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Diagnostic delay in axial spondyloarthritis - a past or current problem?

Curr Opin Rheumatol 2021 Apr 20. Epub 2021 Apr 20.

Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany.

Purpose Of Review: To evaluate recent data on diagnostic delay in axial spondyloarthritis (axSpA), factors affecting the delay, potential ways of early diagnosis improvement, and risks associated with early diagnostic approaches.

Recent Findings: Although axSpA can be diagnosed nowadays within the first months after symptom onset, the diagnostic delay remains with several years still remarkably high in many parts of the world. Female gender, human leukocyte antigen-B27 negativity, and younger age at disease onset are among factors associated with a delayed referral to a rheumatologist and consequently with a larger diagnostic delay. Read More

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Association between breastfeeding during infancy and white matter microstructure in early childhood.

Neuroimage 2021 Apr 18:118084. Epub 2021 Apr 18.

Alberta Children's Hospital Research Institute; Hotchkiss Brain Institute, Departments of; Radiology. Electronic address:

Introduction: Associations between breastfeeding and brain development, in the context of child, perinatal, and sociodemographic variables, remain unclear. This study investigated whether exclusive breastfeeding for the first 6 months and total duration of breastfeeding were associated with brain white matter microstructure in young children.

Methods: This study included 85 typically developing children (42 males) born to 83 mothers that were predominantly white, highly educated, and in high incomes households. Read More

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Better late than never? Maternal biopsychosocial predictors of late follow-up from new Jersey's early hearing detection and intervention program.

Int J Pediatr Otorhinolaryngol 2021 Apr 18;145:110708. Epub 2021 Apr 18.

Montclair State University, USA.

Objectives: Early hearing detection and intervention programs are designed to mitigate consequences of hearing loss in infants. Most research examining compliance with program protocols has examined factors related to being lost to follow-up. Another group that warrants study are babies who return for follow-up outside the timelines recommended by public health organizations. Read More

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Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1.

Cell Rep 2021 Apr;35(3):109010

Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Edgbaston, Birmingham B152TT, UK. Electronic address:

Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signaling machinery that control hematopoietic progenitor cell growth and differentiation. Here, we show that the transcription factor WT1 forms a major node in the rewired mutation-specific gene regulatory networks of multiple AML subtypes. WT1 is frequently either mutated or upregulated in AML, and its expression is predictive for relapse. Read More

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Urinary exosomal CD26 is associated with recovery from acute kidney injury in intensive care units: a prospective cohort study.

Clin Chem Lab Med 2021 Apr 21. Epub 2021 Apr 21.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P. R. China.

Objectives: Currently there is no validated method to predict renal reversal and recovery after acute kidney injury (AKI). As exosomes have the potential for AKI prognosis and CD26 is involved in the mechanisms in AKI, this study aims to investigate whether urinary exosomal CD26 is associated with renal-related outcomes and explore its prospect as a novel prognosis biomarker.

Methods: This was a single-center, prospective cohort study. Read More

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Imaging diagnosis and legal implications of brain injury in survivors following single intrauterine fetal demise from monochorionic twins - a review of the literature.

J Perinat Med 2021 Apr 22. Epub 2021 Apr 22.

Obstetrics and Gynecology I, Mother and Child Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Brain injury of the surviving twin from monochorionic pregnancies following intrauterine fetal demise during the second and third trimesters is a rare but severe complication. Monochorionicity and gestational age at the time of stillbirth seem to be decisive factors in terms of long-term neurologic outcome prediction for the survivor. Magnetic resonance imaging (MRI), diffusion weighted imaging (DWI) in particular, seem to bring the earliest and most accurate diagnosis. Read More

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Multiple dimensions of social motivation in adult female degus.

PLoS One 2021 21;16(4):e0250219. Epub 2021 Apr 21.

Department of Psychology, University of Montana, Missoula, Montana, United States of America.

Many animals become more motivated to interact after a period of isolation. This phenomenon may involve general drives, e.g. Read More

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4-phenylbutyrate exerts stage-specific effects on cardiac differentiation via HDAC inhibition.

PLoS One 2021 21;16(4):e0250267. Epub 2021 Apr 21.

School of Medicine, Hunan Normal University, Changsha, Hunan, China.

4-phenylbutyrate (4-PBA), a terminal aromatic substituted fatty acid, is used widely to specifically attenuate endoplasmic reticulum (ER) stress and inhibit histone deacetylases (HDACs). In this study, we investigated the effect of 4-PBA on cardiac differentiation of mouse embryonic stem (ES) cells. Herein, we found that 4-PBA regulated cardiac differentiation in a stage-specific manner just like trichostatin A (TSA), a well-known HDAC inhibitor. Read More

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Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018.

PLoS One 2021 21;16(4):e0249864. Epub 2021 Apr 21.

Unit AIDS Research Network Cohort (CoRIS), National Center of Epidemiology (CNE), Health Institute Carlos III (ISCIII), Madrid, Spain.

Objectives: With the purpose of reducing the well-known negative impact of late presentation (LP) on people living with HIV (PLWH), guidelines on early HIV diagnosis were published in 2014 in Spain, but since then no data on LP prevalence have been published. To estimate prevalence and risk factors of LP and to evaluate their impact on the development of clinical outcomes in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) during 2004-2018.

Methods: CoRIS is an open prospective multicenter cohort of PLWH, adults, naive to ART at entry. Read More

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The Astrogenic Balance in the Aging Brain.

Curr Neuropharmacol 2021 Apr 19. Epub 2021 Apr 19.

Neuroscience Program, Biology Department, University of Hartford, West Hartford, CT 06117, United States.

An inverse correlation between the incidence of cancer and neurodegenerative disease has been observed, with the prevalence of cancer peaking around 60 years of age, then slowly tapering off as neurodegenerative diseases increase in the elderly. Although the diseases rarely occur concurrently, the same genes are differentially expressed between the diseases, with four transcription factors found to be in common for their expression. In the brain, mature astrocytes are the origin of astrocytoma, which make up 58. Read More

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Differentially expressed genes , , and are potential prognostic biomarkers for gastric cancer.

Sci Prog 2021 Apr-Jun;104(2):368504211011344

Clinical Laboratory, Danyang People's Hospital of Jiangsu Province, Danyang, Jiangsu, China.

Gastric cancer (GC) is one of the most common malignant tumors in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of GC. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. Read More

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Factors and mechanisms contributing to the development of preschool wheezing disorders.

Expert Rev Respir Med 2021 Apr 21:1-16. Epub 2021 Apr 21.

Inflammation, Repair & Development Section, National Heart & Lung Institute, Imperial College London, London, UK.

Introduction: Half of all children will experience an episode of wheezing by their sixth birthday and acute episodes of wheezing in preschool children account for the majority of all childhood hospital admissions for wheeze. Recurrent preschool wheezing associates with early loss of lung function and a life-long impact on lung health.

Areas Covered: We reviewed the literature on PubMed from August 2010-2020 focussing on factors associated with wheeze inception and persistence, paying specific attention to mechanistic studies that have investigated the impact of early life exposures in shaping immune responses in children with underlying susceptibility to wheezing. Read More

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The outcome of laparoscopic pancreatoduodenectomy is improved with patient selection and the learning curve.

Surg Endosc 2021 Apr 21. Epub 2021 Apr 21.

Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.

Background: In our first experience, laparoscopic pancreatoduodenectomy (LPD) was associated with higher morbidity than open PD. Since, the surgical technique has been improved and LPD was avoided in some patients at very high risk of postoperative pancreatic fistula (POPF). We provide our most recent results. Read More

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Treatment of Scars with Laser-Assisted Delivery of Growth Factors and Vitamin C: A Comparative, Randomised, Double-blind, Early Clinical Trial.

Aesthetic Plast Surg 2021 Apr 21. Epub 2021 Apr 21.

Pharmaceutical Research Group, Faculty of Health, School of Allied Health, Education, Medicine and Social Care, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, CM1 1SQ, UK.

Background: Scarring can jeopardize the final result of plastic surgeries. Deep dermal injuries activate dermal fibroblasts that produce excessive amount of collagen and inflammatory cytokines and growth factors, which contributes to increased fibrous tissue and scarring tissue formation.

Objectives: The aim of this early study, double-blind, prospective, randomised clinical trial was to investigate the use of laser-assisted drug delivery (LADD) for scar improvement to support the establishment of LADD as standard therapy modality and to indicate suitable drugs for dermal administration. Read More

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Migraine associated with early onset postpartum depression in women with major depressive disorder.

Arch Womens Ment Health 2021 Apr 21. Epub 2021 Apr 21.

Psychological Medicine, University of Worcester, Henwick Grove, Worcester, WR2 6AJ, UK.

Major depressive disorder (MDD) and migraine are both more common among women than men. Women's reproductive years are associated with increased susceptibility to recurrence of both conditions, suggesting a potential role of sex hormones in aetiology. We examined associations between comorbid migraine and clinical features of MDD in women, including relationships with lifetime reproductive events such as childbirth. Read More

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Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open 2021 Apr 1;4(4):e216156. Epub 2021 Apr 1.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.

Importance: Female gender is a major risk factor for dementia; however, gender has not yet been adequately addressed by clinical trials. A recent study demonstrated that sodium benzoate, a D-amino acid oxidase inhibitor, improved cognitive function in early-phase Alzheimer disease.

Objective: To examine the potential gender difference in the effects of benzoate treatment on the behavioral and psychological symptoms of dementia (BPSD). Read More

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Extracellular vesicles shed by follicular lymphoma B cells promote the polarization of bone marrow stromal cell niche.

Blood 2021 Feb 24. Epub 2021 Feb 24.

Faculté de Médecine, Rennes, France.

Follicular Lymphoma (FL) originates in the lymph nodes (LN) and infiltrates bone marrow (BM) early in the course of the disease. BM FL B cells are characterized by a lower cytological grade, a decreased proliferation, and a specific phenotypic and subclonal profile. Mesenchymal stromal cells (MSC) obtained from FL BM display a specific gene expression profile (GEP), including enrichment for a lymphoid-stromal cell signature, and an increased capacity to sustain FL B-cell growth. Read More

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February 2021

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data.

JAMA Psychiatry 2021 Apr 21. Epub 2021 Apr 21.

Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Importance: Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered brain glutamatergic function may be associated with the pathophysiology of schizophrenia and the response to antipsychotic treatment. However, the association of altered glutamatergic function with clinical and demographic factors is unclear.

Objective: To assess the associations of age, symptom severity, level of functioning, and antipsychotic treatment with brain glutamatergic metabolites. Read More

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The relation between neutrophil/lymphocyte and platelet/lymphocyte ratios with mortality and limb amputation after acute limb ischaemia.

Vascular 2021 Apr 21:17085381211010012. Epub 2021 Apr 21.

Department of Department of Medicine, Surgery and Neuroscience, 9313University of Siena, Vascular Surgery Unit, Siena, Italy.

Objective: Acute limb ischaemia is still considered a significant event, with considerable early- and long-term amputation and mortality risk. Our study aims to investigate the predictive role of pre-operative neutrophil/lymphocyte and platelet/lymphocyte ratios in terms of mortality and amputation risk in patients with acute limb ischaemia.

Methods: Pre-operative blood samples of all patients admitted with acute limb ischaemia were used to calculate neutrophil/lymphocyte and platelet/lymphocyte ratios. Read More

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Vitamin B status in health and disease: a critical review. Diagnosis of deficiency and insufficiency - clinical and laboratory pitfalls.

Crit Rev Clin Lab Sci 2021 Apr 21:1-31. Epub 2021 Apr 21.

The Nutristasis Unit, Viapath, St. Thomas' Hospital, London, UK.

Vitamin B (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained principally from food of animal origin. Cobalamin becomes bioavailable through a series of steps pertaining to its release from dietary protein, intrinsic factor-mediated absorption, haptocorrin or transcobalamin-mediated transport, cellular uptake, and two enzymatic conversions ( methionine synthase and methylmalonyl-CoA-mutase) into cofactor forms: methylcobalamin and adenosylcobalamin. Read More

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Factors associated with the knowledge of obstetric danger signs, and perceptions of the need for obstetric care amongst married young women in northern Nigeria.

Afr J Prim Health Care Fam Med 2021 Mar 26;13(1):e1-e9. Epub 2021 Mar 26.

UKAid/ Nigeria MNCH2 Programme, Kano State, Nigeria; and, Palladium, Abuja.

Background: Married adolescents contribute to poor maternal health indicators in many low-and middle-income countries, where restrictive social norms hinder access to, and utilisation of maternal health services. Addressing these barriers is key to improving health outcomes of young mothers and their children.

Aim: This study assessed married young women's knowledge of obstetric danger signs and perceptions of the need to attend obstetric services. Read More

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[Epidemiology of primitive digestive cancers in adult in three specialized health centers in Cotonou (Benin Republic)].

Bull Soc Pathol Exot 2020 ;113(5):254-257

Clinique universitaire d'hépatogastroentérologie, Centre national hospitalier universitaire Hubert-Koutoukou-Maga (CNHU-HKM) de Cotonou, Bénin.

Health research studies are increasingly focusing on digestive cancers because of their increasing frequency and severity. The objective of this work was to study the epidemiological aspects of primary digestive cancers in adults in three hospital centers in the commune of Cotonou. A total of 676 cases of digestive cancers were identified out of 25,093 patients received during the study period (2. Read More

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January 2020

Nutri-epigenetics: the effect of maternal diet and early nutrition on the pathogenesis of autoimmune diseases.

Minerva Pediatr (Torino) 2021 Apr;73(2):98-110

Unit of Maternal and Child Health, Department of Research, Sidra Medicine, Doha, Qatar -

Autoimmune diseases comprise a wide group of diseases involving a self-response of the immune system against the host. The etiopathogenesis is very complex involving disease-specific factors but also environmental factors, among which the diet. Maternal diet during pregnancy as well as early nutrition recently attracted the interest of the scientists as contributing to the immune programming. Read More

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Platelet Rich Plasma Enhances Mechanical Strength of Strattice in Rat Model of Ventral Hernia Repair.

J Tissue Eng Regen Med 2021 Apr 20. Epub 2021 Apr 20.

University San Raffaele and IRCCS San Raffaele, 00166, Rome, Italy.

Incisional hernia continues to be a common complication of hernia repair in spite of the development of various synthetic and bio-synthetic repair materials. Poor long-term mechanical strength, leading to high recurrence rates, has limited the use of acellular dermal matrices (ADM) in ventral hernia repair (VHR). Biologically-derived meshes have been an area of increasing interest, but these materials bring the risk of more aggressive immune response and fibrosis in addition to the mechanical failures suffered by synthetic materials. Read More

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Identification of prognostic marker genes in head and neck squamous cell carcinoma: a study based on TCGA database and experimental validation.

J Oral Pathol Med 2021 Apr 20. Epub 2021 Apr 20.

Department of Ear-Nose-Throat, Maoming People's Hospital, Maoming, 525000, P.R. China.

Background: Early detection and prognostic prediction are crucial in improving the survival of patients with head and neck squamous cell carcinoma (HNSCC). Therefore, we provided potential molecular markers in this study for early diagnosis and prognosis of this cancer based on the The Cancer Genome Atlas (TCGA) database analysis and experimental validations.

Methods: Differentially expressed genes (DEGs) between HNSCC tumor and normal samples were identified by TCGA database-based analyses. Read More

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Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation.

Drugs Aging 2021 Apr 21. Epub 2021 Apr 21.

ICES, Toronto, ON, Canada.

Background: Atrial fibrillation (AF) is relatively common among nursing home residents, and decisions regarding anticoagulant therapy in this setting may be complicated by resident frailty and other factors.

Objectives: The aim of this study was to examine trends and correlates of oral anticoagulant use among newly admitted nursing home residents with AF following the approval of direct-acting oral anticoagulants (DOACs).

Methods: We conducted a retrospective cohort study of all adults aged > 65 years with AF who were newly admitted to nursing homes in Ontario, Canada, between 2011 and 2018 (N = 36,466). Read More

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Multimorbidity Accumulation among Middle-Aged Americans: Differences by Race/Ethnicity and Body-Mass Index.

J Gerontol A Biol Sci Med Sci 2021 Apr 21. Epub 2021 Apr 21.

School of Public Health, Oregon Health & Science University, Portland, Oregon, United States.

Background: Obesity and multimorbidity are more prevalent among U.S. racial/ethnic minority groups. Read More

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Epidemiology, clinical characteristics, and virologic features of COVID-19 patients in Kazakhstan: A nation-wide retrospective cohort study.

Lancet Reg Health Eur 2021 May 16;4:100096. Epub 2021 Apr 16.

Department of Public Health, Semey Medical University, 103 Abai street, Semey 071400, Kazakhstan.

Background: The earliest coronavirus disease-2019 (COVID-19) cases in Central Asia were announced in March 2020 by Kazakhstan. Despite the implementation of aggressive measures to curb infection spread, gaps remain in the understanding of the clinical and epidemiologic features of the regional pandemic.

Methods: We did a retrospective, observational cohort study of patients with laboratory-confirmed COVID-19 hospitalized in Kazakhstan between February and April 2020. Read More

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Stereotactic Ablative Radiotherapy for Central and Ultra-Central Lung Tumors.

Ther Radiol Oncol 2019 May 24;3. Epub 2019 May 24.

Department of Radiation Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Stereotactic ablative radiotherapy (SABR) has emerged as a standard-of-care treatment for patients with early stage non-small cell lung cancer (NSCLC) who are poor surgical candidates. Current evidence supports the consensus that lung SABR with BED ≥100 Gy leads to high local tumor control, and that the treatment is generally well-tolerated when applied to peripheral lung tumors. However, several studies present conflicting evidence for the treatment of central and ultra-central lung tumors, with some showing superb outcomes and others showing concerning rates of morbidity and mortality. Read More

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Role and Risk Factors of Glycosylated Hemoglobin Levels in Early Disease Screening.

J Diabetes Res 2021 8;2021:6626587. Epub 2021 Apr 8.

Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, China.

Objective: To clarify the correlation among glycosylated hemoglobin (HbA1c), gender, age, fatty liver, and biochemical indicators through the analysis of big database, and to further investigate the risk factors affecting HbA1c, so as to lay a foundation for the study of HbA1c-related diseases and disease management.

Methods: People who have been examined in Health Promotion Center from July 2018 to June 2019 were selected as the research objects. All data were analyzed using the Windows R software (version 3. Read More

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