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Marine phytoplankton improves recovery and sustains immune function in humans and lowers proinflammatory immunoregulatory cytokines in a rat model.

Phys Act Nutr 2021 Mar 31;25(1):42-55. Epub 2021 Mar 31.

Department of Animal Nutrition, Firat University, Elazig, Turkey.

Purpose: This study investigated the effects of marine phytoplankton supplementation (Oceanix®, Tetraselmis chuii) on 1) maximal isometric strength and immune function in healthy humans following a oneweek high-intensity resistance-training program and 2) the proinflammatory cytokine response to exercise in a rat model.

Methods: In the human trial, 22 healthy male and female participants were randomly divided into marine phytoplankton and placebo groups. Following baseline testing, participants underwent a 14-day supplement loading phase before completing five consecutive days of intense resistance training. Read More

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Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: a Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group.

Cancer Res Treat 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Pusan National University School of Medicines, Yangsan, Korea.

Purpose: Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.

Materials And Methods: Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Read More

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Management of patients with X-linked hypophosphatemic rickets during Covid-19 pandemic lockdown.

J Pediatr Endocrinol Metab 2021 Apr 23. Epub 2021 Apr 23.

Division of Pediatrics, Department of Obstetrics, Gynecology and Pediatrics, University-Hospital, Pisa, Italy.

Objectives: To identify a safe pathway for management and treatment of patients with X-linked hypophosphatemic rickets (XLH) during Covid-19 pandemic lockdown.

Methods: Twenty-six patients with XLH (age 3.1-25. Read More

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Carbon Monoxide Poisoning and Chronic Kidney Disease Risk: A Nationwide, Population-Based Study.

Am J Nephrol 2021 Apr 22:1-12. Epub 2021 Apr 22.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Introduction: Patients with carbon monoxide poisoning (COP) commonly have long-term morbidities. However, it is not known whether patients with COP exhibit an increased risk of developing chronic kidney disease (CKD) and whether hyperbaric oxygen therapy (HBOT) alters this risk.

Methods: This study identified 8,618 patients who survived COP and 34,464 propensity score-matched non-COP patients from 2000 to 2013 in a nationwide administrative registry. Read More

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Prophylactic Treatment in Hereditary Angioedema Is Associated with Reduced Anxiety in Patients in Leipzig, Germany.

Int Arch Allergy Immunol 2021 Apr 22:1-8. Epub 2021 Apr 22.

Department of Dermatology, Venereology and Allergology, University Hospital Leipzig, Leipzig, Germany.

Background: Hereditary angioedema (HAE) is associated with relevant disease-related burden. We aimed at investigating prevalence of depression and anxiety in patients with HAE in Leipzig, Germany.

Methods: Questionnaire-based evaluation of medical history, Angioedema Control Test (AECT), Angioedema Quality of Life Questionnaire (AE-QoL), Generalized Anxiety Disorder Scale-7 (GAD-7), and Hospital Anxiety and Depression Scale (HADS). Read More

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Diagnostic Utility of LEF1 Immunostain in Cytology Specimens of Solid Pseudopapillary Neoplasm of Pancreas.

Acta Cytol 2021 Apr 22:1-7. Epub 2021 Apr 22.

Department of Pathology, University of California, Irvine, Orange, California, USA.

Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm. Diagnosis of SPN requires an integrated approach with aid of radiology, biopsy, cytology, and immunohistochemical stains. Although morphological features in combination with nuclear positivity of β-catenin IHC have been the gold standard of SPN diagnosis, but overlapping morphology and immunohistochemical findings with other entities in differential diagnoses such as pancreatic neuroendocrine tumors and pancreatic ductal adenocarcinoma make the diagnosis of SPN difficult particularly in limited cytology specimens. Read More

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Studying the lifetime of charge and heat carriers due to intrinsic scattering mechanisms in FeVSb half-Heusler thermoelectric.

J Phys Condens Matter 2021 Apr 22. Epub 2021 Apr 22.

School of Engineering, Indian Institute of Technology, South Campus, Kamand, Mandi, Himachal Pradesh, 175075, INDIA.

This work, presents a study of lifetime of carriers due to intrinsic scattering mechanismselectron-electron (EEI), electron-phonon (EPI) and phonon-phonon interactions (PPI) in a promising half-Heusler thermoelectric FeVSb. Using the full-GW method, the effect of EEI and temperature on the valence and conduction band extrema and band gap are studied. The lifetime of carriers with temperature are estimated at these band extrema. Read More

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Wrapping double-mattress anastomosis for pancreaticojejunostomy in minimally invasive pancreaticoduodenectomy can significantly reduce postoperative pancreatic fistula rate compared with conventional pancreaticojejunostomy in open surgery: An analysis of a propensity score-matched sample.

Surg Oncol 2021 Apr 9;38:101577. Epub 2021 Apr 9.

Department of Surgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: Minimally invasive pancreaticoduodenectomy (MIPD), including laparoscopic pancreaticoduodenectomy (LPD) and robotic pancreaticoduodenectomy (RPD), is technically demanding because of pancreaticojejunostomy (PJ). Postoperative pancreatic fistula (POPF) is the most serious complication of MIPD and open pancreaticoduodenectomy (OPD). Contrary to expectations, conventional PJ in MIPD did not improve POPF rate and length of hospital stay. Read More

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Bovine cysticercosis in the State of São Paulo, Brazil: Prevalence, risk factors and financial losses for farmers.

Prev Vet Med 2021 Apr 18;191:105361. Epub 2021 Apr 18.

Centro Universitário Central Paulista (UNICEP), Rua Miguel Petroni, 5111, 13563-470, São Carlos, Brazil. Electronic address:

Taenia saginata is the causative agent of bovine cysticercosis (BCC) and human taeniasis, two diseases that have economical and public health importance, respectively. This research focused on determining BCC prevalence in the state of São Paulo state, Brazil, in the period of 2017-2019, as well as associating risk factors related to disease occurrence and estimate the economic impact to beef producers. Data from 6,277,758 bovine carcasses originating from 571 municipalities and 15 different mesoregions in the state of São Paulo was gathered and analyzed. Read More

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Monte Carlo determination of a nanoDot OSLD response using quality index for diagnostic kilovoltage X-ray beams.

Fujio Araki

Phys Med 2021 Apr 19;84:101-108. Epub 2021 Apr 19.

Department of Health Sciences, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, Kumamoto 862-0976, Japan. Electronic address:

Purpose: This study aims to investigate the energy response of an optically stimulated luminescent dosimeter known as nanoDot for diagnostic kilovoltage X-ray beams via Monte Carlo calculations.

Methods: The nanoDot response is calculated as a function of X-ray beam quality in free air and on a water phantom surface using Monte Carlo simulations. The X-ray fluence spectra are classified using the quality index (QI), which is defined as the ratio of the effective energy to the maximum energy of the photons. Read More

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Simulation of preoperative flexion contracture in a computational model of total knee arthroplasty: Development and evaluation.

J Biomech 2021 Mar 9;120:110367. Epub 2021 Mar 9.

Department of Biomechanics, Hospital for Special Surgery, Weill Cornell Medicine of Cornell University, New York, NY, USA.

Preoperative flexion contracture is a risk factor for patients' dissatisfaction following primary total knee arthroplasty (TKA). Previous studies utilizing surgical navigation technology and cadaveric models attempted to identify operative techniques to correct knees with flexion contracture and minimize undesirable outcomes such as knee instability. However, no consensus has emerged on a surgical strategy to treat this clinical condition. Read More

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The Symbol Digit Modalities Test (SDMT) is sensitive but non-specific in MS: Lexical access speed, memory, and information processing speed independently contribute to SDMT performance.

Mult Scler Relat Disord 2021 Apr 11;51:102950. Epub 2021 Apr 11.

Department of Neurology, Icahn School of Medicine at Mount Sinai, 5 East 98th Street, Box 1138, New York, NY 10029, USA.. Electronic address:

Background: The Symbol Digit Modalities Test (SDMT) is the most sensitive metric of neurocognitive function in multiple sclerosis (MS), and is consistently interpreted as a measure of information processing speed (IPS).

Objective: To evaluate the cognitive psychometric profile captured by the SDMT to identify whether different cognitive processes independently underlie performance.

Methods: Three samples of MS patients (total n=661; 185 research patients at MS center; 370 clinical patients at MS center; 106 persons with MS from the community) completed objective assessments of neuropsychological function across cognitive domains. Read More

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Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.

Redox Biol 2021 Apr 19;43:101970. Epub 2021 Apr 19.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL-33136, USA; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, 33136, USA. Electronic address:

Background: Chronic gastroesophageal reflux disease (GERD) is a major risk factor for the development of metaplastic Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Uncontrolled accumulation of reactive oxygen species (ROS) in response to acidic bile salts (ABS) in reflux conditions can be lethal to cells. In this study, we investigated the role of APE1/REF1 in regulating nuclear erythroid factor-like 2 (NRF2), the master antioxidant transcription factor, in response to reflux conditions. Read More

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Violence risk assessment for young adults receiving treatment for early psychosis.

Int J Law Psychiatry 2021 Apr 19;76:101701. Epub 2021 Apr 19.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.

Aim: Although the absolute risk of violence is small for individuals with mental illnesses, a specific subgroup of individuals who appear to be at increased risk for violence includes young people experiencing emerging or early psychosis. Prior research has identified risk factors for violence in this population, though no prior studies using a formal risk assessment tool have been identified. This study used the Historical Clinical Risk Management-20, version 3 (HCR-20) to identify risk of future violence among a sample of young adults with early psychosis and relevant predictors of risk unique to this population. Read More

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Generation of induced pluripotent stem cell line (IGIBi007-A) from a patient with a novel acromesomelic dysplasia, PRKG2 type (AMDP).

Stem Cell Res 2021 Apr 19;53:102340. Epub 2021 Apr 19.

Genomics and Molecular Medicine Division, CSIR - Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Division of Investigations of Human Pathology by Application Genomics and Stem Cells (iHPSCs-AG), India. Electronic address:

Biallelic PRKG2 (Protein Kinase, cGMP dependent Type-2) mutations cause a novel acromesomelic dysplasia PRKG2 type. We report generation of induced pluripotent stem cell line from lymphoblastoid cell lines of the patient carrying the reported frameshift mutation (p.Asn164Lysfs*2). Read More

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CD45RACD25CD127CD4 activated regulatory T cells are correlated with de novo donor-specific anti-HLA antibody formation after kidney transplantation in standard immunosuppression.

Int Immunopharmacol 2021 Apr 19;97:107661. Epub 2021 Apr 19.

Department of Transplant Surgery, Tokai University School of Medicine, Kanagawa, Japan.

Although de novo donor-specific anti-HLA antibodies (dnDSA) remain a barrier for human kidney transplantation (KTx), the role of regulatory T (Treg) cells in dnDSA formation remains unknown. To address this question, we evaluated Treg cell subsets in peripheral blood mononuclear cells in 15 healthy volunteers and 59 KTx recipients using flow cytometric analysis. The post-transplant CD25CD127CD4 Treg cells in KTx recipients were down-regulated compared with those of healthy volunteers (P < . Read More

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Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration.

Int Immunopharmacol 2021 Apr 19;97:107667. Epub 2021 Apr 19.

Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, China; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, China; Shenzhen Research Institute of Nanjing University, Shenzhen, China. Electronic address:

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the digestive tract. The treatment commonly includes anti-inflammatory agents like 5-aminosalicylic acid or corticosteroids or biologics for people with UC who are no longer responding to corticosteroids. The radices of Paeonia lactiflora Pall. Read More

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Low skeletal muscle mass predicts poor clinical outcomes in patients with abdominal trauma.

Nutrition 2021 Mar 4;89:111229. Epub 2021 Mar 4.

Department of Intensive Care Unit, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China. Electronic address:

Objective: The aim of this study was to investigate whether low skeletal muscle mass is associated with clinical outcomes in patients with abdominal trauma.

Methods: Patients presenting to our institution with abdominal trauma from January 2010 to April 2020 were retrospectively included. Low skeletal muscle mass was defined, using computed tomography, as skeletal muscle index (SMI) at the third lumbar vertebra below the lowest sex-specific quartile within 1 wk of admission. Read More

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The clinical and prognostic role of ALK in glioblastoma.

Pathol Res Pract 2021 Apr 15;221:153447. Epub 2021 Apr 15.

Department of Oncology, AUSL Bologna, Bologna, Italy.

Background: anaplastic lymphoma kinase (ALK) overexpression and gene alterations have been detected in several malignancies, with prognostic and therapeutic implications. However, few studies investigated the correlation between ALK altered expression and prognosis in patients with glioblastoma (GBM).

Methods: We performed an evaluation of ALK overexpression and structural/quantitative chromosome alterations through immune-histochemical assay (IHC with D5F3 antibody) and fluorescent in situ hybridization (FISH) in patients with isocitrate dehydrogenase (IDH) wild type (wt) GBM. Read More

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Protective effect of scorpion venom heat-resistant synthetic peptide against PM-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.

J Neuroimmunol 2021 Apr 2;355:577567. Epub 2021 Apr 2.

College of Medical Laboratory, Dalian Medical University, Dalian 116044, Liaoning Province, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R & D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, Liaoning Province, China. Electronic address:

There is growing evidence that fine particulate matter (PM) is a considerable risk factor for neurodegenerative diseases. Scorpion venom heat-resistant synthetic peptide (SVHRSP) plays a neuroprotective effect by promoting neurogenesis and neuron axon growth. In this study, SVHRSP inhibited the level of TLR4, autophagy and PM2. Read More

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Ribosomal proteins as distinct "passengers" of microvesicles: new semantics in myeloma and mesenchymal stem cells' communication.

Transl Res 2021 Apr 19. Epub 2021 Apr 19.

Oncogenetic laboratory; Sackler faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Aberrant mesenchymal stem cells (MSCs) in multiple myeloma (MM) bone marrows (BM) promote disease progression and drug resistance. Here, we assayed the protein cargo transported from MM-MSCs to MM cells via microvesicles (MVs) with focus on ribosomal proteins (RPs) and assessment of their influence on translation initiation and design of MM phenotype. Proteomics analysis (mass spectrometry) demonstrated increased levels and repertoire of RPs in MM-MSCs MVs compared to normal donors (ND) counterparts (n=3-8; p= 9. Read More

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Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia.

J Reprod Immunol 2021 Apr 15;145:103322. Epub 2021 Apr 15.

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

The underlying mechanism of preeclampsia by which an angiogenic imbalance results in systemic vascular endothelial dysfunction remains unclear. Complement activation directly induces endothelial dysfunction and is known to be involved in preeclampsia; nevertheless, the association between complement activation and angiogenic imbalance has not been established. This study aimed to evaluate whether angiogenic imbalance affects the expression and secretion of inhibitory complement factor H (CFH) in endothelial cells, resulting in complement activation and systemic vascular endothelial dysfunction. Read More

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Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway.

Pulm Pharmacol Ther 2021 Apr 19:102034. Epub 2021 Apr 19.

Institute of Respiratory Diseases, The First Hospital of China Medical University, Shenyang City, Liaoning Province, People's Republic of China. Electronic address:

Allergic asthma is a common airway inflammatory disorder with increasing morbidity and mortality worldwide. Gentiopicroside (GPS) is a secoiridoid glycoside compound that exhibits anti-inflammatory property. However, the effect of GPS on allergic asthma has not been reported yet. Read More

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Women as Authors of Randomized Controlled Trials of Minimally Invasive Surgery: A Systematic Review and Meta-Analysis of 3 Decades of Trials.

J Am Coll Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Urology, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Background: Female authorship opportunities have lagged behind those of their male counterparts, with gender disparities most prominent in surgical specialties. Our objective was to determine trends of female first, last, and first or last authorships across time and surgical specialties and whether female first or last authorship was associated with journal impact factor.

Study Design: A systematic review of EMBASE (OvidSP®), MEDLINE (OvidSP®), and Cochrane (Wiley®) from inception till December 22,2017 was performed to identify all RCTs evaluating MIS versus classical surgical techniques. Read More

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Aftermarket effects of cenegermin for neurotrophic keratopathy in pediatric patients.

Ocul Surf 2021 Apr 19. Epub 2021 Apr 19.

Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Nashville, TN, USA. Electronic address:

Purpose: Neurotrophic keratopathy (NK) is a rare condition characterized by poor corneal sensation and healing. Cenegermin (topical recombinant nerve growth factor) has gained traction as a medical therapy for NK in recent years, and is FDA-approved for patients over two years old. However, no major trials have demonstrated the drug's efficacy in children. Read More

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Tai chi improves psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemic.

Exp Gerontol 2021 Apr 19:111363. Epub 2021 Apr 19.

Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.

The aim of this study was to determine the effect of a 10-week tai chi intervention on psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemic. Participants aged 60-78 years were randomized to either a control group (n = 15) or a tai chi group (n = 15) for a 10-week period. The tai chi group received two, 8-form tai chi classes of 60 min duration per week. Read More

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