3,110 results match your criteria failure-associated

Incidence of Complications from Percutaneous Biopsy in Chronic Liver Disease: A Systematic Review and Meta-Analysis.

Dig Dis Sci 2021 Jun 15. Epub 2021 Jun 15.

Global Liver Institute, Washington, USA.

Background: Approaches to liver biopsy have changed over the past decade in patients with chronic liver disease.

Aims: We conducted a systematic review and meta-analysis on the incidence of all complications and technical failure associated with percutaneous liver biopsy.

Methods: We systematically searched PubMed and the Cochrane Library for cohort studies reporting on complications resulting from liver biopsy published between 2010 and 2020. Read More

View Article and Full-Text PDF

Short-term and long-term safety and efficacy of tenofovir alafenamide, tenofovir disoproxil fumarate and entecavir treatment of acute-on-chronic liver failure associated with hepatitis B.

BMC Infect Dis 2021 Jun 14;21(1):567. Epub 2021 Jun 14.

Department of Infectious Diseases, First Affiliated Teaching Hospital, School of Medicine, Xi'an Jiaotong University, Yanta Road (w), No. 277, Xi'an City, 710061, Shaanxi Province, China.

Background & Aims: There is limited evidence on the efficacy and safety of nucleos(t) ide analogues (NAs) in the treatment of HBV-ACLF. Our objective was to evaluate the outcomes among TAF, TDF and ETV, three first-line antivirals against chronic hepatitis B, in patients with HBV-ACLF.

Methods: Patients with HBV-related ACLF were recruited and received daily TAF (25 mg/d), TDF (300 mg/d) and ETV (0. Read More

View Article and Full-Text PDF

[The acute and long-term outcome of patients with ST segment elevation myocardial infarction concurrent with chronic total occlusion].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):586-592

Coronary Heart Disease Center, National Center for Cardiovascular Diseases and Fuwai Hospital, China Academy of Medical Science and Peking Union Medical College, Beijing 100037, China.

To evaluate the acute and long-term outcome of patients with ST segment elevation myocardial infarction (STEMI) concurrent with chronic total occlusion (CTO) undergoing primary percutaneous coronary intervention (PCI). 11 905 STEMI patients from the China Acute Myocardial Infarction Registry were enrolled in this study and divided into CTO group and non-CTO group according to the angiography results of primary PCI. 1∶3 propensity score matching was used to match the patients between the two groups. Read More

View Article and Full-Text PDF

A Cohort Study to Evaluate the Risk of Hospitalisation for Congestive Heart Failure Associated with the Use of Aclidinium and Other Chronic Obstructive Pulmonary Disease Medications in the UK Clinical Practice Research Datalink.

Int J Chron Obstruct Pulmon Dis 2021 31;16:1461-1475. Epub 2021 May 31.

RTI Health Solutions, Barcelona, Spain.

Background: The long-acting anticholinergic (LAMA) aclidinium was approved in Europe in 2012 to relieve symptoms in adults with chronic obstructive pulmonary disease (COPD). A Post-Authorisation Safety Study (PASS) was initiated to assess potential cardiovascular safety concerns for aclidinium.

Objective: To estimate the adjusted incidence rate ratio (IRR) for hospitalisation for heart failure in patients with COPD who were new users of aclidinium, tiotropium, other LAMA, long-acting beta-agonists/inhaled corticosteroids (LABA/ICS), and LAMA/LABA were compared with initiators of LABA. Read More

View Article and Full-Text PDF

An Unusual Case of Early Dental Implant Failure in an Otherwise-Healthy Patient due to Actinomycosis.

J Oral Implantol 2021 Jun 5. Epub 2021 Jun 5.

Associate Professor, Hacettepe University Faculty of Dentistry, Periodontology Department, Ankara, Turkey.

Actinomyces spp. are members of normal oral flora that may give rise to a rare disease- oral actinomycosis . Here we present a case of early implant failure associated with actinomycosis in an otherwise -healthy 43-year-old female and the treatment adopted following explantation. Read More

View Article and Full-Text PDF

PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice.

Cardiovasc Res 2021 Jun 4. Epub 2021 Jun 4.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

Aims: Biological sex has fundamental effects on mammalian heart physiology and pathogenesis. While it has been established that female sex is a protective factor against most cardiovascular diseases (CVDs), this beneficial effect may involve pathways associated with cardiac energy metabolism. Our aim was to elucidate the role of transcriptional coactivator PGC-1α in sex dimorphism of heart failure development. Read More

View Article and Full-Text PDF

Consequences of oral antithrombotic use in patients with chronic kidney disease.

Clin Transl Sci 2021 Jun 3. Epub 2021 Jun 3.

Department of Clinical Pharmacology, Amiens University Hospital, Amiens, France.

We assessed the risks of bleeding, acute kidney injury (AKI) and kidney failure associated with the prescription of antithrombotic agents (oral anticoagulants and/or antiplatelet agents) in patients with moderate-to-advanced CKD. CKD-REIN is a prospective cohort of 3022 nephrology outpatients with CKD stages 2-5 at baseline. We used cause-specific Cox proportional hazard models to estimate hazard ratios (HRs) for bleeding (identified through hospitalizations), AKI and kidney failure. Read More

View Article and Full-Text PDF

The first pediatric case of hemophagocytic lymphohistiocytosis secondary to Crimean-Congo haemorrhagic fever successfully treated with therapeutic plasma exchange accompanying ribavirin and intravenous immunoglobulin.

J Clin Apher 2021 Jun 1. Epub 2021 Jun 1.

Faculty of Medicine, Department of Pediatrics, Division of Pediatric Pediatric Gastroenterology Hepatology and Nutrition, Karadeniz Technical University, Trabzon, Turkey.

Although Crimean-Congo hemorrhagic fever (CCHF) is mild and self-limited in children, some patients may develop excessive bleeding, massive liver necrosis, and multiple organ failure associated with secondary hemophagocytic lymphohistiocytosis (HLH) induced by cytokine storm. Treatment of CCHF is mainly symptomatic and supportive. The efficacy of ribavirin, which is the only antiviral drug in the treatment of CCHF, remains controversial. Read More

View Article and Full-Text PDF

Re: Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study.

Eur Urol 2021 May 28. Epub 2021 May 28.

Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address:

View Article and Full-Text PDF

Differences in the safety line of the future liver remnant plasma clearance rate of indocyanine green necessary to prevent post-hepatectomy liver failure associated with underlying diseases.

Surg Today 2021 May 29. Epub 2021 May 29.

Division of Hepato- Biliary-Pancreatic Surgery, Shizuoka Cancer Center, 1007, Shimo-Nagakubo, Sunto- Nagaizumi, Shizuoka, 4118777, Japan.

Purpose: To evaluate differences in the safety line of the future liver remnant plasma clearance rate of indocyanine green (RemK) necessary to prevent posthepatectomy liver failure (PHLF) associated with liver tumors and comorbidities.

Methods: The subjects of this retrospective study were patients who underwent trisectionectomy, hemihepatectomy, or sectionectomy, other than left lateral sectionectomy, between 2011 and 2018, at the Shizuoka Cancer Center. We analyzed the risk factors for PHLF grades B and C and then evaluated the RemK in these groups, according to various risk factors. Read More

View Article and Full-Text PDF

The Case for Cadmium and Lead Heavy Metal Screening.

Am J Med Sci 2021 May 25. Epub 2021 May 25.

Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY, USA.

Exposure to cadmium and lead is widespread, and is related to environmental contamination, occupational sources, food, tobacco and other consumer products. Lower socioeconomic status increases the risk of heavy metal exposure and the diseases associated with cadmium and lead toxicity. Concurrent toxicity with both cadmium and lead is likely but has not often been assessed. Read More

View Article and Full-Text PDF

Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter.

J Urol 2021 May 18:101097JU0000000000001892. Epub 2021 May 18.

Istanbul Training and Research Hospital, Istanbul, Fatih, Turkey.

View Article and Full-Text PDF

Acute flaccid paralysis and neurogenic respiratory failure associated with enterovirus D68 infection in children: Report of two cases.

World J Clin Cases 2021 May;9(14):3327-3333

Department of Hyperbaric Oxygen, The Sixth Medical Center of PLA General Hospital, Beijing 100048, China.

Background: Acute flaccid paralysis (AFP) and neurogenic respiratory failure rarely occur in children. At the end of 2018, some children with such symptoms were admitted to our hospital. In this study, we aimed to assess two children with AFP and neurogenic respiratory failure associated with enterovirus D68 (EV-D68). Read More

View Article and Full-Text PDF

Cardiac Energy Metabolism in Heart Failure.

Circ Res 2021 May 13;128(10):1487-1513. Epub 2021 May 13.

Division of Endocrinology and Metabolism, University of Iowa Carver College of Medicine, Iowa City (E.D.A.).

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart failure are complex and are dependent not only on the severity and type of heart failure present but also on the co-existence of common comorbidities such as obesity and type 2 diabetes. The failing heart faces an energy deficit, primarily because of a decrease in mitochondrial oxidative capacity. Read More

View Article and Full-Text PDF

Hepatobiliary Manifestations of Short Bowel Syndrome and Intestinal Failure-Associated Liver Disease.

Clin Liver Dis (Hoboken) 2021 Apr 1;17(4):297-300. Epub 2021 May 1.

Department of Internal Medicine Section of Gastroenterology, Hepatology and Nutrition University of Chicago Medicine Chicago IL.

View Article and Full-Text PDF

Quality of Life in Patients With Heart Failure With Recovered Ejection Fraction.

JAMA Cardiol 2021 May 5. Epub 2021 May 5.

University of Utah School of Medicine, Salt Lake City.

Importance: Heart failure with recovered ejection fraction (HFrecEF) is a recently recognized phenotype of patients with a history of reduced left ventricular ejection fraction (LVEF) that has subsequently normalized. It is unknown whether such LVEF improvement is associated with improvements in health status.

Objective: To examine changes in health-related quality of life in patients with heart failure with reduced ejection fraction (HFrEF) whose LVEF normalized, compared with those whose LVEF remains reduced and those with HF with preserved EF (HFpEF). Read More

View Article and Full-Text PDF

Evaluation of the fibrosis-4 index for detection of advanced fibrosis among individuals at risk for intestinal failure-associated liver disease.

JPEN J Parenter Enteral Nutr 2021 Apr 30. Epub 2021 Apr 30.

Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Intestinal failure-associated liver disease (IFALD) refers to the spectrum of liver injury secondary to IF and parenteral nutrition use. Our aim was to evaluate the use of noninvasive indices of liver fibrosis to detect advanced fibrosis among individuals at risk for IFALD.

Methods: We performed a secondary analysis of a retrospective study, including all liver biopsies performed on individuals undergoing intestinal transplantation (ITx) between January 2000 and May 2014. Read More

View Article and Full-Text PDF

A Review of Corrosion in Aircraft Structures and Graphene-Based Sensors for Advanced Corrosion Monitoring.

Sensors (Basel) 2021 Apr 21;21(9). Epub 2021 Apr 21.

Department of Electronics Engineering, Carleton University, Ottawa, ON K1S 5B6, Canada.

Corrosion is an ever-present phenomena of material deterioration that affects all metal structures. Timely and accurate detection of corrosion is required for structural maintenance and effective management of structural components during their life cycle. The usage of aircraft materials has been primarily driven by the need for lighter, stronger, and more robust metal alloys, rather than mitigation of corrosion. Read More

View Article and Full-Text PDF

Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease.

Front Physiol 2021 7;12:656441. Epub 2021 Apr 7.

Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Read More

View Article and Full-Text PDF

Congestive Heart Failure-associated Chronic Diffuse Alveolar Hemorrhage.

Am J Respir Crit Care Med 2021 Apr 21. Epub 2021 Apr 21.

Koseiren Takaoka Hospital, 13869, Respiratory Medicine, Takaoka, Japan.

View Article and Full-Text PDF

In neonatal-onset surgical short bowel syndrome survival is high, and enteral autonomy is related to residual bowel length.

JPEN J Parenter Enteral Nutr 2021 Apr 21. Epub 2021 Apr 21.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

Background: In an era of improved management and treatment options, this study aims to describe the long-term outcomes and factors predictive of outcomes of neonatal-onset intestinal failure (IF) due to surgical short bowel syndrome (SBS).

Methods: Retrospective, single-center cohort study of infants born between January 2011 and December 2018 with inclusion criteria: <44 weeks postmenstrual age at SBS diagnosis, <28 days on admission, parenteral nutrition dependence >60 days, and documented intestinal resection. Primary outcomes included survival and achievement of enteral autonomy (EA). Read More

View Article and Full-Text PDF

Guillain-Barre Syndrome Associated With COVID-19 Pneumonia-The First Documented Case in a U.S. Military Intensive Care Unit.

Mil Med 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurology, Tripler Army Medical Center, Honolulu, HI 96859-5001, USA.

Coronavirus disease 2019 (COVID-19) is a significant cause for intensive care unit (ICU) admission worldwide. Most COVID-19 infections are associated with lower respiratory abnormalities but it has been increasingly associated with extra-pulmonary manifestations. Guillain-Barre syndrome (GBS) is a rarely diagnosed but severe disease associated with COVID-19 infection. Read More

View Article and Full-Text PDF

Impact of Body Mass Index and Initial Respiratory Support on Pediatric Subjects in Acute Respiratory Failure.

Respir Care 2021 Apr 20. Epub 2021 Apr 20.

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Background: It is unknown how the initial choice of respiratory support by pediatric ICU providers contributes to outcomes of nonintubated obese children with respiratory failure. We hypothesized that body mass index and the type of initial respiratory support applied are associated with poor clinical outcomes in patients who carry respiratory failure-associated diagnoses.

Methods: This is a retrospective analysis of de-identified patient data obtained from the Virtual PICU System database (2009-2018). Read More

View Article and Full-Text PDF

"Unusual Pattern of Cerebral Microbleeds and Petechial Hemorrhages after Veno-Arterial Extracorporeal Membrane Oxygenation Support. A Report of 2 Cases".

J Stroke Cerebrovasc Dis 2021 Jul 15;30(7):105792. Epub 2021 Apr 15.

Department of Radiology, Bichat Hospital, 46 rue Henri Huchard, 75018 -Paris, France; Assistance Publique-Hôpitaux de Paris. Electronic address:

Objective: to report an unusual pattern of brain petechial hemorrhages in 2 patients after veno-arterial extracorporeal membrane oxygenation support (VA-ECMO) CASE 1: a 28-year-old man (Marfan disease) presented in the early post-operative period a multi-organ failure associated with a disseminated intravascular coagulation (DIC). He was placed on continuous veno-venous hemofiltration and VA-ECMO. He was weaned from ECMO 4 days later. Read More

View Article and Full-Text PDF

Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement.

Michael Dandel

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

German Centre for Heart and Circulatory Research (DZHK) Partner Site, Berlin, Berlin, Germany.

Due to the SARS-CoV-2 infection-related severe pulmonary tissue damages associated with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of heart-lung interactions becomes crucial for the development and progression of right ventricular (RV) dysfunction. The high resistance in the pulmonary circulation, as a result of small vessel thrombosis and hypoxemia, is the major cause of right heart failure associated with a particularly high mortality in severe COVID-19. Timely identification of patients at high risk for RV failure, optimization of mechanical ventilation to limit its adverse effects on RV preload and afterload, avoidance of medication-related increase in the pulmonary vascular resistance, and the use of extracorporeal membrane oxygenation in refractory respiratory failure with hemodynamic instability, before RV failure develops, can improve patient survival. Read More

View Article and Full-Text PDF

Approach to Intestinal Failure in Children.

Curr Gastroenterol Rep 2021 Apr 15;23(6). Epub 2021 Apr 15.

Division of Gastroenterology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Purpose Of Review: Pediatric intestinal failure is a complex condition requiring specialized care to prevent potential complications. In this article, we review the available evidence supporting recent advances in care for children with intestinal failure.

Recent Findings: Multidisciplinary intestinal rehabilitation teams utilize medical and surgical management techniques to help patients achieve enteral autonomy (EA) while preventing and treating the complications associated with intestinal failure. Read More

View Article and Full-Text PDF

Invasive and noninvasive ventilation strategies for acute respiratory failure in children with coronavirus disease 2019.

Curr Opin Pediatr 2021 06;33(3):311-318

Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School.

Purpose Of Review: Severe Acute Respiratory Syndrome Coronavirus 2 presents as symptomatic coronavirus disease 2019 (COVID-19) disease in susceptible patients. Severe pediatric COVID-19 disease is rare, limiting potential data accumulation on associated respiratory failure in children. Pediatric intensivists and pulmonologists managing COVID-19 patients look to adult guidelines and pediatric-specific consensus statements to guide management. Read More

View Article and Full-Text PDF

Prednisone-induced sustained remission in a patient with familial fibronectin glomerulopathy (GFND).

CEN Case Rep 2021 Apr 10. Epub 2021 Apr 10.

Nephrology Division, Department of Medicine, University of Rochester, 601 Elmwood Avenue, Box 675, Rochester, NY, 14642, USA.

Glomerulopathy with Fibronectin Deposits (GFND) is a rare, autosomal dominant disease characterized by proteinuria, hematuria and progressive renal failure associated with glomerular deposition of fibronectin, frequently resulting in end-stage renal disease (ESRD). There is no established treatment for this condition beyond conservative measures such as blood pressure control and the use of angiotensin-converting enzyme (ACE) inhibitors. We present a case of GFND associated with progressive chronic kidney disease (CKD) and nephrotic range proteinuria showing a sustained response to prednisone treatment. Read More

View Article and Full-Text PDF

Lentinan protects against pancreatic β-cell failure in chronic ethanol consumption-induced diabetic mice via enhancing β-cell antioxidant capacity.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China.

Chronic ethanol consumption is a well-established independent risk factor for type 2 diabetes mellitus (T2DM). Recently, increasing studies have confirmed that excessive heavy ethanol exerts direct harmful effect on pancreatic β-cell mass and function, which may be a mechanism of pancreatic β-cell failure in T2DM. In this study, we evaluated the effect of Lentinan (LNT), an active ingredient purified from the bodies of Lentinus edodes, on pancreatic β-cell apoptosis and dysfunction caused by ethanol and the possible mechanisms implicated. Read More

View Article and Full-Text PDF

Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population Based Study. Letter.

J Urol 2021 Jul 27;206(1):175-176. Epub 2021 Mar 27.

Başkent University Faculty of Medicine, Department of Urology, Alanya/Antalya, Turkey.

View Article and Full-Text PDF