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Long-term survival after Carpentier-Edwards Perimount aortic valve replacement in Western Denmark: a multi-centre observational study.

J Cardiothorac Surg 2021 May 14;16(1):130. Epub 2021 May 14.

Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.

Background: This study describes the long-term survival, risk of reoperation and clinical outcomes of patients undergoing solitary surgical aortic valve replacement (SAVR) with a Carpentier-Edwards Perimount (CE-P) bioprosthetic in Western Denmark. The renewed interest in SAVR is based on the questioning regarding the long-term survival since new aortic replacement technique such as transcatheter aortic-valve replacement (TAVR) probably have shorter durability, why assessment of long-term survival could be a key issue for patients.

Methods: From November 1999 to November 2013 a cohort of a total of 1604 patients with a median age of 73 years (IQR: 69-78) undergoing solitary SAVR with CE-P in Western Denmark was obtained November 2018 from the Western Danish Heart Registry (WDHR). Read More

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Impact of concomitant medication on clinical outcomes in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors: A retrospective study.

Thorac Cancer 2021 May 14. Epub 2021 May 14.

Department of Pharmacometrics and Pharmacokinetics, Meiji Pharmaceutical University, Tokyo, Japan.

Background: It has recently been suggested that concomitant medication may affect the clinical outcome of patients treated with immune checkpoint inhibitors (ICIs). However, only a few studies on the impact of concomitant medication on immune-related adverse events (irAEs) have previously been reported. Here, we aimed to determine the impact of concomitant medication on the efficacy and safety of ICIs. Read More

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Phylogeny and mechanisms of shared hierarchical patterns in birdsong.

Curr Biol 2021 May 11. Epub 2021 May 11.

Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada; Centre for Research on Brain, Language, and Music, McGill University, Montreal, QC H3G 2A8, Canada. Electronic address:

Organizational patterns can be shared across biological systems, and revealing the factors shaping common patterns can provide insight into fundamental biological mechanisms. The behavioral pattern that elements with more constituents tend to consist of shorter constituents (Menzerath's law [ML]) was described first in speech and language (e.g. Read More

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Prognostic value of pre-treatment systemic immune-inflammation index in patients with endometrial cancer.

PLoS One 2021 14;16(5):e0248871. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.

Background: The systemic immune-inflammation index (SII), which is calculated using absolute platelet, neutrophil, and lymphocyte counts, has recently attracted attentions as a prognostic indicator in patients with solid malignancies. In the current study, we retrospectively investigated the prognostic significance of pre-treatment SII among patients with endometrial cancer.

Method: Endometrial cancer patients treated at Nara medical university hospital between 2008 and 2018 were included in the current study. Read More

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The transcription factor KNAT2/6b mediates changes in plant architecture in response to drought via downregulating GA20ox1 in Populus alba × P. glandulosa.

J Exp Bot 2021 May 14. Epub 2021 May 14.

State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.

Plant architecture is genetically controlled but is influenced by environmental factors. Plants have evolved adaptive mechanisms that allow changes in their architectures under stress, in which phytohormones play a central role. However, the gene regulators that connect growth and stress signals are rarely reported. Read More

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Risk factors and outcomes of intraoperative atrial fibrillation in patients undergoing thoracoscopic anatomic lung surgery.

Ann Transl Med 2021 Apr;9(7):543

Department of Anesthesiology Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: Atrial fibrillation (AF) is common after thoracoscopic anatomic lung surgery and can be associated with increased adverse outcomes. However, the incidence, risk factors, and related outcomes of intraoperative AF in thoracoscopic anatomical lung surgery are unknown.

Methods: We retrospectively analyzed the files of 14,986 patients who had presented to the Shanghai Chest Hospital for thoracoscopic anatomic lung operations between January 2016 and December 2018. Read More

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Response of net primary productivity to grassland phenological changes in Xinjiang, China.

PeerJ 2021 30;9:e10650. Epub 2021 Apr 30.

College of Resource and Environment Sciences, Key Laboratory of Oasis Ecology, Xinjiang University, Urumqi, China.

Determining the relationship between net primary productivity (NPP) and grassland phenology is important for an in-depth understanding of the impact of climate change on ecosystems. In this study, the NPP of grassland in Xinjiang, China, was simulated using the Carnegie-Ames-Stanford approach (CASA) model with Moderate Resolution Imaging Spectroradiometer (MODIS) grassland phenological (MCD12Q2) data to study trends in phenological metrics, grassland NPP, and the relations between these factors from 2001-2014. The results revealed advancement of the start of the growing season (SOS) for grassland in most regions (55. Read More

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Operational factor analysis of the aggressive taxi speeders using random parameters Bayesian LASSO modeling approach.

Accid Anal Prev 2021 May 10;157:106183. Epub 2021 May 10.

School of Transportation and Logistics, Southwest Jiaotong University, Chengdu 611756, China.

Partial taxi speeders are observed with both high speeding frequency and severity (range). They thereby can be viewed as aggressive speeders whose behaviors may result in more hazards than others. Among the factors contributing to taxi speeding, the operational factors are proven to be deterministic. Read More

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Sleep Difficulties among Mexican Adolescents: Subjective and Objective Assessments of Sleep.

Behav Sleep Med 2021 May 13:1-15. Epub 2021 May 13.

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan.

: Self-reported sleep difficulties, such as insomnia symptoms, have been reported among adolescents. Yet, studies of their prevalence and correlates are scarce among Latin Americans. This study sought (1) to describe associations between sociodemographic and lifestyle factors with self-reported sleep difficulties and (2) to examine associations between self-reported sleep difficulties and actigraphy-based sleep. Read More

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Velocity mismatch effect on the dynamic MTF of a TDI image sensor.

Appl Opt 2021 May;60(14):4191-4196

By analyzing the process of time delay integration dynamic imaging, we establish a model of velocity mismatch. Based on this model, we analyze the influence of different factors on the dynamic imaging process, and a modulation transfer function (MTF) is used to evaluate imaging quality. According to the simulation, the velocity mismatch and scan stage are the main factors for image quality. Read More

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Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young.

Histopathology 2021 May 13. Epub 2021 May 13.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Aims: The aim of this study was to characterize endometrioid carcinoma, G1, in the elderly, using clinicopathological features and immunohistochemical features of surrogate markers of molecular subtypes.

Methods And Results: We retrospectively analyzed tumour samples from 268 patients with endometrioid carcinoma, G1 (<40 years: n=24, 40-59 years: n=169, ≥60 years: n=75), for whom long-term clinical follow-up data were available. Endometrioid carcinoma, G1, in the elderly (≥60 years) was characterized by frequent deep myometrial invasion, less frequent endometrioid intraepithelial neoplasia (EIN), lack of benign hyperplasia (BH), less frequent squamous differentiation and occasional aberrant p53 expression. Read More

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Racial Variation in Membranous Urethral Length and Postprostatectomy Urinary Function.

Eur Urol Open Sci 2021 May 23;27:61-64. Epub 2021 Mar 23.

Department of Urology, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA.

Urinary incontinence remains a significant post-prostatectomy sequalae. While many patient and technical factors have been found to contribute to post-prostatectomy incontinence, the impact of anatomical differences by races has not been studied . Shorter preoperative membranous urethral length (MUL) on prostate MRI has been associated with higher risk of post-prostatectomy incontinence. Read More

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Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy.

Gastrointest Tumors 2021 Apr 17;8(2):87-95. Epub 2021 Mar 17.

Department of Digestive Surgery, Kawasaki Medical School, Kurashiki, Japan.

Introduction: We studied whether perioperative nutritional, immunological factors or postoperative inflammatory responses predicted esophageal cancer (EC) progression and prognosis in patients who received esophagectomies.

Methods: We evaluated preoperative prognostic nutritional index (PNI), BMI, neutrophil-to-lymphocyte ratio (NLR), intraoperative blood loss, postoperative C-reactive protein (CRP) max, recurrence-free survival (RFS), and overall survival (OS) in 111 patients with pStage I-IV squamous cell EC who received esophagectomies. Optimal cutoff values for each continuous parameter were determined by receiver operating characteristic curves and Youden indices. Read More

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Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients.

Front Endocrinol (Lausanne) 2021 26;12:587518. Epub 2021 Apr 26.

Department for Diagnostic Laboratory Medicine, Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany.

Thyroxine and triiodothyronine (T3) are classical thyroid hormones and with relatively well-understood actions. In contrast, the physiological role of thyroid hormone metabolites, also circulating in the blood, is less well characterized. These molecules, namely, reverse triiodothyronine, 3,5-diiodothyronine, 3-iodothyronamine, tetraiodoacetic acid and triiodoacetic acid, mediate both agonistic (thyromimetic) and antagonistic actions additional to the effects of the classical thyroid hormones. Read More

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First Evaluation of a Newly Constructed Underwater Pulse Oximeter for Use in Breath-Holding Activities.

Front Physiol 2021 26;12:649674. Epub 2021 Apr 26.

Environmental Physiology Group, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.

Studying risk factors in freediving, such as hypoxic blackout, requires development of new methods to enable remote underwater monitoring of physiological variables. We aimed to construct and evaluate a new water- and pressure proof pulse oximeter for use in freediving research. The study consisted of three parts: (I) A submersible pulse oximeter (SUB) was developed on a ruggedized platform for recording of physiological parameters in challenging environments. Read More

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Comparison of hypofractionation and standard fractionation for post-prostatectomy salvage radiotherapy in patients with persistent PSA: single institution experience.

Radiat Oncol 2021 May 12;16(1):88. Epub 2021 May 12.

Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Vinogradska 29, 10000, Zagreb, Croatia.

Background: Hypofractionated post-prostatectomy radiotherapy is emerging practice, however with no randomized evidence so far to support it's use. Additionally, patients with persistent PSA after prostatectomy may have aggressive disease and respond less well on standard salvage treatment. Herein we report outcomes for conventionally fractionated (CFR) and hypofractionated radiotherapy (HFR) in patients with persistent postprostatectomy PSA who received salvage radiotherapy to prostate bed. Read More

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The influence on oxidative stress markers, inflammatory factors and intestinal injury-related molecules in Wahui pigeon induced by lipopolysaccharide.

PLoS One 2021 12;16(5):e0251462. Epub 2021 May 12.

College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, Jiangxi, China.

Introduction: The intestinal structure is the foundation for various activities and functions in poultry. An important question concerns the changes in the intestinal status under endotoxin stimulation. This study aimed to investigate the mechanism of intestinal injury induced by lipopolysaccharide (LPS) in Wahui pigeons. Read More

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Cumulative Burden of Postoperative Complications in Patients Undergoing Surgery for Primary Retroperitoneal Sarcoma.

Ann Surg Oncol 2021 May 12. Epub 2021 May 12.

Department of Sarcoma and General Surgery, Midlands Abdominal and Retroperitoneal Sarcoma Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

Background: Correlations between postoperative complications and oncological outcomes have been reported in several malignancies, but their impact in retroperitoneal sarcoma (RPS) is unclear. Our study aimed to evaluate the association between postoperative complications and prognosis in patients with RPS.

Methods: Patients undergoing surgery for primary RPS from 2008 to 2019 at a sarcoma center were evaluated. Read More

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The evolution of hummock-depression micro-topography in an alpine marshy wetland in Sanjiangyuan as inferred from vegetation and soil characteristics.

Ecol Evol 2021 May 25;11(9):3901-3916. Epub 2021 Mar 25.

School of Environment University of Auckland Auckland New Zealand.

The hummock-depression micro-topography characteristics of the alpine marshy wetland in Sanjiangyuan are indicative of wetland degradation and the process by which healthy wetlands are transformed into flat grasslands. The aim of the present study was to examine changes in plant community structure and soil characteristics in a hummock-depression micro-topography along a degradation gradient. We observed that: (a) the height and cover of dominant hydrophytes decreased gradually with an increase in degradation severity, leading to replacement by xerophytes; (b) with the transition from healthy to degraded wetlands, hummocks became sparser, shorter, and broader and became merged with nearby depressions; water reserves in the depressions shifted from perennial to seasonal, until they dried out completely; and (c) soil moisture content, porosity, hardness, and organic matter gradually decreased by 30. Read More

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Risk Factors for Falls in Patients with Alzheimer Disease: A Retrospective Study of Balance, Cognition, and Visuospatial Ability.

Dement Geriatr Cogn Dis Extra 2021 Jan-Apr;11(1):58-63. Epub 2021 Mar 22.

Department of Occupational Therapy, Kyorin University, Mitaka, Japan.

Aim: This study aimed to determine the main risk factors for falls in patients with Alzheimer disease (AD) by comparing balance, cognition, and visuospatial ability between those who have experienced a fall and those who have not.

Methods: Forty-seven AD patients were admitted to a ward for patients with dementia (22 men and 25 women). The balance of patients was evaluated using the Functional Reach Test (FRT), the one-leg standing duration, and the Timed Up and Go (TUG) test. Read More

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Absolute Neutrophil Count in the Peripheral Blood Predicts Prognosis in Lung Cancer Patients Treated with Anlotinib.

Cancer Manag Res 2021 3;13:3619-3627. Epub 2021 May 3.

Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Purpose: Anlotinib is a multi-targeted tyrosine kinase inhibitor that inhibits tumor angiogenesis and cell proliferation. It is widely used as a third-line therapy for lung cancer. However, reliable prognostic biomarkers for predicting the efficacy of anlotinib are lacking. Read More

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Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy.

Drug Des Devel Ther 2021 3;15:1861-1872. Epub 2021 May 3.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China.

Objective: This study aimed to explore the effects of lidocaine on postoperative quality of recovery (QoR) and immune function in patients undergoing laparoscopic radical gastrectomy.

Methods: In total, 135 patients were enrolled and were equally randomized to receive low-dose lidocaine (Group LL: 1.5 mg/kg bolus followed by an infusion at 1. Read More

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Age and gender differences in objective sleep properties using large-scale body acceleration data in a Japanese population.

Sci Rep 2021 May 11;11(1):9970. Epub 2021 May 11.

Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Using large-scale objective sleep data derived from body acceleration signals of 68,604 Japanese residents ranging from adolescents to the elderly (10-89 years old), we found significant age- and gender-related differences in sleep properties (timing, duration, and quality) in real-life settings. Time-in-bed and total sleep time (TST) showed a U-shaped association with age, indicating their decrease in adulthood following their increase in the elderly. There was a remarkable shift in sleep phase toward earlier bedtime and earlier wake time with increasing age (> 20 years), together with worsening of sleep quality, which is estimated by sleep efficiency (SE) and wake time after sleep onset. Read More

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Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice.

Proc Biol Sci 2021 May 12;288(1950):20202895. Epub 2021 May 12.

Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, USA.

Muscle contraction results from force-generating cross-bridge interactions between myosin and actin. Cross-bridge cycling kinetics underlie fundamental contractile properties, such as active force production and energy utilization. Factors that influence cross-bridge kinetics at the molecular level propagate through the sarcomeres, cells and tissue to modulate whole-muscle function. Read More

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Population-Level Uptake of Moderately Hypofractionated Definitive Radiotherapy in the Treatment of Prostate Cancer.

Int J Radiat Oncol Biol Phys 2021 May 8. Epub 2021 May 8.

School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia; Department of Radiation Oncology, Calvary Mater Newcastle, NSW, Australia. Electronic address:

Background And Purpose: Recent evidence shows the non-inferiority of hypofractionated radiation therapy regimens compared to conventional regimens in the treatment of prostate cancer (PCa). Hypofractionation has benefits for both the patient and healthcare system, due to the shorter treatment duration. Despite this, the uptake of hypofractionation can be slow. Read More

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Management of scope-induced type I duodenal perforations: Over-the-scope clip versus surgery.

Indian J Gastroenterol 2021 May 11. Epub 2021 May 11.

Department of Gastroenterology, G B Pant Institute of Postgraduate Medical Education and Research, 1, J L N Marg, New Delhi, 110 002, India.

Background: Scope-induced duodenal perforation is a life-threatening complication and surgery remains the standard of care. With the advent of over-the-scope clip (OTSC), scope-induced perforations are increasingly managed conservatively, though there is no study comparing this form of non-surgical treatment with surgery. We aimed to compare OTSC and surgery in the management of scope-induced perforation of the duodenum. Read More

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Short and long-term outcome after common femoral artery hybrid procedure in patients with intermittent claudication and chronic limb threatening ischemia.

Vasa 2021 May 11:1-9. Epub 2021 May 11.

Department of Vascular Surgery, Barmherzige Brüder Hospital Regensburg, Germany.

This study aimed to evaluate the differences between the outcomes of patients with intermittent claudication (IC) and chronic limb threatening ischemia (CLTI) who underwent a hybrid procedure comprising common femoral artery endarterectomy and endovascular therapy. This was a retrospective single-center study of all patients with peripheral arterial occlusive disease (PAD) who underwent the hybrid procedure between March 2007 and August 2018. The primary endpoint was primary patency after 7 years. Read More

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Clinical and molecular characteristics and treatment patterns of adolescent and young adult patients with chronic lymphocytic leukaemia.

Br J Haematol 2021 May 10. Epub 2021 May 10.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Chronic lymphocytic leukaemia (CLL) rarely presents in adolescent and young adult (AYA) patients (patients aged 15-39 years). Disease characteristics and outcomes of AYA patients with CLL are not well understood, particularly in the era of novel oral targeted therapies. We analysed outcomes of 227 AYA patients with CLL diagnosed in the last two decades and evaluated at our institution. Read More

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Surgical Outcome of Pulmonary Metastasectomy for Hepatocellular Carcinoma Recurrence in Liver Transplant Patients.

Ann Transplant 2021 May 11;26:e930383. Epub 2021 May 11.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

BACKGROUND Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) results in poor survival outcome. This study assessed the clinical outcomes of pulmonary metastasectomy in LT recipients with pulmonary metastasis of HCC in a high-volume transplant center and analyzed factors prognostic of survival following metastasectomy. MATERIAL AND METHODS This study analyzed outcomes in 52 patients who underwent pulmonary resection due to pulmonary metastasis as the first recurrence of HCC after LT from January 2004 to December 2017 in a single center. Read More

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