59 results match your criteria eyes ierm


Comparison of the effect of air tamponade versus no tamponade after pars plana vitrectomy for idiopathic epiretinal membrane.

Sci Rep 2021 Mar 3;11(1):5082. Epub 2021 Mar 3.

Department of Ophthalmology, Hangil Eye Hospital, 35 Bupyeong-daero, Bupyeong-gu, Incheon, 21388, South Korea.

This study aimed to compare the surgical outcomes of pars plana vitrectomy (PPV) with and without air tamponade in patients with idiopathic epiretinal membrane (iERM). We prospectively enrolled 145 patients with iERM who underwent a 25-gauge transconjunctival sutureless PPV. Patients were assigned to either the air tamponade (air) group (79 eyes) or balanced salt solution (BSS; no tamponade) group (66 eyes). Read More

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The predictive value of ectopic inner retinal layer staging scheme for idiopathic epiretinal membrane: surgical results at 12 months.

Eye (Lond) 2021 Feb 9. Epub 2021 Feb 9.

Bursa Retina Eye Hospital, Bursa, Turkey.

Background/objectives: To assess the effect of ectopic inner foveal layers (EIFL) based staging scheme, foveal avascular zone (FAZ) alterations and other microstructural optical coherence tomography (OCT) findings on visual function for patients undergoing idiopathic epiretinal membrane (iERM) surgery.

Subjects/methods: In this retrospective study, patients who underwent 27 G pars plana vitrectomy (PPV) for idiopathic ERM with a minimum follow-up of 12 months were included. Preoperative and postoperative OCT scans, FAZ area measurements on en face OCT angiography images and mean retinal sensitivity (MRS) using microperimetry were recorded in all cases. Read More

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February 2021

With or without internal limiting membrane peeling during idiopathic epiretinal membrane surgery: A meta-analysis.

PLoS One 2021 19;16(1):e0245459. Epub 2021 Jan 19.

Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Background: Although previously published meta-analyses have compared the surgical effects between the methods of Idiopathic epiretinal membrane (iERM) removal with or without ILM peeling, they did not reach an agreement.

Purpose: We aimed to provide more evidence for the treatment of iERM and whether additional ILM peeling was better or not by analyzing more updated studies and randomized control trials (RCTs).

Method: The search was conducted in Pubmed, Embase, Cochrane Library, Web of Science and Open Grey without language limitation and the studies included were from inception to December 2019. Read More

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January 2021

Assessment of macular microvasculature features before and after vitrectomy in the idiopathic macular epiretinal membrane using a grading system: An optical coherence tomography angiography study.

Acta Ophthalmol 2021 Jan 10. Epub 2021 Jan 10.

Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, China.

Purpose: To evaluate pre- and postoperative microvasculature features in eyes with different idiopathic macular epiretinal membrane (iERM) classifications using optical coherence tomography angiography (OCTA).

Methods: In this retrospective study, 100 eyes with iERM were enrolled; 62 eyes underwent pars plana vitrectomy (PPV). All iERM eyes were evaluated and graded using optical coherence tomography (OCT). Read More

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January 2021

Identification of Postoperative Foveal Displacement after Macular Surgery for Idiopathic Epiretinal Membrane.

Semin Ophthalmol 2020 Nov 31;35(7-8):365-369. Epub 2020 Dec 31.

Department of Ophthalmology, Eberhard Karls University , Tuebingen, Germany.

: To analyze foveal displacement after macular surgery for idiopathic epiretinal membrane (iERM). : Twenty-eight patients who underwent macular surgery for symptomatic iERM in one eye by one physician were included in this retrospective study. Spectral domain optical coherence tomography (SD-OCT) volume scans were acquired with a Spectralis OCT device (Heidelberg Spectralis). Read More

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November 2020

Correlation between Visual Acuity and Optical Coherence Tomography Angiography Parameters in Unilateral Idiopathic Epiretinal Membrane.

J Clin Med 2020 Dec 24;10(1). Epub 2020 Dec 24.

Department of Ophthalmology, Taipei City Hospital, Zhongxiao Branch, No. 87, Tonde Road, Nankang District, Taipei 10002, Taiwan.

Background: The tangential traction by idiopathic epiretinal membrane (iERM) may alter the hemodynamics of the macula. We investigated the correlation between visual acuity and the optical coherence tomography angiography (OCTA) parameters in unilateral iERM.

Methods: We included 61 eyes of 61 consecutive patients with unilateral iERM between January 2018 and December 2018. Read More

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December 2020

Optical coherence tomography biomarkers for visual acuity in patients with idiopathic epiretinal membrane.

Eur J Ophthalmol 2020 Dec 14:1120672120980951. Epub 2020 Dec 14.

Vitreoretinal and Uveitis Department, Ophthalmica Clinic, Thessaloniki, Greece.

Purpose: To investigate the correlation between outer and inner retina optical coherence tomography (OCT) biomarkers and visual acuity in patients with idiopathic epiretinal membrane (iERM) and identify which of them may be predictive of visual function.

Methods: A retrospective cross-sectional single-center study was conducted that included patients diagnosed with iERM. Spectral domain OCT images were obtained and assessed qualitatively and quantitatively. Read More

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December 2020

The effect of epiretinal membrane surgery on macular microvasculature: an optical coherence tomography angiography study.

Int Ophthalmol 2021 Mar 17;41(3):777-786. Epub 2020 Nov 17.

Department of Ophthalmology, Cukurova University School of Medicine, Adana, Turkey.

Purpose: To investigate both the possible effects of both idiopathic epiretinal membrane (IERM) itself and surgery on macular microvascular structure using optical coherence tomography angiography (OCT-A) and to determine the associations with structural and visual outcomes.

Methods: Twenty-four eyes of 24 patients with IERM and 24 eyes of 12 healthy controls were included. Vascular parameters, including the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were evaluated by OCT-A prior to and 6 months after ERM removal. Read More

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Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane.

Br J Ophthalmol 2020 Oct 5. Epub 2020 Oct 5.

Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Background/aims: Pars plana vitrectomy (PPV) is widely performed in patients with idiopathic epiretinal membrane (iERM) to improve vision. Postoperative visual field defects (VFDs) have been previously reported. However, whether they occur when using the most recent PPV system, and the frequency of VFDs as measured by standard automated perimetry, remain poorly documented and were examined in this study. Read More

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October 2020

The Central Subfoveal Bouquet in Idiopathic Epiretinal Membranes.

Clin Ophthalmol 2020 17;14:2353-2359. Epub 2020 Aug 17.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: To report both the unoperated clinical course and the surgical outcomes of eyes with a central foveal bouquet (CB) secondary to idiopathic epiretinal membranes (iERMs).

Design: Retrospective, consecutive, and observational case series.

Methods: All patients examined between January 1, 2014, and December 31, 2019, for evaluation of epiretinal membrane with a CB lesion identified on spectral domain optical coherence tomography (SD-OCT) were included. Read More

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Gene expression analysis identifies two distinct molecular clusters of idiopatic epiretinal membranes.

Biochim Biophys Acta Mol Basis Dis 2020 12 20;1866(12):165938. Epub 2020 Aug 20.

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. Electronic address:

Idiopathic epiretinal membranes (ERMs) are fibrocellular membranes containing extracellular matrix proteins and epiretinal cells of retinal and extraretinal origin. iERMs lead to decreased visual acuity and their pathogenesis has not been completely defined. Aim of this study was to provide a molecular characterization of iERMs by gene expression analysis. Read More

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December 2020

One-year outcomes of 27G core-pars plana vitrectomy of idiopathic epiretinal membrane.

Exp Ther Med 2020 Sep 13;20(3):2721-2729. Epub 2020 Jul 13.

Department of Ophthalmology, Shanghai 10th People's Hospital affiliated to Tongji University, Shanghai 200072, P.R. China.

The present study aimed to assess the feasibility and safety of 27G core-pars plana vitrectomy (PPV) for idiopathic epiretinal membrane (IERM). A retrospective analysis was performed on 38 eyes from 38 patients with IERM with a mean age of 62.73±5. Read More

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September 2020

One-year follow-up evaluation of combined phacovitrectomy for idiopathic epiretinal membrane.

Int J Ophthalmol 2020 18;13(6):952-959. Epub 2020 Jun 18.

Department of Ophthalmology, the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

Aim: To evaluate the therapeutic effect of combined phacovitrectomy with membrane peeling and intraocular lens (IOL) implantation in patients with severe idiopathic epiretinal membrane (iERM) and concurrent cataract.

Methods: A total of 34 eyes from 34 patients who underwent phacovitrectomy and epiretinal membrane (ERM) peeling at the First Affiliated Hospital of Zhejiang University between 2015 and 2017. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were measured preoperatively and at 1, 3, 6mo and 1y postoperatively. Read More

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Ocular Blood Flow Changes Impact Visual Acuity Gain after Surgical Treatment for Idiopathic Epiretinal Membrane.

J Clin Med 2020 Jun 7;9(6). Epub 2020 Jun 7.

Department of Ophthalmology, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Background: Idiopathic epiretinal membrane (iERM) is a common eye disease, which can be treated by surgical removal of the fibrotic tissue. Morphological outcome is generally evaluated by optical coherence tomography (OCT). Here, we investigate the impact of surgery on hemodynamics of the posterior pole, using OCT angiography (OCTA). Read More

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Baseline visual acuity and interdigitation zone as predictors in idiopathic epiretinal membranes: A retrospective cohort study.

Eur J Ophthalmol 2020 Jun 8:1120672120932094. Epub 2020 Jun 8.

Faculdade de Medicina Universidade do Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal.

Objective: Determine which functional and anatomical characteristics may be predictors of final visual acuity in patients with idiopathic ERM (iERM) submitted to pars plana vitrectomy (PPV) with ERM and internal and internal limiting membrane (ILM) peeling.

Design: Retrospective cohort study.

Subjects: Patients with iERM submitted to PPV between 2016 and 2017. Read More

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Comparison of Vitreomacular Interface Changes in Myopic Foveoschisis and Idiopathic Epiretinal Membrane Foveoschisis.

Am J Ophthalmol 2020 09 29;217:152-161. Epub 2020 Apr 29.

Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

Purpose: To compare characteristics of the vitreomacular interface (VMI) in myopic foveoschisis (mFS) and idiopathic epiretinal membrane foveoschisis (iERM-FS), and to correlate with optical coherence tomography and clinical data.

Design: Clinicopathologic study.

Methods: Epiretinal membrane and internal limiting membrane (ILM) specimens were removed from eyes with mFS (5 eyes) and iERM-FS (5 eyes). Read More

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September 2020

A study analyzing macular microvasculature features after vitrectomy using OCT angiography in patients with idiopathic macular epiretinal membrane.

BMC Ophthalmol 2020 Apr 22;20(1):165. Epub 2020 Apr 22.

Eye Hospital of Wenzhou medical university, Zhejiang, China.

Background: To evaluate postoperative changes in retinal capillary plexus and to assess contributing factors in postoperative visual improvement using optical coherence tomography angiography (OCT-A) in patients with idiopathic epiretinal membrane (iERM) post membrane removal.

Methods: Patients scheduled for vitrectomy and membrane peel for iERM were enrolled. 35 subjects were included for this study. Read More

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Anaphylatoxin concentration in aqueous and vitreous humor in the eyes with vitreoretinal interface abnormalities.

Exp Eye Res 2020 06 26;195:108025. Epub 2020 Mar 26.

Department of Immunology, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.

The complement system may be activated in the posterior segment of the eye with chorioretinal disease, which may be reflected to the concentration of anaphylatoxins in the aqueous humor. Little is known about the distribution of anaphylatoxins in the aqueous and vitreous humor. The aim of the present study was to investigate the distribution of anaphylatoxin concentration in the aqueous and vitreous humor of the eyes with idiopathic epiretinal membrane or idiopathic macular hole. Read More

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Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment.

PLoS One 2019 31;14(12):e0227266. Epub 2019 Dec 31.

Ophthalmology Department, University Hospital Of Ioannina, Ioannina, Greece.

Purpose: To measure vitreous levels of Lipocalin2 (LCN2) in patients with rhegmatogenous retinal detachment (RRD) and investigate potential association with presence of proliferative vitreoretinopathy (PVR).

Materials And Methods: Collection of undiluted vitreous samples from 24 patients suffering from RRD and 10 control patients undergoing vitrectomy for: vitreomacular traction (VMT) (n = 2), idiopathic epiretinal membrane (iERM) (n = 6) and full thickness macular hole (FTMH) (n = 2). Quantitative analysis of LCN2 has been made with flow cytometry. Read More

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The Clinical Course of Patients with Idiopathic Epiretinal Membranes and Good Visual Acuity Managed Without Surgery.

Clin Ophthalmol 2019 12;13:2469-2475. Epub 2019 Dec 12.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, FL, USA.

Background/aims: To report the clinical course of patients with idiopathic epiretinal membranes (iERMs) and good baseline best-corrected visual acuity (BCVA) managed without surgical treatment.

Methods: Retrospective, observational case series of patients with iERMs and 20/50 or better BCVA who did not undergo surgery between January 2014 and December 2017 with a 1-year follow-up. Secondary epiretinal membranes were excluded. Read More

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December 2019

Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy.

Sci Rep 2019 12 13;9(1):19056. Epub 2019 Dec 13.

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

We evaluated predictive factors for visual outcomes in patients with idiopathic epiretinal membrane (iERM) after pars plana vitrectomy (PPV). Clinical records for 114 eyes (114 patients, mean age: 70.6 years) with iERM treated by PPV between March 2012 and March 2018 were retrospectively reviewed. Read More

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December 2019

Early retinal flow changes after vitreoretinal surgery in idiopathic epiretinal membrane using swept source optical coherence tomography angiography.

J Clin Med 2019 Nov 24;8(12). Epub 2019 Nov 24.

Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. d'Annunzio Chieti-Pescara, Chieti, 66100, Italy.

(1) Background: The aim of this observational cross-sectional work was to investigate early retinal vascular changes in patients undergoing idiopathic epiretinal membrane (iERM) surgery using swept source optical coherence tomography angiography (SS-OCTA); (2) Methods: 24 eyes of 24 patients who underwent vitrectomy with internal limiting membrane (ILM) peeling were evaluated pre- and postoperatively using SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). For each eye, five 6x6-mm OCTA volume scans were acquired by two observers independently. Read More

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November 2019

Changes in Metamorphopsia, Visual Acuity, and Central Macular Thickness after Epiretinal Membrane Surgery in Four Preoperative Stages Classified with OCT B-Scan Images.

J Ophthalmol 2019 17;2019:7931654. Epub 2019 Jun 17.

Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, China.

Purpose: To observe the changes in metamorphopsia, visual acuity, and central macular thickness (CMT) in patients undergoing vitrectomy for idiopathic epiretinal membranes (iERM); all of which were preoperatively stratified into 4 stages according to the anatomical structure of the macula seen on the optical coherence tomography (OCT) b-scan images.

Methods: A total of 108 eyes of 106 patients were included. We evaluated and classified the severity of each preoperative ERM based on OCT. Read More

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ALTERATIONS OF MACULAR BLOOD FLOW IN SUPERFICIAL AND DEEP CAPILLARY PLEXUSES IN THE FELLOW AND AFFECTED EYES OF PATIENTS WITH UNILATERAL IDIOPATHIC EPIRETINAL MEMBRANE.

Retina 2020 Aug;40(8):1540-1548

Surgical Retina Department, IRCCS - Fondazione Bietti, Rome, Italy.

Purpose: Previous research suggests that proliferation of the idiopathic epiretinal membrane (IERM) is related to microbreaks in the inner limiting membrane, which are caused by posterior vitreous detachment. In this study, we used optical coherence tomography angiography to determine whether a vascular defect in the inner retina is present before the mechanical damage caused by posterior vitreous detachment.

Methods: For patients with unilateral IERM (N = 23), optical coherence tomography angiography with blood flow measurement was performed in both eyes at the superficial capillary plexuses (SCP) and deep capillary plexuses (DCP) with 6 mm × 6-mm scans and ETDRS grids centered on the fixation point. Read More

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Proteomics reveals a set of highly enriched proteins in epiretinal membrane compared with inner limiting membrane.

Exp Eye Res 2019 09 11;186:107722. Epub 2019 Jul 11.

Department of Clinical Medicine, Aalborg University Hospital, Denmark; Department of Biomedicine, Aarhus University, Denmark.

Few data exist regarding the protein composition of idiopathic epiretinal membrane (iERM). In the present study we compared the proteome of epiretinal membrane of iERM with the proteome of the inner limiting membrane (ILM) of idiopathic macular hole (iMH). Twelve epiretinal membrane samples were obtained from patients with iERM undergoing therapeutic vitrectomy. Read More

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September 2019

The Role of Disorganization of Retinal Inner Layers as Predictive Factor of Postoperative Outcome in Patients with Epiretinal Membrane.

Ophthalmic Res 2020 23;63(1):13-17. Epub 2019 Apr 23.

2nd Department of Ophthalmology, University of Athens, Athens, Greece,

Purpose: The purpose of this retrospective study was to evaluate the disorganization of the retinal inner layers (DRIL) as a potential predictive factor of postoperative visual outcome in patients with idiopathic epiretinal membrane (iERM), treated with pars plana vitrectomy (PPV).

Methods: Participants in the study were 46 consecutive patients diagnosed with iERM, who underwent PPV. Best corrected visual acuity (BCVA) measurement and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline (preoperatively), and at months 3 and 6 postoperatively. Read More

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February 2020

Long-term natural history of idiopathic epiretinal membranes with good visual acuity.

Eye (Lond) 2019 05 19;33(5):714-723. Epub 2019 Apr 19.

Department of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.

Background/objectives: To evaluate the long-term progression of idiopathic epiretinal membranes (iERMs) with good baseline visual acuity, and to identify predictors of visual decline.

Design: Retrospective case series SUBJECTS METHODS: We reviewed records of 145 eyes with iERM and best-corrected visual acuity (BCVA) of 20/40 or greater at presentation, including BCVA, lens status, and central macular thickness (CMT) at yearly visits; as well as anatomic biomarkers including vitreomacular adhesion, pseudohole, lamellar hole, intraretinal cysts, disorganization of the inner retinal layers (DRIL), and disruption of outer retinal layers. Linear mixed effects and mixed-effects Cox proportional hazards models were used to identify clinical and anatomic predictors of vision change and time to surgery. Read More

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Surgical Outcomes of Idiopathic Macular Epiretinal Membrane Peeling.

J Coll Physicians Surg Pak 2019 Mar;29(3):245-248

Department of Ophthalmology, Al-Ibrahim Eye Hospital, Karachi, Pakistan.

Objective: To evaluate the surgical outcomes of idiopathic macular epiretinal membrane (IERM) peeling in terms of visual acuity and macular thickness.

Study Design: Observational cross-sectional study.

Place And Duration Of Study: Al-Ibrahim Eye Hospital, Karachi, from June 2017 to February 2018. Read More

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Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases.

Aging Cell 2018 Oct 2;17(5):e12809. Epub 2018 Jul 2.

Institute of Biotechnology and Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Aging is a phenomenon that is associated with profound medical implications. Idiopathic epiretinal membrane (iEMR) and macular hole (MH) are the major vision-threatening vitreoretinal diseases affecting millions of aging people globally, making these conditions an important public health issue. iERM is characterized by fibrous tissue developing on the surface of the macula, which leads to biomechanical and biochemical macular damage. Read More

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October 2018

Evaluation of TGF-Beta 2 and VEGF Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes.

J Ophthalmol 2018 23;2018:8293452. Epub 2018 Apr 23.

Department of Ophthalmology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.

Purpose: To evaluate the expression profiles of the VEGF and TGF in the ERMs and ILMs in retinal disorders.

Methods: In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. The samples of ERMs and ILMs collected during PPV were immediately put in TRIzol® Reagent (Life Technologies, USA) and stored at -70°C until RNA extraction. Read More

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