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Novel Approach for Laparoscopically Placed Chronic Amniotic Fluid Catheters in Sheep.

Fetal Diagn Ther 2021 May 5:1-7. Epub 2021 May 5.

Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, USA.

Introduction: Several fetal therapies involve repeated amniotic fluid intervention. We hypothesize that a minimally invasive approach can be used to safely implant an intrauterine catheter infusion system in a fetal ovine model for chronic use during pregnancy.

Method: Five pregnant sheep underwent operation between gestational days 110 and 115 (term 145 days). Read More

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FACTORS AFFECTING THE EFFECTIVENESS OF CONSERVATIVE MANAGEMENT OF APPENDICULAR MASS.

Authors:
Haithem Ali

Pol Przegl Chir 2021 Jun;93(3):1-5

University of Basrah, Al-Zahraa College of Medicine, Basrah, Iraq.

INTRODUCTION/ PURPOSE Acute appendicitis is the most common surgical emergency in children. Appendicular mass is a relatively common complication in improperly treated patients. The management of appendicular mass remains controversial. Read More

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Pilot test of an accrual Common Metric for the NIH Clinical and Translational Science Awards (CTSA) Consortium: Metric feasibility and data quality.

J Clin Transl Sci 2020 Sep 11;5(1):e44. Epub 2020 Sep 11.

Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.

Failure to accrue participants into clinical trials incurs economic costs, wastes resources, jeopardizes answering research questions meaningfully, and delays translating research discoveries into improved health. This paper reports the results of a pilot test of the Median Accrual Ratio (MAR) metric developed as a part of the Common Metrics Initiative of the NIH's National Center for Advancing Translational Science (NCATS) Clinical and Translational Science Award (CTSA) Consortium. Using the metric is intended to enhance the ability of the CTSA Consortium and its "hubs" to increase subject accrual into trials within expected timeframes. Read More

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September 2020

Charge Carrier Mobility Improvement in Diketopyrrolopyrrole Block-Copolymers by Shear Coating.

Polymers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.

Shear coating is a promising deposition method for upscaling device fabrication and enabling high throughput, and is furthermore suitable for translating to roll-to-roll processing. Although common polymer semiconductors (PSCs) are solution processible, they are still prone to mechanical failure upon stretching, limiting applications in e.g. Read More

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Hybrid Drugs-A Strategy for Overcoming Anticancer Drug Resistance?

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Community Pharmacy, Faculty of Pharmacy, Medical University of Lodz, 1 Muszynskiego Street, 90-151 Lodz, Poland.

Despite enormous progress in the treatment of many malignancies, the development of cancer resistance is still an important reason for cancer chemotherapy failure. Increasing knowledge of cancers' molecular complexity and mechanisms of their resistance to anticancer drugs, as well as extensive clinical experience, indicate that an effective fight against cancer requires a multidimensional approach. Multi-target chemotherapy may be achieved using drugs combination, co-delivery of medicines, or designing hybrid drugs. Read More

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Emerging role of interleukin-13 in cardiovascular diseases: A ray of hope.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Despite the great progress made in the treatment for cardiovascular diseases (CVDs), the morbidity and mortality of CVDs remains high due to the lack of effective treatment strategy. Inflammation is a central pathophysiological feature of the heart in response to both acute and chronic injury, while the molecular basis and underlying mechanisms remains obscure. Interleukin (IL)-13, a pro-inflammatory cytokine, has been known as a critical mediator in allergy and asthma. Read More

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Polypharmacy in Heart Failure with Reduced Ejection Fraction: Progress - not Problem.

Am J Med 2021 Apr 30. Epub 2021 Apr 30.

Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

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Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19.

Front Mol Biosci 2021 15;8:635337. Epub 2021 Apr 15.

Department of Biotechnology, Faculty of Agricultural Technology, Al-Balqa Applied University, Al-Salt, Jordan.

Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, arose at the end of 2019 as a zoonotic virus, which is the causative agent of the novel coronavirus outbreak COVID-19. Without any clear indications of abatement, the disease has become a major healthcare threat across the globe, owing to prolonged incubation period, high prevalence, and absence of existing drugs or vaccines. Development of COVID-19 vaccine is being considered as the most efficient strategy to curtail the ongoing pandemic. Read More

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Contextual Embeddings from Clinical Notes Improves Prediction of Sepsis.

AMIA Annu Symp Proc 2020 25;2020:197-202. Epub 2021 Jan 25.

Division of Biomedical Informatics, University of California San Diego, La Jolla, CA, US.

Sepsis, a life-threatening organ dysfunction, is a clinical syndrome triggered by acute infection and affects over 1 million Americans every year. Untreated sepsis can progress to septic shock and organ failure, making sepsis one of the leading causes of morbidity and mortality in hospitals. Early detection of sepsis and timely antibiotics administration is known to save lives. Read More

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January 2021

SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation.

Pharmacol Res 2021 Apr 30;169:105642. Epub 2021 Apr 30.

Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. Electronic address:

Anthracyclines including doxorubicin (DOX) are still the most widely used and efficacious antitumor drugs, although their cardiotoxicity is a significant cause of heart failure. Despite considerable efforts being made to minimize anthracycline-induced cardiac adverse effects, little progress has been achieved. In this study, we aimed to explore the role and underlying mechanism of SNX17 in DOX-induced cardiotoxicity. Read More

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Molecularly targeted therapy for advanced gastrointestinal noncolorectal cancer treatment: how to choose? Past, present, future.

Anticancer Drugs 2021 Apr 23. Epub 2021 Apr 23.

Department of Medical Oncology, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Gastrointestinal cancer is a leading cause of death worldwide. Conventional cytotoxic chemotherapy has been the backbone of advanced gastrointestinal cancer treatment for decades and still represents a key element of the therapeutic armamentarium. However, only small increments in survival outcomes have been reached. Read More

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Heterogeneity is a common ground in familial hypomagnesemia with hypercalciuria and nephrocalcinosis caused by CLDN19 gene mutations.

J Nephrol 2021 Apr 30. Epub 2021 Apr 30.

Fisiopatologia Renal, Centre D'Investigacions en Bioquímica I Biologia Molecular (CIBBIM), Institut de Recerca Vall D'Hebron (VHIR), Barcelona, Spain.

Background: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare tubulopathy caused by mutations in the CLDN16 or CLDN19 genes. Patients usually develop hypomagnesemia, hypercalciuria, nephrocalcinosis and renal failure early in life. Patients with CLDN19 mutations may also have ocular abnormalities. Read More

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Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis.

Thorax 2021 Apr 29. Epub 2021 Apr 29.

Department of Respiratory Medicine, Children's Hospital at Westmead, Westmead, New South Wales, Australia

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV decline in adolescence and adulthood have not slowed. Read More

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ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96817, USA.

Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and cardiovascular tissues, is a model for ectopic mineralization disorders. ABCC6 dysfunction is the primary cause of PXE, but also some cases of generalized arterial calcification of infancy (GACI). Read More

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Energy-Efficient and Reliable Face-Routing Scheme in Wireless Networks.

Sensors (Basel) 2021 Apr 13;21(8). Epub 2021 Apr 13.

Department of Computer Engineering, Chungnam National University, Daejeon 34134, Korea.

Face-routing is one of the reliable recovery schemes when geographic routing fails to transmit data packets. Although studies on face-routing can overcome the failure of the data transmission, they lead to much energy consumption due to frequent data transmissions between adjacent nodes for carrying out the rule of face-routing. To avoid the frequent data transmissions, several face-routing schemes have been recently proposed to transmit data packets to the farthest-neighbor node. Read More

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Potential of Honeycomb-Filled Composite Structure in Composite Cross-Arm Component: A Review on Recent Progress and Its Mechanical Properties.

Polymers (Basel) 2021 Apr 20;13(8). Epub 2021 Apr 20.

Department of Aerospace Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Nowadays, pultruded glass fiber-reinforced polymer composite (PGFRPC) structures have been used widely for cross-arms in high transmission towers. These composite structures have replaced cross-arms of conventional materials like wood due to several factors, such as better strength, superior resistance to environmental degradation, reduced weight, and comparatively cheaper maintenance. However, lately, several performance failures have been found on existing cross-arm members, caused by moisture, temperature changes in the atmosphere, and other environmental factors, which may lead to a complete failure or reduced service life. Read More

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Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress.

Cancers (Basel) 2021 Apr 24;13(9). Epub 2021 Apr 24.

Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.

The development of drug resistance is one of the main causes of cancer treatment failure. This phenomenon occurs very frequently in different types of cancer, including colon and pancreatic cancers. However, the underlying molecular mechanisms are not fully understood. Read More

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A Narrative Review of the History of Skin Grafting in Burn Care.

Medicina (Kaunas) 2021 Apr 15;57(4). Epub 2021 Apr 15.

Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, TX 77550, USA.

Thermal injuries have been a phenomenon intertwined with the human condition since the dawn of our species. Autologous skin translocation, also known as skin grafting, has played an important role in burn wound management and has a rich history of its own. In fact, some of the oldest known medical texts describe ancient methods of skin translocation. Read More

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Structural and Functional Remodeling of Mitochondria in Cardiac Diseases.

Int J Mol Sci 2021 Apr 17;22(8). Epub 2021 Apr 17.

Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA.

Mitochondria undergo structural and functional remodeling to meet the cell demand in response to the intracellular and extracellular stimulations, playing an essential role in maintaining normal cellular function. Merging evidence demonstrated that dysregulation of mitochondrial remodeling is a fundamental driving force of complex human diseases, highlighting its crucial pathophysiological roles and therapeutic potential. In this review, we outlined the progress of the molecular basis of mitochondrial structural and functional remodeling and their regulatory network. Read More

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Spatio-Temporal Context, Correlation Filter and Measurement Estimation Collaboration Based Visual Object Tracking.

Sensors (Basel) 2021 Apr 17;21(8). Epub 2021 Apr 17.

Department of Electrical and Computer Engineering, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Despite eminent progress in recent years, various challenges associated with object tracking algorithms such as scale variations, partial or full occlusions, background clutters, illumination variations are still required to be resolved with improved estimation for real-time applications. This paper proposes a robust and fast algorithm for object tracking based on spatio-temporal context (STC). A pyramid representation-based scale correlation filter is incorporated to overcome the STC's inability on the rapid change of scale of target. Read More

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Recent Progress and Challenges for Drug-Resistant Tuberculosis Treatment.

Pharmaceutics 2021 Apr 21;13(5). Epub 2021 Apr 21.

Bioinformatics Research Group, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.

Control of infection continues to be an issue, particularly in countries with a high tuberculosis (TB) burden in the tropical and sub-tropical regions. The effort to reduce the catastrophic cost of TB with the WHO's End TB Strategy in 2035 is still obstructed by the emergence of drug-resistant TB (DR-TB) cases as result of various mutations of the MTB strain. In the approach to combat DR-TB, several potential antitubercular agents were discovered as inhibitors for various existing and novel targets. Read More

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The Impact of Peer Educators or Community Health Workers on the Progress of the UNAIDS 90-90-90 Targets in Africa: A Systematic Review and Meta-Analysis Protocol.

Int J Environ Res Public Health 2021 Apr 8;18(8). Epub 2021 Apr 8.

Public Health, College of Medicine and Public Health, Flinders University, Adelaide 5042, Australia.

Background: Africa is far behind from achieving the Joint United Nations Program on HIV and AIDS (UNAIDS) 90-90-90 targets. Evidence shows that the participation of HIV patients as peer educators and other community health workers is substantially improving the entire HIV care continuum and subsequently the UNAIDS targets. This review aims to provide the best available evidence on the impact of peer educators and/or community health workers for the three targets in Africa. Read More

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Recent Progress of Exosomes in Multiple Myeloma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Strategies.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu 610000, China.

Multiple myeloma (MM) is a hematological malignancy that is still incurable. The bone marrow microenvironment (BMM), with cellular and non-cellular components, can create a favorable environment for the survival, proliferation and migration of MM cells, which is the main reason for the failure of MM therapies. Many studies have demonstrated that exosomes play an important role in the tumor-supportive BMM. Read More

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Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia.

PLoS One 2021 29;16(4):e0250955. Epub 2021 Apr 29.

Department of Internal Medicine, College of Medicine, University of Bisha, Bisha, Saudi Arabia.

Background: Although the coronavirus disease 2019 (COVID-19) pandemic continues to rage worldwide, clinical and laboratory studies of this disease have been limited in many countries. We investigated the epidemiologic, clinical, and laboratory findings of COVID-19 infected patients to identify the effective indicators correlated with the disease.

Methods: A retrospective study was conducted at King Abdullah Hospital in Bisha Province, Saudi Arabia, from March 20 to June 30, 2020. Read More

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Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis.

Circ Res 2021 Apr 29;128(9):1371-1397. Epub 2021 Apr 29.

Cardiovascular Division, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences (M.C.B., E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging, obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over the next 3 decades. This is of particularly dire clinical relevance, as calcific aortic valve disease can progress rapidly to aortic stenosis, heart failure, and eventually premature death. Unlike in atherosclerosis, and despite the heavy clinical toll, to date, no pharmacotherapy has proven effective to halt calcific aortic valve disease progression, with invasive and costly aortic valve replacement representing the only treatment option currently available. Read More

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IMPROVING OUR UNDERSTANDING OF THE ENVIRONMENTAL PERSISTENCE OF CHEMICALS.

Integr Environ Assess Manag 2021 Apr 29. Epub 2021 Apr 29.

Institute for Environmental Research, Aachen University, Germany.

Significant progress has been made in the scientific understanding of factors which influence the outcome of biodegradation tests used to assess the persistence (P) of chemicals. This needs to be evaluated to assess whether recently acquired knowledge could enhance existing regulations and environmental risk assessments. Biodegradation tests have limitations, which are accentuated for 'difficult to test' substances and failure to recognise these can potentially lead to inappropriate conclusions regarding a chemical's environmental persistence. Read More

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Cardiac Magnetic Resonance for Early Detection of Radiation Therapy-Induced Cardiotoxicity in a Small Animal Model.

JACC CardioOncol 2021 Mar 16;3(1):113-130. Epub 2021 Mar 16.

Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Over half of all cancer patients receive radiation therapy (RT). However, radiation exposure to the heart can cause cardiotoxicity. Nevertheless, there is a paucity of data on RT-induced cardiac damage, with limited understanding of safe regional RT doses, early detection, prevention and management. Read More

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Rare presentation of bilateral thumb psoriatic arthritis treated with arthrodesis: a case report.

AME Case Rep 2021 25;5:18. Epub 2021 Apr 25.

Department of Orthopaedic Surgery, Georgetown University School of Medicine, Washington, DC, USA.

Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis that occurs concomitantly with cutaneous manifestations and tendinous pathology that affects up to 1% of the general population. While the majority of cases are mild, nearly 20% of PsA patients will progress to severe disease manifesting as debilitating polyarticular inflammation and joint destruction. PsA is most commonly asymmetric and bilateral severe disease involving the same joints in each hand has rarely been reported in the literature. Read More

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Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis: A case report.

Medicine (Baltimore) 2021 Apr;100(17):e25694

Aerospace Clinic Academy, Peking University Health Science Centre, Beijing, China.

Introduction: : Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a subtype of glutamate receptor that mediates most of the fast excitatory neurotransmission in the brain. Anti-AMPAR encephalitis is an autoimmune-mediated neurological disorder, frequently accompanied by the presence of neoplasms, comprising a spectrum of paraneoplastic syndrome.

Patient Concerns: A 56-year-old man was admitted for deterioration in memory and aberrant psychological behaviors, which lasted for at least 20 days. Read More

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Seromadesis following total hip resurfacing by aspiration and injection of doxycycline.

BMJ Case Rep 2021 Apr 26;14(4). Epub 2021 Apr 26.

Trauma and Orthopaedics, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, Tyne and Wear, UK.

Here, we present an interesting case of seroma following hip resurfacing arthroplasty in a 69-year-old man. During the postoperative recovery, the patient made rapid progress and returned to intense activity within the 6-week period. He subsequently developed further right hip pain and swelling. Read More

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