134,592 results match your criteria failure test

Will Mutations in the Spike Protein of SARS-CoV-2 Lead to the Failure of COVID-19 Vaccines?

J Korean Med Sci 2021 May 10;36(18):e124. Epub 2021 May 10.

Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research, 8th Medical Center, Chinese PLA General Hospital, Beijing, China.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has spread worldwide since it was first identified in Wuhan, China, at the end of 2019. With the global transmission of the virus, a large number of SARS-CoV-2 variants have also appeared, especially, emerging strains that have recently been discovered in the United Kingdom (variant 20I/501Y.V1, lineage B. Read More

View Article and Full-Text PDF

New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via Sodium/Hydrogen Exchanger inhibition.

Eur J Pharmacol 2021 May 8:174123. Epub 2021 May 8.

Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Sweden. Electronic address:

Cystic fibrosis (CF) is a recessive inherited disease caused by mutations affecting anion transport by the epithelial ion channel cystic fibrosis transmembrane conductance regulator (CFTR). The disease is characterized by mucus accumulation in the airways and intestine, but the major cause of mortality in CF is airway mucus accumulation, leading to bacterial colonization, inflammation and respiratory failure. Several drug targets are under evaluation to alleviate airway mucus obstruction in CF and one of these targets is the epithelial sodium channel ENaC. Read More

View Article and Full-Text PDF

Clinical and radiographic evaluation of jumping distance management using a collagen matrix in flapless immediate implant placement.

Dent Med Probl 2021 May 11. Epub 2021 May 11.

Private practice, El Paso, USA.

Background: Improvement in implant design has made implant dentistry a challenging treatment modality worldwide.

Objectives: This study aimed to investigate the efficacy of a xenogeneic collagen matrix in managing 3-4-millimeter gaps in flapless immediate implant placement.

Material And Methods: Twenty-two patients received 39 immediate implants via the flapless approach. Read More

View Article and Full-Text PDF

Long-Term Results of Hybrid Left Ventricular Reconstruction in the Treatment of Ischemic Cardiomyopathy.

J Cardiovasc Transl Res 2021 May 11. Epub 2021 May 11.

Department of Cardiology, Na Homolce Hospital, Röentgenova 37/2, 150 30, Prague 5, Czech Republic.

The evidence supporting surgical aneurysmectomy in ischemic heart failure is inconsistent. The aim of the study was to describe long-term effect of minimally invasive hybrid transcatheter and minithoracotomy left ventricular (LV) reconstruction in patients with ischemic cardiomyopathy. Twenty-three subjects with transmural anterior wall scarring, LV ejection fraction 15-45%, and New York Heart Association class ≥ II were intervened using Revivent TC anchoring system. Read More

View Article and Full-Text PDF

An immunoinformatics approach for the design of a multi-epitope vaccine targeting super antigen TSST-1 of Staphylococcus aureus.

J Genet Eng Biotechnol 2021 May 11;19(1):69. Epub 2021 May 11.

Department of Biotechnology, Vignan's Foundation for Science, Technology and Research (Deemed to be University), Vadlamudi, Guntur - District, Andhra Pradesh, 522 213, India.

Background: TSST-1 is a secretory and pyrogenic superantigen that is being responsible for staphylococcal mediated food poisoning and associated clinical manifestations. It is one of the main targets for the construction of vaccine candidates against Staphylococcus aureus. Most of the vaccines have met failure due to adverse reactions and toxicity reported during late clinical studies. Read More

View Article and Full-Text PDF

Improving Health for People Living With Heart Failure: Focus Group Study of Preconditions for Co-Production of Health and Care.

J Particip Med 2021 May 11;13(2):e27125. Epub 2021 May 11.

Jönköping Academy for Improvement of Health and Welfare, School of Health and Welfare, Jönköping University, Jönköping, Sweden.

Background: Co-production of health and care involving patients, families of patients, and professionals in care processes can create joint learning about how to meet patients' needs. Although barriers and facilitators to co-production have been examined previously in various health care contexts, the preconditions in Swedish chronic cardiac care contexts are yet to be explored. This study is set in the health system of the Swedish region of Jönköping County and is part of system-wide efforts to promote better health for persons with heart failure (HF). Read More

View Article and Full-Text PDF

Recruitment of patients with chronic kidney disease and obstructive sleep apnoea for a clinical trial.

J Sleep Res 2021 May 11:e13384. Epub 2021 May 11.

Sleep Centre, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada.

Obstructive sleep apnoea is common in chronic kidney disease (CKD) and may accelerate the decline in kidney function. Recruitment for a randomised controlled trial to address whether treatment of sleep apnoea with continuous positive airway pressure (CPAP) slows the progression of kidney failure may be challenging because sleep apnoea is often asymptomatic in this patient population. The present report outlines recruitment challenges and how to address them. Read More

View Article and Full-Text PDF

AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury.

J Appl Lab Med 2021 May 11. Epub 2021 May 11.

Program of Applied Translational Research, Yale School of Medicine, New Haven, CT, USA.

Background: Acute kidney injury (AKI) is a sudden episode of kidney damage or failure affecting up to 15% of hospitalized patients and is associated with serious short- and long-term complications, mortality, and health care costs. Current practices to diagnose and stage AKI are variable and do not factor in our improved understanding of the biological and analytical variability of creatinine. In addition, the emergence of biomarkers, for example, cystatin C, insulin-like growth factor binding protein 7, and tissue inhibitor of metalloproteinases 2, and electronic notification tools for earlier detection of AKI, highlights the need for updated recommendations to address these developments. Read More

View Article and Full-Text PDF

SARS-CoV-2 infectivity by viral load, S gene variants and demographic factors and the utility of lateral flow devices to prevent transmission.

Clin Infect Dis 2021 May 11. Epub 2021 May 11.

NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Background: How SARS-CoV-2 infectivity varies with viral load is incompletely understood. Whether rapid point-of-care antigen lateral flow devices (LFDs) detect most potential transmission sources despite imperfect clinical sensitivity is unknown.

Methods: We combined SARS-CoV-2 testing and contact tracing data from England between 01-September-2020 and 28-February-2021. Read More

View Article and Full-Text PDF

Sucrase-Isomaltase Deficiency Causing Persistent Bloating and Diarrhea in an Adult Female.

Cureus 2021 Apr 7;13(4):e14349. Epub 2021 Apr 7.

Gastroenterology and Hepatology, Medical College of Georgia at Augusta University, Augusta, USA.

Congenital sucrase isomaltase deficiency (CSID) is an autosomal recessive disorder which leads to chronic intestinal malabsorption of nutrients from ingested starch and sucrose. Symptoms usually present after consumption of fruits, juices, grains, and starches, leading to failure to thrive and malnutrition. Diagnosis is suspected on detailed patient history and confirmed by a disaccharidase assay using small intestinal biopsies or sucrose hydrogen breath test. Read More

View Article and Full-Text PDF

Barriers-enablers-ownership approach: a mixed methods analysis of a social intervention to improve surgical antibiotic prescribing in hospitals.

BMJ Open 2021 May 10;11(5):e046685. Epub 2021 May 10.

Southern Cross University, Lismore, New South Wales, Australia.

Objectives: To assess an intervention for surgical antibiotic prophylaxis (SAP) improvement within surgical teams focused on addressing barriers and fostering enablers and ownership of guideline compliance.

Design: The Queensland Surgical Antibiotic Prophylaxis (QSAP) study was a multicentre, mixed methods study designed to address barriers and enablers to SAP compliance and facilitate engagement in self-directed audit/feedback and assess the efficacy of the intervention in improving compliance with SAP guidelines. The implementation was assessed using a 24-month interrupted time series design coupled with a qualitative evaluation. Read More

View Article and Full-Text PDF

Very low lipoprotein(a) and increased mortality risk after myocardial infarction.

Eur J Intern Med 2021 May 7. Epub 2021 May 7.

Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Palacky University Medical School, Olomouc, Czech Republic.

Background: Inconclusive data exist on risk associated with Lp(a) in patients after myocardial infarction (MI). Aims of the present study were to evaluate the association of Lp(a) level with total mortality and recurrent cardiovascular events.

Design And Methods: Single center prospective registry of consecutive patients hospitalized for acute myocardial infarction between June 2017 and June 2020 at a large tertiary cardiac center with available blood samples drawn <24h of admission. Read More

View Article and Full-Text PDF

Multifocal pleural capillary hemangioma: a rare cause of hemorrhagic pleural effusion-case report.

BMC Pulm Med 2021 May 10;21(1):156. Epub 2021 May 10.

Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Capillary hemangioma can be found in many organs, but rarely in pleura. Previously, only localized pleural capillary hemangioma cases have been reported. Corticosteroids are the most commonly recommended drugs in capillary hemangioma. Read More

View Article and Full-Text PDF

Effect of a figure-of-eight cerclage wire with two Kirschner wires on fixation strength for transverse metacarpal shaft fractures: an in vitro study with artificial bone.

BMC Musculoskelet Disord 2021 May 10;22(1):431. Epub 2021 May 10.

School of Dentistry, College of Dentistry, China Medical University, Taichung, 404, Taiwan.

Background: Metacarpal shaft fractures are a common type of hand fracture. Despite providing strong fixation strength, plate fixation has numerous shortcomings. Concerning internal fixation with Kirschner wires (K-wires), although this approach is frequently used to treat metacarpal shaft fractures, the lack of functional stability may result in fixation failure. Read More

View Article and Full-Text PDF

Stapes Surgery in Far-Advanced Otosclerosis.

Ear Nose Throat J 2021 May 11:1455613211013093. Epub 2021 May 11.

ENT Department, L. Vanvitelli University, Naples, Italy.

Introduction: Surgical treatment of patients with far-advanced otosclerosis (FAO) has not yet been standardized. Patients with FAO are the candidates for stapes surgery or cochlear implant (CI). Although many surgeons consider stapes surgery as the first choice, other authors prefer CI because of the excellent hearing results. Read More

View Article and Full-Text PDF

Acute on chronic liver failure by SARS-CoV-2 in active alcohol use disorder cirrhotic patient: a case report.

Minerva Gastroenterol (Torino) 2021 May 10. Epub 2021 May 10.

Unit of Gastroenterology, Molinette Hospital, Turin, Italy.

World Gastroenterology Organization define acute on chronic liver failure (ACLF) a syndrome in patients with chronic liver disease with or without previously diagnosed cirrhosis, characterized by acute hepatic decompensation resulting in liver failure and one or more extrahepatic organ failures, associated with increased mortality up to three months. A-56-year-old gentleman with alcohol related liver cirrhosis (ARLC) and history of variceal bleeding with insertion of transjugular intrahepatic porto-systemic stent shunt presented with two days history of fever, dry cough and worsening of the sensory. The severe acute respiratory coronavirus-2 (SARS-CoV-2) nasopharingeal C-reactive protein test was positive. Read More

View Article and Full-Text PDF

Non-parameningeal head and neck rhabdomyosarcoma in children, adolescents, and young adults: Experience of the European paediatric Soft tissue sarcoma Study Group (EpSSG) - RMS2005 study.

Eur J Cancer 2021 May 7;151:84-93. Epub 2021 May 7.

SIREDO Oncology Center, Institute Curie, PSL University, Paris, France.

Background/objectives: The primary aim of this study was to analyse and evaluate the impact of different local treatments on the pattern of relapse in children with primary head and neck non-parameningeal (HNnPM) rhabdomyosarcoma (RMS), treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) RMS2005 study. The secondary aim was to assess whether current risk stratification is valid for this specific site.

Design/methods: This study includes all patients with localised HNnPM RMS enrolled in the RMS2005 study between 2005 and 2016. Read More

View Article and Full-Text PDF

B cells modulate the expression of MHC-II on cardiac CCR2 macrophages.

J Mol Cell Cardiol 2021 May 7. Epub 2021 May 7.

Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA. Electronic address:

The uninjured murine heart contains a heterogeneous population of macrophages with disparate ontogenies and functions. These macrophages are often associated with blood vessels and can be subclassified based on the expression of CC chemokine receptor 2 (CCR2) and major histocompatibility complex class II (MHC-II). The biological cues that modulate these macrophage pool subpopulations have not been completely identified. Read More

View Article and Full-Text PDF

Improving the continuum of care monitoring in Brazilian HIV healthcare services: An implementation science approach.

PLoS One 2021 10;16(5):e0250060. Epub 2021 May 10.

Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, estado de São Paulo, Brazil.

Objective: To evaluate the impact of an intervention improving the continuum of care monitoring (CCM) within HIV public healthcare services in São Paulo, Brazil, and implementing a clinical monitoring system. This system identified three patient groups prioritized for additional care engagement: (1) individuals diagnosed with HIV, but not receiving treatment (the treatment gap group); (2) individuals receiving treatment for >6 months with a detectable viral load (the virologic failure group); and (3) patients lost to follow-up (LTFU).

Methods: The implementation strategies included three training sessions, covering system logistics, case discussions, and development of maintenance goals. Read More

View Article and Full-Text PDF

Safe Polycationic Dendrimers as Potent Oral In Vivo Inhibitors of : A New Therapy to Take Down Tuberculosis.

Biomacromolecules 2021 May 10. Epub 2021 May 10.

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, BP 44099, 31077 Toulouse Cedex 4, France.

The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment, resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. Inadequate bioavailability of the drug is the main factor for therapeutic failure, which leads to the development of drug-resistant cases. Therefore, there is an urgent need to design and develop novel antimycobacterial agents minimizing the period of treatment and reducing the propagation of resistance at the same time. Read More

View Article and Full-Text PDF

Functional joint models for chronic kidney disease in kidney transplant recipients.

Stat Methods Med Res 2021 May 10:9622802211009265. Epub 2021 May 10.

Division of Nephrology, University of Nebraska Medical Center, NE, USA.

This functional joint model paper is motivated by a chronic kidney disease study post kidney transplantation. The available kidney organ is a scarce resource because millions of end-stage renal patients are on the waiting list for kidney transplantation. The life of the transplanted kidney can be extended if the progression of the chronic kidney disease stage can be slowed, and so a major research question is how to extend the transplanted kidney life to maximize the usage of the scarce organ resource. Read More

View Article and Full-Text PDF

Effect of 10 sets versus 5 sets of resistance training on muscular endurance.

J Sports Med Phys Fitness 2021 May 10. Epub 2021 May 10.

NICM Health Research Institute, Western Sydney University, Westmead, Australia.

Background: A paucity of research exists examining whether resistance training with a greater number of sets per exercise enhances the development of muscular endurance. The aim of this study was to investigate the effects of ten sets versus five sets of resistance training on muscle endurance.

Methods: Fifteen healthy males (age 23. Read More

View Article and Full-Text PDF

Acute shock efficacy of the Subcutaneous Implantable Cardioverter-Defibrillator According to the Implantation Technique.

J Cardiovasc Electrophysiol 2021 May 9. Epub 2021 May 9.

Institute of Cardiology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy.

Background: The traditional technique for subcutaneous implantable cardioverter defibrillator (S-ICD) implantation involves 3 incisions and a subcutaneous (SC) pocket. An intermuscular (IM) 2-incision technique has been recently adopted.

Aims: We assessed acute defibrillation efficacy of S-ICD (DE ≤65J) according to the implantation technique. Read More

View Article and Full-Text PDF

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO).

Adv Compos Hybrid Mater 2021 May 3:1-18. Epub 2021 May 3.

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, 210009 Nanjing, China.

Abstract: Since extracorporeal membrane oxygenator (ECMO) has been utilized to save countless lives by providing continuous extracorporeal breathing and circulation to patients with severe cardiopulmonary failure. In particular, it has played an important role during the COVID-19 epidemic. One of the important composites of ECMO is membrane oxygenator, and the core composite of the membrane oxygenator is hollow fiber membrane, which is not only a place for blood oxygenation, but also is a barrier between the blood and gas side. Read More

View Article and Full-Text PDF

Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance.

Front Pharmacol 2021 22;12:648491. Epub 2021 Apr 22.

Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Chemoresistance is one of the leading causes for the failure of tumor treatment. Hence, it is necessary to study further and understand the potential mechanisms of tumor resistance to design and develop novel anti-tumor drugs. Post-translational modifications are critical for proteins' function under physiological and pathological conditions, among which ubiquitination is the most common one. Read More

View Article and Full-Text PDF

Cost-Utility Analysis of Bilateral Cochlear Implantation in Adults With Severe to Profound Sensorineural Hearing Loss in Poland.

Otol Neurotol 2021 Jun;42(5):706-712

World Hearing Center, Institute of Physiology and Pathology of Hearing.

Objective: The aim of the study was to develop a Markov model and apply it for the evaluation of three different treatment scenarios for adult patients with severe to profound bilateral sensorineural hearing loss.

Study Design: Prospective Observational Study.

Settings: Hospital. Read More

View Article and Full-Text PDF

Functional Outcomes and Their Association With Physical Performance in Mechanically Ventilated Coronavirus Disease 2019 Survivors at 3 Months Following Hospital Discharge: A Cohort Study.

Crit Care Med 2021 May 10. Epub 2021 May 10.

Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. Department of Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands. NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands. Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands. Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands. GROW School of Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands Department of rehabilitation, Maastricht University, Maastricht, The Netherlands CARIM Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands Department of General, Visceral and Transplantation Surgery, RWTH University Hospital Aachen, Aachen, Germany.

Objectives: We performed a comprehensive health assessment in mechanically ventilated coronavirus disease 2019 survivors to assess the impact of respiratory and skeletal muscle injury sustained during ICU stay on physical performance at 3 months following hospital discharge.

Design: Preregistered prospective observational cohort study.

Setting: University hospital ICU. Read More

View Article and Full-Text PDF

Osteotomy in the newborn classic bladder exstrophy patient: A comparative study.

J Pediatr Urol 2021 Apr 22. Epub 2021 Apr 22.

Robert D. Jeffs Division of Pediatric Urology, James Buchanan Brady Urological Institutions, Johns Hopkins Hospital, Johns Hopkins Medical Institutions, Charlotte Bloomberg Children's Hospital, Baltimore, MD, USA. Electronic address:

Introduction: Pelvic osteotomy is indicated in classic bladder exstrophy (CBE) patients with a wide pubic diastasis or non-malleable pelvis. While the safety of pelvic osteotomy in delayed and failed closures is established, there remains less clarity on their safety in newborns. The authors herein sought to present their experience with CBE patients who underwent pelvic osteotomy for assistance with bladder closure during both the newborn and delayed time periods. Read More

View Article and Full-Text PDF

[Endoscopic Hemostasis and Its Related Factors of Duodenal Hemorrhage].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):222-229

Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To analyze clinical characteristics and short-term efficacy of endoscopic hemostasis in acute duodenal hemorrhage. Methods A retrospective study was conducted for the patients who received endoscopy in the PUMC Hospital due to upper gastrointestinal bleeding and were confirmed to be on account of duodenal lesions for bleeding from January 2011 to December 2018.Clinical information of patients was collected,including demographics,comorbidities,and medication use. Read More

View Article and Full-Text PDF

Improving motorcycle motion perception by using innovative motorcycle headlight configurations: Evidence from simulator and test-track experiments.

Accid Anal Prev 2021 May 6;157:106118. Epub 2021 May 6.

COSYS-PICS-L, Univ Gustave Eiffel, IFSTTAR, F-78000 Versailles, France. Electronic address:

Many motorcycle accidents occur at intersections and are caused by other vehicle drivers who misperceive the speed and time-to-arrival of an approaching motorcycle. The two experiments reported here tested different motorcycle headlight configurations likely to counteract this perceptual failure. In the first experiment, conducted on a driving simulator, car drivers turned left in front of cars and motorcycles approaching an intersection under nighttime lighting conditions. Read More

View Article and Full-Text PDF