechanical coupling. Read More

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September 2021

Five Key Papers About Emergency Department Fall Evaluation: A Curated Collection for Emergency Physicians.

Cureus 2021 Sep 4;13(9):e17717. Epub 2021 Sep 4.

Emergency Medicine, University of Iowa Carver College of Medicine, Iowa, USA.

The evaluation of patients who have experienced a fall has been an integral part of geriatric emergency care. All physicians who engage in the care of the geriatric population in acute settings need to familiarize themselves with the current literature on this topic. However, it can be challenging to navigate the large body of literature on this topic. Read More

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September 2021

Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis.

Sci Rep 2021 Oct 14;11(1):20415. Epub 2021 Oct 14.

Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau, Mas Casanovas, 90, 08041, Barcelona, Spain.

The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. Read More

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October 2021

Trauma in northern Quebec, 2005-2014: epidemiologic features, transfers and patient outcomes.

Can J Surg 2021 Sep-Oct;64(5):E527-E533. Epub 2021 Sep 1.

From the Department of Surgery, McGill University, Montréal, Que. (Moon); the Faculty of Medicine, McGill University, Montréal, Que. (Pop); the Centre de santé Tulattavik de l'Ungava, Kuujjuaq, Que. (Talaat, Boulanger); the Quebec Coroner's Office, Montréal, Que. (Perron); and the Division of General and Trauma Surgery, McGill University, Montréal, Que. (Deckelbaum, Grushka, Wong, Razek).

Background: The Inuit people residing in Nunavik, Quebec, are vulnerable to major trauma owing to environmental and social factors; however, there is no systematic data collection for trauma in Nunavik, and, apart from data regarding patients who are transferred to tertiary care centres, no data enter the Quebec trauma registry directly from Nunavik. We performed a study to characterize the epidemiologic features of trauma in Nunavik, and describe indications for transfer and outcomes of patients referred to the tertiary trauma centre.

Methods: We collected data retrospectively for all patients with trauma admitted to the Centre de santé Tulattavik de l'Ungava in Kuujjuaq from 2005 to 2014. Read More

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September 2021

Benefits outweigh the risks: a consensus statement on the risks of physical activity for people living with long-term conditions.

Br J Sports Med 2021 Oct 14. Epub 2021 Oct 14.

Moving Medicine, Faculty of Sport And Exercise Medicine, Edinburgh, UK

Introduction: The benefits of physical activity for people living with long-term conditions (LTCs) are well established. However, the risks of physical activity are less well documented. The fear of exacerbating symptoms and causing adverse events is a persuasive barrier to physical activity in this population. Read More

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October 2021

Short- and long-term effects of different exercise programs on the gait performance of older adults with subjective cognitive decline: A randomized controlled trial.

Exp Gerontol 2021 Oct 11:111590. Epub 2021 Oct 11.

Institute of Innovation for Future Society, Nagoya University, Nagoya, Japan; Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Background: Older adults, especially those with cognitive decline, often have poor gait performance, which results in poor clinical outcomes due to falls or decreased daily physical activity. The effects of various exercises on gait performance have been studied, whereas the short-term and long-term effects of different exercise modalities remain unknown.

Objective: To compare the short- and long-term effects of aerobic training (AT), resistance training (RT), and combined training (CT) on the gait performance of community-dwelling older adults with subjective cognitive decline (SCD). Read More

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October 2021

Differences in State Traumatic Brain Injury-Related Deaths, by Principal Mechanism of Injury, Intent, and Percentage of Population Living in Rural Areas - United States, 2016-2018.

MMWR Morb Mortal Wkly Rep 2021 Oct 15;70(41):1447-1452. Epub 2021 Oct 15.

Division of Injury Prevention, National Center for Injury Prevention and Control, CDC.

Traumatic brain injuries (TBIs) have contributed to approximately one million deaths in the United States over the last 2 decades (1). CDC analyzed National Vital Statistics System (NVSS) mortality data for a 3-year period (2016-2018) to examine numbers and rates of TBI-related deaths, the percentage difference between each state's rate and the overall U.S. Read More

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October 2021

A retrospective registry analysis of the transport-related health burden of wheeled recreational devices in Queensland, Australia.

Aust N Z J Public Health 2021 Oct 14. Epub 2021 Oct 14.

Centre for Accident Research and Road Safety Queensland (CARRS-Q), Queensland University of Technology.

Objective: Evaluate injury patterns from wheeled recreational devices (WRD) in the public space and explore risk factors for hospital admission.

Method: A cross-sectional analysis of WRD injury prevalence and risk factors for hospital admissions was conducted using data from the Queensland Injury Surveillance Unit (QISU) database for 2007 to 2017. Descriptive statistics and a log-binomial regression model were used to calculate adjusted relative risk for hospital admission. Read More

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October 2021

Expression of acid cleavable Asp-Pro linked multimeric AFP peptide in E. coli.

J Genet Eng Biotechnol 2021 Oct 14;19(1):155. Epub 2021 Oct 14.

JSC Russian Research Center for Molecular Diagnostics and Therapy, 8 Simferopolsky boulevard, Moscow, 117638, Russia.

Background: Difficult to express peptides are usually produced by co-expression with fusion partners. In this case, a significant mass part of the recombinant product falls on the subsequently removed fusion partner. On the other hand, multimerization of peptides is known to improve its proteolytic stability in E. Read More

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October 2021

Daily Functionality in Adults with POTS: Predictive Factors.

Occup Ther Health Care 2021 Oct 14:1-16. Epub 2021 Oct 14.

College of Information, University of North Texas, Denton, TX, USA.

Symptoms associated with postural orthostatic tachycardia syndrome (POTS) hinder overall functionality. This study examined factors that impacted daily life and contributed to overall daily functionality in adults with POTS ( = 958, ages 18-60). Descriptive and multiple linear regression analyses indicated that participants with fewer challenges in ADLs, IADLs, work, school, leisure, and socializing had overall better functionality. Read More

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October 2021

Safety of Laser and Thermal Therapy During Rigid Bronchoscopy Using Manual Hand Jet Ventilation.

Surg Technol Int 2021 10 13;39. Epub 2021 Oct 13.

Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.

Introduction: Thermal ablative therapies (laser, radiofrequency ablation, electrocautery, argon plasma coagulation) are often used during rigid bronchoscopy for the treatment of central airway obstructions (CAO). An airway fire is a feared complication that can occur during endobronchial thermal ablation.

Materials And Methods: This was a single-center, retrospective, observational study. Read More

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October 2021

Temporary Internal Bracing for Pediatric Odontoid Synchondrosis Fracture.

Cureus 2021 Sep 1;13(9):e17639. Epub 2021 Sep 1.

Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, USA.

Children are predisposed to injuries of the upper cervical spine given their relatively immature osteology, ligamentous laxity, underdeveloped musculature, and larger ratios of head to body mass. Odontoid process fractures involving the synchondroses are among the most common of these injuries. Though many of these fractures can be treated conservatively with external bracing, fractures with significant displacement that are unable to be reduced require operative management. Read More

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September 2021

SMART technologies: the challenges and potential for addressing falls.

JBI Evid Synth 2021 Oct;19(10):2476-2477

The Scottish Centre for Evidence-based, Multi-professional Practice: A JBI Centre of Excellence, Aberdeen, UK.

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October 2021

A rare case of rectal bleeding and sepsis due to solitary fibrous tumour originating from the mesentery.

BMJ Case Rep 2021 Oct 13;14(10). Epub 2021 Oct 13.

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, USA.

Solitary fibrous tumours (SFTs) are rare mesenchymal tumours that are mostly seen in the pleura. Lately, they have also been described in other locations. Recent discovery of the NAB2-STAT6 fusion gene which is specific for SFTs has led to an accurate diagnosis of SFTs. Read More

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October 2021