1,146,508 results match your criteria factors associated

COVID-19 and atrial fibrillation in older patients. Does oral anticoagulant therapy provide a survival benefit? An insight from the GeroCovid Registry.

Thromb Haemost 2021 May 7. Epub 2021 May 7.

Department of Medicine, Campus Bio-Medico University, Roma, Italy.

Introduction: Atrial fibrillation (AF), the most frequent arrhythmia of older patients, associates with serious thrombo-embolic complications and high mortality. COVID-19 severely affects aged subjects, determining an important prothrombotic status. Aim of this study was to evaluate mortality-related factors in older AF patients with COVID-19. Read More

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Venous Thromboembolism among Noncritically Ill Hospitalized Children: Key Considerations for the Pediatric Hospital Medicine Specialist.

Semin Thromb Hemost 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Venous thromboembolism (VTE) is a leading cause of morbidity and preventable harm among noncritically ill hospitalized children. Several clinical factors relevant to the noncritically ill hospitalized child significantly increase the risk of VTE including the presence of central venous catheters, systemic inflammation, and prolonged immobilization. Although risk mitigation strategies have been described, the diagnosis, treatment, and prevention of VTE require standardization of institutional practices combined with multidisciplinary collaboration among pediatric hospitalists, hematologists, and other care providers. Read More

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Identifying patients at risk for nonroutine discharge after surgery for cervical myelopathy: an analysis from the Quality Outcomes Database.

J Neurosurg Spine 2021 May 7:1-9. Epub 2021 May 7.

15Department of Neurological Surgery, University of Utah, Salt Lake City, Utah.

Objective: Optimizing patient discharge after surgery has been shown to impact patient recovery and hospital/physician workflow and to reduce healthcare costs. In the current study, the authors sought to identify risk factors for nonroutine discharge after surgery for cervical myelopathy by using a national spine registry.

Methods: The Quality Outcomes Database cervical module was queried for patients who had undergone surgery for cervical myelopathy between 2016 and 2018. Read More

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Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Pulse wave velocity is decreased in acromegaly compared to non-acromegaly study participants with similar cardiovascular risk profile.

Growth Horm IGF Res 2021 Apr 29;57-58:101395. Epub 2021 Apr 29.

Almazov National Medical Research Centre, Ulica Akkuratova 2, St. Petersburg 197341, Russia.

Objective: Acromegaly patients were reported to have an increased arterial stiffness that could contribute to the frequent cardiovascular complications in this population. The chronic excess of GH and IGF-1 may lead to arterial stiffening via different mechanisms, including hypertension, impaired glucose tolerance and dyslipidemia, however, it is not known whether the activation of GH/IGF-1 axis might influence arterial stiffening independently of cardiovascular risk factors. The objective of this prospective case-control study was to compare arterial stiffness assessed with pulse-wave velocity (PWV) in acromegaly versus non-acromegaly group with similar cardiovascular risk profile. Read More

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The challenging scenario of beliefs and attitudes toward chronic low back pain among final year undergraduate students: A cross-sectional investigation.

Musculoskelet Sci Pract 2021 Mar 31;53:102375. Epub 2021 Mar 31.

Department of Physical Therapy, Faculty of Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.

Objective: To identify the beliefs and attitudes of students in four health courses about chronic low back pain (CLBP) management, and to investigate personal and undergraduate training-related factors associated with their beliefs.

Methods: Cross-sectional study conducted with 173 Brazilian medicine, physiotherapy, nursing and pharmacy students. Participants provided information on age, personal experience with LPB, training or class on CLBP management, and contact with patients with CLBP, followed by their first therapeutic choices. Read More

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Identifying factors associated with criminal responsibility by analyzing court trial verdicts.

Int J Law Psychiatry 2021 May 4;77:101702. Epub 2021 May 4.

Chiba University Center for Forensic Mental Health, Inohana 1-8-1, Chuo-ku, Chiba-shi, Chiba, Japan. Electronic address:

The criminal responsibility of offenders with mental disorders is a key issue in forensic psychiatry. Japan's implementation of the Medical Treatment and Supervision Act and Lay Judge Act in the early 2000s raised public awareness of this issue. To determine how criminal court judges in Japan assess the criminal responsibility of offenders, we examined 453 district court verdicts that mention psychiatric evidence. Read More

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Asymptomatic acute ischemic lesions in intracerebral hemorrhage: Its frequency, MRI features, and risk factors.

J Neurol Sci 2021 Apr 29;426:117472. Epub 2021 Apr 29.

Department of Neurology, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Asymptomatic acute ischemic lesions (AIL) may be coincidentally found on brain magnetic resonance imaging (MRI) obtained during the acute phase of intracerebral hemorrhage, but its clinical significance has yet to be determined. The objective of this study is to determine the frequency of asymptomatic AIL, its characteristic features of brain MRI and risk factors in patients with acute intracerebral hemorrhage.

Methods: We retrospectively reviewed the clinical information of 108 patients with intracerebral hemorrhage who underwent brain MRIs within 30 days of hospitalization between April 2013 and January 2018. Read More

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Long-term exposure to particulate matter and residential greenness in relation to androgen and progesterone levels among rural Chinese adults.

Environ Int 2021 May 4;153:106483. Epub 2021 May 4.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Background: Population-based studies on the associations of long-term exposure to particulate matter (PM) with androgen and progesterone are still scant. Residential greenness is benefits health by promoting physical activity, reducing air pollution, and improving mental health, but it remains unclear whether it is related to androgen and progesterone levels among humans.

Aims: This study aimed to explore the individual and interactive effects of PM and residential greenness on serum testosterone and progesterone levels among rural Chinese adults. Read More

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Waiting lists and prioritization of children for services: Speech-language pathologists' perspectives.

J Commun Disord 2021 May 4;91:106099. Epub 2021 May 4.

Charles Sturt University, Australia.

Background: Waiting lists occur when the availability of speech-language pathology services does not meet the demand. Speech-language pathologists (SLPs) commonly manage waiting lists and their consequences using prioritization.

Aims: The aims of this study were to: (1) describe speech-language pathology waiting lists for children and factors associated with their presence in workplaces throughout the world, and (2) describe factors considered in and influencing SLPs' prioritization of children for services. Read More

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Caregiver burden and related factors during active cancer treatment: A latent growth curve analysis.

Eur J Oncol Nurs 2021 Apr 17;52:101962. Epub 2021 Apr 17.

National Institutes of Health, Clinical Center, Bethesda, MD, USA.

Purpose: Caregiver burden is frequently studied cross-sectionally, but longitudinal studies on family caregiver burden during active cancer treatment are lacking. The goals of this study were to characterize trajectories of caregivers' burden during a 6-month active treatment period, and to examine which predictors are associated with their burden.

Method: This study was a secondary analysis of data from a prospective study. Read More

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Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort.

Int J Hyg Environ Health 2021 May 4;235:113755. Epub 2021 May 4.

Department of Public Health, University of Southern Denmark, Odense, J.B. Winsløws Vej 17A, 5000, Odense, Denmark; Hans Christian Andersen Children's Hospital, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark.

Background: Prenatal exposure to organophosphate and pyrethroid insecticides has been associated with impaired neurodevelopment. Few longitudinal studies have investigated associations with early language development in populations with mainly low dietary exposure.

Objective: To investigate associations between biomarkers of maternal gestational exposure to organophosphate and pyrethroid insecticides and the child's language development at age 20-36 months in the prospective Odense Child Cohort. Read More

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Measurement of Trauma Caregiver Stress: Validation of HRV in a Real-World Surgical Setting.

J Surg Res 2021 May 4;265:252-258. Epub 2021 May 4.

Georgetown University School of Medicine, Washington, District of Columbia; MedStar Washington Hospital Center, Washington, District of Columbia.

Background: Acute stress is a potentially modifiable risk-factor that contributes to errors in trauma care. Research on stress mitigation is limited by the lack of a validated objective measure of surgeon stress. We sought to validate HRV in a real-world surgical setting by comparison to the Subjective Units of Distress Score (SUDS), and correlation with self-reported peak stress moments. Read More

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Association between household debt and depressive mood among Chinese residents.

Public Health 2021 May 4;194:202-207. Epub 2021 May 4.

Department of Business Management, School of Management, Ocean University of China, Qingdao, PR China.

Objectives: The aim of this study was to examine the association of household debt and depressive mood among Chinese adults and to evaluate whether the association varies across types of debt.

Study Design: This is a secondary data analysis of a nationally representative survey.

Methods: A prospective cohort study of participants was drawn from the China Family Panel Studies (CFPS). Read More

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Predictors of asthma control and exacerbations: a real-world study.

J Allergy Clin Immunol Pract 2021 May 4. Epub 2021 May 4.

CIUSSS du nord de l'île de Montréal, Hôpital du Sacré-Coeur de Montréal, Université de Montréal. Electronic address:

Background: Achieving optimal asthma control and minimizing the risk of exacerbation are the main goals of asthma treatment.

Objective: This study aimed to assess the predictors of poor asthma control and asthma exacerbations within a population of moderate to severe asthmatic patients treated in a tertiary care center.

Methods: We conducted a cohort study assessing 738 patients enrolled in the Quebec registry in respiratory health (RESP) with a diagnosis of asthma confirmed by a respirologist and treated in a tertiary care center from April 2010 to March 2016. Read More

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Biomarkers of the severity of honeybee sting reactions and the severity and threshold of systemic adverse events during immunotherapy.

J Allergy Clin Immunol Pract 2021 May 4. Epub 2021 May 4.

University Hospital of Respiratory and Allergic Diseases, Golnik, Slovenia. Electronic address:

Background: A biomarker that could identify individuals at high risk for severe honeybee sting allergic reaction and/or systemic adverse events (SAEs) during venom immunotherapy (VIT) would improve the management of patients with honeybee (HB) venom allergy.

Objective: To identify biomarkers for risk of severe sting reactions or SAEs during VIT.

Methods: We recruited 332 patients undergoing honeybee VIT. Read More

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Pharmacotherapy of obesity: an update.

Pharmacol Res 2021 May 4:105649. Epub 2021 May 4.

Center for the Study and the Integrated Management of Obesity, Padova University Hospital; and Department of Medicine, Internal Medicine 3, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.

Several pharmacological approaches to controlling body weight have been developed over the last decades, albeit with limited success. Currently available agents include centrally acting appetite suppressants and peripherally acting compounds. Efficacy and safety of these agents in the clinical setting require a difficult balance. Read More

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The relevance of vitamin D in the oral health of HIV infected patients.

J Steroid Biochem Mol Biol 2021 May 4:105905. Epub 2021 May 4.

Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.

HIV infection affects 36.9 million people globally, and vitamin D deficiency is a global public health concern for HIV patients. Approximately 70% to 80% of HIV-infected patients have vitamin D deficiency. Read More

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Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes. Results from a multicentre prospective cohort in Spain (PRO-BAC study).

Int J Antimicrob Agents 2021 May 4:106352. Epub 2021 May 4.

Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena / Departamento de Medicina, Universidad de Sevilla / Instituto de Biomedicina de Sevilla, Sevilla, Spain.

Background: The epidemiology of bloodstream infections (BSI) is dynamic because it depends on microbiological, host, and healthcare system factors. The aim of this study is to update the information about the epidemiology of BSI in Spain considering the types of acquisition.

Methods: An observational, prospective cohort study in 26 Spanish hospitals from October 2016 throughout March 2017 including all episodes of BSI in adults was performed. Read More

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Molecular cloning and functional characterization of TaIRI9 gene in wheat (Triticum aestivum L.).

Gene 2021 May 4:145694. Epub 2021 May 4.

National Engineering Research Center for Wheat, College of Agronomy, National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou 450002, China. Electronic address:

The vernalization of wheat is one of the important factors that determine the planting region, introduction and cultivation techniques of wheat. However, the known vernalization genes (molecular marker) cannot precisely distinguish the vernalization requirement of winter wheat cultivars. Therefore, it is important to explore new vernalization genes and elucidate the mechanism of vernalization regulation. Read More

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Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) decisions in people admitted with suspected COVID-19: Secondary analysis of the PRIEST observational cohort study.

Resuscitation 2021 May 4. Epub 2021 May 4.

ScHARR, University of Sheffield, Regent Court, Regent Street, Sheffield, S1 4DA, UK. Electronic address:

Aims: We aimed to describe the characteristics and outcomes of adults admitted to hospital with suspected COVID-19 according to their DNACPR decisions, and identify factors associated with DNACPR decisions.

Methods: We undertook a secondary analysis of 13977 adults admitted to hospital with suspected COVID-19 and included in the Pandemic Respiratory Infection Emergency System Triage (PRIEST) study. We recorded presenting characteristics and outcomes (death or organ support) up to 30 days. Read More

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Household Income and Loss of Control Eating in Adolescence: Examining the Role of Food Insecurity.

Appetite 2021 May 4:105291. Epub 2021 May 4.

Department of Psychological Sciences, Kent State University, Kent, OH, United States.

Loss of control (LOC) eating is prevalent among adolescents and has been related to significant mental and physical health concerns. A growing body of research suggests that youth from lower income households are at risk for LOC eating. Food insecurity is an understudied contextual factor that may compound the risk for LOC eating in adolescents from low-income backgrounds. Read More

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Lacto-N-fucopentaose-III (LNFPIII) ameliorates acute aberrations in hippocampal synaptic transmission in a Gulf War Illness animal model.

Brain Res 2021 May 4:147513. Epub 2021 May 4.

Department of Physiology and Pharmacology; Interdisciplinary Toxicology Program. Electronic address:

Approximately one-third of Persian Gulf War veterans are afflicted by Gulf War Illness (GWI), a chronic multisymptom condition that fundamentally presents with cognitive deficits (i.e., learning and memory impairments) and neuroimmune dysfunction (i. Read More

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Preoperative Modified Spermatic Cord Block PREDICTS SUCCESS in Candidates for Microscopic Spermatic cord denervation.

Urology 2021 May 4. Epub 2021 May 4.

Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA; Department of Urology, United Health Services, Johnson City, NY, USA.

Objective: To examine the utility of a modified spermatic cord block (MSCB) that targets known contributors to refractory chronic scrotal content pain (CSCP) at predicting postoperative pain relief following a microscopic spermatic cord denervation (MSCD).

Methods: A MSCB was performed in all patients with refractory CSCP. This was performed by injecting anesthetic circumferentially around the vas deferens and over the external ring. Read More

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Metformin protects against neuroinflammation through integrated mechanisms of miR-141 and the NF-ĸB-mediated inflammasome pathway in a diabetic mouse model.

Eur J Pharmacol 2021 May 4:174146. Epub 2021 May 4.

Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa. Electronic address:

The brain responds to diabetic stress by inducing the inflammatory response. Under normal circumstances this process is tightly regulated. However, uncontrolled inflammatory responses lead to compromised function and eventual neurodegeneration. Read More

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The role of CD44 in cancer chemoresistance: a concise review.

Eur J Pharmacol 2021 May 4:174147. Epub 2021 May 4.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells. The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis, and expression of the chemoresistant phenotype. The overexpression of CD44 impedes the cytotoxic effect of chemotherapy medications in various cancers. Read More

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Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway.

Life Sci 2021 May 4:119584. Epub 2021 May 4.

Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, PR China. Electronic address:

Aims: Ferulic acid (FA) is a component found in plants that has free radical scavenging and liver-protective properties. Acute liver injury (ALI) is a serious complication of sepsis and is closely associated with changes in the levels of inflammatory factors. This study was taken to examine the role of FA in cecal ligation and perforation (CLP)-induced murine ALI and lipopolysaccharide (LPS)-induced cellular ALI models. Read More

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The molecular targets of taurine confer anti-hyperlipidemic effects.

Life Sci 2021 May 4:119579. Epub 2021 May 4.

Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, China; Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 LuJiang Road, Hefei 230001, Anhui, China. Electronic address:

Hyperlipidemia, an independent risk factor for atherosclerosis, is regarded as a lipid metabolism disorder associated with elevated plasma triglyceride and/or cholesterol. Genetic factors and unhealthy lifestyles, such as excess caloric intake and physical inactivity, can result in hyperlipidemia. Taurine, a sulfur-containing non-essential amino acid, is abundant in marine foods and has been associated with wide-ranging beneficial physiological effects, with special reference to regulating aberrant lipid metabolism. Read More

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Response and Adherence of Nursing Home Residents to a Nutrition/Exercise Intervention.

J Am Med Dir Assoc 2021 May 4. Epub 2021 May 4.

Stockholms Sjukhem R&D Unit, Stockholm, Sweden; Theme Aging, Karolinska University Hospital, Stockholm, Sweden; Division of Nursing, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Stockholm, Sweden.

Objectives: Interindividual response variability to nutrition and exercise interventions is extensive in older adults. A group of nursing home (NH) residents participated in a combined intervention. The objective of this post-hoc analysis was to identify factors associated with intervention response measured by change in physical function and body composition. Read More

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Variants in the degron of AFF3 are associated with intellectual disability, mesomelic dysplasia, horseshoe kidney, and epileptic encephalopathy.

Am J Hum Genet 2021 May;108(5):857-873

GeneDx, Gaithersburg, MD 20877, USA.

The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants in the degron of AFF3, a nine amino acid sequence important for its binding to ubiquitin ligase, or with de novo deletions of this region. The sixteen affected individuals we identified, along with two previously reported individuals, present with a recognizable pattern of anomalies, which we named KINSSHIP syndrome (KI for horseshoe kidney, NS for Nievergelt/Savarirayan type of mesomelic dysplasia, S for seizures, H for hypertrichosis, I for intellectual disability, and P for pulmonary involvement), partially overlapping the AFF4-associated CHOPS syndrome. Read More

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