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Metabolic Disorders/Obesity Is a Primary Risk Factor in Hidradenitis Suppurativa: An Immunohistochemical Real-World Approach.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Background: Hidradenitis suppurativa (HS) is an inflammatory, potentially scarring disease of the hair follicle, affecting the apocrine gland-bearing skin areas. The major comorbid disorders associated with the occurrence or the aggravation of the disease are obesity and smoking. Numerous efforts to dissociate these factors led to controversial results. Read More

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Deep learning for sex classification in resting-state and task functional brain networks from the UK Biobank.

Neuroimage 2021 Jul 20;241:118409. Epub 2021 Jul 20.

Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire CB2 0SZ, UK.

Classification of whole-brain functional connectivity MRI data with convolutional neural networks (CNNs) has shown promise, but the complexity of these models impedes understanding of which aspects of brain activity contribute to classification. While visualization techniques have been developed to interpret CNNs, bias inherent in the method of encoding abstract input data, as well as the natural variance of deep learning models, detract from the accuracy of these techniques. We introduce a stochastic encoding method in an ensemble of CNNs to classify functional connectomes by sex. Read More

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Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension.

Biophys J 2021 Jul 19. Epub 2021 Jul 19.

Department of Mechanical Engineering, Columbia University, New York, New York, 10027, USA. Electronic address:

Distinct patterns of actomyosin contractility are often associated with particular epithelial tissue shape changes during development. For example, a planar polarized pattern of myosin II localization regulated by Rho1 signaling during Drosophila body axis elongation is thought to drive cell behaviors that contribute to convergent extension. However, it is not well understood how specific aspects of a myosin pattern influence the multiple cell behaviors-including cell intercalation, cell shape changes, and apical cell area fluctuations-that simultaneously occur during morphogenesis. Read More

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Updated understanding of Staphylococcus aureus in atopic dermatitis: from virulence factors to commensals and clonal complexes.

Exp Dermatol 2021 Jul 22. Epub 2021 Jul 22.

University of Arkansas for Medical Sciences, Department of Dermatology, 4301 West Markham, Slot 576, Little Rock, Arkansas, 72205, USA.

Atopic dermatitis (AD) is a common inflammatory dermatosis that has multiple contributing factors including genetic, immunologic, and environmental. Staphylococcus aureus (SA) has long been associated with exacerbation of AD. SA produces many virulence factors that interact with the human skin and immune system. Read More

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Role of lungs in the hemostasis system (review of literature).

Klin Lab Diagn 2021 Jul;66(7):411-416

Tashkent institute of postgraduate medical education.

The lung tissue contains various hemostatic system elements, which can be released from the lungs, both under physiological and pathological conditions. The COVID-19 pandemic has led to an increase in the number of patients with acute respiratory distress syndrome (ARDS) in intensive care units worldwide. When the lungs are damaged, coagulation disorders are mediated by tissue factor (TF) - factor VIIa (F VIIa), and inhibition of this pathway completely eliminates intrapulmonary fibrin deposition. Read More

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Does the Size-Arrival Effect Occur With an Active Collision-Avoidance Task in an Immersive 3D Virtual Reality Environment?

Hum Factors 2021 Jul 22:187208211031043. Epub 2021 Jul 22.

Fisk University, Nashville, Tennessee, USA.

Objective: Determine whether the size-arrival effect (SAE) occurs with immersive, 3D visual experiences and active collision-avoidance responses.

Background: When a small near object and a large far object approach the observer at the same speeds, the large object appears to arrive before the small object, known as the size-arrival effect (SAE), which may contribute to crashes between motorcycles and cars. Prior studies of the SAE were limited because they used two dimensional displays and asked participants to make passive judgments. Read More

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L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus.

JCI Insight 2021 07 22;6(14). Epub 2021 Jul 22.

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated with dysfunction of multiple organs, but some infected cells do not express ACE2, the canonical entry receptor for SARS-CoV-2. Here, we report that the C-type lectin receptor L-SIGN interacted in a Ca2+-dependent manner with high-mannose-type N-glycans on the SARS-CoV-2 spike protein. Read More

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Anxiety levels of breast cancer patients in Turkey during the COVID-19 pandemic.

Future Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, Bezmialem Vakif University, Istanbul, 34093, Turkey.

To assess the anxiety levels of breast cancer patients during the COVID-19 pandemic. A total of 298 patients completed the State-Trait Anxiety Inventory (STAI-S and STAI-T) and the Visual Analogue Scale for Anxiety (VAS) and VAS for Anxiety in COVID-19 (VAS-CoV). 144 patients were in the high anxiety category for STAI-S, and 202 patients were in the high anxiety category for STAI-T. Read More

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Posterior Reversible Encephalopathy Syndrome and brain haemorrhage as COVID-19 complication: a review of the available literature.

J Neurol 2021 Jul 21. Epub 2021 Jul 21.

Neurology, Neurophysiology and Neurobiology Unit, Department of Medicine, Università Campus Bio-Medico di Roma, Viale Alvaro del Portillo, 21, 00128, Rome, Italy.

Background: SARS-CoV-2 infection has been associated with various neurological manifestations. Since patients affected by SARS-CoV-2 infection present coagulation and immune system dysregulation, ischemic or haemorragic stroke is not uncommon, irrespective of respiratory distress. However, the occurrence of focal neurological deficits together with other symptoms like headache, cortical blindness, seizure and altered mental status should prompt the diagnosis of Posterior Reversible Encephalopathy Syndrome (PRES). Read More

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microRNAs involved in psoriasis and cardiovascular diseases.

Vasc Biol 2021 3;3(1):R49-R68. Epub 2021 Jun 3.

Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Via Fosso del Cavaliere, Rome, Italy.

Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular disease (CVD), and cerebrovascular diseases (CeVD). Read More

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Anonymous Living Liver Donation: Literature Review and Case Series Report.

Transplant Direct 2021 Aug 16;7(8):e726. Epub 2021 Jul 16.

Division of Transplant Surgery, University of Virginia Health System, Charlottesville, VA.

Background: Anonymous living liver donations (ALLDs) raise ethical concerns regarding the donors' motivations. Thus, ALLDs are not as widely accepted as directed donations from friends and family. Literature on ALLDs is limited. Read More

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Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai.

Glob Pediatr Health 2021 8;8:2333794X211031782. Epub 2021 Jul 8.

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. Read More

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Role of Threat and Coping Appraisal in Protection Motivation for Adoption of Preventive Behavior During COVID-19 Pandemic.

Front Public Health 2021;9:678566. Epub 2021 Jul 5.

World Health Organization RNTCP Technical Support Network, Swasthya Bhawan, Kolkata, India.

With more than 100 million cases and over 2 million deaths globally, the COVID-19 pandemic continues to remain a major threat. Identifying the behavioral factors influencing preventive behaviors for COVID-19 are crucial in devising public health policies to promote essential strategies to combat the pandemic in an efficient manner. The current study was therefore conducted to estimate the prevalence of COVID-19 preventive behaviors and measure their association with behavioral constructs like threat perception, response efficacy, and self-efficacy, as per socio-demographic background. Read More

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Empirical Evidence Supporting Neural Contributions to Episodic Memory Development in Early Childhood: Implications for Childhood Amnesia.

Child Dev Perspect 2020 Mar 19;14(1):41-48. Epub 2020 Jan 19.

University of Maryland, College Park.

Memories for events that happen early in life are fragile-they are forgotten more quickly than expected based on typical adult rates of forgetting. Although numerous factors contribute to this phenomenon, data show one major source of change is the protracted development of neural structures related to memory. Recent empirical studies in early childhood reveal that the development of specific subdivisions of the hippocampus (i. Read More

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KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples.

Front Genet 2021 5;12:635429. Epub 2021 Jul 5.

Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.

Keratin 18 (KRT18), one of the most abundant keratins in epithelial and endothelial cells, has been reported to be aberrantly expressed in many malignancies and extensively regarded as a biomarker and important regulator in multiple cancers, including gastric cancer (GC). But the molecular regulatory mechanisms of KRT18 in GC patients and cells are largely unknown. In the present study, we analyzed the expression level of KRT18 in 450 stomach adenocarcinoma tissue samples from TCGA database and found a significantly higher expression level in tumor tissues. Read More

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Hair-Pulling Does Not Necessarily Serve an Emotion Regulation Function in Adults With Trichotillomania.

Front Psychol 2021 5;12:675468. Epub 2021 Jul 5.

South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Trichotillomania (TTM) has been associated with childhood trauma and perceived stress. While it has been hypothesized that hair-pulling regulate negative emotions, the relationship between childhood trauma, perceived stress, emotion regulation, and hair-pulling has not been well-studied. Fifty-six adults with TTM and 31 healthy controls completed the Childhood Trauma Questionnaire (CTQ), Perceived Stress Scale (PSS), and Difficulties in Emotion Regulation Scale (DERS). Read More

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Maternal Psychological Control and Rural Left-Behind Children's Anxiety: The Moderating Role of Externalizing Problem Behavior and Teacher Support.

Front Psychol 2021 5;12:624372. Epub 2021 Jul 5.

College of Education, Linyi University, Linyi, China.

Based on the risk and protective factor framework and context-dependent theory, the present study investigated the association between maternal psychological control and anxiety among left-behind children in rural China as well as the moderating roles of externalizing problem behavior and teacher support in this association. A total of 149 children with two migrant parents, 306 children with only a migrant father, and 287 accompanied children aged 11-16 years (M = 13.85 years, SD = 0. Read More

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Violent Behavior Prior to Admission Is Not a Factor in Further Prolonged Length of Stay: A Retrospective Cohort Study in a Japanese Psychiatric Hospital.

Front Psychiatry 2021 5;12:600456. Epub 2021 Jul 5.

Forensic Mental Health Unit, Department of Psychiatry and Behavioral Sciences, Division of Cognitive and Behavioral Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

This study assessed the hypothesis that violent behavior prior to admission prolongs psychiatric hospitalization and evaluated the likelihood of hospital discharge to a community care setting based on demographic and clinical factors, with an emphasis on violent behavior. We retrospectively selected 362 patients who were involuntarily admitted to a psychiatric hospital in Japan from December 1, 2015 to November 30, 2017, stayed longer than planned, and underwent review by a multidisciplinary team. We assessed (a) education and marital status and history of substance abuse, (b) the presence/absence and type of violent behavior that led to hospital admission, and (c) the discharge criteria. Read More

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Factors Underlying Individual Differences in Speech-Recognition Threshold (SRT) in Noise Among Older Adults.

Larry E Humes

Front Aging Neurosci 2021 5;13:702739. Epub 2021 Jul 5.

Department of Speech, Language, and Hearing Sciences, Indiana University, Bloomington, IN, United States.

Many older adults have difficulty understanding speech in noisy backgrounds. In this study, we examined peripheral auditory, higher-level auditory, and cognitive factors that may contribute to such difficulties. A convenience sample of 137 volunteer older adults, 90 women, and 47 men, ranging in age from 47 to 94 years ( = 69. Read More

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Increasing frequency of hospital admissions for retinal detachment and vitreo-retinal surgery in England 2000-2018.

Eye (Lond) 2021 Jul 21. Epub 2021 Jul 21.

University Hospitals Bristol and Weston NHS Foundation Trust, Bristol Eye Hospital, Bristol, United Kingdom.

Objectives: To analyse the changes in reported frequency of retinal detachment admissions and vitreo-retinal surgery procedures performed between 2000 and 2018 in England. To obtain information useful to contribute towards the planning of service delivery.

Methods: Analysis of England's Hospital Episode Statistics from the Health and Social Care Information Centre and population data from the United Kingdom's Office for National Statistics. Read More

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Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence.

Sci Rep 2021 Jul 21;11(1):14825. Epub 2021 Jul 21.

Center for Substance Abuse Research, Temple University, 3500 N Broad St, MERB/ Rm 847, Philadelphia, PA, 19140, USA.

Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key factor contributing to this problem is the long-lasting nature of drug-seeking behavior associated with opioid use. We modeled this behavior in a rat drug self-administration paradigm in which drug-seeking is higher after extended abstinence than during the acute abstinence phase. Read More

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Case-control study of hypertension and Parkinson's disease.

NPJ Parkinsons Dis 2021 Jul 21;7(1):63. Epub 2021 Jul 21.

Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9. Read More

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Contributing factors to advanced brain aging in depression and anxiety disorders.

Transl Psychiatry 2021 Jul 21;11(1):402. Epub 2021 Jul 21.

Department of Psychiatry, Amsterdam University Medical Centers, Vrije Universiteit and GGZ inGeest, Amsterdam Neuroscience, Amsterdam, The Netherlands.

Depression and anxiety are common and often comorbid mental health disorders that represent risk factors for aging-related conditions. Brain aging has shown to be more advanced in patients with major depressive disorder (MDD). Here, we extend prior work by investigating multivariate brain aging in patients with MDD, anxiety disorders, or both, and examine which factors contribute to older-appearing brains. Read More

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Work-life balance: a comparison of women in cardiology and other specialties.

Open Heart 2021 Jul;8(2)

Westmead Applied Research Centre, University of Sydney, Sydney, New South Wales, Australia

Objective: Significant gender disparities exist in some medical specialties, particularly cardiology. We assessed work, personal life and work-life balance in women in cardiology in Australia and New Zealand (NZ), compared with other specialties, to determine factors that may contribute to the lack of women in the specialty.

Methods: This study is a prospective survey-based cohort study comparing cardiology and non-cardiology specialties. Read More

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Physical activity, sedentary behavior, and incidence of obstructive sleep apnea in three prospective US cohorts.

Eur Respir J 2021 Jul 21. Epub 2021 Jul 21.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Reduced physical activity and increased sedentary behavior may independently contribute to development of obstructive sleep apnea (OSA) through increased adiposity, inflammation, insulin resistance and body fluid retention. However, epidemiologic evidence remains sparse, and is primarily limited to cross-sectional studies.We prospectively followed 50 332 women from the Nurses' Health Study (2002-2012), 68 265 women from the Nurses' Health Study II (1995-2013), and 19 320 men from the Health Professionals Follow-up Study (1996-2012). Read More

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Effect of relationships among clinical mastitis incidence, reproductive performance, and culling rate on the lifetime of dairy cows at Hiroshima University Farm.

Anim Sci J 2021 Dec;92(1):e13591

Japan International Research Center for Agricultural Sciences, Tsukuba, Japan.

Farm managers' decision to cull dairy cows is based on the cows' milk production, history of disorder(s), and reproductive performance, each of which affects dairy cows' lifetime (herd life and productive lifespan). We investigated the relationships among the incidence of clinical mastitis (CM), the reproductive performance, and the culling rate. We also assessed the effects of these relationships on the lifetimes of dairy cows, using the records made before and after the introduction of an automatic milking system (AMS) at Hiroshima University Farm. Read More

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December 2021

Assessment of children's writing features: A pilot method study of pen-grip kinetics and writing surface pressure.

Assist Technol 2021 Jul 21. Epub 2021 Jul 21.

Department of Mechanical Engineering and Mechatronics, Faculty of Engineering, Ariel University.

The writing process is a complex task involving dexterous manipulation of the writing instrument by the hand digits and biomechanical ergonomic factors that contribute to handwriting efficiency and productivity. We describe a pilot study using an instrumented writing apparatus-a sensor (pen) and a digitized writing surface (tablet)-to measure the pen-grip kinetics (digit forces) and the pen pressure applied to the tablet during a writing task. Eight elementary school students with no handwriting difficulties copied a short story. Read More

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Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.

Clin Exp Pharmacol Physiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology and Andrology, Al-Azhar University (Assuit), Egypt.

Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, forty-seven patients received (0. Read More

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The Impact of Peripheral Artery Disease (PAD) on Lower Limb Kinematics in Type 2 Diabetes Mellitus.

Rev Diabet Stud 2021 10;17(1):11-16. Epub 2021 May 10.

Faculty of Health Sciences, University of Malta.

Background: Peripheral artery disease (PAD) and diabetes mellitus are factors known to influence gait characteristics. However, there is a lack of knowledge on the extent to which type 2 diabetes mellitus (T2D) and PAD as comorbidities cause limb and gait complications.

Aim: The purpose of this study was to investigate the impact of PAD as a complication of T2D on ankle joint dorsiflexion and knee joint flexion angles using an optoelectronic motion analysis system and to find out whether these alterations are complications secondary to neuropathy or reduced blood perfusion. Read More

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Experiences of menstruation in high income countries: A systematic review, qualitative evidence synthesis and comparison to low- and middle-income countries.

PLoS One 2021 21;16(7):e0255001. Epub 2021 Jul 21.

Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Victoria, Australia.

Background: There is growing recognition of the importance of menstruation in achieving health, education, and gender equality for all. New policies in high income countries (HICs) have responded to anecdotal evidence that many struggle to meet their menstrual health needs. Qualitative research has explored lived experiences of menstruating in HICs and can contribute to designing intervention approaches. Read More

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