Gastroenterology 2021 Aug 8. Epub 2021 Aug 8.
State Key Laboratory for Oncogenes and Related Genes, Shanghai, China; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai, China; Division of Gastroenterology and Hepatology, Shanghai Cancer Institute, Shanghai, China; Shanghai Institute of Digestive Disease, Shanghai, China; Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Background & Aims: Enterotoxigenic Bacteroides fragilis (ETBF) is strongly associated with the occurrence of inflammatory bowel disease (IBD), colitis-associated colorectal cancer, and colorectal cancer (CRC). However, the mechanism of ETBF-induced intestinal inflammation and tumorigenesis remains unclear.
Methods: microRNA sequencing was used to detect the differentially expressed microRNAs in both ETBF-treated cells and exosomes derived from ETBF-inoculated cells. Read More