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Generation of a homozygous LRP2 knockout human embryonic stem cell line (FDCHDPe010-A-56) by CRISPR/Cas9 system.

Stem Cell Res 2021 Apr 8;53:102342. Epub 2021 Apr 8.

Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China. Electronic address:

LRP2 is mainly expressed in the cell membrane of epithelia, maintaining normal endocytosis of nutrients from the extracellular microenvironment and mediating growth factor signals. The deficiency of LRP2 can result in abnormal lysosomal and mitochondrial function as well as insufficient resistance to oxidative stress. LRP2-KO animals show enlarged eyes and malfunction of the retinal pigment epithelium (RPE). Read More

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Fluorescent and colorimetric dual-mode detection of tetracycline in wastewater based on heteroatoms-doped reduced state carbon dots.

Environ Pollut 2021 Apr 9;283:117109. Epub 2021 Apr 9.

College of Environment and Resources, Xiangtan University, Xiangtan, 411105, Hunan Province, China. Electronic address:

A large amount of tetracycline (TC) persists in water, soil, food, and feed due to the overuse of antibiotics, causing serious environmental problems such as damage to ecosystems and posing risks to human health. Thus, there is an urgent need to find a method to detect TC that is practical, rapid, sensitive, and offers ready visualization of TC levels so that adequate remediation measures can be immediately implemented. Herein, we report a fluorescent and colorimetric dual-mode nanosensor for the detection of TC based on reduced state carbon dots (r-CDs). Read More

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Opioid prescribing practices in academic otolaryngology: A single institutional survey.

Am J Otolaryngol 2021 Apr 15;42(5):103038. Epub 2021 Apr 15.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Objectives: Opioids are highly addictive medications and otolaryngologists have a responsibility to practice opioid stewardship. We investigated postoperative opioid prescribing patterns among resident and attending physicians as an educational platform to underscore the importance of conscientious opioid prescribing.

Methods: This quality improvement study was designed as a cross-sectional electronic survey. Read More

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Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration.

Exp Eye Res 2021 Apr 17:108583. Epub 2021 Apr 17.

Departments of Ophthalmology, USA; Ralph H. Johnson VA Medical Center, Division of Research, Charleston, SC, USA; Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Purpose: Age-related macular degeneration is a slowly progressing disease. Studies have tied disease risk to an overactive complement system. We have previously demonstrated that pathology in two mouse models, the choroidal neovascularization (CNV) model and the smoke-induced ocular pathology (SIOP) model, can be reduced by specifically inhibiting the alternative complement pathway (AP). Read More

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Protective effects of sunlight exposure against PRK-induced myopia in infant rhesus monkeys.

Ophthalmic Physiol Opt 2021 Apr 20. Epub 2021 Apr 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: Extensive clinical evidence suggests that time spent outdoors might reduce the risk of myopia. This study aimed to determine whether increasing sunlight exposure has a protective effect on hyperopic-defocus induced myopia in a non-human primate.

Methods: Twelve 2-month-old rhesus monkeys were treated monocularly with photorefractive keratectomy (PRK) (4. Read More

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Corneal thickness changes in myopic children during and after short-term orthokeratology lens wear.

Ophthalmic Physiol Opt 2021 Apr 20. Epub 2021 Apr 20.

Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.

Purpose: To evaluate thickness changes in the central and mid-peripheral cornea (CCT and mPCT), corneal epithelium (CET and mPET) and stroma (CST and mPST) of myopic children during and after short-term orthokeratology (ortho-k) lens wear, with conventional (CCF, 0.75 D) and increased compression factors (ICF, 1.75 D). Read More

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The effect of low light levels on postural stability in older adults with age-related macular degeneration.

Ophthalmic Physiol Opt 2021 Apr 20. Epub 2021 Apr 20.

Centre for Vision and Eye Research, School of Optometry & Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Purpose: To investigate the effect of low light levels on postural stability in older adults with and without age-related macular degeneration (AMD).

Methods: Participants included 28 older adults [14 with AMD (mean age ± S.D. Read More

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Cornea donation process and tissue quality for transplantation.

PLoS One 2021 20;16(4):e0249927. Epub 2021 Apr 20.

Nursing Department, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Introduction: The quality of the corneal tissue can be influenced by several factors inherent to the recipient, donor, and to the donation and transplantation process. The donated corneal tissue can be classified by its quality as excellent, good, regular, bad, or unacceptable for transplantation, evaluating it in a slit lamp.

Objective: To analyze the relationship between the clinical and sociodemographic variables of the donors and the donation process and the classification of the quality of the corneal tissue collected for transplantation. Read More

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Continuous Contact Lens Wear in Boston Type 1 Keratoprosthesis: Why Are We Still Debating?

Authors:
Maria S Cortina

Eye Contact Lens 2021 Apr 15. Epub 2021 Apr 15.

Department of Ophthalmology and Visual Sciences, University of Illinois Eye and Ear Infirmary, Chicago, IL.

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Bilateral Pseudomonas aeruginosa Keratitis in 7 Patients.

Eye Contact Lens 2021 Apr 16. Epub 2021 Apr 16.

Renaissance Stony Brook University School of Medicine (B.P.), Stony Brook, NY; Department of Ophthalmology (R.E., R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA; and The Charles T Campbell Ophthalmic Microbiology Laboratory (R.P.K., V.J.), University of Pittsburgh Medical Center, Pittsburgh, PA.

Purpose: To report 7 patients (14 eyes) with bilateral Pseudomonas aeruginosa keratitis (PAK).

Methods: Case records of patients with bilateral PAK were reviewed at a single academic medical center from April 2009 to December 2020.

Results: Seven patients aged 29 to 94 years presented with bilateral P. Read More

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The Effects of a Senofilcon A Contact Lens With and Without a Photochromic Additive on Positive Dysphotopsia Across Age.

Eye Contact Lens 2021 May;47(5):265-270

Department of Psychology (B.R.H.), Vision Sciences Laboratory, Behavioral and Brain Sciences Program, The University of Georgia, Athens, GA; Johnson and Johnson Vision Care, Inc (L.S.), Jacksonville, FL; and Department of Health Promotion and Behavior (L.R.-H.), Human Biofactors Laboratory, Institute of Gerontology, College of Public Health, The University of Georgia, Athens, GA.

Objective: The visual effects of wearing a photochromic contact lens (test) were directly compared with a nonphotochromic contact lens (control). Positive dysphotopsia (halos, starbursts) and intraocular scatter (behaviorally determined) were assessed. Both younger and middle-aged subjects were evaluated to examine the influence of age. Read More

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Continuous Contact Lens Wear in Boston Type 1 Keratoprosthesis: Why Are We Still Debating?

Authors:
Maria S Cortina

Eye Contact Lens 2021 May;47(5):233-234

Department of Ophthalmology and Visual Sciences, University of Illinois Eye and Ear Infirmary, Chicago, IL.

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Parents' attitudes towards school students' overuse of smartphones and its detrimental health impacts: A qualitative study.

JMIR Pediatr Parent 2021 Apr 20. Epub 2021 Apr 20.

Department of Immunology, Ministry of Health-Kuwait, Kuwait, KW.

Background: Parents' awareness of the risks of the overuse of smartphones (SPs) among their children and parents' attitudes towards this societal phenomenon are crucial factors to consider when investigating the causes and effects of, as well as interventions to control, this public health issue.

Objective: This study aimed to explore the awareness and attitudes of parents regarding SP overuse among their children and the detrimental impacts associated with it.

Methods: The qualitative method of semi-structured face-to-face interviews was used to collect data from fathers and mothers of children aged 6-18 years. Read More

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Quantification of Cover Test Prior and Post Pyridostigmine in Diagnosis of Myasthenia Gravis.

J Binocul Vis Ocul Motil 2021 Apr 20:1-6. Epub 2021 Apr 20.

Unit of Neurophthalmology, Consorci Parc de Salut MAR de Barcelona, Barcelona, Spain.

: To assess the value of measuring diplopia before and after pyridostigmine intake to differentiate myasthenia gravis from sagging eye syndrome.To establish a threshold for a positive response to pyridostigmine in the diagnosis of myasthenia gravis.: 15 patients with myasthenia gravis and 15 with sagging eye syndrome diplopia were evaluated. Read More

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Health-related quality of life in children at the diagnosis of Vernal Keratoconjunctivitis.

Pediatr Allergy Immunol 2021 Apr 20. Epub 2021 Apr 20.

Translational Specialized Pediatrics Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Background: Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, allergic condition mostly affecting children. Clinical evaluations may not necessarily reflect the impact of the disease on the patients' health-related quality of life (HRQoL). We aimed to evaluate HRQoL in children at VKC diagnosis and to analyze correlations between HRQoL and clinical and laboratory variables. Read More

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How Reliably Do Eye Parameters Indicate Internal Versus External Attentional Focus?

Cogn Sci 2021 Apr;45(4):e12977

Institute of Psychology, University of Graz.

Eye behavior is increasingly used as an indicator of internal versus external focus of attention both in research and application. However, available findings are partly inconsistent, which might be attributed to the different nature of the employed types of internal and external cognition tasks. The present study, therefore, investigated how consistently different eye parameters respond to internal versus external attentional focus across three task modalities: numerical, verbal, and visuo-spatial. Read More

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The mental health and wellbeing survey of Australian optometrists.

Ophthalmic Physiol Opt 2021 Apr 20. Epub 2021 Apr 20.

Centre of Vision and Eye Research, School of Optometry and Vision Science, Queensland University of Technology, Brisbane, Queensland, Australia.

Purpose: To investigate the prevalence of mental health conditions and burnout among practising optometrists in Australia.

Methods: A cross-sectional survey of registered practising Australian optometrists was undertaken over a three-week period from mid-November 2019. The survey comprised three well-established mental health scales (Kessler Psychological Distress Scale [K10], Depression Anxiety Stress Scales [DASS-21] and Maslach Burnout Inventory [MBI]) and an open-ended question inviting comments. Read More

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Anaphylactic reaction following administration of topical eyedrops.

CJEM 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, National University Health System, Singapore, Singapore.

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Material properties and effect of preconditioning of human sclera, optic nerve, and optic nerve sheath.

Biomech Model Mechanobiol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, CA, USA.

The optic nerve (ON) is a recently recognized tractional load on the eye during larger horizontal eye rotations. In order to understand the mechanical behavior of the eye during adduction, it is necessary to characterize material properties of the sclera, ON, and in particular its sheath. We performed tensile loading of specimens taken from fresh postmortem human eyes to characterize the range of variation in their biomechanical properties and determine the effect of preconditioning. Read More

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Correlation between intraocular pressure obtained with water drinking test versus modified diurnal tension curve measurement in pseudoexfoliation glaucoma.

Int Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, Malatya State Hospital, Malatya, Turkey.

Purpose: The aim of this paper was to study the correlation and agreement between the intraocular pressure (IOP) peak value and fluctuations detected with the modified diurnal tension curve (mDTC) and the water drinking test (WDT) in pseudoexfoliation glaucoma (XFG) patients.

Methods: This prospective observational study enrolled 42 eyes of 42 XFG patients. The IOPs were measured at 2-h intervals from 8 am to 4 pm with a Goldmann applanation tonometer by a single observer to establish the mDTC. Read More

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Long-term follow-up of a patient with JAG1-associated retinopathy.

Doc Ophthalmol 2021 Apr 20. Epub 2021 Apr 20.

Newcastle Eye Centre, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK.

Purpose: To report the long-term structural and functional changes in the posterior segments of an adult with an unusual retinal dystrophy caused by a novel mutation in JAG1.

Methods: A 33-year-old female underwent comprehensive ophthalmic examination, including best corrected visual acuity (BCVA) measurement, dilated fundus imaging (wide-angle fundus colour and short wavelength autofluorescence imaging), macular and peripheral spectral-domain optical coherence tomography (SD-OCT) and electroretinography (ERG) at baseline and 10 years later at the age of 43. The patient also underwent systemic review with detailed cardiac, brain and renal investigations. Read More

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Assessing the cone of economy in patients with spinal disease using only a force plate: an observational retrospective cohort study.

Eur Spine J 2021 Apr 20. Epub 2021 Apr 20.

Texas Back Institute, 6020 West Parker Road, Plano, TX, 75093, USA.

Study Design: This is a retrospective cohort with multiple regression modeling.

Objective: The aim is to develop a new method for estimating cone of economy (CoE) using a force plate rather than traditional motion capture.

Background: Currently, most spinal deformity surgeons rely on static radiographic parameters for alignment, balance, and outcomes data alongside patient-reported outcome measures. Read More

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A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development.

G3 (Bethesda) 2019 Jul;9(7):2061-2070

Department of Biology, Indiana University, 1001 East Third Street, Bloomington, IN 47405.

The metabolic enzymes that compose glycolysis, the citric acid cycle, and other pathways within central carbon metabolism have emerged as key regulators of animal development. These enzymes not only generate the energy and biosynthetic precursors required to support cell proliferation and differentiation, but also moonlight as regulators of transcription, translation, and signal transduction. Many of the genes associated with animal metabolism, however, have never been analyzed in a developmental context, thus highlighting how little is known about the intersection of metabolism and development. Read More

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LncRNA LPAL2/miR-1287-5p/EGFR axis modulates TED derived orbital fibroblast activation through cell adhesion factors.

J Clin Endocrinol Metab 2021 Apr 20. Epub 2021 Apr 20.

Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background And Aims: The activation of orbital fibroblasts, the prime targets in thyroid eye disease, is central to its underlying pathogenesis. We aimed to investigate the mechanism of thyroid eye disease orbital fibroblast activation from the perspective of non-coding RNA regulation.

Methods: Immunofluorescence (IF) staining was applied to evaluate the fibrotic changes in target cells. Read More

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Coadministration With Carbidopa Enhances the Antimyopic Effects of Levodopa in Chickens.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):25

Centre for Research in Therapeutic Solutions, Faculty of Science and Technology, University of Canberra, Canberra, Australia.

Purpose: Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this protection and compare the effectiveness of topical versus systemic administration. We also investigate the degree to which topical and systemic administration of these compounds alters retinal dopamine release and examine whether this is the mechanism by which they inhibit experimental myopia. Read More

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Posture-Dependent Collapse of the Optic Nerve Subarachnoid Space: A Combined MRI and Modeling Study.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):26

Department of Radiation Sciences, Umeå University, Umeå, Sweden.

Purpose: We hypothesize that a collapse of the optic nerve subarachnoid space (ONSAS) in the upright posture may protect the eyes from large translamina cribrosa pressure differences (TLCPD) believed to play a role in various optic nerve diseases (e.g., glaucoma). Read More

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Oculoplastic Abstracts.

Ophthalmic Plast Reconstr Surg 2020 Jul-Aug 01;36(4):429-430

Watany Eye Hospital, Cairo, Egypt.

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Aesthetic Abstracts.

Ophthalmic Plast Reconstr Surg 2020 Jul-Aug 01;36(4):426-428

Chief Oculofacial Surgery, Duke University Medical Center, Durham, North Carolina, U.S.A.

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… or 5-6-year-olds can identify the prosody of compounds but not lists.

J Child Lang 2021 Apr 20:1-13. Epub 2021 Apr 20.

Department of Linguistics and Centre for Language Sciences, Macquarie University, Australia.

Learning to use word versus phrase level prosody to identify compounds from lists is thought to be a protracted process, only acquired by 11 years (Vogel & Raimy, 2002). However, a recent study has shown that 5-year-olds can use prosodic cues other than stress for these two structures in production, at least for early-acquired noun-noun compounds (Yuen et al., 2021). Read More

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Optic Nerve Parameters and Cognitive Function in the Northern Finland Birth Cohort Eye Study.

Ophthalmic Epidemiol 2021 Apr 20:1-9. Epub 2021 Apr 20.

Department of Ophthalmology, PEDEGO Research Unit and Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Purpose: The optic nerve head (ONH) is a part of the brain that can be easily studied through the transparent medium of the eye. We explored the relationship between the properties of the optic nerve head, the retinal nerve fiber layer (RNFL) and cognitive function.

Methods: Participants of the Northern Finland Birth Cohort (NFBC) 1966 underwent an ophthalmic and cognitive assessment after randomization at age 46. Read More

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