Eur J Pharm Sci 2021 Jun 6;161:105790. Epub 2021 Mar 6.
Biochemical Engineering Research Centre, Anhui University of Technology, Ma'anshan, Anhui Province, 243032, P.R. China; Department of Chemical Biology, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui Province, 243032, P.R. China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P.R. China. Electronic address:
In our previous study, a novel cell penetrating peptide (CPP) R7 (Arg-Arg-Arg-Arg-Arg-Trp-Trp, RRRRRWW) has been developed to help cellular internalization of paclitaxel (PTX) through the non-covalent interaction with CPP. However, the facilitation mechanism of R7 mediated PTX translocation is not clear. Here the uptake pathways of R7 and R7-PTX were investigated by in vitro test and molecular simulations. Read More