25 results match your criteria extracts membranacea

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Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities.

Food Res Int 2017 09 3;99(Pt 1):485-494. Epub 2017 Jun 3.

Center for Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; Center for Neurosciences and Cell Biology, University of Coimbra, Azinhaga de Santa Comba, 3004-517 Coimbra, Portugal.

Urtica dioica and other less studied Urtica species (Urticaceae) are often used as a food ingredient. Fifteen hydroxycinnamic acid derivatives and sixteen flavonoids, flavone and flavonol-type glycosides were identified in hydroalcoholic extracts from aerial parts of Urtica dioica L., Urtica urens L. Read More

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September 2017

Effects of 5,6-Dihydroxy-2,4-Dimethoxy-9,10-Dihydrophenanthrene on G/M Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells.

Am J Chin Med 2016 25;44(7):1473-1490. Epub 2016 Oct 25.

§ Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University (Rangsit Campus), Klongluang, Thailand.

5,6-dihydroxy-2,4-dimethoxy-9,10-dihydrophenanthrene (HMP) is an active compound isolated from the rhizome extracts of Dioscorea membranacea Pierre, a Thai medicinal plant. This study aimed to investigate the growth-inhibitory and apoptosis-inducing effects of HMP in human lung cancer A549 cells. The antiproliferative and cytotoxic effects of HMP were analyzed by a Sulforhodamine B assay. Read More

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January 2017

Evaluation of the Genotoxicity and Cytotoxicity of Semipurified Fractions from the Mediterranean Brown Algae, .

Pharmacogn Mag 2016 Jul;12(Suppl 4):S395-S399

Toxicology Unit, O.D. Food, Medicines and Consumer Safety, Scientific Institute of Public Health, J. Wytsmanstraat 14, B-1050 Brussels, Belgium; Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium.

, a species of Mediterranean brown algae, is believed to have potential pharmacological and nutritional applications. However, such potentials only make sense when devoid of any adverse health consequences. The present study should be seen in this context. Read More

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Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.

Phytother Res 2015 Dec 22;29(12):1926-33. Epub 2015 Oct 22.

Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, 12121, Thailand.

Malaria and cholangiocarcinoma remain important public health problems in tropical countries including Southeast Asian nations. Newly developed chemotherapeutic and plant-derived drugs are urgently required for the control of both diseases. The aim of the present study was to investigate the propensity to inhibit cytochrome P450-mediated hepatic metabolism (CYP1A2, CYP2C19, CYP2D6 and CYP3A4) of the crude ethanolic extract of eight Thai medicinal plants with promising activities against malaria and cholangiocarcinoma, using human liver microsomes in vitro. Read More

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December 2015

Evaluating medicinal plants for anticancer activity.

ScientificWorldJournal 2014 13;2014:721402. Epub 2014 Nov 13.

Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada (IMRIC), Hebrew University Hadassah Medical School, 91120 Jerusalem, Israel.

Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Our hypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple molecules with antitumor activities that could be very effective in killing human cancer cells. Read More

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[[Anti-leishmanial activity in plants from a Biological Reserve of Costa Rica].

Rev Biol Trop 2014 Sep;62(3):1229-40

Leishmaniosis is an important human disease very difficult to treat. For this reason, many researchers in the world have been look- ing for anti-leishmanial chemical components present in several plant species. In Costa Rica, since no studies have been done in this field, this work aimed at the search of active chemical components in local plants that may have an activity against Leishmania sp. Read More

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September 2014

Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells.

BMC Complement Altern Med 2014 Oct 24;14:413. Epub 2014 Oct 24.

Division of Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Khlong Luang, Pathum Thani 12120, Thailand.

Background: Dioscoreanone (DN) isolated from Dioscorea membranacea Pierre has been reported to exert potent cytotoxic effects against particular types of cancer. The present study was carried out to investigate the cytotoxicity of DN against a panel of different human lung cancer cell lines. The study further examined the underlying mechanisms of its anticancer activity in the human lung adenocarcinoma cell line A549. Read More

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October 2014

Immunomodulatory activity of Dioscorea membranacea Pierre rhizomes and of its main active constituent Dioscorealide B.

BMC Complement Altern Med 2014 Oct 16;14:403. Epub 2014 Oct 16.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.

Background: The rhizomes of Dioscorea membranacea Pierre, also called Hua-Khao-Yen by Thai name, are used as ingredients in many Thai traditional medicines for the alternative or complementary treatment of cancer and AIDs. Preliminary in vitro studies have indicated that D. membranacea extracts exhibited high cytotoxic activity with several cancer cell lines, but the underlining mechanisms are far from clear. Read More

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October 2014

Water soluble polysaccharides extracted from Pterocladia capillacea and Dictyopteris membranacea and their biological activities.

Carbohydr Polym 2014 Nov 7;113:62-6. Epub 2014 Jul 7.

Pharmacognosy Department, National Research Centre, Dokki, Cairo 12311, Egypt.

Cold and hot water extracts (CWE, HWE) of both the red alga Pterocladia capillacea (P. capillacea) and the brown alga Dictyopteris membranacea (D. membranacea) were studied for their polysaccharide contents. Read More

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November 2014

Isolation and characterization of a new cytotoxic dihydrophenanthrene from Dioscorea membranacea rhizomes and its activity against five human cancer cell lines.

J Ethnopharmacol 2014 Oct 20;156:130-4. Epub 2014 Aug 20.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12120, Thailand; Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani 12120, Thailand.

Ethnopharmacological Relevance: The rhizomes of Dioscorea membranacea Pierre (DM) have been used as ingredients in anticancer herbal formulations in Thai traditional medicine (TTM). Thus, the aim of this study was to investigate the active constituents of DM for cytotoxic activity in order to support its TTM use.

Materials And Methods: A bioassay-guided isolation procedure was used to separate the cytotoxic constituents from ethanolic extract of Dioscorea membranacea rhizomes by testing against five human cancer cell lines, i. Read More

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October 2014

In vitro antimalarial activity of extracts of some plants from a biological reserve in Costa Rica.

Rev Biol Trop 2012 Jun;60(2):881-91

Laboratorio de Investigación Universidad de Ciencias Medicas "Dr. Andrds Vesalio Guzmin" (UCIMED), San JosC, Costa Rica, Amdrica Central.

Treatment with the usual antimalarial drugs, have induced parasite resistance, reinforcing the need to finding natural antimalarial components that would be found on plants from the forest. Therefore, we decided to look for these components in Costa Rican plants from a protected forest area. Fresh and dry extracts of roots, bark, leaves, flowers and fruits of 25 plants from a biological reserve in Costa Rica, Reserva Biol6gica Alberto Manuel Brenes (REBAMB), were studied in vitro for the presence of substances with antimalarial activity. Read More

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Antiplasmodial potential of extracts from two species of genus Blumea.

Pharm Biol 2013 Oct 14;51(10):1326-30. Epub 2013 Jun 14.

Medicinal Chemistry Department, Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, India.

Context: A number of Blumea (Asteraceae) species are being used in traditional Chinese and Indian folklore medicines to cure various diseases including cancer, fungal and bacterial infections.

Objective: To evaluate the in vitro antiplasmodial potential and cytotoxicity of various extracts and fractions of B. membranacea DC and B. Read More

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October 2013

Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine.

Parasitol Res 2013 Apr 23;112(4):1475-81. Epub 2013 Jan 23.

Thailand Center of Excellence in Drug Discovery and Development (TCEDDD), Thammasat University, Rangsit Campus, Rangsit, Pathumtani, 12121, Thailand.

Malaria is one of the world's leading killer infectious diseases with high incidence and morbidity. The problem of multidrug-resistant Plasmodium falciparum has been aggravating particularly in Southeast Asia. Therefore, development of new potential antimalarial drugs is urgently required. Read More

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Cytotoxic effect and its mechanism of dioscorealide B from Dioscorea membranacea against breast cancer cells.

J Med Assoc Thai 2010 Dec;93 Suppl 7:S277-82

Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background: Dioscorealide B is an active compound from the rhizome of Dioscorea membranacea Pierre which locally known as "Hua-Khao-Yen". This medicinal plant has long been used in the anticancer prescription of Thai traditional medicine.

Objective: To examine the cytotoxic effect and mechanism of Dioscorealide B in human breast carcinoma cells. Read More

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December 2010

The effect of epibionts on the susceptibility of the red seaweed Cryptonemia seminervis to herbivory and fouling.

Biofouling 2008 ;24(3):209-18

Programa de Pós-Graduação em Biologia Marinha, Universidade Federal Fluminense, Niteroi, Brasil.

Epibiosis or fouling on living organisms can have direct and indirect detrimental effects, in particular on photosynthetic organisms such as seaweeds. It thus seems reasonable to hypothesize that macroalgae have been selected for the presence or induction of antifouling (AF) defences. The red seaweed Cryptonemia seminervis is usually found in nature with an elevated cover of epibionts. Read More

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The ingestion of a Nectandra membranacea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs.

Biol Res 2007 21;40(2):131-5. Epub 2007 Nov 21.

Programa de Pós-Graduacáo em Ciencias Médicas, Universidade Federal Fluminense, Niterói, RJ, Brazil.

The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranacea extract on the bioavailability of the sodium pertechnetate (Na(99m)TcO(4)) radiobiocomplex in rat organs. The animals were treated with a N. Read More

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Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea.

J Ethnopharmacol 2007 Feb 15;109(3):412-6. Epub 2006 Aug 15.

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

Thai medicinal plants locally known as Hua-Khao-Yen were examined for their inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW 264.7 cell lines. Among the plant species studied, an ethanolic extract of Dioscorea membranacea exhibited the most potent inhibitory activity, with an IC(50) value of 23. Read More

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February 2007

Anti-allergic substances from the rhizomes of Dioscorea membranacea.

Bioorg Med Chem 2006 Dec 30;14(24):8707-11. Epub 2006 Aug 30.

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

Extracts of five species of Thai medicinal plants, locally known as Hua-Khao-Yen, were screened for anti-allergic activities using RBL-2H3 cells. Of the five species studied, the ethanolic extract of Dioscorea membranacea exhibited potent inhibitory activity against beta-hexosaminidase release as a marker of degranulation in RBL-2H3 cells, with an IC(50) value of 37.5microg/mL. Read More

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December 2006

Anti-HIV-1 protease- and HIV-1 integrase activities of Thai medicinal plants known as Hua-Khao-Yen.

J Ethnopharmacol 2006 Apr 6;105(1-2):312-5. Epub 2006 Jan 6.

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

Ethanolic- and water extracts from five species of Thai medicinal plants known as Hua-Khao-Yen were tested for their inhibitory effects against HIV-1 protease (HIV-PR) and HIV-1 integrase (HIV-1 IN). The result revealed that the ethanolic (EtOH) extract of Smilax corbularia exhibited anti-HIV-1 IN activity with an IC50 value of 1.9 microg/ml, followed by the water extract of Dioscorea birmanica (IC50 = 4. Read More

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In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer.

J Ethnopharmacol 2004 Jan;90(1):33-8

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Science, Prince of Songkhla University, Hat-Yai, Songkhla 90110, Thailand.

The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of 11 Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. Read More

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January 2004

Antitumor and antiviral activity of Colombian medicinal plant extracts.

Mem Inst Oswaldo Cruz 1999 Jul-Aug;94(4):531-5

Laboratorio de Virología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type 2 (HSV-2). Read More

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December 1999

GENETIC VARIATION AND POLYMORPHISM IN THE INDUCIBLE SPINES OF A MARINE BRYOZOAN.

Authors:
C Drew Harvell

Evolution 1998 Feb;52(1):80-86

Section of Ecology and Systematics, Division of Life Sciences, Cornell University, Ithaca, New York, 14853.

Of particular value in understanding the evolution of genotypes with broad phenotypic ranges (phenotypic plasticity) are the few examples of organisms with adaptive plasticity, such as those that develop a defensive morphology in response to cues from predators. We know little about the heritability of inducible defensive characters or the range of phenotypes available for selection to act on in the field. Membranipora membranacea is a colonial marine bryozoan that produces spines within two days of exposure to waterborne predator extracts. Read More

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February 1998

Differentiation of Candida guilliermondii varieties by lectin-like substances from marine algae.

Res Microbiol 1989 Jul-Aug;140(6):373-8

Departamento de Microbiología y Parasitología, Universidad de Santiago, Spain.

Lectin-like substances of 54 marine algae, corresponding to 30 red algae and 24 brown algae, were studied to estimate the agglutination activity against Candida guilliermondii. Extracts of Dictyopteris membranacea, Bifurcaria bifurcata, Halidrys siliquosa, Ascophyllum nodosum, Fucus serratus and F. spiralis algae showed selective agglutinating activities for C. Read More

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Algae as possible sources of antitumoural agents. Preliminary evaluation of the "in vitro" cytostatic activity of crude extracts.

Pharmacol Res Commun 1988 Dec;20 Suppl 5:27-31

Department of Biology, University of Trieste, Italy.

Aqueous, ethanolic and chloroformic extracts of 13 algae from the Gulf of Trieste (North Adriatic Sea) were assayed in vitro against human tumour established cell line (KB). Some of them exhibit a noteworthy cytostatic activity, in particular Dictyopteris membranacea (Stackh.) Batt. Read More

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December 1988

Some pharmacological actions of the essential oil of Blumea membranacea.

Indian J Physiol Pharmacol 1986 Apr-Jun;30(2):149-54

The essential oil obtained from the plant Blumea membranacea produced a marked and long lasting fall in blood pressure in anaesthetized dogs. The oil exerted a direct depressant action on frog heart and spasmolytic effect on rabbit ileum. It also depressed the conditioned avoidance response, adversely affected rotarod performance and potentiated the pentobarbitone induced hypnosis in rats. Read More

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