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Degree of interruptions experienced by emergency department nurses and interruption related factors.

Int Emerg Nurs 2021 Jul 28;58:101036. Epub 2021 Jul 28.

College of Nursing, Woosuk University, Jeonju, Republic of Korea. Electronic address:

Aims: This study examined the degree of interruptions experienced by emergency department nurses and related factors.

Methods: This study is a descriptive survey using standardized observation tools. A total of 23 nurses working in an emergency department participated in this study. Read More

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NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator.

Biochem Biophys Res Commun 2021 Jul 28;571:201-209. Epub 2021 Jul 28.

Divison of Molecular and Vascular Biology, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. Electronic address:

Cell signaling and the following gene regulation are tightly regulated to keep homeostasis. NF-κB is a famous key transcription factor for inflammatory cell regulations that obtain a closed feedback loop with IκB. Similarly, we show here, NFAT is also tightly regulated via its downstream target, down syndrome critical region (DSCR)-1. Read More

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A survey of bedroom ventilation types and the subjective sleep quality associated with them in Danish housing.

Sci Total Environ 2021 Jul 24;798:149209. Epub 2021 Jul 24.

International Centre for Indoor Environment and Energy, Department of Civil Engineering, Technical University of Denmark, Denmark.

We performed a survey of the types of bedroom ventilation in Danish dwellings (January-February 2020) and the associated subjective sleep quality. Five hundred and seventeen people responded. Their median age was 33 years old and 55. Read More

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Risk factors for irreversible airway obstruction after infant bronchiolitis.

Respir Med 2021 Jul 24;187:106545. Epub 2021 Jul 24.

Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland; Department of Paediatrics, Tampere University Hospital, Tampere, Finland.

Background: Increasing evidence shows that environmental factors in childhood play a role in development of irreversible airway obstruction. We evaluated early-life and preschool-age risk factors for irreversible airway obstruction in adolescence after bronchiolitis in infancy.

Methods: This study is a secondary analysis of data collected during prospective long-term follow-up of our post-bronchiolitis cohort. Read More

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Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease.

Phytomedicine 2021 Jul 12;91:153648. Epub 2021 Jul 12.

Mr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease. Deposition of amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs) is the key pathological hallmark of AD. Accumulating evidence suggest that impairment of autophagy-lysosomal pathway (ALP) plays key roles in AD pathology. Read More

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2,6-Dimethoxy-1,4-benzoquinone increases skeletal muscle mass and performance by regulating AKT/mTOR signaling and mitochondrial function.

Phytomedicine 2021 Jul 10;91:153658. Epub 2021 Jul 10.

Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, South Korea; Division of Food Biotechnology, University of Science and Technology, Daejeon 34113, South Korea. Electronic address:

Background: 2,6-Dimethoxy-1,4-benzoquinone (DMBQ), a natural phytochemical present in fermented wheat germ, has been reported to exert anti-cancer, anti-inflammatory, and anti-adipogenic effects. However, the effect of DMBQ on muscle hypertrophy and myoblast differentiation has not been elucidated.

Purpose: We investigated the effect of DMBQ on skeletal muscle mass and muscle function and then determined the possible mechanism of DMBQ. Read More

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NAC antagonizes arsenic-induced neurotoxicity through TMEM179 by inhibiting oxidative stress in Oli-neu cells.

Ecotoxicol Environ Saf 2021 Jul 28;223:112554. Epub 2021 Jul 28.

Department of Occupational Health, Army Medical University, 400038, Chongqing, People's Republic of China. Electronic address:

Arsenic is one of the most common environmental pollutants. Neurotoxicity induced by arsenic has become a major public health concern. However, the effects of arsenic-induced neurotoxicity in the brain and the underlying molecular mechanisms are not well understood. Read More

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Effect of lycopene supplementation to bovine oocytes exposed to heat shock during in vitro maturation.

Theriogenology 2021 Jul 24;173:48-55. Epub 2021 Jul 24.

Department of Reproduction, Obstetrics, and Herd Health, Ghent University, 9820, Merelbeke, Belgium; Department of Veterinary Sciences, Gamete Research Center, Veterinary Physiology and Biochemistry, University of Antwerp, Wilrijk, Belgium. Electronic address:

We investigated the effect of the antioxidant lycopene supplemented into the in vitro maturation medium (TCM-199 with 20 ng/mL epidermal growth factor and 50 mg/mL gentamycin) in a heat shock (HS) model to mimic in vivo heat stress conditions. Bovine cumulus-oocyte complexes were supplemented with 0.2 μM lycopene (or not supplemented; control) under HS (40. Read More

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Respiratory syncytial virus nonstructural protein 1 breaks immune tolerance in mice by downregulating Tregs through TSLP-OX40/OX40L-mTOR axis.

Mol Immunol 2021 Jul 28;138:20-30. Epub 2021 Jul 28.

Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address:

Respiratory syncytial virus (RSV) infection in early life is associated strongly with the subsequent development and exacerbation of asthma, however, the mechanism is still ambiguous. In this study, we identified that RSV nonstructural protein (NS) 1 plays a critical role. Plasmid-mediated overexpression of NS1 induced significant airway hyperresponsiveness, eosinophilia, and mucus hyperproduction in mice. Read More

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Impact of fate properties, groundwater fluctuations and the presence of worm burrows on pesticide leaching assessments through golf areas.

Environ Pollut 2021 Jul 21;289:117822. Epub 2021 Jul 21.

Geological Survey of Denmark and Greenland (GEUS), Department of Geochemistry, Øster Voldgade 10, Copenhagen K, 1350, Denmark.

The risk of pesticide leaching from recreational areas such as golf course turfs is not distinguished in a regulative framework within the EU where the focus is on agricultural soils. But with increasing popularity of golf, and thus, increasing number of golf courses leading to potentially increasing use of pesticides, understanding the processes determining pesticide leaching are critical to ensure optimal quality of both groundwater and golf turf. This study input the measured variation in fate properties of tebuconazole (TBZ) and MCPA as pure active ingredients and commercial products in simulations with realistic hydrological conceptualizations to investigate their implication in leaching assessments. Read More

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Dural Tear Does Not Increase the Rate of Venous Thromboembolic Disease in Patients Undergoing Elective Lumbar Decompression with Instrumented Fusion.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Maryland Medical Center, Baltimore, MD. Electronic address:

Objective: Evaluate if dural tears (DT) are an indirect risk factor for venous thromboembolic disease through increased recumbency in patients undergoing elective lumbar decompression and instrumented fusion.

Methods: A retrospective cohort study of consecutive patients undergoing elective lumbar decompression and instrumented fusion at a single institution between 2016 and 2019. Patients were divided into cohorts: those who sustained a dural tear and those who did not. Read More

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Immune Checkpoint Inhibitor Induced Colitis: A Nationwide Population-Based Study.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101778. Epub 2021 Jul 28.

Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic Foundation, Cleveland, OH.

Background: ICIs are used in the management of several malignancies. However, they can result in immune-related adverse events, such as colitis. The aim of this study is to obtain an epidemiological survey of patients who develop immune checkpoint inhibitor (ICI)-induced colitis and identify underlying risk factors. Read More

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Male Sex, Cartilage Surgery, Tobacco Use, and Opioid Disorders are Associated with an Increased Risk of Infection after ACL Reconstruction.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, VA. Electronic address:

Purpose: To identify patient-related risk factors for infection following anterior cruciate ligament reconstruction (ACLR).

Methods: The Mariner database within PearlDiver was queried for patients from 2010 to 2019 undergoing primary arthroscopic ACLR. Patients undergoing ACLR with concomitant open surgery or additional ligament reconstructions were excluded. Read More

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Peripheral Levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and interleukin-1β across the mood spectrum in bipolar disorder: a meta-analysis of mean differences and variability.

Brain Behav Immun 2021 Jul 28. Epub 2021 Jul 28.

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia. Electronic address:

Importance: It is unclear whether differences exist in the magnitude and variability of pro-inflammatory mediators in the different phases of bipolar disorder (BD) and among subjects with BD, as compared to healthy controls.

Objective: To run a comparative meta-analysis of C-Reactive Protein (CRP), IL-1, IL-6, TNF-α in BD vs healthy controls, measuring mean and variability effects on all subjects. Sensitivity analyses include disease activity. Read More

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Combined therapy of adenovirus vector mediated IGF-1 gene with anti-CD20 mAbs exerts potential beneficial role on type 1 diabetes in nonobese diabetic mice.

Life Sci 2021 Jul 28:119853. Epub 2021 Jul 28.

Department of Medical College, Shenzhen Polytechnic, Shenzhen 518055, Guangdong Province, PR China. Electronic address:

Aims: To assess the protective effects of combined treatment with anti-CD20 monoclonal antibody (mAb) and adenovirus mediated mouse insulin-like growth factor 1 (Adv-mIGF-1) gene on type 1 diabetes (T1D) in nonobese diabetic (NOD) mice at early stage.

Methods: To simultaneously restore the proportion of Th cells and block the interaction of B cells, NOD model mice were assigned to four groups which received PBS, Adv-mIGF-1 gene and anti-CD20 mAbs alone or combination, respectively. After 16 weeks of therapeutic intervention, blood samples and pancreatic tissues of mice were measured via the methods of ELISA, RT-PCR, western blotting, H&E staining, TUNEL and immunohistochemistry assays. Read More

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Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade.

Eur J Pharmacol 2021 Jul 28:174385. Epub 2021 Jul 28.

Division of Thoracic Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Chronic obstructive asthma is characterized by airway fibrosis. Hypoxia and connective tissue growth factor (CTGF) play important roles in airway fibrosis. Preadipocyte factor-1 (Pref-1) participates in adipocyte differentiation and liver fibrosis. Read More

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Midkine: a multifaceted driver of atherosclerosis.

Clin Chim Acta 2021 Jul 28. Epub 2021 Jul 28.

Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou 570100, Hainan, China. Electronic address:

Atherosclerosis constitutes the pathological basis of life-threatening events, including heart attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein family with pleiotrophin. Under inflammatory or hypoxic conditions, midkine expression is up-regulated. Read More

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Down-staging Outcomes for Hepatocellular Carcinoma: Results from the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium.

Gastroenterology 2021 Jul 28. Epub 2021 Jul 28.

Division of Gastroenterology, Department of Medicine, University of California, San Francisco; Division of Transplant Surgery, Department of Surgery, University of California, San Francisco.

Background/aims: United Network of Organ Sharing (UNOS) has adopted uniform criteria for down-staging (UNOS-DS) of hepatocellular carcinoma (HCC) prior to liver transplantation (LT), but down-staging success rate and intention-to-treat outcomes across broad geographic regions are unknown.

Methods: In this first multi-regional study (7 centers, 4 UNOS regions), consecutive patients with HCC undergoing down-staging based on UNOS-DS criteria were prospectively evaluated from 2016-2019 (n=209).

Results: Probability of successful down-staging to Milan criteria and dropout at 2 years from initial down-staging procedure was 87. Read More

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Challenging patient phenotypes in the management of anemia of chronic kidney disease.

Int J Clin Pract 2021 Jul 31:e14681. Epub 2021 Jul 31.

Department of Medicine, Division of Nephrology, NYU School of Medicine, New York, NY, USA.

Background: Chronic kidney disease (CKD) is often complicated by anemia, which is associated with disease progression and increased hospital visits, decreased quality of life, and increased mortality.

Methods: A comprehensive literature search of English language peer-reviewed articles in PubMed/MedLine published between 1998 and 2020 related to the treatment of anemia of CKD was conducted. The United States Renal Database System and Dialysis Outcomes and Practice Patterns Study (DOPPS) data reports, the Centers for Disease Control and Prevention and the US Food and Drug Administration websites, and published congress abstracts in 2020 were surveyed for relevant information. Read More

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Synthesis, characterization, and evaluation of curcumin-loaded endodontic reparative material.

J Biochem Mol Toxicol 2021 Jul 31:e22854. Epub 2021 Jul 31.

Stem Cell Research Center and Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Curcumin (CUR) is an ancient therapeutic agent with remarkable antimicrobial and anti-inflammatory properties. The purpose of the current study was to synthesize and evaluate a curcumin-based reparative endodontic material to reduce infection and inflammation besides the induction of mineralization during the healing of the dentin-pulp complex. Poly-ɛ-caprolactone (PCL)/gelatin (Gel)/CUR scaffold was synthesized and assessed by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermo-gravimetric analysis (TGA). Read More

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Reduced infiltration of T-regulatory cells in tumours from mice fed daily with gamma-tocotrienol supplementation.

Clin Exp Immunol 2021 Jul 31. Epub 2021 Jul 31.

Pathology Division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia.

Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including immune-modulatory properties. This study reports the immune-modulatory effects of daily supplementation of γT3 on host T-helper (Th) and T-regulatory (Treg) populations in a syngeneic mouse model of breast cancer. Female BALB/c mice were fed with either γT3 or vehicle (soy oil) for 2-weeks via oral gavage before they were inoculated with syngeneic 4T1 mouse mammary cancer cells (4T1 cells). Read More

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Ventral calcification in the common femoral artery: A risk factor for major transcatheter aortic valve intervention access site complications.

Catheter Cardiovasc Interv 2021 Jul 31. Epub 2021 Jul 31.

Department of Cardiology and Angiology I, University Hospital Freiburg and Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objectives: We aimed to identify risk factors for major transcatheter aortic valve intervention (TAVI) access site complications based on detailed analysis of the preprocedural computed tomography angiogram (CTA).

Background: Transfemoral TAVI has become the treatment of choice for severe aortic stenosis in elderly patients, especially with increased perioperative risk. Frailty, however, favors complications at the vascular access site due to the large bore vascular sheath devices necessary for valve deployment. Read More

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The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials.

Adv Exp Med Biol 2021 ;1291:251-263

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints, which is prevalent in about 0.5-1.0% of the world population. Read More

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January 2021

The Role of DMP1 in CKD-MBD.

Curr Osteoporos Rep 2021 Jul 31. Epub 2021 Jul 31.

Division of Nephrology and Hypertension, Center for Translational Metabolism and Health, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, IL, 60611, USA.

Purpose Of Review: Chronic kidney disease-mineral and bone disorder (CKD-MBD) has become a global health crisis with very limited therapeutic options. Dentin matrix protein 1 (DMP1) is a matrix extracellular protein secreted by osteocytes that has generated recent interest for its possible involvement in CKD-MBD pathogenesis. This is a review of DMP1 established regulation and function, and early studies implicating DMP1 in CKD-MBD. Read More

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Impact of aquaculture on distribution of dissolved organic matter in coastal Jeju Island, Korea, based on absorption and fluorescence spectroscopy.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Instrumental Development and Management Center, Korea Institute of Ocean Science and Technology (KIOST), Busan, 49111, Republic of Korea.

In Jeju Island, multiple land-based aquafarms were fully operational along most coastal region. However, the effect of effluent on distribution and behaviours of dissolved organic matter (DOM) in the coastal water are still unknown. To decipher characteristics of organic pollution, we compared physicochemical parameters with spectral optical properties near the coastal aquafarms in Jeju Island. Read More

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microRNA-149-5p mediates the PM-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.

Cell Biol Toxicol 2021 Jul 31. Epub 2021 Jul 31.

Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, No. 10, Xitoutiao Youanmen Street, Beijing, 100069, China.

Epidemiological evidence has shown that fine particulate matter (PM)-triggered inflammatory cascades are pivotal causes of chronic obstructive pulmonary disease (COPD). However, the specific molecular mechanism involved in PM-induced COPD has not been clarified. Herein, we found that PM significantly downregulated miR-149-5p and activated the mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways and generated the inflammatory response in COPD mice and in human bronchial epithelial (BEAS-2B) cells. Read More

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Current salivary biomarkers for detection of human papilloma virus-induced oropharyngeal squamous cell carcinoma.

Head Neck 2021 Jul 31. Epub 2021 Jul 31.

Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Human papilloma virus (HPV) infection is a key risk factor and etiology for oropharyngeal squamous cell carcinoma (OPSCC). HPV-induced OPSCC is rapidly increasing in incidence, with men experiencing increased mortality. When identified at an early stage, HPV-induced OPSCC can be successfully treated. Read More

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Activation of Aquaporin 5 by carcinogenic Helicobacter pylori infection promotes epithelial-mesenchymal transition via the MEK/ERK pathway.

Helicobacter 2021 Jul 30:e12842. Epub 2021 Jul 30.

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer. The water channel protein Aquaporin 5 (AQP5) is involved in the tumorigenesis and progression of various cancers. Read More

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Metformin stimulates intestinal glycolysis and lactate release: A single-dose study of metformin in patients with intrahepatic portosystemic stent.

Clin Pharmacol Ther 2021 Jul 31. Epub 2021 Jul 31.

Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200, Aarhus N, Denmark.

The pharmacodynamic effects of metformin remain elusive, but several lines of evidence suggest a critical role of direct effects in the gastrointestinal (GI) tract. We investigated if metformin stimulates intestinal glucose metabolism and lactate release in the prehepatic circulation. We included eight patients with transjugular intrahepatic portosytemic stent (TIPS) in an open label study. Read More

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Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma.

Br J Cancer 2021 Jul 30. Epub 2021 Jul 30.

Department of Medical Oncology, The First Affiliated Hospital Zhejiang, University School of Medicine, Hangzhou, China.

Background: Colorectal neuroendocrine carcinomas (CRNECs) are highly aggressive tumours with poor prognosis and low incidence. To date, the genomic landscape and molecular pathway alterations have not been elucidated.

Methods: Tissue sections and clinical information of CRNEC (n = 35) and CR neuroendocrine tumours (CRNETs) (n = 25) were collected as an in-house cohort (2010-2020). Read More

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